Heating device of nucleic acid extractor and nucleic acid extractor

Abstract

The utility model relates to the technical field of accounting extraction, in particular to a heating device of a nucleic acid extraction instrument and the nucleic acid extraction instrument, which comprises a heating assembly and a carrying table structure, a heating block is arranged at the top of the heating assembly in a penetrating manner, and a plurality of heating stations are uniformly arranged on the end surface, deviating from the heating assembly, of the heating block along the extension direction of the heating block; the carrying table structure is connected to the top of the heating assembly, the heating block is arranged on the carrying table structure in a penetrating mode, a mounting groove is formed in the carrying table structure towards the heating station, a kit is arranged in the mounting groove in a penetrating mode, and the heating station wraps the kit. The utility model aims to improve the heating efficiency of the heating device so as to better meet the heating requirement of the kit.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of accounting extraction, especially relates to a nucleic acid extraction instrument heating device and nucleic acid extraction instrument. BACKGROUND

[0002] Nucleic acid extraction technology is an important method for realizing precision medicine in the biological and medical fields. In nucleic acid extraction experiments, some reagents need to be heated to the appropriate reaction temperature. The role of the heating device of the nucleic acid extraction instrument is to heat the reagents to the appropriate temperature to ensure the accuracy of the nucleic acid extraction experiment. When the volume of the reagent to be heated is large or the reaction temperature is high, an efficient heating device is a powerful guarantee for the smooth and rapid progress of the experiment.

[0003] Currently, the heating block of the heating device of the nucleic acid extraction instrument on the market only contacts the bottom of the extraction reagent box. This can better achieve heating when the amount of reagent in the reaction well is small and the temperature requirement is not high. However, when the amount of reagent in the reaction well is large or the temperature requirement is high, the above-mentioned heating device is difficult to control the heating temperature, and cannot guarantee good heating effect, thereby affecting the extraction effect. UTILITY MODEL CONTENT

[0004] The main purpose of the utility model is to provide a nucleic acid extraction instrument heating device, which aims to improve the heating efficiency of the heating device to better meet the heating needs of the reagent box.

[0005] To achieve the above-mentioned purpose, the utility model provides a nucleic acid extraction instrument heating device, which comprises a heating assembly, a stage structure:

[0006] A heating block is provided on the top of the heating assembly, the heating block penetrates the heating assembly, and the end face of the heating block away from the heating assembly is uniformly provided with a plurality of heating stations along the extension direction of the heating block;

[0007] The stage structure is connected to the top of the heating assembly, the heating block penetrates the stage structure, the stage structure is provided with a mounting groove facing the heating station, a reagent box is provided in the mounting groove, and the heating station surrounds the reagent box.

[0008] In an embodiment of the present application, the heating assembly comprises a heating plate cover, a heating plate PCB and a heating plate cover:

[0009] The heating plate PCB is connected to the heating plate cover, and the heating block is connected to the top of the heating plate PCB;

[0010] The heating plate cover is provided with a clearance hole facing the heating block, the heating plate cover is connected to the heating plate cover and covers the heating plate PCB, and the heating block penetrates the clearance hole.

[0011] In an embodiment of the present application, the contact surface formed at the connecting position of the heating block and the heating plate PCB is located in the area of the orthogonal projection of the accommodation hole on the heating plate PCB.

[0012] In an embodiment of the present application, the heating block is provided in at least two, and the two heating blocks are arranged in parallel and spaced apart along the arrangement direction of the kit.

[0013] In an embodiment of the present application, the heating station is provided in multiple groups, and each group of the heating station corresponds to one heating block.

[0014] In an embodiment of the present application, the heating station includes an elution hole position and a lysis hole position, the elution hole position is opened in one heating block, the lysis hole position is opened in another heating block, and the heating plate PCB is provided with an independent temperature adjusting module relative to each heating block.

[0015] In an embodiment of the present application, at least two temperature sensors are symmetrically provided in the heating block along the central axis, the temperature sensors are provided through the heating block and are connected to the heating plate PCB.

[0016] In an embodiment of the present application, the carrier structure includes a carrier plate and a carrier:

[0017] The carrier plate is connected to the top of the heating assembly, and the heating block is provided through the carrier plate;

[0018] The carrier is connected to the top of the carrier plate, one end of the mounting slot is opened in the carrier, the other end is opened in the carrier plate, and the mounting slot is wrapped around the heating station.

[0019] In an embodiment of the present application, the mounting slot is opened in the carrier structure along one side direction of the heating assembly, the heating block is arranged along a direction perpendicular to the extension direction of the mounting slot, and each heating station corresponds to a mounting slot.

[0020] To achieve the above-mentioned purpose, the utility model provides a nucleic acid extraction instrument, including above-mentioned nucleic acid extraction instrument heating device, the nucleic acid extraction instrument includes extraction instrument body, warehouse cover assembly and magnetic bar moving mechanism:

[0021] The installation cavity is provided in the extraction instrument body, the bottom of the installation cavity is provided with a slide rail assembly, the slide rail assembly includes a slide rail and a driving structure, the heating assembly is slidably connected to the slide rail, and the driving structure is drivingly connected to the slide rail and connected to the carrier structure.

[0022] The cover assembly is wrapped around the heating assembly and the carrier structure, the slide rail assembly is arranged in the cover assembly, and a lifting groove is formed in the top of the cover assembly along the extension direction of the heating block;

[0023] The magnetic rod moving mechanism is connected to the inner wall of the mounting cavity and located at one side of the cover assembly, a sheath frame is arranged on the magnetic rod moving mechanism and faces the lifting groove, and a plurality of magnetic rods are arranged on the sheath frame and face the heating assembly.

[0024] By adopting the above technical scheme, the nucleic acid extraction instrument heating device has the following advantages:

[0025] 1. The heating device only comprises the heating assembly and the carrier structure, the reagent box is fixed in the mounting cavity arranged on the carrier structure, and the reagent box is suspended above the heating assembly, the whole heating device is simple in structure and low in assembly cost.

[0026] 2. The heating block arranged in the heating assembly is arranged in the carrier structure and connected with the mounting groove, the carrier structure is wrapped around the heating block to ensure the stability of the heating block and avoid the influence of the outside, meanwhile, the heating block is arranged with the heating station in the mounting groove, the reagent box is arranged in the mounting groove, the upper end of the reagent box is fixed by the carrier structure, the lower end of the reagent box is arranged in the heating station and fixed by the heating block, and the stability of the reagent box can be ensured, and the liquid in the reagent box can be stably heated even if the heating assembly is conveyed by the slide rail assembly.

[0027] 3. The heating block can increase the contact area with the reagent box through the heating station, so that the heating efficiency can be improved, and the liquid in the reagent box can be heated more uniformly. BRIEF DESCRIPTION OF DRAWINGS

[0028] In order to more clearly illustrate the technical scheme in the embodiments of the present application or the prior art, the drawings needed to be used in the following embodiment or prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained according to the structures shown in the drawings without creative labor for those skilled in the art.

[0029] Figure 1 It is a structural schematic view of the nucleic acid extraction instrument heating device of the present application;

[0030] Figure 2 It is a one-directional sectional view of the nucleic acid extraction instrument heating device of the present application;

[0031] Figure 3 It is another directional sectional view of the nucleic acid extraction instrument heating device of the present application;

[0032] Figure 4 It is the overhead structure schematic view of the nucleic acid extractor heating device of the utility model;

[0033] Figure 5 It is the heating block structure schematic view of the nucleic acid extractor heating device of the utility model;

[0034] Figure 6 It is the internal structure schematic view of the nucleic acid extractor of the utility model.

[0035] Explanation of drawing reference numeral:

[0036] 1, heating assembly; 11, heating plate cover; 12, heating plate PCB; 13, heating plate cover; 14, let hole; 2, heating block; 21, heating station; 22, elution hole position; 23, lysis hole position; 24, temperature sensor; 3, stage structure; 31, stage plate; 32, connecting piece; 33, installation groove; 4, reagent box; 5, slide rail assembly; 51, drive structure; 6, extractor body; 61, installation cavity; 7, bin cover assembly; 71, extraction groove; 8, magnetic bar moving mechanism; 81, sheath frame.

[0037] The utility model discloses the realization, functional characteristics and advantages will be further described with reference to the embodiment, the drawing. Specific implementation

[0038] In order to make the purpose, technical scheme and advantage of the application more clear and obvious, the application is further described in detail below with reference to the drawings and examples.It should be understood that the specific examples described here are only used to explain the application and not to limit the application.

[0039] Reference Figures 1 to 6 In order to achieve the above object, the utility model discloses a nucleic acid extractor heating device, including heating assembly 1, stage structure 3, the top of heating assembly 1 is equipped with heating block 2, heating block 2 is out of heating assembly 1, and the end face of heating block 2 away from heating assembly 1 is evenly provided with a plurality of heating stations 21 along the extension direction of heating block 2;Stage structure 3 is connected to the top of heating assembly 1, heating block 2 is equipped in stage structure 3, and installation groove 33 is opened towards heating station 21 in stage structure 3, reagent box 4 is equipped in installation groove 33, and heating station 21 is wrapped around reagent box 4.

[0040] The heating device only includes heating assembly 1 and stage structure 3, and the reagent box 4 is fixed in the installation cavity 61 provided on the stage structure 3, so that the reagent box 4 is suspended directly above the heating assembly 1, and the whole heating device structure is simple, and the assembly cost is lower.

[0041] The heating block 2 arranged in the heating assembly 1 is arranged through the carrier structure 3 and connected with the mounting groove 33, the carrier structure 3 wraps the heating block 2 to ensure the stability of the working of the heating block 2, and avoid being affected by the outside world, meanwhile, the heating block 2 is provided with a heating station 21 towards the mounting groove 33, the reagent box 4 is arranged through the mounting groove 33, the upper end of the reagent box 4 is fixed by the carrier structure 3, the lower end of the reagent box 4 is arranged into the heating station 21 and fixed by the heating block 2, which can ensure the stability of the reagent box 4, even if the heating assembly 1 is conveyed by the sliding rail assembly 5, the liquid in the reagent box 4 can also be stably heated.

[0042] The heating block 2 can increase the contact area with the reagent box 4 through the heating station 21, so as to improve the heating efficiency, and make the liquid in the reagent box 4 more uniform when heated.

[0043] For your reference Figures 1 to 3 In an embodiment of the present application, the heating assembly 1 comprises a heating plate cover 11, a heating plate PCB 12 and a heating plate cover 13, the heating plate PCB 12 is connected to the heating plate cover 11, and the heating block 2 is connected to the top of the heating plate PCB 12; the heating plate cover 13 is provided with a clearance hole 14 towards the heating block 2, the heating plate cover 13 is connected to the heating plate cover 11 and covers the heating plate PCB 12, and the heating block 2 is arranged through the clearance hole 14.

[0044] The heating plate cover 11 and the heating plate cover 13 can wrap the heating plate PCB 12 inside to protect the heating plate PCB 12 and make it work normally, meanwhile, the heating plate cover 11 can be provided with a sliding structure to facilitate sliding along the guide rail and facilitate the transfer of the reagent box 4, the heating block 2 is arranged on the heating plate PCB 12 and arranged out of the clearance hole 14, which can protect the electrical connection part of the heating block 2 and make the heating block 2 work in a safe environment to ensure the efficiency and stability of heating.

[0045] For your reference Figure 5 In an embodiment of the present application, the contact surface formed at the connection between the heating block 2 and the heating plate PCB 12 is in the area of the orthographic projection of the clearance hole 14 on the heating plate PCB 12.

[0046] The area of the orthographic projection of the clearance hole 14 on the heating plate PCB 12 is larger than the area of the contact surface formed at the connection between the heating block 2 and the heating plate PCB 12, and the heating plate cover 13 wraps the heating block 2, since the heating plate cover 13 is generally made of metal material, the mutual separation of the cover and the heating block 2 can avoid increasing the heat dissipation area of the heating block 2, save energy and avoid waste of heat.

[0047] For your reference Figures 1 to 5 In an embodiment of the present application, the heating block 2 is provided with at least two, and the two heating blocks 2 are arranged in parallel and spaced apart along the arrangement direction of the reagent box 4.

[0048] The kit 4 has a plurality of hole positions along the extension direction, and a group of test tubes can be arranged in each hole position. A plurality of heating blocks 2 are arranged to simultaneously heat different test tubes, and the whole structure is simple and practical, and the cost can be effectively reduced.

[0049] For better understanding Figures 1 to 5 In an embodiment of the present application, the heating station 21 is provided in multiple groups, and each group of heating stations 21 corresponds to a heating block 2.

[0050] Because a plurality of installation cavities 61 can be arranged in parallel on the carrier structure 3, and a plurality of kits 4 are correspondingly arranged, in order to uniformly heat the kits 4 at the same time, a plurality of heating stations 21 can be arranged on the heating block 2 to correspond to the plurality of kits 4. At the same time, in order to make the whole heating process more flexible, the heating stations 21 on different heating blocks 2 can have different temperatures to achieve different functions, so that the use of the heating device is more flexible.

[0051] For better understanding Figure 5 In an embodiment of the present application, the heating station 21 includes an elution hole position 22 and a lysis hole position 23. The elution hole position 22 is arranged on one heating block 2, and the lysis hole position 23 is arranged on another heating block 2. The heating plate PCB 12 is provided with an independent temperature adjusting module corresponding to each heating block 2.

[0052] In the present application, the heating plate PCB 12 is provided with an independent temperature adjusting module corresponding to each heating block 2, so that different heating blocks 2 can be independently adjusted in temperature, ensuring the stability of different functions. Independent temperature adjustment can more accurately control the temperature of the two different heating stations 21, so that the reagent can smoothly complete the required function whether in the elution hole position 22 or the lysis hole position 23.

[0053] For better understanding Figure 3 In an embodiment of the present application, at least two temperature sensors 24 are symmetrically arranged in the heating block 2 along the central axis. The temperature sensors 24 are arranged in the heating block 2 and connected to the heating plate PCB 12.

[0054] The heating block 2 is provided with a plurality of temperature sensors 24, which are symmetrically arranged along the central axis to ensure the consistent relative position of the two temperature sensors 24. By comparing the two, the temperature of the current heating block 2 can be accurately obtained, so that the temperature can be easily adjusted. When one sensor is damaged, the other sensor can continue to work, avoiding the loss of temperature data of the heating block 2 by the user, which may cause damage to the heating block 2. The damaged sensor can be replaced after receiving the work, which can effectively improve the work efficiency.

[0055] For better understanding Figures 1 to 5In an embodiment of the present application, the carrier structure 3 comprises a carrier plate 31 and a carrier, the carrier plate 31 is connected to the top of the heating assembly 1, and the heating block 2 is arranged in the carrier plate 31; the carrier is connected to the top of the carrier plate 31, and the mounting groove 33 is arranged at one end of the carrier and at the other end of the carrier plate 31, and the mounting groove 33 is arranged around the heating station 21.

[0056] The carrier plate 31 is connected to the heating assembly 1 at one end through a support column and is arranged around the heating block 2, and a connecting portion can be arranged at the other end, through which the carrier plate 31 can be connected to some external structures such as the driving structure 51, so that the driving structure 51 can drive the heating assembly 1 to move when in operation, and the carrier can be connected to the carrier plate 31 through a longer bolt column, so that the carrier can support the reagent box 4 with the help of the mounting groove 33, thereby ensuring the stability of the installation of the reagent box 4 and protecting the test tube and the reagent inside the test tube.

[0057] In combination with Figures 1 to 3 In an embodiment of the present application, the mounting groove 33 is arranged in the carrier structure 3 along the direction of one side of the heating assembly 1, and the heating block 2 is arranged perpendicular to the extension direction of the mounting groove 33, and each heating station 21 corresponds to one mounting groove 33.

[0058] Generally, in order to facilitate the extraction and transfer of the reagent after the heating of the reagent by the heating assembly 1, the heating assembly 1 itself needs to be continuously fed, and the mounting groove 33 and the heating block 2 are arranged perpendicularly, and generally the mounting groove 33 is arranged along the running direction of the heating assembly 1, so that the reagent box 4 can be arranged along the extension direction of the slide rail, which can reduce the interference of the reagent in the transfer state and ensure the stability of the placement of the test tube, and the heating block 2 perpendicular to the mounting groove 33 can ensure the same heating temperature at the same position of the adjacent reagent box 4 and ensure the heating efficiency.

[0059] Referring to Figure 6 The utility model also proposes a nucleic acid extraction instrument, the nucleic acid extraction instrument includes above-mentioned nucleic acid extraction instrument heating device, the specific structure of this nucleic acid extraction instrument heating device refers to above-mentioned embodiment, because this nucleic acid extraction instrument adopts all the technical schemes of above-mentioned all embodiments, thus at least has all the beneficial effects brought by the technical scheme of above-mentioned embodiment, here will not repeat.

[0060] The utility model provides a kind of nucleic acid extractor, including extractor body 6, storehouse cover subassembly 7 and magnet bar moving mechanism 8, installation cavity 61 is equipped in extractor body 6, the bottom of installation cavity 61 is equipped with slide rail assembly 5, slide rail assembly 5 includes slide rail and drive structure 51, heating assembly 1 is slidably connected in slide rail, drive structure 51 is driven connection in slide rail, and is connected to stage structure 3;Storehouse cover subassembly 7 is wrapped in heating assembly 1 and stage structure 3, slide rail assembly 5 is worn in storehouse cover subassembly 7, and extraction groove 71 is opened in the top of storehouse cover subassembly 7 along the extension direction of heating block 2;Magnet bar moving mechanism 8 is connected to the inner wall of installation cavity 61, and it is in one side of storehouse cover subassembly 7, and magnet bar moving mechanism 8 is equipped with sheath frame 81 towards extraction groove 71, and sheath frame 81 is equipped with a plurality of magnet bars towards heating assembly 1, and each magnet bar corresponds to one heating station 21.

[0061] Extractor body 6 has protective effect, and the above heating assembly 1, stage structure 3, slide rail assembly 5 are all in installation cavity 61 in it, guarantee the stability of work, and storehouse cover subassembly 7 is wrapped in the above heating assembly 1, stage structure 3, slide rail assembly 5, can reduce the heat loss of heating assembly 1, so that heating is more uniform, and extraction groove 71 is also for taking material position, under the help of the drive structure 51 of slide rail assembly 5, reagent box 4 is stopped after sliding to extraction groove 71, can be taken by magnet bar moving mechanism 8, and drive structure 51 can be provided with connecting piece 32 towards stage plate 31, so that slide rail assembly 5 can smoothly drive heating assembly 1, so that it reciprocates between the feeding position of extractor body 6 and extraction groove 71, and because the upper end of test tube inserted into reagent box 4 is provided with magnet bar sheath, the magnet bar on sheath frame 81 is inserted into test tube by lifting sheath frame 81 through magnet bar moving mechanism 8, and the magnet bar will attract magnet bar sheath, after driving sheath frame 81 to ascend by magnet bar moving mechanism 8, test tube can be extracted from reagent box 4, and can be easily transferred, and different test tubes in reagent box 4 can be transferred to extraction groove 71 under the help of slide rail assembly 5, and are taken respectively, which is simple and practical, can be relatively stable and easy to transfer test tube, improve the heating transfer efficiency of the whole structure.

[0062] Same or similar reference numerals in the drawings of the embodiment correspond to same or similar components; in the description of the present application, it is understood that if there are terms such as "upper", "lower", "left", "right" and the like indicating the orientation or positional relationship, only for the convenience of describing the present application and simplifying the description, and not indicating or implying that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, therefore the positional relationship described in the drawings is only used for exemplary illustration, and cannot be understood as a limitation of the present patent, for ordinary skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0063] The above merely provides preferred embodiments of the present application, and is not used to limit the present application. Any modification, equivalent replacement, and improvement made in the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A heating device for a nucleic acid extractor, characterized in that, include: A heating assembly, wherein a heating block is provided through the top of the heating assembly, the heating block protrudes from the heating assembly, and multiple heating stations are evenly provided along the extension direction of the heating block away from the end face of the heating assembly; A platform structure is connected to the top of the heating assembly. The heating block passes through the platform structure. The platform structure has an installation groove facing the heating station. The reagent kit is inserted into the installation groove. The heating station surrounds the reagent kit.

2. The heating device for a nucleic acid extractor according to claim 1, characterized in that, The heating component includes: Heating plate cover; A heating plate PCB, wherein the heating plate PCB is connected to the heating plate cover, and the heating block is connected to the top of the heating plate PCB; A heating plate cover is provided with a clearance hole facing the heating block. The heating plate cover is connected to the heating plate cover and covers the heating plate PCB. The heating block passes through the clearance hole.

3. The heating device for a nucleic acid extractor according to claim 2, characterized in that, The contact surface formed at the connection between the heating block and the heating plate PCB is located within the area of ​​the orthogonal projection of the clearance hole on the heating plate PCB.

4. The heating device for a nucleic acid extractor according to claim 2, characterized in that, At least two heating blocks are provided, and the two heating blocks are arranged parallel to each other and spaced apart along the arrangement direction of the reagent kit.

5. The heating device for a nucleic acid extractor according to claim 4, characterized in that, The heating station is provided in multiple groups, and each group of heating stations corresponds to one heating block.

6. The heating device for a nucleic acid extractor according to claim 5, characterized in that, The heating station includes elution holes and pyrolysis holes. The elution holes are located on one of the heating blocks, and the pyrolysis holes are located on another heating block. The heating plate PCB has an independent temperature control module relative to each heating block.

7. The heating device for a nucleic acid extractor according to claim 2, characterized in that, At least two temperature sensors are symmetrically arranged along the central axis inside the heating block. The temperature sensors pass through the heating block and are connected to the heating plate PCB.

8. The heating device for a nucleic acid extractor according to claim 1, characterized in that, The platform structure includes: A platform plate is connected to the top of the heating assembly, and the heating block passes through the platform plate; A platform is connected to the top of the platform plate. One end of the mounting groove is opened on the platform, and the other end is opened on the platform plate. The mounting groove surrounds the heating station.

9. The heating device for a nucleic acid extractor according to claim 8, characterized in that, The mounting slot is formed on the platform structure along one side of the heating component, and the heating block is arranged along the extension direction perpendicular to the mounting slot. Each heating station corresponds to one mounting slot.

10. A nucleic acid extractor, comprising a heating device for a nucleic acid extractor as described in any one of claims 1 to 9, characterized in that, The nucleic acid extractor includes: The extractor body has a mounting cavity inside, and a slide rail assembly is provided at the bottom of the mounting cavity. The slide rail assembly includes a slide rail and a driving structure. The heating component is slidably connected to the slide rail, and the driving structure is drivenly connected to the slide rail and connected to the platform structure. A housing assembly, which surrounds the heating assembly and the platform structure, and a slide rail assembly passes through the housing assembly. An extraction groove is formed on the top of the housing assembly along the extension direction of the heating block. A magnetic rod moving mechanism is connected to the inner wall of the mounting cavity and is located on one side of the shroud assembly. The magnetic rod moving mechanism is provided with a protective sleeve facing the extraction slot. The protective sleeve is provided with multiple magnetic rods facing the heating assembly, and each magnetic rod corresponds to a heating station.

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