Multifunctional expired gas online sampling device

Abstract

The utility model provides a multifunctional expired gas online sampling device. The device comprises a pressure measuring system, a flow measuring system, a mode switching system and a cleaning system. The working method of the online expired gas sampling device comprises the following steps: before sampling, NC of the two-position three-way electromagnetic valve is closed, NO is opened, and gas in the online expired gas sampling device is emptied through the normally-open two-way electromagnetic valve; nO of the two-position three-way electromagnetic valve is closed, and NC is opened; air is blown into the expired air on-line sampling device through the blowing nozzle, expired air flows through the pressure sensor, the expired air pressure is measured, and saliva is collected into the saliva bin in a centralized mode; exhaled air flows from the high-pressure detection port to the low-pressure detection port, and the flow of the exhaled air is measured through the flow sensor; exhaled air flows to the electromagnetic valve frame from the low-pressure detection port, flows through the sampling port through the passage NO, and is collected by a sample container or analyzed on line by an analysis instrument; and the expired gas pressure, the expired gas flow and an online analysis result are displayed through a screen and a control system.

Description

Technical Field

[0001] This utility model relates to the field of gas sampling technology, and in particular to a multifunctional online exhaled breath sampling device. Background Technology

[0002] Exhaled breath vapor (EBV) contains hundreds of endogenous volatile organic compounds (VOCs), which are byproducts of metabolism in both healthy and disease-related processes. For example, a fishy odor may indicate liver disease, acetone may indicate diabetes, ammonia may indicate kidney failure, and NO may indicate asthma. Breath analysis has clinical and diagnostic potential. By measuring VOCs in exhaled breath samples, biomarkers of health conditions can be established, thus providing new clinical diagnostic tools.

[0003] Breath analysis is an attractive non-invasive diagnostic tool for patients, but detecting extremely low concentrations of compounds is challenging. Gas chromatography, mass spectrometry, FeNO, ion mobility spectrometry, and laser absorption spectroscopy are widely used to separate and identify volatile organic compounds (VOCs) in human respiration. Breath measurement conditions, such as expiratory flow rate, environment, breath-holding, forced exhalation, and nasal contamination, significantly affect concentrations. A key issue in measuring VOC concentrations in exhaled air is how to sample the breath, as VOC concentrations can change during transportation, storage, pretreatment, or collection at the inhaler.

[0004] Depending on the scope of medical diagnosis, breath samples can be collected in two ways: mixed expiratory sampling and end-tidal sampling. The first method collects the total respiratory volume, primarily consisting of air from the upper respiratory tract. The second method collects air containing components relevant to blood (alveolar air). Currently, there is no universally accepted standard for breath sampling, but for nitric oxide measurements, it is recommended that expiratory breaths be collected and tested at a constant flow rate and pressure.

[0005] Currently, there are various breath sampling techniques in use, mainly divided into online (connecting the breath device to a gas analyzer) and offline sampling (breath detection in a sample container, such as an air bag, or enrichment detection using adsorption tubes). Generally, online direct sampling is preferred. With this technique, the possibility of sample variation is minimized. Exhaled volume and other expiratory variables (e.g., airway flow rate or pressure) are captured and displayed in real time, allowing test administrators to monitor exhalation to ensure compliance. However, in some cases, online sampling is not feasible, making appropriate offline methods much more convenient. But diffusion loss of breath gas within the storage bag, adsorption on the inner surface, and interactions between sample components can irreversibly alter the original composition of the sample, thus interfering with the final analytical results.

[0006] An analytical method for detecting acetone concentration in exhaled breath (CN202111490775.8) discloses an offline method for collecting exhaled breath: when exhaled gas passes through a gas flow sensor on a breathing tube via a mouthpiece, if the flow rate exceeds a set threshold, the sensor's signal is transmitted to a solenoid valve. The solenoid valve switches the gas path, expelling the gas at the front end of the exhaled breath that is below the set flow rate. The exhaled breath is collected into a Tedra bag, which gradually expands and is filled after one or more breaths. Although this patent can track exhaled breath flow (indicator light) in real time, the exhaled breath flow is only used as a threshold and cannot achieve constant pressure, constant flow, or constant volume collection. It also cannot allow the observer to track pressure and flow parameters in real time. The sampling device cannot perform online data collection or purge the sampling device.

[0007] An enrichment device (CN219417371U) for improving the sensitivity of ammonia detection at the end of nasal exhalation discloses a method for online sampling and enrichment of nasal exhalation gas by using a bypass detection method to collect the exhaled CO2 curve in real time. At the same time, the bypass principle is used to achieve ion mobility spectrum purging. However, this device causes some exhaled gas to be lost, affecting the collection efficiency.

[0008] A portable exhaled air collection device (CN209884147U) allows for the measurement of exhaled air volume via a flow meter, and a three-way solenoid valve enables switching of the air collection path. Using a gas sensor, temperature and humidity sensor, and pressure sensor as sensing devices, it triggers the three-way solenoid valve and air pump to collect exhaled air from the upper and lower respiratory tracts of the test subject. However, this device has a complex design and is not suitable for online exhaled air collection.

[0009] Therefore, there is a need for an online exhaled breath sampling device to achieve online collection and automatic cleaning. Summary of the Invention

[0010] To address the aforementioned technical problems, a multifunctional online exhaled air sampling device is provided. This invention is used to collect air from the upper respiratory tract and alveoli for clinical research. After expelling dead air from the device, the collector exhales using a mask (mouthpiece) equipped with a biofilter, connecting the sampling end to a sample container or analytical instrument. The exhaled air is automatically transferred to the sample container or analytical sampling port by a solenoid valve controlled by data detected by a pressure sensor and a differential pressure flow sensor. Mixed exhaled air or end-tidal gas is automatically collected according to the program. Through the screen, the collector can obtain real-time control of the exhaled air pressure and flow rate, and adjust the breathing force to achieve constant pressure, constant flow, or constant volume exhaled air collection.

[0011] The technical means adopted in this utility model are as follows:

[0012] A multifunctional online exhaled breath sampling device includes: a pressure measurement system, a flow measurement system, a mode switching system, and a cleaning system, wherein:

[0013] The pressure measurement system is connected to a handle at one end and a flow measurement system at the other end, and is used to measure exhaled air pressure; the handle is connected to the mouthpiece.

[0014] The flow measurement system is connected to the pressure measurement system at one end and the gas switching system at the other end to measure the exhaled air flow rate.

[0015] The mode switching system is connected to the flow measurement system at one end and the cleaning system at the other end, and is used to switch the working mode of the online exhaled breath sampling device to detection mode or cleaning mode;

[0016] The cleaning system is connected to a mode switching system for reverse cleaning of the online exhaled breath sampling device.

[0017] Furthermore, the pressure measurement system includes: a sensor holder, a saliva tank, and a pressure sensor, wherein:

[0018] The sensor frame has a hollow structure and is connected to the mouthpiece via a handle. A saliva chamber is located at the bottom of the sensor frame, and a pressure sensor is located at the top. A high-pressure detection port is located at the tail end of the sensor frame.

[0019] A sealing screw is installed below the saliva chamber. When the exhaled air online sampling device is in cleaning mode, the sealing screw is removed to clean the saliva chamber.

[0020] Furthermore, the flow measurement system includes: a gas resistance pipeline, a flow sensor, a high-pressure detection port, and a low-pressure detection port, wherein:

[0021] The air resistance tube is connected to the sensor frame, blocking the exhaled air passage and driving the exhaled air from the high-pressure detection port into the flow sensor; the flow sensor is a differential pressure flow sensor, with one end connected to the high-pressure detection port and the other end connected to the low-pressure detection port.

[0022] Furthermore, the mode switching system includes: a solenoid valve holder, a sampling port, an exhaust port, and a two-position three-way solenoid valve, wherein:

[0023] The solenoid valve frame has a hollow structure. The front end of the solenoid valve frame is connected to a low-pressure detection port. The two-position three-way solenoid valve is installed inside the solenoid valve frame. The two-position three-way solenoid valve includes two channels, NO and NC. In detection mode, NO is closed and NC is open, connecting to the sampling port. In cleaning mode, NC is closed and NO is open, connecting to the exhaust port.

[0024] During online data collection, the sampling port is connected to the analysis instrument, allowing for direct online analysis of exhaled air; during offline data collection, the sampling port is connected to the sample container, allowing for the sampling and collection of exhaled air.

[0025] Furthermore, the cleaning system includes: a three-way pipe, a cleaning pump, and a normally open two-way solenoid valve, wherein:

[0026] The three ports of the three-way pipe are respectively connected to the exhaust port, the cleaning pump, and the normally open two-way solenoid valve; before sampling, the exhaled gas online sampling device empties the gas in the exhaled gas online sampling device through the normally open two-way solenoid valve;

[0027] The cleaning pump is used to deliver high-pressure gas from the cleaning system through the mode switching system, flow measurement system, pressure measurement system, and handle in the cleaning mode, and then blow it out from the nozzle to complete the cleaning.

[0028] Furthermore, the exhaled breath online sampling device also includes a screen and a control system, which can display the measurement results of the pressure sensor and flow sensor in real time, and can display the online analysis results of the analysis instrument in real time during online data acquisition.

[0029] Compared with the prior art, the present invention has the following advantages:

[0030] This invention provides a multifunctional online exhaled breath sampling device, comprising: a pressure measurement system, a flow measurement system, a mode switching system, and a cleaning system. It monitors the pressure, flow rate, and total volume of exhaled breath in real time, and works with a solenoid valve to achieve automatic breath sampling. This invention allows the sampling port to be directly connected to the device's inlet for online analysis of exhaled breath, reducing interference and ensuring the original composition and form of the sample. It can also collect VOCs from the breath into a sample container, enabling clinical respiratory researchers to overcome geographical limitations and share laboratory samples.

[0031] This utility model provides a multifunctional online exhaled air sampling device. By selecting different control sampling parameters, it can collect air from the upper respiratory tract or alveoli for clinical research. The sampling device is also designed with automatic cleaning and automatic saliva collection functions, making the device more comprehensive. This device is an easily assembled exhaled air VOC sampling device for studying respiratory VOCs. It is small in size, lightweight, low in cost, and easy to use in clinical and commercial environments.

[0032] Based on the above reasons, this utility model can be widely promoted in fields such as gas sampling. Attached Figure Description

[0033] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0034] Figure 1 This is a schematic diagram of the multifunctional online exhaled breath sampling device of this utility model.

[0035] In the diagram: 1. Mouthpiece; 2. Handle; 3. Sensor holder; 4. Sealing screw; 5. Saliva tank; 6. Air resistance tubing; 7. Solenoid valve holder; 8a. Sample container; 8b. Analytical instrument; 9. Sampling port; 10. Exhaust port; 11. T-connector; 12. Normally open two-way solenoid valve; 13. Cleaning pump; 14. Two-position three-way solenoid valve; 15. Low-pressure detection port; 16. Flow sensor; 17. High-pressure detection port; 18. Pressure sensor; 19. Screen and control system. Detailed Implementation

[0036] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other. The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0037] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The following description of at least one exemplary embodiment is merely illustrative and is in no way intended to limit the present invention or its application or use. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0038] It should be noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of exemplary embodiments according to the invention. As used herein, the singular form is intended to include the plural form as well, unless the context clearly indicates otherwise. Furthermore, it should be understood that when the terms "comprising" and / or "including" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.

[0039] Unless otherwise specifically stated, the relative arrangement, numerical expressions, and values ​​of the components and steps described in these embodiments do not limit the scope of the invention. It should also be understood that, for ease of description, the dimensions of the various parts shown in the drawings are not drawn to actual scale. Techniques, methods, and devices known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and devices should be considered part of the specification. In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not as limitations. Therefore, other examples of exemplary embodiments may have different values. It should be noted that similar reference numerals and letters in the following figures denote similar items; therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0040] In the description of this invention, it should be understood that the orientation or positional relationship indicated by directional terms such as "front, back, up, down, left, right", "horizontal, vertical, horizontal" and "top, bottom" is generally based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing this invention and simplifying the description. Unless otherwise stated, these directional terms do not indicate or imply that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this invention. The directional terms "inner" and "outer" refer to the inner and outer contours relative to the outline of each component itself.

[0041] For ease of description, spatial relative terms such as "above," "over," "on the upper surface of," "above," etc., are used herein to describe the spatial positional relationship of a device or feature as shown in the figures to other devices or features. It should be understood that spatial relative terms are intended to encompass different orientations in use or operation besides the orientation of the device as described in the figures. For example, if the device in the figures is inverted, a device described as "above" or "above" other devices or structures would subsequently be positioned as "below" or "under" other devices or structures. Thus, the exemplary term "above" can include both "above" and "below." The device may also be positioned in other different ways (rotated 90 degrees or in other orientations), and the spatial relative descriptions used herein will be interpreted accordingly.

[0042] Furthermore, it should be noted that the use of terms such as "first" and "second" to define components is merely for the purpose of distinguishing the corresponding components. Unless otherwise stated, the above terms have no special meaning and therefore should not be construed as limiting the scope of protection of this invention.

[0043] like Figure 1As shown, this utility model provides a multifunctional online exhaled breath sampling device, including: a pressure measurement system, a flow measurement system, a mode switching system, and a cleaning system, wherein:

[0044] The pressure measurement system is connected to the handle 2 at one end and the flow measurement system at the other end, and is used to measure the exhaled air pressure; the handle 2 is connected to the mouthpiece 1.

[0045] In practice, the mouthpiece 1 can be replaced by a mask or a blowpipe, and can be with or without a filter.

[0046] The flow measurement system is connected to the pressure measurement system at one end and the gas switching system at the other end to measure the exhaled air flow rate.

[0047] The mode switching system connects to the flow measurement system on one end and the cleaning system on the other, and is used to switch the operating mode of the online exhaled breath sampling device to detection mode or cleaning mode.

[0048] The cleaning system and connection mode switching system are used for reverse cleaning of the online exhaled breath sampling device.

[0049] In a specific implementation, as a preferred embodiment of this utility model, the pressure measurement system includes: a sensor holder 3, a saliva tank 5, and a pressure sensor 18, wherein:

[0050] The sensor frame 3 has a hollow structure and is connected to the mouthpiece 1 through the handle 2. A saliva chamber 5 is set at the bottom of the sensor frame 3, and a pressure sensor 18 is set at the top. A high-pressure detection port 17 is set at the tail end of the sensor frame 3.

[0051] A sealing screw 4 is installed below the saliva tank 5. When the exhaled air online sampling device is in cleaning mode, the sealing screw 4 is removed to clean the saliva tank 5.

[0052] During implementation, the pressure sensor 18 can be replaced or added with a humidity sensor, CO2 sensor or other types of sensors according to actual detection needs.

[0053] In a specific implementation, as a preferred embodiment of this utility model, the flow measurement system includes: a gas resistance pipeline 6, a flow sensor 16, a high-pressure detection port 17, and a low-pressure detection port 15, wherein:

[0054] The air resistance line 6 is connected to the sensor frame 3, blocking the exhaled air passage and driving the exhaled air from the high pressure detection port 17 into the flow sensor 16; the flow sensor 16 is a differential pressure flow sensor, with one end connected to the high pressure detection port 17 and the other end connected to the low pressure detection port 15.

[0055] In practice, the flow sensor 16 can be replaced with other types of sensors, such as thermal flow sensors, invasive flow sensors, or non-invasive flow sensors, depending on the detection requirements.

[0056] In a specific implementation, as a preferred embodiment of this utility model, the mode switching system includes: a solenoid valve holder 7, a sampling port 9, an exhaust port 10, and a two-position three-way solenoid valve 14, wherein:

[0057] The solenoid valve frame 7 has a hollow structure. The front end of the solenoid valve frame 7 is connected to the low-pressure detection port 15. The two-position three-way solenoid valve 14 is located inside the solenoid valve frame 7. The two-position three-way solenoid valve 14 includes two passages, NO and NC. In the detection mode, NO is closed and NC is open, connecting to the sampling port 9. In the cleaning mode, NC is closed and NO is open, connecting to the exhaust port 10.

[0058] During online data collection, sampling port 9 is connected to the analyzer 8b, allowing for direct online analysis of exhaled air; during offline data collection, sampling port 9 is connected to the sample container 8a, allowing for the sampling and collection of exhaled air.

[0059] In a specific implementation, as a preferred embodiment of this utility model, the cleaning system includes: a three-way pipe 11, a cleaning pump 13, and a normally open two-way solenoid valve 12, wherein:

[0060] The three ports of the three-way pipe 11 are respectively connected to the exhaust port 10, the cleaning pump 13 and the normally open two-way solenoid valve 12; before sampling, the exhaled gas online sampling device empties the gas in the exhaled gas online sampling device through the normally open two-way solenoid valve 12.

[0061] The cleaning pump 13 is used to pump high-pressure gas from the cleaning system through the mode switching system, flow measurement system, pressure measurement system, and handle 2 in sequence during the cleaning mode, and blow it out from the nozzle 1 to complete the cleaning.

[0062] In a specific implementation, as a preferred embodiment of this utility model, the exhaled breath online sampling device also includes a screen and a control system. The screen and control system can display the measurement results of the pressure sensor 18 and the flow sensor 16 in real time, and can display the online analysis results of the analysis instrument 8b in real time during online data acquisition.

[0063] During implementation, the control system has the function of uploading the detected data in real time, making it convenient for operators to check whether the exhaled breath collection is qualified.

[0064] In practice, the specific working method of the multifunctional online exhaled breath sampling device of this utility model includes:

[0065] Before sampling, the NC of the two-position three-way solenoid valve 14 is closed and the NO is opened, so that the gas in the exhaled gas online sampling device is vented through the normally open two-way solenoid valve 12; then the NO of the two-position three-way solenoid valve 14 is closed and the NC is opened.

[0066] By blowing air into the online exhaled air sampling device through the mouthpiece 1, the exhaled air flow passes through the pressure sensor 18 to measure the exhaled air pressure, and the saliva is collected into the saliva tank 5.

[0067] Exhaled air flows from the high-pressure detection port 17 to the low-pressure detection port 15, and the exhaled air flow rate is measured by the flow sensor 16;

[0068] Exhaled air flows from the low-pressure detection port 15 to the solenoid valve frame 7, and then through the NO passage to the sampling port 9, where it is collected using the sample container 8a or analyzed online using the analytical instrument 8b.

[0069] Exhaled air pressure, exhaled air flow, and the results of online analysis are displayed on the screen and control system 19.

[0070] In a specific implementation, as a preferred embodiment of this utility model, the working method of the exhaled breath online sampling device in cleaning mode is as follows:

[0071] Close the NC position of the two-position three-way solenoid valve 14 and open the NO position. Close the normally open two-way solenoid valve 12 and turn on the cleaning pump 13 to make the high-pressure gas flow from the cleaning system through the mode switching system, the flow measurement system, the pressure measurement system, and the handle 2 in sequence, and blow it out from the nozzle 1 to complete the cleaning.

[0072] Example

[0073] like Figure 1 As shown, this utility model provides a multifunctional online exhaled breath sampling device, which has two working modes: sampling and cleaning.

[0074] Sampling Mode: The cleaning pump 13 is off, the normally open two-way solenoid valve 12 is open, and the gas is vented from the exhaust port 10. The collector holds the handle 2 and blows air into the device through the mouthpiece 1. At this time, the screen and control system 19 will display the current pressure and flow rate. When the pressure or flow rate reaches the set value, the two-position three-way solenoid valve 14 switches to NC and opens. The screen and control system 19 will issue a prompt sound and begin recording the volume of the collected gas, exhaled air is discharged from the sampling port 9. When the sampling port 9 is connected to the sample container 8a, offline sampling is achieved; when connected to the analytical instrument 8b, online sampling is achieved. The device has multiple sampling modes. The collector observes the sample pressure, flow rate, or volume on the screen in real time and adjusts it to the required sample pressure, flow rate, or volume through positive feedback to achieve constant pressure, constant flow, or constant volume sampling. It can also achieve mixed exhaled breath sampling and end-tidal sampling through delay.

[0075] When the exhaled air contains saliva during the collection process, it flows downwards along the airway and collects in the saliva chamber 5. When the chamber is full, the sealing screw 4 can be loosened to clean it. The screen and control system 19 have the function of uploading the detected data in real time, making it convenient for the operator to check whether the exhaled air collection is qualified.

[0076] Cleaning mode: Cleaning pump 13 is turned on, normally open two-way solenoid valve 12 is closed, and two-position three-way solenoid valve 14 is turned on (NO). The device performs reverse cleaning, with gas flowing along the three-way pipe 11, solenoid valve bracket 7, two-position three-way solenoid valve 14, air resistance pipe 6, sensor bracket 3, and handle 2, finally exiting from nozzle 1 to achieve reverse cleaning. The screen and control system 19 allow setting the cleaning time for convenient operation.

[0077] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A multi-functional exhaled breath online sampling device, characterized by, The application relates to an online sampling device for collecting exhaled breath, which comprises a pressure measuring system, a flow measuring system, a mode switching system and a cleaning system, wherein: The pressure measuring system is connected with a handle (2) at one end and with the flow measuring system at the other end, and is used for measuring the pressure of exhaled breath; the handle (2) is connected with a blowing nozzle (1); The flow measuring system is connected with the pressure measuring system at one end and with a gas switching system at the other end, and is used for measuring the flow of exhaled breath; The mode switching system is connected with the flow measuring system at one end and with the cleaning system at the other end, and is used for switching the working mode of the online sampling device for collecting exhaled breath into a detection mode or a cleaning mode; The cleaning system is connected with the mode switching system, and is used for reversely cleaning the online sampling device for collecting exhaled breath. The pressure measuring system comprises a sensor holder (3), a saliva tank (5) and a pressure sensor (18), wherein:

2. The multi-functional exhaled breath on-line sampling device according to claim 1, wherein, The sensor holder (3) is a hollow structure, is communicated with the blowing nozzle (1) through the handle (2), is provided with the saliva tank (5) below and is provided with the pressure sensor (18) above, and is provided with a high-pressure detection port (17) at the tail end; The saliva tank (5) is provided with a sealing screw (4) below, the sealing screw (4) is disassembled when the online sampling device for collecting exhaled breath is in the cleaning mode, and the saliva tank (5) is cleaned. The flow measuring system comprises a gas resistance pipeline (6), a flow sensor (16), a high-pressure detection port (17) and a low-pressure detection port (15), wherein:

3. The multi-functional exhaled breath on-line sampling device according to claim 1, wherein, The gas resistance pipeline (6) is connected with the sensor holder (3), blocks the exhaled breath passage, and drives the exhaled breath to pass into the flow sensor (16) from the high-pressure detection port (17); the flow sensor (16) is a differential pressure type flow sensor, one end of which is communicated with the high-pressure detection port (17) and the other end of which is communicated with the low-pressure detection port (15). The mode switching system comprises an electromagnetic valve holder (7), a sampling port (9), an exhaust port (10) and a two-position three-way electromagnetic valve (14), wherein:

4. The multi-functional exhaled breath on-line sampling device according to claim 1, wherein, The electromagnetic valve holder (7) is a hollow structure, the low-pressure detection port (15) is connected with the front end of the electromagnetic valve holder (7), the two-position three-way electromagnetic valve (14) is arranged in the electromagnetic valve holder (7), the two-position three-way electromagnetic valve (14) comprises NO and NC two passages, in the detection mode, the NO is closed, the NC is opened, the sampling port (9) is communicated, in the cleaning mode, the NC is closed, the NO is opened, and the exhaust port (10) is communicated; When the online collection is carried out, the sampling port (9) is communicated with an analysis instrument (8b), and the exhaled breath is directly subjected to online analysis; when the offline collection is carried out, the sampling port (9) is communicated with a sample container (8a), and the exhaled breath is sampled and collected. The cleaning system comprises a three-way pipeline (11), a cleaning pump (13) and a normally open two-way electromagnetic valve (12), wherein:

5. The multi-functional exhaled breath on-line sampling device according to claim 1, wherein, Three ports of the three-way pipeline (11) are connected with the exhaust port (10), the cleaning pump (13) and the normally open two-way electromagnetic valve (12) respectively; before sampling, the online sampling device for collecting exhaled breath is emptied of the gas in the online sampling device for collecting exhaled breath through the normally open two-way electromagnetic valve (12). ​ The cleaning pump (13) is used to flow high-pressure gas from the cleaning system to the mode switching system, the flow measurement system, the pressure measurement system, the handle (2) and the blow nozzle (1) in sequence in the cleaning mode to complete the cleaning.

6. The multi-functional exhaled breath on-line sampling device according to claim 1, wherein, The exhaled air online sampling device further comprises a screen and a control system, which can display the measurement results of the pressure sensor (18) and the flow sensor (16) in real time and can display the online analysis results of the analysis instrument (8b) in real time during online collection.

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