Air treatment system for refrigeration electron microscope chamber
By using a cold radiation plate and a dehumidification system in the cryo-electron microscope chamber, noise and vibration problems were solved, a windless and quiet cooling environment was achieved, temperature stability and magnetic shielding effect were improved, and the energy efficiency of the air conditioning system was enhanced.
Patent Information
- Application Number
- CN202520263209.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-02-18
- Publication Date
- 2025-12-02
- Estimated Expiration
- 2035-02-18
AI Technical Summary
High-end cryo-electron microscopes are sensitive to environmental temperature, humidity, noise, and vibration. Existing air conditioning systems have large air volume, which causes noise and vibration, and large-sized supply and return air vents affect the magnetic shielding effect.
The system combines a radiant cooling panel with a refrigeration and dehumidification system. The sensible heat load is handled by the radiant cooling panel, while a chiller, cooling tower, and heat exchanger are used to create a windless cooling environment. Fresh air is treated by a rotary dehumidifier, avoiding the need for large supply and return air vents.
It achieves a windless and quiet cooling environment, improves temperature stability and magnetic shielding effect, while reducing noise and vibration and improving the energy efficiency of the air conditioning system.
Smart Images

Figure CN223623042U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of air treatment technology, and in particular to an air treatment system for a cryo-electron microscope chamber. Background Technology
[0002] High-end cryo-electron microscopes are highly sensitive to ambient temperature and humidity, as well as noise and vibration caused by airflow. Typically, the indoor air temperature needs to be maintained at 18–22℃ (±0.5℃ / 24h), the relative humidity needs to be controlled below 30%RH, the air velocity at the microscope tube should be ≤0.08m / s, and the indoor noise level should be ≤50dB(C). To ensure a stable room temperature of ±0.5℃, the airflow of a conventional constant temperature and humidity air conditioning unit must be at least 8 airflows / hour. To avoid noise and vibration issues caused by large airflow, large-size ducts and air supply / return vents are usually used. However, large-size ducts require more installation space, and large air supply / return vents reduce the magnetic shielding effect of the electron microscope chamber enclosure. Utility Model Content
[0003] The purpose of this invention is to provide an air handling system for cryo-electron microscope chambers, which uses a cold radiation plate to create a windless and quiet cooling environment.
[0004] To achieve the above objectives, this utility model provides an air handling system for a cryo-electron microscope chamber, comprising a refrigeration system, a dehumidification system, and a cold radiation panel installed in the wall of the cryo-electron microscope chamber. The refrigeration system includes a chiller unit, a cooling tower, and a heat exchanger. The chiller unit is provided with a chilled water supply inlet, a chilled water return inlet, a cooling water inlet, and a cooling water outlet. The chilled water supply inlet is connected to a chilled water supply pipe, the chilled water supply pipe is connected to the inlet of the cold radiation panel, the chilled water return inlet is connected to a chilled water return pipe, a chilled water pump is installed between the chilled water return inlet and the chilled water return pipe, the chilled water return pipe is connected to the outlet of the cold radiation panel, the cooling water inlet is connected to the outlet of the cooling tower, a cooling water pump is installed between the cooling water inlet and the outlet of the cooling tower, and the cooling water outlet is connected to the inlet of the cooling tower.
[0005] As a preferred embodiment of this utility model, the cryo-electron microscope chamber is provided with a fresh air inlet, and the dehumidification system includes a rotary dehumidifier, a fresh air duct, and a regeneration air duct. The fresh air duct is provided with a surface cooler, the processing area of the rotary dehumidifier, a temperature-regulating surface cooler, and a fresh air fan in sequence along the air inlet direction. The air inlet of the fresh air duct is connected to the outside, and the air outlet of the fresh air duct is connected to the fresh air inlet.
[0006] The regeneration duct is provided with an electric heater, the regeneration zone of the rotary dehumidifier and a regeneration exhaust fan in sequence along the air inlet direction. The air inlet of the regeneration duct is connected to the outside, and the air outlet of the regeneration duct is connected to the outside.
[0007] As a preferred embodiment of this utility model, the water supply temperature of the chilled water supply pipe is greater than or equal to 9°C.
[0008] As a preferred embodiment of this invention, the fresh air supply outlet is located on the magnetically shielded ceiling of the cryo-electron microscope chamber.
[0009] As a preferred embodiment of this utility model, a fresh air valve is provided at the air inlet of the fresh air duct, a fresh air coarse filter is provided between the fresh air valve and the surface cooler, and a fresh air medium filter is provided at the air outlet of the fresh air duct.
[0010] As a preferred embodiment of this utility model, a fresh air volume regulating valve is provided on the air outlet of the fresh air duct.
[0011] As a preferred embodiment of this utility model, the air inlet of the regeneration air duct is provided with a regeneration air coarse filter.
[0012] This utility model provides an air handling system for a cryo-electron microscope chamber, which, compared with the prior art, has the following advantages:
[0013] This invention uses a cold radiation plate to bear the sensible heat load in the cryo-electron microscope chamber, solving the noise and vibration problems of existing all-air air conditioning systems. At the same time, it avoids opening large-sized supply and return air vents on the magnetic shield of the cryo-electron microscope chamber, creating a windless and quiet cooling environment and improving the stability of the indoor temperature. Attached Figure Description
[0014] To more clearly illustrate the technical solutions of the embodiments of this utility model, the accompanying drawings of the embodiments will be briefly described below.
[0015] Figure 1 A schematic diagram of the arrangement of the cold radiation plate provided by this utility model;
[0016] Figure 2 A schematic diagram of the refrigeration system provided by this utility model;
[0017] Figure 3 A schematic diagram of the dehumidification system provided by this utility model;
[0018] In the diagram, 1 is a cold radiant panel; 2 is a chiller unit; 21 is a chilled water supply inlet; 22 is a chilled water return inlet; 23 is a cooling water inlet; 24 is a cooling water outlet; 25 is a chilled water supply pipe; 26 is a chilled water return pipe; 27 is a chilled water pump; 28 is a cooling water pump; 29 is a heat recovery water pump; 3 is a cooling tower; 4 is a fresh air outlet; 5 is a rotary dehumidifier; 51 is the processing area of the rotary dehumidifier; 52 is the regeneration area of the rotary dehumidifier; 6 is a fresh air duct; 61 is a surface cooler; 62 is a temperature-regulating surface cooler; 63 is a fresh air fan; 64 is a fresh air valve; 65 is a fresh air coarse filter; 66 is a fresh air medium filter; 67 is a fresh air volume regulating valve; 7 is a regeneration duct; 71 is an electric heater; 72 is a regeneration exhaust fan; and 73 is a regeneration air coarse filter. Detailed Implementation
[0019] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings and examples. The following examples are used to illustrate this utility model, but are not intended to limit its scope.
[0020] In the description of this utility model, it should be understood that the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.
[0021] like Figures 1 to 3 As shown, a preferred embodiment of the present invention provides an air handling system for a cryo-electron microscope chamber, comprising a refrigeration system, a dehumidification system, and cold radiation panels 1 installed within the walls of the cryo-electron microscope chamber. Specifically, cold radiation panels 1 are evenly distributed within the four walls of the cryo-electron microscope chamber to achieve cooling. A temperature and humidity sensor is installed within the cryo-electron microscope chamber. Chilled water coils are installed within the cold radiation panels 1. The refrigeration system includes a chiller unit 2, a cooling tower 3, and a heat exchanger 4. The heat exchanger 4 is preferably a water-to-water heat exchanger 4. The chiller unit 2 is equipped with a chilled water supply port 21, a chilled water return port 22, a cooling water inlet 23, and a cooling water outlet 24. The chilled water supply inlet 21 is connected to the chilled water supply pipe 25, the chilled water supply pipe is connected to the inlet of the chilled water coil of the cold radiant plate 1, the chilled water return inlet 22 is connected to the chilled water return pipe 26, a chilled water pump 27 is provided between the chilled water return inlet 22 and the chilled water return pipe 26, the chilled water return pipe 26 is connected to the outlet of the chilled water coil of the cold radiant plate 1, the cooling water inlet 23 is connected to the outlet of the cooling tower 3, a cooling water pump 28 is provided between the cooling water inlet 23 and the outlet of the cooling tower 3, and the cooling water outlet 24 is connected to the inlet of the cooling tower 3.
[0022] For example, the cryo-electron microscope chamber is equipped with a fresh air inlet 4. The dehumidification system includes a rotary dehumidifier 5, a fresh air duct 6, and a regeneration air duct 7. The fresh air duct 6 is arranged along the air intake direction as follows: a surface cooler 61, the processing area 51 of the rotary dehumidifier 5, a temperature-controlled surface cooler 62, and a fresh air fan 63. The chilled water supply pipe 25 is connected to the inlet of the surface cooler 61 and the inlet of the temperature-controlled surface cooler 62, respectively. The chilled water return pipe 26 is connected to the outlet of the surface cooler 61 and the outlet of the temperature-controlled surface cooler 62, respectively. The air intake of the fresh air duct 6 is connected to the outside, and the air outlet of the fresh air duct 6 is connected to the fresh air inlet 4. The regeneration air duct 7 is arranged along the air intake direction. The airflow path is sequentially equipped with an electric heater 71, a regeneration zone 52 of the rotary dehumidifier 5, and a regeneration exhaust fan 72. The air inlet of the regeneration duct 7 is connected to the outside, and the air outlet of the regeneration duct 7 is also connected to the outside. The fresh air duct 6 delivers dehumidified outdoor fresh air into the cryo-electron microscope chamber. The regeneration duct 7 uses high-temperature air to desorb water vapor in the regeneration zone 52 of the rotary dehumidifier 5. The dehumidification system fully handles the moisture load of the outdoor fresh air and indoor personnel, while the cold radiant plate 1 handles the sensible heat load of the cryo-electron microscope chamber. The indoor humidity and temperature are independently controlled, achieving an indoor temperature and humidity control target of 18℃ / 30%RH in hot and humid climate regions.
[0023] For example, the chilled water supply pipe 25 has a supply temperature of ≥9°C. In hot and humid climates, a medium-temperature cold source (chilled water supply temperature ≥9°C) is used to improve the energy efficiency of the refrigeration system by increasing the chilled water supply temperature.
[0024] For example, the fresh air outlet 4 is installed on the magnetically shielded ceiling of the cryo-electron microscope chamber to achieve laminar flow air supply and greatly reduce the fresh air outlet velocity.
[0025] For example, a fresh air valve 64 is provided on the air inlet of the fresh air duct 6, a fresh air coarse filter 65 is provided between the fresh air valve 64 and the surface cooler, and a fresh air medium filter 66 is provided on the air outlet of the fresh air duct 6 to ensure the cleanliness of the fresh air entering the cryo-electron microscope chamber; furthermore, a fresh air volume regulating valve 67 is provided on the air outlet of the fresh air duct 6 to adjust the air volume of the fresh air duct 6.
[0026] For example, the air inlet of the regeneration air duct 7 is provided with a regeneration air coarse filter 73 to prevent air impurities from entering the rotary dehumidifier 5 and effectively protect the rotary dehumidifier 5.
[0027] In summary, this invention uses a cold radiation plate 1 to bear the sensible heat load in the cryo-electron microscope chamber, solving the noise and vibration problems of existing all-air air conditioning systems. At the same time, it avoids opening large-sized supply and return air vents on the magnetic shield of the cryo-electron microscope chamber, creating a windless and quiet cooling environment and improving the stability of the indoor temperature. Moreover, the heat exchanger 4 can recover the condensation heat generated by the chiller unit 2, which can be used to heat other equipment, realizing the cascade utilization of heat and maximizing energy saving and emission reduction.
[0028] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "connected" and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.
[0029] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and substitutions can be made without departing from the technical principles of the present utility model, and these improvements and substitutions should also be considered within the protection scope of the present utility model.
Claims
1. An air handling system for a cryo-electron microscope chamber, characterized in that, The system includes a refrigeration system, a dehumidification system, and a cold radiation panel installed in the wall of the cryo-electron microscope chamber. The refrigeration system includes a chiller unit, a cooling tower, and a heat exchanger. The chiller unit has a chilled water supply inlet, a chilled water return inlet, a cooling water inlet, and a cooling water outlet. The chilled water supply inlet is connected to a chilled water supply pipe, the chilled water supply pipe is connected to the inlet of the cold radiation panel, the chilled water return inlet is connected to a chilled water return pipe, a chilled water pump is installed between the chilled water return inlet and the chilled water return pipe, the chilled water return pipe is connected to the outlet of the cold radiation panel, the cooling water inlet is connected to the outlet of the cooling tower, a cooling water pump is installed between the cooling water inlet and the outlet of the cooling tower, and the cooling water outlet is connected to the inlet of the cooling tower.
2. The air handling system for a cryo-electron microscope chamber as described in claim 1, characterized in that, The cryo-electron microscope chamber is equipped with a fresh air inlet. The dehumidification system includes a rotary dehumidifier, a fresh air duct, and a regeneration air duct. The fresh air duct is provided with a surface cooler, the processing area of the rotary dehumidifier, a temperature-regulating surface cooler, and a fresh air fan in sequence along the air inlet direction. The air inlet of the fresh air duct is connected to the outside, and the air outlet of the fresh air duct is connected to the fresh air inlet. The regeneration duct is provided with an electric heater, the regeneration zone of the rotary dehumidifier and a regeneration exhaust fan in sequence along the air inlet direction. The air inlet of the regeneration duct is connected to the outside, and the air outlet of the regeneration duct is connected to the outside.
3. The air handling system for a cryo-electron microscope chamber as described in claim 2, characterized in that, The fresh air supply vent is located on the magnetically shielded ceiling of the cryo-electron microscope chamber.
4. The air handling system for a cryo-electron microscope chamber as described in claim 2, characterized in that, The fresh air duct is equipped with a fresh air valve at its air inlet, a fresh air coarse filter is provided between the fresh air valve and the surface cooler, and a fresh air medium filter is provided at the air outlet of the fresh air duct.
5. The air handling system for a cryo-electron microscope chamber as described in claim 2, characterized in that, The fresh air duct is equipped with a fresh air volume regulating valve at its air outlet.
6. The air handling system for a cryo-electron microscope chamber as described in claim 2, characterized in that, The regeneration air duct is equipped with a regeneration air coarse filter at its air inlet.
7. The air handling system for a cryo-electron microscope chamber as described in any one of claims 1 to 6, characterized in that, The chilled water supply pipe has a water supply temperature of 9°C or higher.