Cell tissue crushing equipment

By designing a cell and tissue disruption device with adjustable cavity size and replaceable blades, the problems of manual operation and low efficiency in existing technologies have been solved, achieving automated disruption and highly efficient adaptive disruption.

CN223963517UActive Publication Date: 2026-03-03HEYUAN HEMEI (SHANGHAI) BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202520408619.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2025-03-10
Publication Date
2026-03-03
Estimated Expiration
2035-03-10

AI Technical Summary

Technical Problem

Existing cell and tissue disruption equipment requires manual operation during the initial grinding stage, and the varying cell sizes and strengths increase the workload and time costs, thus reducing disruption efficiency.

Method used

A cell and tissue disruption device was designed, which adopts an expansion mechanism with adjustable cavity size and a replaceable blade structure. The blade is engaged by pressing a spring to achieve automated disruption, and the expansion mechanism can adapt to samples of different types and volumes.

Benefits of technology

It achieves automated crushing, reduces manual operation, improves crushing efficiency and equipment flexibility, and adapts to the needs of samples with different strengths and volumes.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model relates to the technical field of cell tissue crushing equipment, and discloses cell tissue crushing equipment which comprises a machine body, a motor is fixedly connected to the top of the machine body, a fixed long rod is fixedly connected to the output end of the motor, and the outer wall of the fixed long rod penetrates through the bottom end of the machine body and is fixedly connected with a long block. A plurality of hollow long plates are fixedly connected to the periphery of the outer wall of the long block at equal intervals, a groove plate is slidably connected to the interior of each hollow long plate, a plurality of fixing blocks are fixedly connected to the outer wall of each hollow long plate at equal intervals, a fixing short rod is rotatably connected to the middle of each fixing block, and a long short plate is fixedly connected to the outer wall of each fixing short rod. According to the material crushing device, a selected cutter is pushed out by pressing the long short plate, then the long short plate is loosened to enable the arc-shaped clamping block and the groove plate to be clamped and fixed, and finally the motor is started for crushing, so that the effect of performing targeted crushing on materials with different strengths is achieved.
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Description

Technical Field

[0001] This utility model relates to the field of cell and tissue disruption equipment technology, and in particular to a cell and tissue disruption equipment. Background Technology

[0002] Cellular tissues are the basic structural and functional units of cells. Different types of cells have different morphologies, structures, and functions. They are interconnected and coordinated through the intercellular matrix to jointly perform specific physiological functions. Cellular tissues are structures composed of morphologically similar and functionally related cells and intercellular matrix. Cellular tissues are one of the basic building blocks of multicellular organisms. They play an important role in the growth, development, metabolism, and immunity of organisms. Different types of cells have different morphologies, structures, and functions. They are interconnected and coordinated through the intercellular matrix to jointly perform specific physiological functions.

[0003] Existing cell and tissue disruption equipment achieves homogenization of cells through the shearing action between a piston and a valve body within the device. As the piston reciprocates within the valve body, the cell tissue is continuously squeezed and sheared, resulting in cell disruption and homogenization. However, cell tissue is complex, containing large, unbroken tissue fragments, fibrous material, and cell debris. During the piston's reciprocating motion, these larger materials can become stuck between the piston and valve body and accumulate in the channels, clogging the pipes. Current technology involves preliminary disruption of the cell tissue using other mechanical methods before placing it into the homogenizer. For example, larger tissue blocks can be cut into smaller fragments using scissors and a tissue homogenizer, followed by light grinding with a grinding rod to reduce the size of the cell tissue, making it easier to further disrupt in the homogenizer and reducing the risk of blockage. However, this preliminary grinding requires manual operation, and because the size and strength of the disrupted cells vary, the workload and time cost of the preliminary grinding increase, thereby reducing the efficiency of subsequent disruption work. Utility Model Content

[0004] To overcome the above shortcomings, this utility model provides a cell tissue disruption device, which aims to improve the problem that the prior art requires manual operation during the initial grinding process, and that the varying sizes and strengths of the disrupted cells lead to increased workload and time costs.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a cell tissue disruption device, comprising a body, a motor fixedly connected to the top of the body, a fixed long rod fixedly connected to the output end of the motor, an elongated block fixedly connected to the outer wall of the fixed long rod penetrating the bottom of the body, a plurality of hollow long plates fixedly connected at equal intervals around the outer wall of the elongated block, a grooved plate slidably connected inside the hollow long plate, a plurality of fixed blocks fixedly connected at equal intervals to the outer wall of the hollow long plate, a fixed short rod rotatably connected to the middle of the fixed block, an elongated short plate fixedly connected to the outer wall of the fixed short rod, a spring fixedly connected to the upper middle part of the outer wall of the hollow long plate, an arc-shaped locking block fixedly connected to the outer wall of the elongated short plate, blade two and blade one fixedly connected to the bottom adjacent sides of the two grooved plates respectively, a door rotatably connected to the front side of the outer wall of the body, and an expansion mechanism installed inside the body for expanding the size of the disruption chamber.

[0006] As a further description of the above technical solution:

[0007] The expansion mechanism includes a square block installed inside the body. Telescopic columns are fixedly connected to all four sides of the outer wall of the square block. A semi-circular block 1 is fixedly connected to the left side of the outer wall of the left telescopic column, and a semi-circular block 2 is fixedly connected to the other side of the outer wall of the right telescopic column. An arc-shaped expansion plate is provided on the adjacent side of the semi-circular block 2 and the semi-circular block 1. A U-shaped hollow piece is fixedly connected to the top rear side of the semi-circular block 2 and the semi-circular block 1. A serrated plate is rotatably connected to the left and right sides of the inner wall of the U-shaped hollow piece. A long sliding groove plate is fixedly connected to the top front side of the semi-circular block 1 and the semi-circular block 2. A long outer groove plate is slidably connected to the top of the long sliding groove plate. A placement hole is opened on the top of the semi-circular block 1.

[0008] As a further description of the above technical solution:

[0009] A screw is threadedly connected to the right side of the outer wall of the machine body, and a warning sign is threadedly connected to the outer wall of the screw.

[0010] As a further description of the above technical solution:

[0011] A latch is fixedly connected to the right side of the outer wall of the machine body, and a buckle is fixedly connected to the front side of the outer wall of the machine door. The buckle and the latch are engaged and connected.

[0012] As a further description of the above technical solution:

[0013] A handle is fixedly connected to the front side of the outer wall of the machine door, and an anti-slip sleeve is fixedly connected to the outer wall of the handle.

[0014] As a further description of the above technical solution:

[0015] Each of the four corners at the bottom of the body is fixedly connected to a fixed post, and a circular pad is fixedly connected to the bottom of each fixed post.

[0016] As a further description of the above technical solution:

[0017] A hollow box is fixedly connected to the bottom right side of the machine body, and a drawer is slidably connected inside the hollow box.

[0018] As a further description of the above technical solution:

[0019] A second handle is fixedly connected to the right side of the outer wall of the drawer, and a protective sleeve is fixedly connected to the outer wall of the second handle.

[0020] This utility model has the following beneficial effects:

[0021] 1. In this utility model, by pressing the rear side of the long short plate, the spring in the upper middle part of the outer wall of the hollow long plate is compressed, causing the front side of the long short plate to lift up and the arc-shaped locking block at the bottom to separate from the groove of the grooved plate, so that the selected blade two or blade one can be pushed out. Then, the long short plate is released so that the arc-shaped locking block can be locked and fixed with the grooved plate. Finally, the motor is turned on to crush, thereby achieving the effect of targeted crushing of materials with different strengths, avoiding the problem of increased labor intensity and time cost caused by manual crushing.

[0022] 2. In this utility model, the size of the crushing chamber is expanded by pulling the first and second semicircular blocks to both sides. After expansion, the chamber is adjusted to the inside of the U-shaped hollow piece by sliding the elongated outer groove plate. Finally, the serrated plate is rotated and the crushing chamber is reinforced by engaging with the grooves of the elongated outer groove plate. This allows the size of the chamber to be adjusted to accommodate samples of different types and volumes, thereby improving the flexibility and applicability of the equipment. Attached Figure Description

[0023] Figure 1 This is a perspective view of a cell tissue disruption device proposed in this utility model;

[0024] Figure 2 This is a partial structural diagram of a cell tissue disruption device proposed in this utility model;

[0025] Figure 3 This is a partial structural diagram of a cell and tissue disruption device proposed in this utility model;

[0026] Figure 4 This is a diagram illustrating an extension mechanism for a cell tissue disruption device proposed in this utility model.

[0027] Figure 5This is a schematic diagram of the structure of an extension mechanism for a cell tissue disruption device proposed in this utility model.

[0028] Legend:

[0029] 1. Body; 2. Expansion Mechanism; 201. Square Block; 202. Placement Hole; 203. Rectangular Outer Groove Plate; 204. U-shaped Hollow Plate; 205. Serrated Plate; 206. Arc-shaped Expansion Plate; 207. Rectangular Slide Plate; 208. Semicircular Block One; 209. Semicircular Block Two; 210. Telescopic Column; 3. Motor; 4. Handle One; 5. Anti-slip Sleeve; 6. Fixing Column; 7. Hollow Box; 8. Handle 9. Protective cover; 10. Drawer box; 11. Circular pad; 12. Warning sign; 13. Screw 1; 14. Loop ring; 15. Buckle; 16. Machine door; 17. Fixing long rod; 18. Long short plate; 19. Blade 1; 20. Grooved plate; 21. Hollow long plate; 22. Fixing short rod; 23. Fixing block; 24. Blade 2; 25. Arc-shaped locking block; 26. Spring; 27. Long block. Detailed Implementation

[0030] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0031] Reference Figure 1 , Figure 2 and Figure 3This utility model provides an embodiment of a cell tissue disruption device, comprising a body 1, a motor 3 fixedly connected to the top of the body 1, a fixed long rod 17 fixedly connected to the output end of the motor 3, the fixed long rod 17 serving as a rotatable connection, an elongated block 27 fixedly connected to the outer wall of the fixed long rod 17 penetrating the bottom end of the body 1, and a plurality of hollow long plates 21 fixedly connected at equal intervals around the outer wall of the elongated block 27, the elongated block 27 serving as a fixation for the hollow long plates 21, a grooved plate 20 slidably connected inside the hollow long plate 21, the grooved plate 20 serving as a fixing and engaging function, a plurality of fixing blocks 23 fixedly connected at equal intervals on the outer wall of the hollow long plate 21, a fixed short rod 22 rotatably connected to the middle of the fixing block 23, the fixed short rod 22 serving as a rotatable function, and an elongated short plate 18 fixedly connected to the outer wall of the fixing short rod 22, the fixing short rod 22 serving as a fixation for the elongated short plate 18. The rotational action is achieved by a spring 26 fixedly connected to the upper part of the outer wall of the hollow long plate 21, and an arc-shaped locking block 25 fixedly connected to the outer wall of the long short plate 18. The long short plate 18 serves to fix the arc-shaped locking block 25, and the arc-shaped locking block 25 serves to fix and engage. Blade 24 and Blade 19 are fixedly connected to the bottom adjacent sides of the two grooved plates 20, which can increase the selectivity of the equipment. The front side of the outer wall of the machine body 1 is rotatably connected to the machine door 16. An expansion mechanism 2 is installed inside the machine body 1. The expansion mechanism 2 is used to expand the size of the crushing chamber. Screw 13 is threadedly connected to the right side of the outer wall of the machine body 1. A warning sign 12 is threadedly connected to the outer wall of screw 13. The warning sign 12 on the right side of the machine body 1 can serve to warn the surrounding personnel to avoid danger after approaching. A latch 14 is fixedly connected to the right side of the outer wall of the machine body 1. A latch 15 is fixedly connected to the front side of the outer wall of the machine door 16. The latch 15 and the latch 14 are engaged and connected. The engagement of the latch 15 and the latch 14 can improve the sealing of the machine door 16.

[0032] Reference Figure 1 , Figure 4 and Figure 5The expansion mechanism 2 includes a square block 201, which is installed inside the machine body 1. Telescopic columns 210 are fixedly connected to all four sides of the outer wall of the square block 201, serving to expand and contract. A semi-circular block 208 is fixedly connected to the left side of the outer wall of the left telescopic column 210, and a semi-circular block 209 is fixedly connected to the other side of the outer wall of the right telescopic column 210. Pulling the semi-circular blocks 208 and 209 expands the crushing chamber. An arc-shaped expansion plate 206 is provided on the adjacent side of the semi-circular blocks 209 and 208 for expansion. A U-shaped hollow plate 204 is fixedly connected to the top and rear side of both the semi-circular blocks 209 and 208. A serrated plate 205 is rotatably connected to the left and right sides of the inner wall of the U-shaped hollow plate 204. The serrated plate inside the U-shaped hollow plate 204... 205 serves as a fixed locking mechanism. The top front sides of both the semi-circular block 1 208 and the semi-circular block 2 209 are fixedly connected to elongated slide plates 207. The top of the elongated slide plates 207 is slidably connected to an elongated outer slide plate 203. The elongated outer slide plate 203 slidably connected to the top of the elongated slide plates 207 engages with the serrated plate 205 to reinforce and expand the rear cavity. The top of the semi-circular block 1 208 has a placement hole 202. The front side of the outer wall of the machine door 16 is fixedly connected to a handle 4. The handle 4 fixedly connected to the front side of the machine door 16 facilitates opening the machine door 16. The outer wall of the handle 4 is fixedly connected to an anti-slip sleeve 5. The four corners of the bottom of the machine body 1 are fixedly connected to fixed posts 6. The bottom of the fixed posts 6 is fixedly connected to a circular pad 11. The circular pad 11 at the bottom of the fixed posts 6 can separate the machine body 1 from the ground to prevent corrosion after long-term contact.

[0033] Reference Figure 1 A hollow box 7 is fixedly connected to the bottom right side of the body 1. A drawer 10 is slidably connected inside the hollow box 7. The drawer 10 slidably connected inside the hollow box 7 can facilitate the storage of tools for daily use and maintenance for future use. A handle 2 8 is fixedly connected to the right side of the outer wall of the drawer 10. A protective cover 9 is fixedly connected to the outer wall of the handle 2 8. The handle 2 8 fixedly connected to the right side of the drawer 10 can facilitate the opening and closing of the drawer 10.

[0034] Working principle: By selecting blade 24 or blade 19 according to the material to be crushed, after selection, pressing the rear side of the long short plate 18 on the outer wall of the fixing rod 22 in the middle of the fixing block 23 compresses the spring 26 in the upper middle part of the outer wall of the hollow long plate 21, causing the front side of the long short plate 18 to lift up and separate the bottom arc-shaped locking block 25 from the groove of the groove plate 20 that slides inside the hollow long plate 21, so that the selected blade 24 or blade 19 is pushed out. Then, the pressed long short plate 18 is released so that the arc-shaped locking block 25 engages and is fixed with the groove plate 20. Finally, the motor 3 is turned on to crush, thus achieving the effect of targeted crushing of materials with different strengths, avoiding the problem of increased labor intensity and time cost caused by manual crushing.

[0035] By pulling the semicircular blocks 208 and 209 to both sides, the size of the crushing chamber is expanded through the telescopic column 210 on the outer wall of the square block 201 and the arc-shaped expansion plate 206. After expansion, the chamber is adjusted to the inside of the U-shaped hollow piece 204 by sliding the long outer groove plate 203 on the top of the long sliding groove plate 207. Finally, the serrated plate 205 is rotated in sequence, and the crushing chamber is reinforced by engaging with the tooth groove of the long outer groove plate 203. This allows the size of the chamber to be adjusted to accommodate samples of different types and volumes, thereby improving the flexibility and applicability of the equipment.

[0036] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A cell and tissue disruption device, comprising a body (1), characterized in that: A motor (3) is fixedly connected to the top of the body (1). A fixed long rod (17) is fixedly connected to the output end of the motor (3). The outer wall of the fixed long rod (17) penetrates the bottom end of the body (1) and is fixedly connected to an elongated block (27). Multiple hollow long plates (21) are fixedly connected at equal intervals around the outer wall of the elongated block (27). A grooved plate (20) is slidably connected inside the hollow long plate (21). Multiple fixed blocks (23) are fixedly connected at equal intervals on the outer wall of the hollow long plate (21). A fixed short rod is rotatably connected to the middle of the fixed block (23). 22), the outer wall of the fixed short rod (22) is fixedly connected to a long short plate (18), the upper part of the outer wall of the hollow long plate (21) is fixedly connected to a spring (26), the outer wall of the long short plate (18) is fixedly connected to an arc-shaped locking block (25), the bottom adjacent sides of the two groove plates (20) are respectively fixedly connected to a second blade (24) and a first blade (19), the front side of the outer wall of the machine body (1) is rotatably connected to a door (16), the inside of the machine body (1) is equipped with an expansion mechanism (2), the expansion mechanism (2) is used to expand the size of the crushing chamber.

2. The cell tissue disruption device according to claim 1, characterized in that: The expansion mechanism (2) includes a square block (201), which is installed inside the body (1). Telescopic columns (210) are fixedly connected to the outer walls of the square block (201). A semi-circular block one (208) is fixedly connected to the left side of the outer wall of the telescopic column (210) on the left side, and a semi-circular block two (209) is fixedly connected to the other side of the outer wall of the telescopic column (210) on the right side. An arc-shaped expansion plate (206) is provided on the adjacent side of the semi-circular block two (209) and the semi-circular block one (208). The top rear side of the semicircular block 2 (209) and the semicircular block 1 (208) are both fixedly connected to a U-shaped hollow piece (204). The inner wall of the U-shaped hollow piece (204) is rotatably connected to the left and right sides of the wall. The top front side of the semicircular block 1 (208) and the semicircular block 2 (209) are both fixedly connected to a long sliding groove plate (207). The top of the long sliding groove plate (207) is slidably connected to a long outer groove plate (203). The top of the semicircular block 1 (208) is provided with a placement hole (202).

3. The cell tissue disruption device according to claim 1, characterized in that: The outer wall of the body (1) is threaded with a screw (13), and the outer wall of the screw (13) is threaded with a warning sign (12).

4. The cell tissue disruption device according to claim 1, characterized in that: A hook (14) is fixedly connected to the right side of the outer wall of the body (1), and a buckle (15) is fixedly connected to the front side of the outer wall of the door (16). The buckle (15) is engaged with the hook (14).

5. The cell tissue disruption device according to claim 1, characterized in that: A handle (4) is fixedly connected to the front side of the outer wall of the machine door (16), and an anti-slip sleeve (5) is fixedly connected to the outer wall of the handle (4).

6. The cell tissue disruption device according to claim 1, characterized in that: The four corners of the bottom of the body (1) are fixedly connected to a fixed column (6), and a circular pad (11) is fixedly connected to the bottom of the fixed column (6).

7. The cell tissue disruption device according to claim 1, characterized in that: A hollow box (7) is fixedly connected to the bottom right side of the body (1), and a drawer (10) is slidably connected inside the hollow box (7).

8. The cell tissue disruption device according to claim 7, characterized in that: A handle two (8) is fixedly connected to the right side of the outer wall of the drawer (10), and a protective sleeve (9) is fixedly connected to the outer wall of the handle two (8).