Heparin sodium separation and extraction device

Abstract

The utility model relates to the technical field of heparin sodium production, in particular to a heparin sodium separation and extraction device which promotes the solid-liquid separation efficiency through the centrifugal effect, and is convenient to use, high in solid-liquid separation efficiency and high in practicability. Comprising a bottom plate, a support and a box body, the box body is fixedly installed at the upper end of the bottom plate through the support, a cavity is formed in the box body, a drainage pipe communicated with the cavity is arranged on the lower portion of the box body, and a valve is arranged on the drainage pipe; the mixing mechanism is installed on the upper portion of the box body and has a mixing function, the supporting shaft is rotatably installed on the bottom plate and the box body, the barrel is fixedly installed at the upper end of the supporting shaft, a cavity is formed in the barrel, an opening is formed in the upper end of the barrel, and the sealing cover is arranged on the sealing cover. The sealing cover is installed at the upper end of the cylinder through a bolt, and the cylinder is rotationally installed on the box body.

Description

TECHNICAL FIELD

[0001] The utility model relates to the technical field of heparin sodium production, especially to a heparin sodium separation and extraction device. BACKGROUND

[0002] Heparin sodium is an important anticoagulant drug, which has a wide application in medical treatment. Heparin sodium needs to go through scraping intestine, mixing pretreatment, enzymatic extraction, resin adsorption and resin elution to obtain eluate containing heparin sodium, and then alcohol is added to make heparin sodium form a precipitate in the eluate, and then solid-liquid separation is carried out to obtain precipitated heparin sodium. In the prior art, a heparin sodium preparation extraction device is disclosed in the utility model patent with the patent application number 202222610389.4, which is mainly composed of a filter, a box body and a cover body. When the eluate containing heparin sodium after precipitation is subjected to solid-liquid separation, the liquid passes through the filter, and the filter hole on the filter separates the eluate containing heparin sodium into solid and liquid, so that the solid heparin sodium remains on the filter, and the liquid passes through the filter hole of the filter into the box body. The inventor believes that the above-mentioned device has the following problems in solid-liquid separation. It only relies on the diffusion and gravity of the liquid to filter the eluate containing heparin sodium on the filter, and the solid-liquid separation speed is slow, the separation efficiency is low, and the use is not convenient. SUMMARY

[0003] To solve the above technical problems, the utility model provides a heparin sodium separation and extraction device which promotes the efficiency of solid-liquid separation by centrifugal action, is convenient to use, has high solid-liquid separation efficiency and high practicability.

[0004] The utility model discloses a heparin sodium separation and extraction device, including bottom plate, support and box, the box is fixedly installed on the bottom plate upper end through the support, is provided with the chamber in the box, the lower part of box is provided with the drain pipe who communicates with the chamber, is provided with the valve on the drain pipe, still including support shaft, cylinder, sealing cover, mixing mechanism and drive mechanism, mixing mechanism installs on the upper portion of box, and mixing mechanism has mixing function, and support shaft rotatory installation is in the bottom plate and the box, and the upper end of support shaft is fixedly installed in the cylinder, and is provided with the cavity in the cylinder, and the upper end of cylinder is arranged as the opening, and sealing cover is installed through the bolt on the upper end of cylinder, and cylinder rotatory installation is in the box, and is provided with the feeding hopper on sealing cover, and is provided with the valve on the feeding hopper, and is provided with multiple groups filter holes who communicate with the cavity on the cylinder, and is provided with filter cloth on the lateral wall of cylinder, and drive mechanism is used for driving support shaft rotation, first the eluent of heparin sodium is added to mixing mechanism and mixes with alcohol, makes heparin sodium form solid state precipitate under the left and right of alcohol, after making the eluent mixed with solid state heparin sodium enter the cavity of cylinder through the feeding hopper on sealing cover, after closing the valve on feeding hopper, then opens drive mechanism, makes support shaft drive cylinder rotation, and cylinder makes heparin sodium eluent in the cavity of cylinder under the action of centrifugal force and is thrown out to the cavity of box through the filter hole on the cylinder in the process of rotation, and solid state heparin sodium remains in the cavity of cylinder, and the separation and extraction of heparin sodium can be completed, when separating solid state heparin sodium and eluent, the efficiency of solid-liquid separation is promoted through the centrifugal effect, convenient to use, and the solid-liquid separation efficiency is high, and the practicality is high.

[0005] Preferably, the drive mechanism includes bevel gear A, bevel gear B, drive shaft, fixed plate and drive motor, bevel gear A is fixedly sleeved on the support shaft, bevel gear A is engaged with bevel gear B, bevel gear B is fixedly installed on the drive shaft, the drive shaft is rotatory installed on the fixed plate, and the fixed plate and drive motor are fixedly installed on the bottom plate, and the input end of drive shaft is connected with drive motor, when driving the drive shaft rotation, opening drive motor, drive motor makes bevel gear B rotate through the drive shaft, and bevel gear B makes the support shaft drive cylinder rotation through bevel gear A, which is convenient for the rotation of the cylinder, and improves the solid-liquid separation speed in the cavity of the cylinder.

[0006] Preferably, the mixing mechanism comprises a stirring mechanism, a support frame, a mixing cylinder and a discharge pipe, the mixing cylinder is fixedly installed at the upper portion of the box body through the support frame, a mixing cavity is arranged in the mixing cylinder, a discharge pipe communicating with the mixing cavity is arranged at the lower portion of the mixing cylinder, a valve is arranged on the discharge pipe, the discharge pipe is located above the feeding funnel, and the stirring mechanism has a stirring function; the heparin sodium eluent is added into the mixing cavity of the mixing cylinder, then alcohol is added into the mixing cavity of the mixing cylinder, so that the heparin sodium forms a solid-state precipitate under the action of the alcohol, then the valve on the discharge pipe is opened, the eluent containing the solid-state heparin sodium falls into the feeding funnel of the sealing cover through the discharge pipe, and then the eluent enters the cavity of the cylinder body through the feeding funnel for solid-liquid separation.

[0007] Preferably, the stirring mechanism comprises a lifting frame, a servo motor, a rotating shaft and a plurality of stirring blades, the servo motor is fixedly installed at the upper end of the lifting frame, the rotating shaft is rotatably installed on the lifting frame, the upper end of the rotating shaft is connected with the output end of the servo motor, and the plurality of stirring blades are fixedly installed at the lower portion of the rotating shaft and located in the mixing cavity of the mixing cylinder; the lifting frame is fixedly hung on the support in the workshop; when the alcohol and the heparin sodium eluent are mixed in the mixing cavity of the mixing cylinder, the servo motor is turned on, the servo motor drives the plurality of stirring blades to rotate through the rotating shaft, and the plurality of stirring blades promote the mixing between the heparin sodium solution and the alcohol in the rotating process, so that the alcohol can be fully mixed with the heparin sodium solution and the precipitation of the heparin sodium is promoted.

[0008] Preferably, a plurality of waterproof electric heating lamps are further arranged on the inner side wall of the box body; after the solid-liquid separation of the heparin sodium in the cylinder body is completed, the drain pipe on the box body is opened, the liquid in the cavity of the box body is drained through the drain pipe, then the plurality of waterproof electric heating lamps are turned on, the cylinder body is heated, the solid-state heparin sodium in the cavity of the cylinder body is heated, and the residual moisture on the heparin sodium is dried, so that the drying efficiency of the heparin sodium is improved.

[0009] Preferably, a transparent observation window is arranged on the box body; through the above arrangement, the running state of the equipment in the cavity of the box body is monitored.

[0010] Preferably, the material of the box body is stainless steel; through the above arrangement, the rusting of the box body is delayed, and the service life of the box body is prolonged.

[0011] Compared with the prior art, the heparin sodium drying device has the advantages that the centrifugal effect is used to improve the solid-liquid separation efficiency, the device is convenient to use, the solid-liquid separation efficiency is high, and the device is practical. BRIEF DESCRIPTION OF DRAWINGS

[0012] Figure 1 is a sectional view of the device;

[0013] Figure 2It is the first axis measurement structure schematic view of the utility model;

[0014] Figure 3 It is the second axis measurement structure schematic view of the utility model;

[0015] Figure 4 It is the structure schematic view of cylinder, support shaft and bevel gear A etc.;

[0016] Figure 5 It is the structure schematic view of mixing mechanism.

[0017] Mark in drawing: 1, bottom plate;2, support;3, box;4, support shaft;5, cylinder;6, sealing cover;7, bevel gear A;8, bevel gear B;9, drive shaft;10, fixed plate;11, drive motor;12, support frame;13, mixing cylinder;14, discharge pipe;15, hoisting frame;16, servo motor;17, rotating shaft;18, stirring piece;19, waterproof electric heating lamp. DETAILED DESCRIPTION

[0018] In order to facilitate understanding the utility model, the utility model will be described more fully below with reference to relevant drawings. The utility model can be realized in many different forms, and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the utility model more thorough and comprehensive. Example 1

[0019] As Figures 1 to 5The utility model discloses a heparin sodium separation and extraction device, including bottom plate 1, support 2, box 3, support shaft 4, cylinder 5, sealing cover 6, mixing mechanism and drive mechanism, box 3 is fixedly installed on the upper end of bottom plate 1 through support 2, is provided with the chamber in the box 3, the lower part of box 3 is provided with the drain pipe that communicates with the chamber, is provided with the valve on the drain pipe, mixing mechanism is installed on the upper portion of box 3, and mixing mechanism has mixing function, support shaft 4 is rotatably installed on bottom plate 1 and box 3, cylinder 5 is fixedly installed on the upper end of support shaft 4, is provided with cavity in cylinder 5, and the upper end of cylinder 5 is provided as opening, sealing cover 6 is installed on the upper end of cylinder 5 through bolt, cylinder 5 is rotatably installed on box 3, is provided with feeding hopper on sealing cover 6, is provided with the valve on feeding hopper, is provided with multiple groups filter holes that communicate with the cavity on cylinder 5, is provided with filter cloth on the lateral wall of cylinder 5, and drive mechanism is used to drive support shaft 4 rotation;First, the eluent of heparin sodium is added to the mixing mechanism and mixed with alcohol, so that heparin sodium forms solid-state precipitation under the left and right of alcohol, then makes the eluent mixed with solid-state heparin sodium enter the cavity in cylinder 5 through the feeding hopper on sealing cover 6, then closes the valve on feeding hopper, then opens drive mechanism, makes support shaft 4 drive cylinder 5 to rotate, cylinder 5 makes heparin sodium eluent in the cavity of cylinder 5 under the action of centrifugal force and is thrown out to the cavity of box 3 through the filter hole on cylinder 5 in the process of rotating, and solid-state heparin sodium remains in the cavity of cylinder 5, and the separation and extraction of heparin sodium can be completed;When separating solid-state heparin sodium and eluent, the efficiency of solid-liquid separation is promoted by centrifugal effect, is convenient to use, the solid-liquid separation efficiency is high, and the practicality is high.

[0020] As Figure 1 And Figure 4 Drive mechanism includes bevel gear A7, bevel gear B8, drive shaft 9, fixed plate 10 and drive motor 11, bevel gear A7 is fixedly sleeved on support shaft 4, bevel gear A7 is engaged with bevel gear B8, bevel gear B8 is fixedly installed on drive shaft 9, drive shaft 9 is rotatably installed on fixed plate 10, and fixed plate 10 and drive motor 11 are fixedly installed on bottom plate 1, and the input end of drive shaft 9 is connected with drive motor 11;When driving drive shaft 9 to rotate, open drive motor 11, and drive motor 11 makes bevel gear B8 rotate through drive shaft 9, and bevel gear B8 makes support shaft 4 drive cylinder 5 to rotate through bevel gear A7, which is convenient for the rotation of cylinder 5 and improves the solid-liquid separation speed in the cavity of cylinder 5.

[0021] As Figure 1 And Figure 5The mixing mechanism comprises a stirring mechanism, a support frame 12, a mixing cylinder 13 and a discharge pipe 14, the mixing cylinder 13 is fixedly installed on the upper portion of the box body 3 through the support frame 12, a mixing cavity is arranged in the mixing cylinder 13, the lower portion of the mixing cylinder 13 is provided with the discharge pipe 14 which is communicated with the mixing cavity, a valve is arranged on the discharge pipe 14, the discharge pipe 14 is located above the feeding funnel, and the stirring mechanism has a stirring function; the heparin sodium eluent is added into the mixing cavity of the mixing cylinder 13, then alcohol is added into the mixing cavity of the mixing cylinder 13, so that the heparin sodium is formed into solid-state precipitate under the action of the alcohol, then the valve on the discharge pipe 14 is opened, the eluent containing the solid-state heparin sodium falls into the feeding funnel of the sealing cover 6 through the discharge pipe 14, and then the eluent enters the cavity of the cylinder body 5 through the feeding funnel to be subjected to solid-liquid separation, thereby improving convenience.

[0022] As Figure 5 The stirring mechanism comprises a lifting frame 15, a servo motor 16, a rotating shaft 17 and a plurality of stirring blades 18, the servo motor 16 is fixedly installed on the upper end of the lifting frame 15, the rotating shaft 17 is rotatably installed on the lifting frame 15, the upper end of the rotating shaft 17 is connected with the output end of the servo motor 16, and the plurality of stirring blades 18 are all fixedly installed on the lower portion of the rotating shaft 17 and located in the mixing cavity of the mixing cylinder 13; the lifting frame 15 is fixedly hoisted on the support in the workshop; when the alcohol and the heparin sodium eluent are mixed in the mixing cavity of the mixing cylinder 13, the servo motor 16 is opened, the servo motor 16 rotates the plurality of stirring blades 18 through the rotating shaft 17, and the plurality of stirring blades 18 promote the mixing between the heparin sodium solution and the alcohol in the rotating process, so that the alcohol can be fully mixed with the heparin sodium solution and the precipitation of the heparin sodium is promoted.

[0023] A transparent observation window is arranged on the box body 3, and the material of the box body 3 is stainless steel. Embodiment 2

[0024] On the basis of the embodiment 1, a plurality of waterproof electric heating lamps 19 are additionally arranged, and the plurality of waterproof electric heating lamps 19 are all fixedly installed on the inner side wall of the box body 3; after the solid-liquid separation of the heparin sodium in the cylinder body 5 is completed, a drain pipe on the box body 3 is opened, so that the liquid in the chamber of the box body 3 is drained through the drain pipe, then the plurality of waterproof electric heating lamps 19 are opened, and the cylinder body 5 is heated, so that the solid-state heparin sodium in the cavity of the cylinder body 5 is heated, the residual water of the heparin sodium is dried, and the drying efficiency of the heparin sodium is improved.

[0025] The driving motor 11, the servo motor 16, the stirring blade 18 and the waterproof electric heating lamp 19 of the heparin sodium separation and extraction device are all purchased on the market, and the technical personnel in the industry only needs to install and operate according to the attached instruction manual, without the creative labor of the technical personnel in the field.

[0026] The above merely is the preferred implementation manner of the present application, and it should be noted that, for the ordinary skilled in the art, without departing from the technical principles of the present application, a number of improvements and modifications can be made, and these improvements and modifications should also be considered as the protection scope of the present application.

Claims

1. A heparin sodium separation and extraction device, comprising a base plate (1), a support (2) and a box body (3), the box body (3) is fixedly installed on the upper end of the base plate (1) through the support (2), a cavity is arranged in the box body (3), a drain pipe communicating with the cavity is arranged on the lower part of the box body (3), and a valve is arranged on the drain pipe; characterized in that, It also includes support shaft (4), cylinder (5), sealing cover (6), mixing mechanism and driving mechanism, the mixing mechanism is installed on the upper part of the box (3), the mixing mechanism has mixing function, the support shaft (4) is rotatably installed on the bottom plate (1) and the box (3), the cylinder (5) is fixedly installed on the upper end of the support shaft (4), the cavity is arranged in the cylinder (5), the upper end of the cylinder (5) is provided as an opening, the sealing cover (6) is installed on the upper end of the cylinder (5) by bolts, the cylinder (5) is rotatably installed on the box (3), the sealing cover (6) is provided with a feeding hopper, the feeding hopper is provided with a valve, the cylinder (5) is provided with a plurality of filter holes communicated with the cavity, the outer side wall of the cylinder (5) is provided with filter cloth, and the driving mechanism is used for driving the support shaft (4) to rotate.

2. The heparin sodium separation and extraction device according to claim 1, characterized in that, The driving mechanism includes bevel gear A (7), bevel gear B (8), drive shaft (9), fixed plate (10) and drive motor (11), the bevel gear A (7) is fixedly sleeved on the support shaft (4), the bevel gear A (7) is engaged with the bevel gear B (8), the bevel gear B (8) is fixedly installed on the drive shaft (9), the drive shaft (9) is rotatably installed on the fixed plate (10), and the fixed plate (10) and the drive motor (11) are fixedly installed on the bottom plate (1), and the input end of the drive shaft (9) is connected with the drive motor (11).

3. The heparin sodium separation and extraction device according to claim 1, characterized in that, The mixing mechanism includes stirring mechanism, support frame (12), mixing cylinder (13) and discharge pipe (14), the mixing cylinder (13) is fixedly installed on the upper part of the box (3) through the support frame (12), the mixing cylinder (13) is provided with a mixing cavity, the lower part of the mixing cylinder (13) is provided with a discharge pipe (14) communicated with the mixing cavity, the discharge pipe (14) is provided with a valve, and the discharge pipe (14) is located above the feeding hopper, and the stirring mechanism has stirring function.

4. The heparin sodium separation and extraction device according to claim 3, characterized in that, The stirring mechanism includes hoisting frame (15), servo motor (16), rotating shaft (17) and a plurality of stirring blades (18), the servo motor (16) is fixedly installed on the upper end of the hoisting frame (15), the rotating shaft (17) is rotatably installed on the hoisting frame (15), the upper end of the rotating shaft (17) is connected with the output end of the servo motor (16), and a plurality of stirring blades (18) are fixedly installed on the lower part of the rotating shaft (17). A plurality of stirring blades (18) are located in the mixing cavity of the mixing cylinder (13).

5. The heparin sodium separation and extraction device according to claim 1, characterized in that, It also includes a plurality of waterproof electric heating lamps (19), and a plurality of waterproof electric heating lamps (19) are fixedly installed on the inner side wall of the box (3).

6. The heparin sodium separation and extraction device according to claim 1, characterized in that, The box (3) is provided with a transparent observation window.

7. The heparin sodium separation and extraction device according to claim 1, characterized in that, The material of the box (3) is stainless steel.

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