Multi-environmental parameter monitoring stability test box for pharmaceutical production

Abstract

The utility model relates to the technical field of medicine tests, in particular to a medicine production multi-environmental parameter monitoring stability test box which comprises a box body, a motor, a rotating disc, an electric sliding block, a placing flat plate and the like. The left side and the right side of the box body are rotationally connected with a plurality of rotating discs; the box body is fixedly connected with a plurality of motors, and output shafts of the motors are fixedly connected with the rotating disc; each rotating disc is provided with a sliding rail, and each sliding rail is connected with two electric sliding blocks in a sliding mode. Every two corresponding electric sliding blocks are jointly and fixedly connected with a containing flat plate, and the two containing flat plates on the same rotating disc are symmetrically distributed around the center of the rotating disc. The two placing flat plates are combined and rotated to turn over the placed tablets, so that the bottom surfaces of the tablets can be in direct contact with illumination and moisture, the interaction process of the tablets and environmental factors is accelerated, the whole test period is shortened, and the test efficiency is improved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical testing technology, and in particular to a stability test chamber for monitoring multiple environmental parameters in pharmaceutical production. Background Technology

[0002] Stability testing chambers play a crucial role in pharmaceutical production, providing a controlled environmental condition to assess the stability of drugs under various environmental conditions.

[0003] When conducting environmental stability tests on tablet-shaped drugs under conditions such as light and humidity, existing technologies typically use a placement plate with grooves to place the tablets to prevent them from contacting and interfering with each other. However, when testing tablets under environmental conditions such as light and humidity, this placement method results in the bottom surface of the tablet in contact with the placement plate not being fully exposed to the light or humidity environment, thus prolonging the overall test cycle.

[0004] In summary, this application proposes a stability test chamber device for monitoring multiple environmental parameters in drug production, which improves the aforementioned technical problems. Utility Model Content

[0005] To overcome the shortcomings of existing placement methods that prevent the bottom surface of the tablets in contact with the placement plate from being fully exposed to light or humidity, thus prolonging the overall test cycle, this utility model provides a stability test chamber for monitoring multiple environmental parameters in pharmaceutical production.

[0006] Technical Solution: A stability test chamber for monitoring multiple environmental parameters in pharmaceutical production, comprising a chamber body; and further comprising motors, rotating disks, electric sliders, placement plates, support frames, elastic telescopic rods, supporting circular plates, and an adjustment unit; several rotating disks are rotatably connected to the left and right sides of the chamber body; several motors are fixedly connected to the chamber body, with the motor output shafts fixedly connected to the rotating disks; each rotating disk is equipped with a slide rail, and two electric sliders are slidably connected to each slide rail; each pair of corresponding electric sliders is jointly fixedly connected to a placement plate, and the two placement plates on the same rotating disk are symmetrically distributed around the center of the rotating disk; the placement plates have several slots for placing tablets; each placement slot is slidably connected to a supporting circular plate; each placement plate is fixedly connected to several support frames; each support frame is fixedly connected to several elastic telescopic rods, with the telescopic parts of the elastic telescopic rods fixedly connected to the supporting circular plates; the chamber body is connected to an adjustment unit for adjusting environmental parameters.

[0007] To further explain, the adjustment unit includes a light emitter, a humidifier, and a humidification pipe; several light emitters are installed on the inner walls of the left and right sides of the cabinet; the cabinet is equipped with a humidifier; the humidifier is connected to a humidification pipe, and the humidification pipe runs through the cabinet and communicates with the interior of the cabinet.

[0008] Further explanation: It also includes an air supply pipe, a connecting pipe, an air supply pipe 1, and an air blowing pipe; each placement plate is fixedly connected to a connecting pipe; each connecting pipe is connected to an air supply pipe, which is configured as a telescopic flexible hose and connected to an external air supply mechanism; each connecting pipe is connected to several air supply pipe 1s, and each air supply pipe 1 is equipped with an electrically controlled valve; each air supply pipe 1 is connected to several air blowing pipes, which are configured as telescopic flexible hoses and fixedly connected to the supporting circular plate.

[0009] Further explanation: It also includes a second air supply pipe and an airbag; each connecting pipe is connected to a second air supply pipe, and the second air supply pipe is equipped with an electrically controlled valve; each second air supply pipe is connected to an airbag through a telescopic hose, the airbag is fixed to the support frame, and the airbag is located under the supporting circular plate.

[0010] To further clarify, the distance between the air blowing pipe and the center of the supporting circular plate is 2mm-4mm.

[0011] To further explain, the light emitters on the inner wall of the left side of the enclosure are symmetrically distributed with the light emitters on the inner wall of the right side of the enclosure, and the light emitters on the same side are arranged in a rectangular pattern.

[0012] The beneficial effects of this invention are as follows: by rotating two platen tablets together, the tablets are flipped over, allowing the bottom surface of the tablets to directly contact light and moisture, thereby accelerating the interaction between the tablets and environmental factors, shortening the overall test cycle, and improving test efficiency.

[0013] The expansion of the airbag causes the supporting circular plates on the two placement plates to move towards each other, causing the closed space formed by the merging of the placement slots on the two placement plates to contract. As the supporting circular plates continue to move towards each other, they compress the tablets placed on them, thereby testing the physical stability of the tablets under mechanical stress. The expansion of the airbag also lifts the supporting circular plates, making them flush with the upper surface of the placement plates, which facilitates manual removal of the tablets and subsequent cleaning, thus improving cleaning efficiency. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of the multi-environmental parameter monitoring stability test chamber for pharmaceutical production disclosed in this utility model;

[0015] Figure 2 This is a schematic diagram of the internal structure of the pharmaceutical production multi-environmental parameter monitoring stability test chamber disclosed in this utility model.

[0016] Figure 3 This is a schematic diagram of the electric slider, placement plate, support frame and supporting circular plate combination disclosed in the multi-environmental parameter monitoring stability test chamber for pharmaceutical production of this utility model.

[0017] Figure 4This is a schematic diagram of the structure of the support frame, elastic telescopic rod, supporting circular plate, connecting pipe, air supply pipe one, air blowing pipe and air supply pipe two combination disclosed in the multi-environmental parameter monitoring stability test chamber for pharmaceutical production of this utility model.

[0018] Figure 5 This is a schematic diagram of the structure of the connecting pipe, air supply pipe one, air blowing pipe, air supply pipe two and air bag assembly disclosed in the multi-environmental parameter monitoring stability test chamber for pharmaceutical production of this utility model.

[0019] Figure 6 This is a diagram showing the movement of the supporting circular plate and the state of the placement plate being flush with the upper surface of the plate in the multi-environmental parameter monitoring stability test chamber for pharmaceutical production disclosed in this utility model.

[0020] In the attached diagram: 1-box body, 2-motor, 3-rotating disk, 4-electric slider, 5-placement plate, 6-support frame, 7-elastic telescopic rod, 8-supporting circular plate, 101-light emitter, 102-humidifier, 103-humidification pipe, 110-air supply pipe, 111-connecting pipe, 112-air supply pipe one, 113-air blowing pipe, 114-air supply pipe two, 115-airbag, 51-placement slot. Detailed Implementation

[0021] The present invention will now be described more fully below with reference to the accompanying drawings, in which presently preferred embodiments of the invention are shown. However, the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided for thoroughness and completeness and to fully convey the scope of the invention to those skilled in the art. Example

[0022] Drug production multi-environmental parameter monitoring stability test chamber, refer to Figures 1-6 As shown, it includes a box 1;

[0023] It also includes a motor 2, a rotating disk 3, an electric slider 4, a placement plate 5, a support frame 6, an elastic telescopic rod 7, a supporting circular plate 8, and an adjustment unit; several rotating disks 3 are rotatably connected to the inner walls of the left and right sides of the housing 1; the housing 1 is fixedly connected to a motor 2 in the same number as the rotating disks 3, and the output shaft of the motor 2 is fixedly connected to the rotating disk 3; each rotating disk 3 is provided with a slide rail, and two electric sliders 4 are slidably connected to each slide rail; each pair of corresponding electric sliders 4 are jointly fixedly connected to a placement plate 5, and the two placement plates 5 on the same rotating disk 3 are symmetrically distributed around the center of the rotating disk 3; the placement plate 5 has several placement slots 51; a supporting circular plate 8 is slidably connected in each placement slot 51; several support frames 6 are fixedly connected to each placement plate 5; several elastic telescopic rods 7 are fixedly connected to each support frame 6, and the telescopic part of the elastic telescopic rod 7 is fixedly connected to the supporting circular plate 8; the housing 1 is connected to an adjustment unit.

[0024] The adjustment unit includes a light emitter 101, a humidifier 102, and a humidification tube 103; several light emitters 101 are installed on the left inner wall and the right inner wall of the housing 1; the housing 1 is equipped with a humidifier 102; the humidifier 102 is connected to the humidification tube 103, and the humidification tube 103 passes through the housing 1 and communicates with the inside of the housing 1.

[0025] It also includes an air supply pipe 110, a connecting pipe 111, an air supply pipe 112, and an air blowing pipe 113; each placement plate 5 is fixedly connected to a connecting pipe 111; each connecting pipe 111 is connected to an air supply pipe 110, the air supply pipe 110 is configured as a telescopic hose and is connected to an external air supply mechanism; each connecting pipe 111 is connected to several air supply pipes 112, and the air supply pipes 112 are equipped with electrically controlled valves; each air supply pipe 112 is connected to several air blowing pipes 113, the air blowing pipes 113 are configured as telescopic hoses and are fixedly connected to the supporting circular plate 8.

[0026] It also includes an air supply pipe 2 114 and an airbag 115; each connecting pipe 111 is connected to an air supply pipe 2 114, and the air supply pipe 2 114 is equipped with an electrically controlled valve; each air supply pipe 2 114 is connected to an airbag 115 through a telescopic hose, the airbag 115 is fixedly connected to the support frame 6, and the airbag 115 is located on the underside of the supporting circular plate 8.

[0027] The distance between the air blowing pipe 113 and the center of the supporting circular plate 8 is 2mm-4mm. By intermittently blowing air through the air blowing pipe 113, the tablets placed on the supporting circular plate 8 are agitated, causing them to shake in the placement slot 51, thereby simulating the shaking situation encountered by the tablets in actual storage, which helps to evaluate the stability of the drug in the real world.

[0028] The light emitters 101 on the left inner wall of the enclosure 1 and the light emitters 101 on the right inner wall of the enclosure 1 are symmetrically distributed, and the light emitters 101 on the same side are rectangularly distributed to provide a uniform lighting environment.

[0029] The experiment was conducted as follows: the chamber 1 was manually opened, and the tablets were placed one by one into the placement slot 51 of the placement plate 5 below the rotating disk 3. At this time, the tablets were placed on the support circular plate 8. Then, the chamber 1 was manually closed. The tablets underwent a light exposure test under the light emitted by the light emitter 101. In actual storage, the external humidity also affects the stability of the tablets. By controlling the humidifier 102, water mist was introduced into the chamber 1 through the humidification pipe 103 to regulate the humidity inside the chamber 1, thereby simulating the environmental conditions encountered by the tablets during actual use. Subsequently, the stability of the tablets is determined manually based on their changes during the test. However, when the tablets are placed on the supporting circular plate 8, the bottom surface of the tablets cannot be fully exposed to light or moisture, thus prolonging the overall test cycle. Therefore, when the tablets are placed on the supporting circular plate 8 for testing, after the upper surface of the tablets has been exposed to light and moisture for a period of time, the two electric sliders 4 on the control rotating disk 3 move towards each other. The electric sliders 4 drive the two placement plates 5 to move towards each other. When the two placement plates 5 come into contact with each other, the placement grooves 51 on the two placement plates 5 merge into a sealed area. In a closed space, motor 2 drives rotating disk 3 to rotate 180 degrees, exchanging the positions of the two placement plates 5. This flips the tablets over and places them on another placement plate 5. Then, two electric sliders 4 drive the corresponding placement plates 5 to move away from each other, separating the two placement plates 5. At this point, the flipped tablets are exposed to light or moisture, ensuring the bottom surface of the medicine can come into contact with light and moisture for testing. By rotating the two placement plates 5 together, the tablets are flipped over, allowing the bottom surface of the tablets to directly contact light and moisture, thus enhancing the... The interaction process between the fast-acting tablet and environmental factors shortens the overall test cycle and improves test efficiency. Furthermore, during the tablet test, hot air is introduced into the connecting pipe 111 through the air supply pipe 110 via an external air supply mechanism, and the electrically controlled valve of the air supply pipe 112 is opened. Hot air passes through the connecting pipe 111 and the air supply pipe 112 in sequence and is blown out from the air blowing pipe 113. The temperature inside the chamber 1 is adjusted by the hot air, thereby simulating the environmental conditions that the tablet may encounter during use. By increasing the environmental parameters of temperature, the reliability of the tablet stability test is improved.

[0030] Meanwhile, during the production process, tablets are mainly formed by pressing raw material powder into shape using mechanical equipment such as tablet presses. Their physical stability is crucial in practical use. Furthermore, tablets may break due to external pressure or mechanical stress during transportation, packaging, and patient use. Therefore, it is necessary to test the physical stability of the tablets. To address this, when the two placement plates 5 move towards each other and come into contact, the electrically controlled valve of the first air supply pipe 112 is closed, and the electrically controlled valve of the second air supply pipe 114 is opened. The external air supply mechanism continues to supply air, allowing hot air to pass through the connecting pipe 111 and the second air supply pipe 114 into the airbag 115. The airbag 115 inflates, and at this time, the two placement plates 5 come into contact and adhere to each other. The inflation of the airbag 115 causes the supporting circular plate 8 to move, stretching the elastic telescopic rod 7. The supporting circular plates 8 on the two placement plates 5 move towards each other, causing the placement slots 51 on the two placement plates 5 to merge and close. As the supporting circular plates 8 continue to move towards each other, they compress the tablets placed on them, thus simulating the physical stability of the tablets under pressure. After the compression test is completed, the external air supply mechanism is controlled to evacuate the hot air from the airbag 115, causing the airbag 115 to contract and return to its original position. The supporting circular plates 8 are no longer compressed and rebound to their original position under the action of the elastic telescopic rod 7. Subsequently, the electrically controlled valve of the second air supply pipe 114 is closed, and the electrically controlled valve of the first air supply pipe 112 is opened to deliver hot air and adjust the temperature. During the test, the distance between the air blowing pipe 113 and the center of the supporting circular plates 8 is 2mm-4mm. By intermittently blowing air through the air blowing pipe 113, the tablets placed on the supporting circular plates 8 are agitated, causing them to shake in the placement slot 51, thus simulating the shaking situation encountered by the tablets in actual storage, which helps to evaluate the stability of the drug in the real world.

[0031] Meanwhile, after the tablet test is completed, the tablets need to be manually removed one by one from the placement slot 51. However, the gap between the placement slot 51 and the tablets is small, making it inconvenient for manual removal and requiring a lot of time. Furthermore, some tablets may break after the test, leaving drug particles on the supporting disc 8, which are difficult to clean manually. Therefore, after the tablet test is completed, the electrically controlled valve of air supply pipe 112 is kept closed, while the electrically controlled valve of air supply pipe 114 is opened, allowing hot air to enter the airbag 115. The airbag 115 inflates, lifting the supporting disc 8 and stretching the elastic telescopic rod 7. When the supporting disc 8 is level with the upper surface of the placement plate 5, the air supply to the airbag 115 is stopped. Figure 6 As shown, the supporting circular plate 8 is flush with the upper surface of the placing plate 5, so that the tablet is located on the upper surface of the placing plate 5, making it easy for the tablet to be removed manually and for subsequent cleaning. The supporting circular plate 8 is lifted by the expansion of the air bladder 115, so that the supporting circular plate 8 is flush with the upper surface of the placing plate 5, thereby making it easier for the tablet to be removed manually and for subsequent cleaning, thus improving cleaning efficiency.

[0032] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present utility model, and these improvements and modifications should also be considered within the protection scope of the present utility model.

Claims

1. A multi-environment parameter monitoring stability test box for pharmaceutical production, comprising a box body (1); characterized in that, It also includes motor (2), rotating disc (3), electric sliding block (4), placing flat plate (5), support frame (6), elastic telescopic rod (7), bearing round plate (8) and adjusting unit; the left side and the right side of the box body (1) are rotatably connected with a plurality of rotating discs (3); the box body (1) is fixedly connected with a plurality of motors (2), and the output shaft of the motor (2) is fixedly connected with the rotating disc (3); each rotating disc (3) is provided with a sliding rail, and each sliding rail is slidably connected with two electric sliding blocks (4); each two corresponding electric sliding blocks (4) are fixedly connected with a placing flat plate (5), and the two placing flat plates (5) on the same rotating disc (3) are symmetrically distributed around the center of the rotating disc (3); the placing flat plate (5) is provided with a plurality of placing grooves (51) for placing tablets; each placing groove (51) is slidably connected with a bearing round plate (8); each placing flat plate (5) is fixedly connected with a plurality of support frames (6); each support frame (6) is fixedly connected with a plurality of elastic telescopic rods (7), and the telescopic part of the elastic telescopic rod (7) is fixedly connected with the bearing round plate (8); the box body (1) is connected with an adjusting unit for adjusting environmental parameters.

2. The multi-environment parameter monitoring stability test chamber for pharmaceutical production according to claim 1, characterized in that, The adjusting unit comprises light emitters (101), a humidifier (102) and a humidification pipe (103); the left inner wall and the right inner wall of the box body (1) are each provided with a plurality of light emitters (101); the box body (1) is provided with a humidifier (102); the humidifier (102) is communicated with a humidification pipe (103), and the humidification pipe (103) penetrates the box body (1) and communicates with the inside of the box body (1).

3. The multi-environment parameter monitoring stability test chamber for pharmaceutical production according to claim 2, characterized in that, It also includes a gas supply pipe (110), a connecting pipe (111), a gas supply pipe (112) and a blowing pipe (113); each placing flat plate (5) is fixedly connected with a connecting pipe (111); each connecting pipe (111) is communicated with a gas supply pipe (110), which is provided as a flexible hose and communicates with an external gas supply mechanism; each connecting pipe (111) is communicated with a plurality of gas supply pipes (112), and the gas supply pipe (112) is provided with an electric control valve; each gas supply pipe (112) is communicated with a plurality of blowing pipes (113), and the blowing pipe (113) is provided as a flexible hose and is fixedly connected with the bearing round plate (8).

4. The multi-environment parameter monitoring stability test chamber for pharmaceutical production according to claim 3, characterized in that, It also includes a gas supply pipe (114) and a gas bag (115); each connecting pipe (111) is communicated with a gas supply pipe (114), and the gas supply pipe (114) is provided with an electric control valve; each gas supply pipe (114) is communicated with a gas bag (115) through a flexible hose, the gas bag (115) is fixedly connected with the support frame (6), and the gas bag (115) is located below the bearing round plate (8).

5. The multi-environment parameter monitoring stability test chamber for pharmaceutical production according to any one of claims 3-4, characterized in that, The distance between the blowing pipe (113) and the center of the bearing round plate (8) is 2mm-4mm.

6. The multi-environment parameter-monitored stability test chamber for pharmaceutical production according to claim 1, wherein, The light emitters (101) on the left inner wall of the box body (1) and the light emitters (101) on the right inner wall of the box body (1) are symmetrically distributed, and the light emitters (101) on the same side are rectangularly distributed.

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