Preparation device of clinafloxacin key intermediate

Abstract

The utility model provides a preparation device of a clinafloxacin key intermediate, which relates to the field of preparation of clinafloxacin key intermediates and comprises a reaction kettle body, a sealing bearing is embedded in the inner bottom wall of the reaction kettle body, and an inner ring of the sealing bearing is connected with a stirring mechanism. A group of electric heating rods and a group of refrigerators are fixedly mounted on the inner side wall of the reaction kettle body, and a temperature sensor is fixedly mounted on the inner top wall of the reaction kettle body. According to the reaction kettle disclosed by the utility model, firstly, the electric heating rod and the refrigerator can be respectively used for heating or refrigerating, so that temperature control operation can be carried out on the reaction of a clinafloxacin key intermediate, and then the temperature sensor can be used for monitoring the temperature in the reaction kettle body; in this way, the temperature in the reaction kettle body can be transmitted to the interior of the temperature display screen in real time, and then temperature adjusting operation can be conveniently conducted according to the temperature displayed on the temperature display screen, so that the purity of prepared clinafloxacin key intermediates is indirectly improved.

Description

Technical Field

[0001] This utility model relates to the field of preparation technology of key intermediates of clinfloxacin, specifically a preparation device for key intermediates of clinfloxacin. Background Technology

[0002] Clinfloxacin is a quinolone antibacterial drug. The preparation of its key intermediates usually involves multiple organic synthesis reactions. It is effective against Escherichia coli infection, mycoplasma respiratory infection, and Pasteurella multocida serositis in birds. It inhibits bacterial DNA gyrase. Its effects and efficacy are better than quinolone antibacterial drugs such as ciprofloxacin. Its animal toxicity is similar to that of quinolones, so it has high clinical value. The production of clinfloxacin's key intermediates requires a preparation device.

[0003] Current preparation devices for clinfloxacin key intermediates require heating and cooling components to react with the clinfloxacin key intermediates. However, when using these components, operators often need to rely on experience to control them, which can lead to unsatisfactory temperature control and significantly reduce the purity of the clinfloxacin key intermediates. Therefore, the purpose of this invention is to provide a preparation device for clinfloxacin key intermediates to solve the problems mentioned in the background. Utility Model Content

[0004] The purpose of this invention is to provide an apparatus for preparing a key intermediate of clinfloxacin, so as to solve the problems mentioned in the background art and overcome its technical defects.

[0005] To solve the above-mentioned technical problems, the technical solution adopted by this utility model is as follows: It includes a reaction vessel body, with a sealed bearing embedded in the inner bottom wall of the reaction vessel body. A stirring mechanism is connected to the inner ring of the sealed bearing. A set of electric heating rods and a set of coolers are fixedly installed on the inner side walls of the reaction vessel body. A temperature sensor is fixedly installed on the inner top wall of the reaction vessel body. Two fixed columns are connected to the upper surface of the reaction vessel body, and mounting blocks are connected to the tops of the two fixed columns. A temperature display is installed on the front of the mounting blocks. A control box is connected to the outer surface of the reaction vessel body, and two temperature control knobs are connected to the outer surface of the control box.

[0006] As a further embodiment of this utility model: the stirring mechanism includes a rotating rod, and a set of stirring rods arranged at equal intervals are connected to the outer surface of the rotating rod, and a drive motor is installed at the top of the rotating rod.

[0007] As a further embodiment of this utility model: the upper surface of the reactor body is connected to a material inlet, the bottom surface of the reactor body is connected to a material outlet valve, and the outer surface of the reactor body is connected to a model nameplate.

[0008] As a further improvement of this utility model: a fixing block is connected to the upper surface of the control box, and a timer is installed on the outer surface of the fixing block.

[0009] As a further improvement of this utility model: two working indicator lights are installed on the front of the control box, and a buzzer is installed on the back of the control box.

[0010] As a further improvement of this utility model: an observation window is provided on the outer surface of the reaction vessel body, and a transparent glass is connected inside the observation window.

[0011] As a further improvement of this utility model: the upper surface of the reaction vessel body is provided with a vent hole, and a gas filter cotton is placed inside the vent hole.

[0012] As a further improvement of this utility model: a reinforcing ring is connected to the outer surface of the drive motor, and a plurality of connecting rods are connected to the bottom surface of the reinforcing ring, with the bottom end of each connecting rod connected to the upper surface of the reactor body.

[0013] As a further improvement of this utility model: a support plate is connected to the outer surface of the reactor body, and the upper surface of the support plate is connected to the bottom surface of the control box.

[0014] As a further improvement of this utility model: an annular disk is connected to the outer surface of the reactor body, and two sets of L-shaped support columns are connected to the bottom surface of the annular disk, with each L-shaped support column having an installation hole inside.

[0015] Compared with the prior art, the beneficial effects of this utility model include: firstly, the electric heating rod and the cooler can be used for heating or cooling respectively, which can control the temperature of the reaction of the key intermediate of clinfloxacin; then, the temperature sensor can be used to monitor the temperature inside the reactor body, which can transmit the temperature inside the reactor body to the temperature display screen in real time, and then the temperature adjustment can be easily carried out according to the temperature displayed on the temperature display screen, thereby indirectly improving the purity of the preparation of the key intermediate of clinfloxacin. Attached Figure Description

[0016] The disclosure of this utility model is illustrated with reference to the accompanying drawings. It should be understood that the drawings are for illustrative purposes only and are not intended to limit the scope of protection of this utility model. In the drawings, the same reference numerals are used to refer to the same parts. Wherein:

[0017] Figure 1 The schematic diagram shows a three-dimensional structural diagram of an apparatus for preparing a key intermediate of clinfloxacin according to one embodiment of the present invention;

[0018] Figure 2 The schematic diagram shows a side view of an apparatus for preparing a key intermediate of clinfloxacin according to one embodiment of the present invention;

[0019] Figure 3 The schematic diagram shows a top view of an apparatus for preparing a key intermediate of clindamycin according to one embodiment of the present invention;

[0020] Figure 4 The schematic diagram shows a top sectional view of an apparatus for preparing a key intermediate of clinfloxacin according to one embodiment of the present invention;

[0021] Figure 5 The schematic diagram shows a front cross-sectional view of an apparatus for preparing a key intermediate of clinfloxacin according to one embodiment of the present invention;

[0022] Labels in the diagram: 1. Reactor body; 2. Stirring mechanism; 201. Rotating rod; 202. Stirring rod; 203. Drive motor; 3. Sealed bearing; 4. Electric heating rod; 5. Refrigerator; 6. Temperature sensor; 7. Fixed column; 8. Mounting block; 9. Temperature display; 10. Control box; 11. Temperature control knob; 12. Inlet; 13. Discharge valve; 14. Model nameplate; 15. Fixed block; 16. Timer; 17. Buzzer; 18. Working indicator light; 19. Observation window; 20. Transparent glass; 21. Vent hole; 22. Gas filter cotton; 23. Reinforcing ring; 24. Connecting rod; 25. Support plate; 26. Annular disc; 27. L-shaped support column; 28. Mounting hole. Detailed Implementation

[0023] It is readily understood that, based on the technical solution of this utility model, those skilled in the art can propose various interchangeable structural methods and implementations without altering the essential spirit of this utility model. Therefore, the following detailed embodiments and accompanying drawings are merely illustrative descriptions of the technical solution of this utility model and should not be considered as the entirety of this utility model or as limitations or restrictions on the technical solution of this utility model.

[0024] According to one embodiment of the present invention, in conjunction with the appended drawings Figures 1 to 5 As shown.

[0025] An apparatus for preparing a key intermediate of clindamycin includes a reactor body 1. A sealed bearing 3 is embedded in the inner bottom wall of the reactor body 1. A stirring mechanism 2 is connected to the inner ring of the sealed bearing 3. A set of electric heating rods 4 and a set of coolers 5 are fixedly installed on the inner side walls of the reactor body 1. A temperature sensor 6 is fixedly installed on the inner top wall of the reactor body 1. Two fixed columns 7 are connected to the upper surface of the reactor body 1. Mounting blocks 8 are connected to the tops of the two fixed columns 7. A temperature display 9 is installed on the front of the mounting blocks 8. A control box 10 is connected to the outer surface of the reactor body 1. Two temperature control knobs 11 are connected to the outer surface of the control box 10. The stirring mechanism 2 includes a rotating rod 2. 01. A set of equally spaced stirring rods 202 are connected to the outer surface of the rotating rod 201. A drive motor 203 is installed at the top of the rotating rod 201. The temperature sensor 6 can monitor the temperature inside the reactor body 1 in real time. The monitored values ​​can be transmitted to the temperature display 9, which can facilitate temperature control by the staff and improve the accuracy of temperature control. The drive motor 203 can drive the rotating rod 201 and the stirring rods 202 to rotate. The stirring rods 202 can be used to stir the clindamycin key intermediate inside the reactor body 1, thereby improving the preparation efficiency of the clindamycin key intermediate.

[0026] In this embodiment, the upper surface of the reactor body 1 is connected to a material inlet 12, the bottom surface of the reactor body 1 is connected to a discharge valve 13, the outer surface of the reactor body 1 is connected to a model nameplate 14, the upper surface of the control box 10 is connected to a fixing block 15, the outer surface of the fixing block 15 is equipped with a timer 16, the front of the control box 10 is equipped with two working indicator lights 18, the back of the control box 10 is equipped with a buzzer 17, the outer surface of the reactor body 1 is provided with an observation window 19, and the inside of the observation window 19 is connected to a transparent glass 20. The model nameplate 14 allows the staff to easily check the specific brand and model of the device, the timer 16 allows the staff to easily time the preparation of the clinfloxacin key intermediate, the buzzer 17 can emit a buzzing sound after the preparation of the clinfloxacin key intermediate is completed, thereby prompting the staff, and the observation window 19 allows the staff to easily observe the preparation process of the clinfloxacin key intermediate inside the reactor body 1.

[0027] In this embodiment, a vent hole 21 is provided on the upper surface of the reactor body 1, and a gas filter cotton 22 is placed inside the vent hole 21. A reinforcing ring 23 is connected to the outer surface of the drive motor 203, and multiple connecting rods 24 are connected to the bottom surface of the reinforcing ring 23. The bottom end of each connecting rod 24 is connected to the upper surface of the reactor body 1. A support plate 25 is connected to the outer surface of the reactor body 1, and the upper surface of the support plate 25 is connected to the bottom surface of the control box 10. An annular disk 26 is connected to the outer surface of the reactor body 1, and two sets of L-shaped support columns 27 are connected to the bottom surface of the annular disk 26. Each L-shaped support column 27 has an internal mounting hole 28. The vent hole 21 allows the gas inside the reactor body 1 to be discharged to the outside. The reinforcing ring 23 and the connecting rod 24 work together to reinforce the drive motor 203, making the drive motor 203 run more stably. The bearing plate 25 supports the control box 10, making the connection between the control box 10 and the reactor body 1 more secure. The annular disk 26, L-shaped support columns 27 and mounting holes 28 make it easy for workers to fix the reactor body 1 to the ground.

[0028] Working Principle: When using this device, the operator first uses the annular disc 26, L-shaped support column 27, and mounting hole 28 to fix the reactor body 1 to the ground and connect the device to an external power source. Next, the operator adds various raw materials into the reactor body 1 through the feeding port 12. At this time, the operator uses the two temperature control knobs 11 to activate the electric heating rod 4 or the cooler 5. During heating or cooling operations, the temperature sensor 6 inside the reactor body 1 transmits the monitored values ​​to the temperature display 9. Then, the operator... Precise temperature control is performed based on the temperature displayed on the temperature display 9. Simultaneously, when various raw materials react inside the reactor body 1, the operator starts the drive motor 203, which drives the rotating rod 201 and the stirring rod 202 to rotate. The stirring rod 202 stirs the raw materials inside the reactor body 1, thereby improving the reaction efficiency of the raw materials inside the reactor body 1. After the reaction of the raw materials inside the reactor body 1 is completed, the operator uses the discharge valve 13 to discharge the raw materials inside the reactor body 1 to the outside. The above is the complete operation process of this device.

[0029] The technical scope of this utility model is not limited to the content described above. Those skilled in the art can make various modifications and variations to the above embodiments without departing from the technical concept of this utility model, and all such modifications and variations should fall within the protection scope of this utility model.

Claims

1. An apparatus for preparing a key intermediate of clinfloxacin, characterized in that, The reactor body (1) includes a sealed bearing (3) embedded in the inner bottom wall of the reactor body (1), a stirring mechanism (2) connected to the inner ring of the sealed bearing (3), a set of electric heating rods (4) and a set of coolers (5) fixedly installed on the inner side wall of the reactor body (1), a temperature sensor (6) fixedly installed on the inner top wall of the reactor body (1), two fixed columns (7) connected to the upper surface of the reactor body (1), an installation block (8) connected to the top of the two fixed columns (7), a temperature display (9) installed on the front of the installation block (8), a control box (10) connected to the outer surface of the reactor body (1), and two temperature control knobs (11) connected to the outer surface of the control box (10).

2. The apparatus for preparing a key intermediate of clinfloxacin according to claim 1, characterized in that, The stirring mechanism (2) includes a rotating rod (201), and a set of stirring rods (202) arranged at equal distances are connected to the outer surface of the rotating rod (201). A drive motor (203) is installed at the top of the rotating rod (201).

3. The apparatus for preparing a key intermediate of clindamycin according to claim 2, characterized in that, The upper surface of the reactor body (1) is connected to a material inlet (12), the bottom surface of the reactor body (1) is connected to a discharge valve (13), and the outer surface of the reactor body (1) is connected to a model nameplate (14).

4. The apparatus for preparing a key intermediate of clindamycin according to claim 3, characterized in that, A fixing block (15) is connected to the upper surface of the control box (10), and a timer (16) is installed on the outer surface of the fixing block (15).

5. The apparatus for preparing a key intermediate of clindamycin according to claim 4, characterized in that, Two working indicator lights (18) are installed on the front of the control box (10), and a buzzer (17) is installed on the back of the control box (10).

6. The apparatus for preparing a key intermediate of clinfloxacin according to claim 5, characterized in that, An observation window (19) is provided on the outer surface of the reactor body (1), and a transparent glass (20) is connected inside the observation window (19).

7. The apparatus for preparing a key intermediate of clindamycin according to claim 6, characterized in that, The upper surface of the reactor body (1) is provided with a vent hole (21), and a gas filter cotton (22) is placed inside the vent hole (21).

8. The apparatus for preparing a key intermediate of clindamycin according to claim 2, characterized in that, The outer surface of the drive motor (203) is connected to a reinforcing ring (23), and the bottom surface of the reinforcing ring (23) is connected to a plurality of connecting rods (24), the bottom end of each connecting rod (24) being connected to the upper surface of the reactor body (1).

9. The apparatus for preparing a key intermediate of clindamycin according to claim 7, characterized in that, The outer surface of the reactor body (1) is connected to a support plate (25), and the upper surface of the support plate (25) is connected to the bottom surface of the control box (10).

10. The apparatus for preparing a key intermediate of clinfloxacin according to claim 7, characterized in that, The outer surface of the reactor body (1) is connected to an annular disk (26), and the bottom surface of the annular disk (26) is connected to two sets of L-shaped support columns (27). Each L-shaped support column (27) has an installation hole (28) inside.

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