Filtering device and filtering system for intravenous injection of human immune globulin (pH4)

Abstract

The utility model provides a filtering device and a filtering system for intravenous injection human immune globulin (pH4), the filtering device comprises at least two groups of filtering assemblies, each group of filtering assembly comprises a prefilter, the inlet end of the prefilter is connected with the liquid outlet end of a containing part so as to perform primary filtering on the intravenous injection human immune globulin (pH4) to be subjected to virus removal, and the outlet end of the prefilter is connected with the liquid outlet end of the containing part; a primary filtering product is obtained; the inlet end of the nano filter is communicated with the outlet end of the pre-filter so as to filter the primary filtration product, so that the intravenous injection human immune globulin (pH 4) after virus removal is obtained; and the conversion component is arranged between the liquid outlet end of the accommodating component and the prefilter, so that when one group of filtering components is blocked, the conversion component is switched to the other group of filtering components, and the problem that the production efficiency is reduced due to blockage when the filtering device is used for filtering in the prior art is solved.

Description

Technical Field

[0001] This utility model relates to the field of plasma processing technology, and more specifically, to a filtration device and filtration system for intravenous injection of human immunoglobulin (pH4). Background Technology

[0002] Intravenous immunoglobulin (pH4), an important plasma protein product, is derived from the plasma of healthy individuals and refined using advanced separation and purification techniques. Its core function is to supplement or replace the deficiency of immunoglobulins in patients, making it irreplaceable in the treatment of immunodeficiency diseases, certain infections, and inflammatory conditions. Traditionally, nanofiltration technology, with its superior virus removal capabilities, has played a central role in the production process of intravenous immunoglobulin (pH4). Filter membranes with a 20nm pore size are widely used to ensure effective virus interception while maximizing the preservation of the bioactivity and functionality of intravenous immunoglobulin (pH4).

[0003] However, in actual production, small amounts of large-molecule immunoglobulins (IgM) and unavoidable protein aggregates during the production process can become stumbling blocks in the nanofiltration process. These large molecules, whose sizes exceed the effective filtration range of a 20nm pore size membrane, not only reduce filtration efficiency but also cause a significant decrease in filter cartridge throughput, and even lead to serious problems such as filter cartridge clogging. Once the filter cartridge is clogged, it not only affects the production schedule but also prevents the effective components of intravenous immunoglobulin (pH4) from passing through smoothly, thus affecting the quality and yield of the final product. Utility Model Content

[0004] The main objective of this invention is to provide a filtration device and system for intravenous administration of human immunoglobulin (pH4) to solve the problem of reduced production efficiency caused by clogging during filtration in existing filtration devices.

[0005] To achieve the above objectives, according to one aspect of the present invention, a filtration device for intravenous administration of human immunoglobulin (pH4) is provided, the filtration device comprising:

[0006] The receiving component has a receiving cavity for receiving intravenous human immunoglobulin (pH4) to be devirulently administered;

[0007] At least two sets of filter components, each set of filter components including:

[0008] The pre-filter is connected to the outlet of the container to perform a primary filtration of the intravenous immunoglobulin (pH4) to be devirulentized, thereby obtaining a primary filtration product.

[0009] The nanofilter has its inlet end connected to the outlet end of the pre-filter to filter the primary filtration product and obtain intravenous immunoglobulin (pH4) after virus removal.

[0010] The conversion unit is located between the liquid outlet of the receiving unit and the pre-filter to switch to another set of filter components when one set of filter components becomes clogged.

[0011] Furthermore, the filtration device also includes:

[0012] The straight-through pipeline has one end connected to the pipeline between the conversion unit and the pre-filter, and the other end connected to the pipeline between the pre-filter and the nano-filter.

[0013] Furthermore, the straight-through conduit also includes:

[0014] The first on / off valve is located at the end of the straight-through pipeline near the pre-filter;

[0015] The second on / off valve is located at the end of the straight-through pipeline near the nanofilter.

[0016] Furthermore, the straight-through conduit is a purging conduit; and / or,

[0017] The diameter of the purging pipe is 34mm to 35mm.

[0018] Furthermore, the filtering component includes:

[0019] The first pressure gauge is located on the pipeline between the housing component and the pre-filter;

[0020] The second pressure sensor is located on the pipeline between the pre-filter and the nanofilter;

[0021] The first pressure detector and the second pressure detector are respectively connected to the conversion component to control the conversion component to switch between at least two sets of filter components based on the detection results of the first pressure detector and the second pressure detector, so that the receiving component is connected to one of the sets of filter components.

[0022] Furthermore, the filtration device also includes:

[0023] First insulation component;

[0024] The first insulation component is located on the pipeline between the housing component and the pre-filter; and / or,

[0025] The first insulation component is located on the pipeline between the pre-filter and the nano-filter.

[0026] Furthermore, the filtration device also includes:

[0027] The receiving tank is used to connect to the liquid outlet of the nanofilter;

[0028] The receiving tank includes a receiving tank body and a receiving tank shell surrounding the receiving tank body. A temperature-controlled component is provided between the receiving tank body and the receiving tank shell.

[0029] The filtration device also includes a first insulation component on the pipeline between the nanofilter and the receiving tank.

[0030] Furthermore, the filtration device also includes:

[0031] The weight detection component is located inside the receiving tank to detect the real-time weight of the intravenous human immunoglobulin (pH4) inside the receiving tank.

[0032] An alarm component is connected to a weight detection component to issue an alarm warning when the real-time weight does not change within a set time.

[0033] Furthermore, the conversion component is an electronic control valve. The inlet of the electronic control valve is connected to the liquid outlet of the receiving component. The electronic control valve has multiple outlets, each of which is respectively set and connected to one of the filter components.

[0034] According to another aspect of the present invention, a filtration system is provided, which includes the filtration device described above.

[0035] Applying the technical solution of this utility model, during use, the intravenous immunoglobulin (pH4) to be deviralized enters from the outlet end of the receiving component and passes through the conversion component into the pre-filter. The pre-filter performs a primary filtration of the intravenous immunoglobulin (pH4) to be deviralized to remove large particles and obtain a primary filtration product. This primary filtration product is then transported to a nanofilter for deviral filtration, resulting in deviral-free intravenous immunoglobulin (pH4). If one set of filter components becomes clogged, the conversion component can be used to switch to another set of filter components to continue filtering the intravenous immunoglobulin (pH4) to be deviralized, ensuring the normal operation of the entire production process. Attached Figure Description

[0036] The accompanying drawings, which form part of this application, are used to provide a further understanding of the present invention. The illustrative embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an undue limitation of the present invention. In the drawings:

[0037] Figure 1 A schematic diagram of the structure of a filtering device according to an embodiment of this application is shown.

[0038] The above figures include the following reference numerals:

[0039] 1. Housing component; 2. Pre-filter; 201. Pre-filter control valve; 3. Nanofilter; 301. Nanofilter control valve; 4. Straight-through pipeline; 401. First on / off valve; 402. Second on / off valve; 5. First pressure sensor; 6. Second pressure sensor; 7. Receiving tank; 701. Receiving tank body; 702. Receiving tank shell. Detailed Implementation

[0040] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0041] Therefore, the technical objective of this application is to provide a filtration device and filtration system for intravenous administration of human immunoglobulin (pH4) to address the above-mentioned problems.

[0042] First, this application provides a filtration device for intravenous administration of human immunoglobulin (pH4), comprising:

[0043] The receiving component 1 has a receiving cavity for receiving intravenous human immunoglobulin (pH4) to be devirulently administered;

[0044] At least two sets of filter components, each set of filter components including:

[0045] Pre-filter 2, the inlet end of which is connected to the outlet end of the receiving component 1, is used to perform a primary filtration of the intravenous human immunoglobulin (pH4) to be devirulentized, to obtain a primary filtration product.

[0046] At least one nanofilter 3, the inlet end of which is connected to the outlet end of the prefilter 2, is used to filter the primary filtration product to obtain intravenous human immunoglobulin (pH4) after virus removal.

[0047] A switching component is located between the liquid outlet of the receiving component 1 and the pre-filter 2, so as to switch to another set of filter components when one set of filter components becomes clogged.

[0048] Specifically, such as Figure 1As shown, this utility model provides a filtration device for intravenous immunoglobulin (pH4), designed to improve virus removal efficiency and operational flexibility during the production process of intravenous immunoglobulin (pH4). The specific implementation is as follows: The filtration device of this application includes a receiving component 1, which is designed to hold the intravenous immunoglobulin (pH4) to be processed. It is a container with sufficient volume to ensure that the intravenous immunoglobulin (pH4) can pass uniformly through subsequent filtration components. The receiving component 1 is an incubation tank, typically made of biocompatible materials to prevent reaction with the immunoglobulin; this is prior art and will not be described further. The filtration device also includes at least two sets of filtration components, each set including a pre-filter 2 and a nanofilter 3, as well as a pre-filter control valve 201 corresponding to the pre-filter 2 and a nanofilter corresponding to the nanofilter 3. The control valve 301 is used for the filter assembly. It's important to note that each filter assembly may include a pre-filter 2 and a nanofilter 3, or a pre-filter 2 and two nanofilters 3. In special cases, a pre-filter may be connected to N nanofilters 3. There is no limit to the number of nanofilters 3 connected to the pre-filter 2. The purpose of the pre-filter 2 is to remove large molecular weight immunoglobulin M (IgM) and protein aggregates to protect the nanofilters 3 from clogging and ensure their virus removal efficiency. The nanofilters 3 have a pore size of 20 nm and are specifically designed to intercept and remove viruses while allowing intravenous immunoglobulin (pH 4) to pass through. A switching component is located between the outlet end of the receiving component 1 and the pre-filter 2. Its function is to automatically or manually switch to another filter assembly when signs of clogging appear in one set of filter assemblies (pre-filter 2 or nanofilter 3), ensuring the continuity and stability of the filtration process.

[0049] Operating procedure: The intravenous immunoglobulin (pH4) to be deviralized is stored in the receiving component 1. The intravenous immunoglobulin (pH4) to be deviralized is initially filtered through the pre-filter 2, where large molecular impurities are effectively retained, reducing the impact on the nanofilter 3. The pre-filtered product enters the nanofilter 3 for further virus removal, resulting in the deviral intravenous immunoglobulin (pH4).

[0050] The combined use of pre-filter 2 and nanofilter 3 significantly improves the virus removal efficiency of intravenous immunoglobulin (pH4), ensuring the product's viral safety. Opening the pre-filter control valve 201 allows pre-filter 2 to remove large molecular impurities, thereby reducing the risk of clogging of nanofilter 3, extending its lifespan, and minimizing production interruptions. The conversion unit allows for rapid switching to another set of filters when clogging occurs, ensuring production continuity and reducing downtime.

[0051] Furthermore, the filtration device also includes: a straight pipe 4, one end of which is connected to the pipe between the conversion component and the pre-filter 2, and the other end of which is connected to the pipe between the pre-filter 2 and the nano-filter 3.

[0052] Specifically, the filtration device also includes a straight-through pipe 4. Since neither the pre-filter 2 nor the nanofilter 3 can allow airflow, when the straight-through pipe is working, the airflow will enter the pipe connected to the inlet of the nanofilter 3 and blow the liquid in the pipe connected to the inlet of the nanofilter 3 into the nanofilter 3 to increase the yield of intravenous immunoglobulin (pH4).

[0053] The straight-through conduit 4 in this application avoids liquid residue in the corresponding conduit by introducing gas (such as compressed air) into the conduit connected to the inlet of the pre-filter 2 and the nanofilter 3.

[0054] Furthermore, the straight-through pipeline 4 also includes: a first on / off valve 401, located at one end of the straight-through pipeline 4 near the pre-filter 2;

[0055] The second on / off valve 402 is located at one end of the straight-through pipeline 4 near the nanofilter 3.

[0056] Specifically, when both the first on / off valve 401 and the second on / off valve 402 are closed, intravenous immunoglobulin (pH4) before or after pre-filtration by the pre-filter 2 can be prevented from flowing into the straight-through pipeline 4, ensuring that the straight-through pipeline 4 is in a clean state and avoiding contamination before use. In addition, the simultaneous presence of the first on / off valve 401 and the second on / off valve 402 ensures that gas can enter the pipeline connected to the pre-filter 2 and the nanofilter 3 when the straight-through pipeline 4 is in operation, avoiding the problem of excessive liquid residue in the pre-filter 2 and the pipeline connected to the nanofilter 3.

[0057] Furthermore, the receiving component 1 includes a receiving body and a receiving shell sleeved around the receiving body, and a second heat-insulating component is provided between the receiving body and the receiving shell.

[0058] Specifically, the presence of the second heat-insulating component ensures that the interior of the containing component 1 is always within the set temperature range, thus preventing any physical or chemical changes in the intravenous immunoglobulin (pH4) within the containing component 1.

[0059] Furthermore, the straight-through pipe 4 is a purging pipe; and / or, the diameter of the purging pipe is 34mm to 35mm.

[0060] Specifically, the design of the purging pipe diameter directly affects the flow rate and pressure distribution of the purging airflow. In this embodiment, the pipe diameter reduces the resistance of the airflow in the pipe, allowing a larger airflow to pass through quickly, thereby more effectively removing liquid residues from the pre-filter 2 and nano-filter 3, improving the efficiency and effect of purging. A larger pipe diameter reduces the resistance of gas flow, which means that a smaller pressure or a shorter time can be used to achieve the same purging effect, thereby reducing energy consumption during the purging process. Through more efficient purging, the pre-filter 2 and nano-filter 3 can maintain a high-efficiency filtration state for a longer period of time, thereby reducing the frequency of cleaning or replacing the pre-filter 2 and nano-filter 3, improving the efficiency and production capacity of the equipment. At the same time, the optimization of the pipe diameter can improve gas distribution, ensure uniform pressure distribution throughout the purging process, avoid damage to the filters caused by local overpressure, and improve the overall stability and reliability of the system.

[0061] Furthermore, the filtering component includes:

[0062] The first pressure detector 5 is located on the pipeline between the housing component 1 and the pre-filter 2;

[0063] The second pressure detector 6 is located on the pipeline between the pre-filter 2 and the nanofilter 3;

[0064] The first pressure detector 5 and the second pressure detector 6 are respectively connected to the conversion component, so as to control the conversion component to switch between at least two sets of filter components according to the detection results of the first pressure detector 5 and the second pressure detector 6, so that the receiving component 1 is connected to one of the filter components.

[0065] Specifically, integrating a first pressure sensor 5 and a second pressure sensor 6 into the filter assembly and connecting them to the conversion component enables dynamic system management and optimization. The specific benefits include:

[0066] Real-time pressure monitoring: The first pressure sensor 5 and the second pressure sensor 6 can monitor the pressure at different stages in the filtration assembly in real time, including the initial pressure of the unfiltered liquid before entering the pre-filter 2, and the pressure after passing through the pre-filter 2. This real-time monitoring capability helps to detect filter blockage or performance degradation in a timely manner, ensuring that the system operates in optimal condition.

[0067] Automatic Filter Switching: Through connection with the conversion unit, the system can automatically switch to another set of filter components based on the detection results of various pressure gauges. When the pressure of a set of filter components rises above a preset threshold, it indicates that the pre-filter 2 or nano-filter 3 in that set may be clogged. Therefore, the system automatically switches to the backup filter component, preventing excessive system pressure or liquid processing interruption due to clogging, thus improving the system's continuous operation capability and stability. When the filter begins to show signs of clogging, the system can promptly switch to a clean filter component, maintaining the high permeability and filtration efficiency of the pre-filter 2 or nano-filter 3, ensuring that the quality of the treated liquid is not affected. Real-time pressure monitoring and the automatic switching mechanism can promptly address abnormal situations such as filter clogging, avoiding safety hazards caused by abnormal system pressure, such as pipe rupture or equipment damage, thus enhancing the safety and reliability of the entire filtration system.

[0068] In summary, by integrating the first pressure detector 5 and the second pressure detector 6 into the filter assembly and connecting them with the conversion component, intelligent management and optimization of the filtration system can be achieved. This not only improves filtration efficiency and resource utilization but also enhances the system's safety, stability, and automation level. It has significant practical value for industrial applications requiring continuous operation and high-purity liquid processing, such as lithium battery electrolyte preparation and cell culture medium purification in biopharmaceuticals.

[0069] Furthermore, the filtration device also includes: a first heat-insulating component;

[0070] The first insulation component is located on the pipeline between the receiving component 1 and the pre-filter 2; and / or,

[0071] The first insulation component is located on the pipeline between the pre-filter 2 and the nano-filter 3.

[0072] Specifically, the first insulation component ensures that the fluid temperature remains stable as it flows from the receiving component 1 to the pre-filter 2, or from the pre-filter 2 to the nanofilter 3. This is particularly important for processing temperature-sensitive fluids (such as biological agents, chemical solutions, etc.), as temperature fluctuations can affect the physical and chemical properties of the fluid, leading to reduced filtration efficiency or product deterioration. In this embodiment, the first insulation component is insulation cotton, which can be attached to the corresponding pipeline.

[0073] Furthermore, the filtration device also includes:

[0074] The receiving tank 7 is used to connect with the liquid outlet of the nanofilter 3;

[0075] The receiving tank 7 includes a receiving tank body 701 and a receiving tank shell 702 sleeved around the receiving tank body 701. A temperature control component is provided between the receiving tank body 701 and the receiving tank shell 702.

[0076] The filtration device also includes a first insulation component on the pipeline between the nanofilter 3 and the receiving tank 7.

[0077] Specifically, in the design of the receiving tank 7, by setting a receiving tank shell 702 around the receiving tank body 701 and configuring a temperature-controlled component between the two, the following beneficial effects can be achieved:

[0078] The thermostatic component precisely controls the temperature inside the receiving tank 7. By maintaining a stable temperature within the receiving tank 7, the physical and chemical properties of the intravenous immunoglobulin (pH4) to be deviralized remain unchanged throughout the filtration process. This facilitates subsequent processing or storage, preventing issues such as material coagulation, crystallization, or decreased activity caused by temperature variations. By effectively maintaining the internal temperature of the receiving tank 7, the thermostatic component reduces reliance on heating or cooling equipment, thereby lowering the overall system's energy consumption and improving energy efficiency. This energy-saving effect is particularly significant in long-running industrial processes; it also ensures that the fluid temperature remains constant as it flows from the nanofilter 3 to the receiving tank 7.

[0079] Furthermore, the filtration device also includes a weight detection component, which is located inside the receiving tank body 701 to detect the real-time weight of the intravenous human immunoglobulin (pH4) white in the receiving tank body 701.

[0080] An alarm component is connected to a weight detection component to issue an alarm warning when the real-time weight does not change within a set time.

[0081] Specifically, adding a weight detection component and an alarm component to the filtration device, mainly for real-time monitoring and abnormal alarm of the weight of intravenous immunoglobulin (pH4) in the receiving tank body 701, can bring the following beneficial effects:

[0082] The weight detection component can monitor the weight inside the receiving tank 7 in real time. By monitoring weight changes, abnormalities in the filtration process can be detected promptly, such as filter blockage or pump failure, thereby ensuring the continuity and stability of the filtration operation and avoiding production interruptions. The automation of the weight detection and alarm system reduces the need for continuous manual monitoring, lowers the workload of operators, reduces the possibility of human error, and improves operational accuracy and reliability. The alarm component can issue timely warnings when the weight is abnormal, reminding operators to take measures and avoiding potential dangers caused by prolonged unchanged weight, such as pressure buildup or container rupture, thus enhancing the overall safety performance of the equipment.

[0083] Furthermore, the conversion component is an electronic control valve. The inlet of the electronic control valve is connected to the liquid outlet of the receiving component 1. The electronic control valve has multiple outlets, each of which is respectively set and connected to one of the filter components.

[0084] Specifically, the electronic control valve can quickly and accurately switch between multiple filter components. When one of the filter components needs maintenance or experiences clogging, contamination, or other abnormalities, the system can automatically or manually control the electronic control valve to switch to the backup filter component, ensuring the continuity and stability of the filtration operation.

[0085] The filtration system includes any of the filtration devices described above.

[0086] Specifically, this application also provides a filtration system, which includes the control system described in the above embodiments. The entire filtration system includes a filtration device, which is the filtration device described in the above embodiments.

[0087] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the exemplary embodiments according to this application. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0088] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps described in these embodiments do not limit the scope of this invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following drawings denote similar items; therefore, once an item is defined in one drawing, it need not be further discussed in subsequent drawings.

[0089] In the description of this utility model, it should be understood that the directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this utility model. The directional terms "inner" and "outer" refer to the inner and outer contours of each component itself.

[0090] For ease of description, spatial relative terms such as "above," "on top of," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation beyond the orientation of the device as described in the figures. For example, if the device in the figures were inverted, a device described as "above" or "on top of" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0091] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore cannot be construed as limiting the scope of protection of this utility model.

[0092] The above description is merely a preferred embodiment of this utility model and is not intended to limit the utility model. Various modifications and variations can be made to this utility model by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this utility model should be included within the protection scope of this utility model.

Claims

1. A filter device for intravenous human immunoglobulin (pH 4) characterized in that, The filter device comprises: a containing component (1) having a containing cavity containing intravenous human immunoglobulin (pH4) to be de-virused; at least two groups of filter assemblies, each group of filter assemblies comprising: a pre-filter (2) having an inlet end connected to an outlet end of the containing component (1) to filter the intravenous human immunoglobulin (pH4) to be de-virused to obtain a first filtering product; at least one nano-filter (3) having an inlet end in communication with an outlet end of the pre-filter (2) to filter the first filtering product to obtain the intravenous human immunoglobulin (pH4) after being de-virused; a switching component arranged between the outlet end of the containing component (1) and the pre-filter (2) to switch to another group of filter assemblies when one group of filter assemblies is blocked.

2. The filter device for intravenous human immunoglobulin (pH 4) according to claim 1, characterized in that, The filter device further comprises: a bypass pipeline (4) having one end in communication with a pipeline between the switching component and the pre-filter (2) and the other end in communication with a pipeline between the pre-filter (2) and the nano-filter (3).

3. A filter device for intravenous human immunoglobulin (pH 4) according to claim 2, characterized in that The bypass pipeline (4) further comprises: a first on-off valve (401) arranged at one end of the bypass pipeline (4) close to the pre-filter (2); a second on-off valve (402) arranged at the other end of the bypass pipeline (4) close to the nano-filter (3).

4. The filter device for intravenous human immunoglobulin (pH4) according to claim 1, wherein the containing component (1) comprises a containing body and a containing shell sleeved on the periphery of the containing body, and a second heat preservation component is arranged between the containing body and the containing shell.

5. The filter device for intravenous human immunoglobulin (pH 4) according to claim 1, characterized in that, The filter assemblies comprise: a first pressure detector (5) arranged on a pipeline between the containing component (1) and the pre-filter (2); a second pressure detector (6) arranged on a pipeline between the pre-filter (2) and the nano-filter (3); wherein the first pressure detector (5) and the second pressure detector (6) are respectively connected to the switching component to control the switching component to switch between the at least two groups of filter assemblies according to the detection results of the first pressure detector (5) and the second pressure detector (6) so that the containing component (1) is in communication with one group of filter assemblies.

6. The filter device for intravenous human immunoglobulin (pH 4) according to claim 1, characterized in that, The filter device further comprises: a first heat preservation component; the first heat preservation component is arranged on a pipeline between the containing component (1) and the pre-filter (2); and / or the first heat preservation component is arranged on a pipeline between the pre-filter (2) and the nano-filter (3).

7. The filter device for intravenous human immunoglobulin (pH 4) according to claim 1, characterized in that, The filter device further comprises: a receiving tank (7) in communication with an outlet end of the nano-filter (3). The collecting tank (7) comprises a collecting tank body (701) and a collecting tank shell (702) sleeved on the periphery of the collecting tank body (701), and a constant temperature component is arranged between the collecting tank body (701) and the collecting tank shell (702); The filter device further comprises a first heat preservation component arranged on a pipeline between the nano filter (3) and the collecting tank (7).

8. A filter device for intravenous human immunoglobulin (pH 4) according to claim 7, characterized in that The filter device further comprises: A weight detection component arranged in the collecting tank body (701) to detect the real-time weight of the intravenous human immunoglobulin (pH4) in the collecting tank body (701); An alarm component connected with the weight detection component to issue an alarm warning when the real-time weight does not change within a set time.

9. The filter device for intravenous human immunoglobulin (pH4) according to claim 1, wherein The conversion component is an electronic control valve, the inlet of the electronic control valve is connected with the liquid outlet end of the containing component (1), and the electronic control valve has a plurality of outlets, each of which is arranged and communicated with one of the filter assemblies one by one.

10. A filtration system characterized by, The filter system comprises the filter device according to any one of claims 1 to 9.

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