Device for inducing degeneration of intervertebral disc by standing two feet of rat

Abstract

The utility model discloses a device for inducing intervertebral disc degeneration by standing both feet of a rat, which belongs to the technical field of animal models with human diseases and comprises a movable ring and a magic tape, a plurality of support legs are welded around the center of the bottom of the movable ring, universal wheels are arranged at the bottoms of the support legs, a fixed block is welded inside one end of the movable ring, and a fixing block is welded inside the other end of the movable ring. Connecting assemblies are arranged at the tops of the fixing blocks, binding assemblies are arranged on one sides of the connecting assemblies, and the hook-and-loop fasteners are located between the binding assemblies. The movable ring, the connecting assembly and the binding assembly are arranged, rats of different body types are fixed through cooperation of the back fixing plate and the chest fixing plate, spine bending of the rats is prevented, and after the binding assembly is connected with the movable ring through the connecting assembly, the rats can be forced to walk vertically so as to support modeling; the forelimb of the rat can extend out of the forelimb limiting groove, the forelimb is fixed through the forelimb limiting groove to prevent the rat from escaping, so that the forelimb of the rat does not need to be cut off through an operation, and the modeling process is simple and humanized.

Description

Technical Field

[0001] This invention relates to the field of animal models of human diseases, and in particular to a device for inducing intervertebral disc degeneration by making rats stand on two legs. Background Technology

[0002] Lumbar disc herniation has become one of the most common clinical diseases in my country. It is currently believed that the basic pathological change in lumbar disc herniation is the degeneration of the intervertebral disc. However, the main causes and pathogenesis of intervertebral disc degeneration are still unclear, and there are no suitable treatment measures. It is necessary to study the pathogenesis of animals and test and verify the effectiveness of diagnosis and treatment through animal models. Because the intervertebral disc anatomy of rats is very similar to that of human intervertebral discs, rat intervertebral disc degeneration models are currently widely used.

[0003] The commonly used modeling method is the double forelimb castration method, which involves surgically removing both forelimbs of the rat to force the rat's waist to bear the force. This method is complicated and costly, and also quite cruel. Therefore, a device is proposed to induce intervertebral disc degeneration by making the rat stand on both feet to solve the above problems. Utility Model Content

[0004] The purpose of this invention is to solve the problems of cumbersome, costly and cruel process of creating rat intervertebral disc degeneration models in the prior art, and to propose a device that induces intervertebral disc degeneration by making rats stand on both feet.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A device for inducing intervertebral disc degeneration by making rats stand on two legs includes a movable ring and Velcro. The bottom of the movable ring is welded with multiple legs around its center. The bottom of each leg is provided with a caster wheel. A fixing block is welded inside one end of the movable ring. A connecting component is provided on the top of the fixing block. A restraining component is provided on one side of the connecting component. The Velcro is located between the restraining components.

[0007] Preferably, the connecting assembly includes a slide rail, the inner wall of which has an adjusting screw hole, and a fastening bolt is threaded into the screw hole.

[0008] Preferably, the restraint assembly includes a back fixing plate and a chest fixing plate, with first connecting rings fixedly connected to both sides of the back fixing plate, and a slide bar fixedly connected to the side of the back fixing plate facing the slide rail.

[0009] Preferably, a spinal restraint pad is fixedly connected to the inner side of the back fixation plate.

[0010] Preferably, the chest fixation plate has forelimb restriction grooves on both sides, and a second connecting ring is fixedly connected to the chest fixation plate at the corresponding first connecting ring on both sides. The second connecting ring is fixedly connected to the first connecting ring by Velcro.

[0011] Preferably, a rubber pad is fixedly connected to the inner wall of the forelimb limiting groove.

[0012] Compared with the prior art, the beneficial effects of this utility model are as follows:

[0013] 1. This utility model sets up a moving ring, a connecting component, and a restraint component. The tightness of the restraint component is adjusted by Velcro. The rat is fixed by the cooperation of the back fixation plate and the chest fixation plate to prevent the rat's spine from bending. After the back fixation plate is connected to the moving ring through the connecting component, the rat can be forced to walk upright to support the modeling process. During this process, the rat's forelimbs can extend out from the forelimb restriction groove. The forelimbs are fixed by the forelimb restriction groove to prevent the rat from escaping, thus eliminating the need to surgically remove the rat's forelimbs, making the modeling process simple and humane. Attached Figure Description

[0014] Figure 1 This is a three-dimensional structural diagram of a device for inducing intervertebral disc degeneration in rats by making them stand on two legs, as proposed in this utility model.

[0015] Figure 2 This is a schematic diagram of the moving ring and connecting components in a device for inducing intervertebral disc degeneration in rats by making them stand on two legs, as proposed in this utility model.

[0016] Figure 3 This is a schematic diagram of the restraint component in a device for inducing intervertebral disc degeneration in rats by making them stand on two legs, as proposed in this utility model.

[0017] Figure 4 This is a structural assembly diagram of the restraint component in a device for inducing intervertebral disc degeneration in rats by making them stand on two legs, as proposed in this utility model.

[0018] Figure 5 This is a structural assembly diagram of the connecting components in a device for inducing intervertebral disc degeneration in rats by making them stand on two legs, as proposed in this utility model.

[0019] In the diagram: 1. Moving ring; 2. Velcro; 3. Support leg; 4. Caster wheel; 5. Fixing block; 6. Slide rail; 7. Adjusting screw hole; 8. Fastening bolt; 9. Back fixation plate; 10. Chest fixation plate; 11. First connecting ring; 12. Slide bar; 13. Spinal restraint pad; 14. Forelimb restraint groove; 15. Second connecting ring; 16. Rubber pad. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0021] Reference Figure 1-5 A device for inducing intervertebral disc degeneration by making rats stand on two legs includes a movable ring 1 and Velcro 2. Multiple support legs 3 are welded around the bottom center of the movable ring 1. Universal wheels 4 are provided at the bottom of the support legs 3. A fixing block 5 is welded inside one end of the movable ring 1. A connecting component is provided on the top of the fixing block 5. A restraint component is provided on one side of the connecting component. The Velcro 2 is located between the restraint components.

[0022] Furthermore, the connecting assembly includes a slide rail 6, the inner wall of which is provided with an adjusting screw hole 7, and a fastening bolt 8 is threaded into the screw hole for adjusting the distance between the restraint assembly and the ground.

[0023] Furthermore, the restraint assembly includes a back fixation plate 9 and a chest fixation plate 10. First connecting rings 11 are fixedly connected to both sides of the back fixation plate 9, and a slide bar 12 is fixedly connected to the side of the back fixation plate 9 facing the slide rail 6. A spinal restraint pad 13 is fixedly connected to the inner side of the back fixation plate 9 to keep the rat's spine vertical. Forelimb restraint grooves 14 are provided on both sides of the chest fixation plate 10. Second connecting rings 15 are fixedly connected to both sides of the chest fixation plate 10 at the locations corresponding to the first connecting rings 11. The second connecting rings 15 are fixedly connected to the first connecting rings 11 via Velcro 2 to adjust the distance between the back fixation plate 9 and the chest fixation plate 10, thereby fixing rats of different sizes. An adhesive pad 16 is fixedly connected to the inner wall of the forelimb restraint groove 14 to prevent the rat's armpits from being scratched by the chest fixation plate 10.

[0024] It should be noted that the forelimb restriction groove 14 is located near the top of the chest fixation plate 10 to avoid affecting the rat's feeding. The adhesive pad 16 is made by dispensing, which is simple to manufacture.

[0025] A further advantage of the above is that the rat can be fixed by the cooperation of the back fixation plate 9 and the chest fixation plate 10, preventing the rat's spine from bending. After the back fixation plate 9 is connected to the moving ring 1 through the connecting component, the rat can be forced to walk upright. During this process, the rat's forelimbs can extend out of the forelimb restriction groove 14, and the rat is prevented from escaping by the forelimb restriction groove 14. Therefore, it is not necessary to surgically remove the rat's forelimbs, which reduces the difficulty of modeling and makes the modeling process more humane.

[0026] When using this invention, the chest fixation plate 10 is aligned with the rat's chest, and the rat's forelimbs are extended from the forelimb restriction groove 14. During this process, the rat's forelimbs are protected by the rubber pad 16 to prevent scratches. The spinal restriction pad 13 on the inner side of the back fixation plate 9 is aligned with the rat's spine. The first connecting ring 11 and the second connecting ring 15 are connected by Velcro 2. The distance between the back fixation plate 9 and the chest fixation plate 10 is changed by adjusting the Velcro 2, so that the back fixation plate 9 and the chest fixation plate 10 are in close contact with the rat. There is no need to surgically remove the rat's forelimbs, making the modeling process simple and humane.

[0027] After the restraint assembly is put on, the back fixing plate 9 is inserted into the slide rail 6 through the slide bar 12. The height of the restraint assembly can be adjusted by sliding the slide bar 12 in the slide rail 6. When the restraint assembly is adjusted to a suitable position according to the rat's body size, the fastening bolt 8 is tightened. The fastening bolt 8 squeezes the slide bar 12, increasing the friction between the slide bar 12 and the slide rail 6, thereby fixing the restraint assembly and connecting the restraint assembly to the moving ring 1.

[0028] With the combined action of the connecting component and the restraint component, the rat can be forced to remain upright while walking. When the rat walks, it can drive the moving ring 1 to move through the universal wheel 4. During movement, it can maintain stability through multiple support legs 3 to prevent the rat from falling.

[0029] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A device for inducing intervertebral disc degeneration by inducing bipedal standing in rats, comprising a movable ring (1) and Velcro (2), characterized in that, The bottom of the moving ring (1) is welded with multiple support legs (3) around the center. The bottom of the support legs (3) is provided with casters (4). A fixing block (5) is welded inside one end of the moving ring (1). A connecting component is provided on the top of the fixing block (5). A restraining component is provided on one side of the connecting component. The Velcro (2) is located between the restraining components.

2. The device for inducing intervertebral disc degeneration in rats by inducing bipedal standing according to claim 1, characterized in that: The connecting assembly includes a slide rail (6), the inner wall of which is provided with an adjusting screw hole (7), and a fastening bolt (8) is threaded into the screw hole.

3. The device for inducing intervertebral disc degeneration by causing rats to stand on both legs according to claim 2, characterized in that: The restraint assembly includes a back fixing plate (9) and a chest fixing plate (10). The back fixing plate (9) is fixedly connected to both sides with a first connecting ring (11), and a slide bar (12) is fixedly connected to the side of the back fixing plate (9) facing the slide rail (6).

4. The device for inducing intervertebral disc degeneration by causing rats to stand on both legs according to claim 3, characterized in that: The spinal restraint pad (13) is fixedly connected to the inside of the back fixation plate (9).

5. The device for inducing intervertebral disc degeneration by causing rats to stand on both legs according to claim 3, characterized in that: The chest fixation plate (10) has forelimb restriction grooves (14) on both sides. The chest fixation plate (10) has a second connecting ring (15) fixedly connected to the first connecting ring (11) on both sides. The second connecting ring (15) is fixedly connected to the first connecting ring (11) by Velcro (2).

6. The device for inducing intervertebral disc degeneration by causing rats to stand on both legs according to claim 5, characterized in that: A rubber pad (16) is fixedly connected to the inner wall of the forelimb limiting groove (14).

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