Nucleic acid detection plate sealing structure

Abstract

The utility model provides a nucleic acid detection plate sealing structure which is used for repeatedly sealing a nucleic acid detection plate, the nucleic acid detection plate is provided with storage parts arranged in an array, the nucleic acid detection plate comprises a buckle cover and an isolation sealing strip, the buckle cover comprises an elastic covering film and an elastic tightening part, the elastic tightening part is located on the outer side edge of the elastic covering film, and the isolation sealing strip is arranged on the elastic covering film. The elastic covering film is in interference elastic fit with the periphery of the nucleic acid detection plate and is pressed against the opening surface of the nucleic acid detection plate; the isolation sealing strip comprises a long-strip-shaped frame, the interior of the long-strip-shaped frame is divided into more than two isolation chambers which are sequentially arranged in a single row, each isolation chamber is square and is equal in size, one isolation chamber corresponds to one storage part, and the isolation sealing strip is pressed between the elastic covering film and the upper surface of the nucleic acid detection plate to seal and isolate the corresponding storage parts. According to the nucleic acid detection plate, each isolation chamber is separated and sealed by adopting the isolation sealing strips, so that the nucleic acid detection plate can be effectively and conveniently sealed with lower cost, an extraction reagent is prevented from being adhered, and the utilization rate and the accuracy of the extraction plate are improved.

Description

Nucleic acid detection plate sealing structure Technical Field

[0001] This utility model relates to the field of medical device technology, and in particular to a structure that can effectively, conveniently and cost-effectively seal a nucleic acid detection plate. Background Technology

[0002] Currently, molecular biology techniques are developing rapidly. The mainstream nucleic acid extraction technology in laboratories is mostly semi-automated extraction using magnetic beads. This requires manual sample loading into a 96-well plate before instrument extraction. The 96-well plate is often reused depending on the sample volume and usage. However, storing 96-well plates presents problems. There is currently no matching extraction plate cap, and the used nucleic acid detection portion protrudes above the plate surface due to the magnetic sleeve, making it difficult to cover and seal. Currently, laboratories typically use sealed bags for storage, but these bags cannot seal every well, making it easy for nucleic acid to evaporate during storage, contaminating unused reagents and causing erroneous results.

[0003] Therefore, how to effectively, conveniently, and cost-effectively seal nucleic acid testing plates to prevent the adhesion of extraction reagents, thereby improving the utilization rate of extraction plates and avoiding errors in results, is an urgent problem to be solved in the nucleic acid testing industry. Summary of the Invention

[0004] One of the main objectives of this invention is to overcome at least one of the defects of the prior art and provide a nucleic acid detection plate sealing structure that can effectively, conveniently and cost-effectively seal a nucleic acid detection plate.

[0005] To achieve the above-mentioned objectives, the present invention adopts the following technical solution:

[0006] According to one aspect of the present invention, a nucleic acid detection plate sealing structure is provided for repeatedly sealing a nucleic acid detection plate, wherein the nucleic acid detection plate is provided with an array of storage units, including:

[0007] The cover includes an elastic film and an elastic tightening part. The elastic tightening part is located at the outer edge of the elastic film and is in an interference fit with the periphery of the nucleic acid detection plate. The elastic film presses against the opening surface of the nucleic acid detection plate.

[0008] An isolation sealing strip includes a long frame, internally divided into two or more isolation chambers arranged in a single row. Each isolation chamber is square and of equal size. One isolation chamber corresponds to one storage unit. The isolation sealing strip is pressed between the elastic film and the upper surface of the nucleic acid detection plate to seal and isolate the corresponding storage unit.

[0009] According to a specific embodiment of this utility model, the elastic tightening part is a rectangular outer frame structure.

[0010] According to a specific embodiment of this utility model, the length of the elastic tightening part is 1-3 cm.

[0011] According to a specific embodiment of the present invention, the walls of the isolation chamber are smooth, and both the upper and lower surfaces are planar.

[0012] According to a specific embodiment of the present invention, the nucleic acid detection plate sealing structure further includes a pressure film pad, which is sleeved in the isolation chamber and is removable.

[0013] According to a specific embodiment of the present invention, the pressure film pad includes a pressure film and a flexible frame. The pressure film is sealed and applied on the flexible frame, and the flexible frame is compressibly clamped between the elastic film and the upper surface of the nucleic acid detection plate.

[0014] According to a specific embodiment of the present invention, the flexible frame has an outer square and inner circle structure, with the outer side of the flexible frame corresponding to the inner side of the isolation chamber, and the inner side of the flexible frame corresponding to the storage section.

[0015] According to a specific embodiment of the present invention, the radius of the inner circular hole of the flexible frame is less than or equal to the radius of the outer circle of the storage part.

[0016] According to a specific embodiment of the present invention, a positioning protrusion is provided on the outer side of the flexible frame, and a positioning recess is provided on the inner side of the isolation chamber, with the positioning protrusion and the positioning recess corresponding to each other.

[0017] According to a specific embodiment of the present invention, the nucleic acid detection plate has a cuboid structure, and the storage unit has a total of 96 units arranged in a 12×8 array. The isolation sealing strip is set in a row or column corresponding to the outer edge of the plate.

[0018] As can be seen from the above technical solution, the advantages and positive effects of the nucleic acid detection plate sealing structure of this utility model are as follows:

[0019] This invention uses an isolation sealing strip to separate and seal each isolation chamber, which can effectively and conveniently seal the nucleic acid detection plate at a low cost, prevent the extraction reagent from adhering, improve the utilization rate of the extraction plate and avoid error in the results. Attached Figure Description

[0020] Figure 1 is a schematic diagram of the overall assembly of an embodiment of the nucleic acid detection plate sealing structure of this utility model.

[0021] Figure 2 is a schematic diagram of the structure of a nucleic acid detection plate.

[0022] Figure 3 is a schematic diagram of the isolation sealing strip in one embodiment of the nucleic acid detection plate sealing structure of this utility model.

[0023] Figure 4 is a top view of the pressure film pad in one embodiment of the sealing structure of the nucleic acid detection plate of this utility model.

[0024] Figure 5 is a cross-sectional view of the pressure film pad in one embodiment of the sealing structure of the nucleic acid detection plate of this utility model.

[0025] Drawing number explanation:

[0026] 1. Cover; 2. Isolation sealing strip; 3. Pressure film pad; 4. Nucleic acid detection plate; 11. Elastic tightening part; 12. Elastic covering film; 21. Isolation room; 31. Pressure film; 32. Flexible frame; 41. Storage part. Detailed Implementation

[0027] Exemplary embodiments will now be described more fully with reference to the accompanying drawings. However, these exemplary embodiments can be implemented in many forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that the present invention will be thorough and complete, and will fully convey the concept of the exemplary embodiments to those skilled in the art. The same reference numerals in the drawings denote the same or similar structures, and therefore their detailed description will be omitted.

[0028] In the following description of various examples of the present invention, reference is made to the accompanying drawings, which form part of the present invention, and which illustrate by way of example different exemplary structures, systems, and steps that can implement various aspects of the present invention. It should be understood that other specific embodiments of the components, structures, exemplary devices, systems, and steps may be used, and structural and functional modifications may be made without departing from the scope of the present invention. Furthermore, although the terms “top,” “bottom,” “front,” “rear,” “side,” etc., may be used in this specification to describe various exemplary features and elements of the present invention, these terms are used herein only for convenience, such as the orientation according to the examples shown in the accompanying drawings. Nothing in this specification should be construed as requiring a specific three-dimensional orientation of the structure to fall within the scope of the present invention.

[0029] As shown in Figures 1 to 5, this utility model discloses a sealing structure for a nucleic acid detection plate, used for repeatedly sealing a nucleic acid detection plate 4. The nucleic acid detection plate 4 is provided with an array of storage sections 41. This utility model includes a cover 1 and an isolation sealing strip 2. The cover 1 includes an elastic membrane 12 and an elastic tightening part 11. The elastic tightening part 11 is located at the outer edge of the elastic membrane 12 and is in an interference fit with the periphery of the nucleic acid detection plate 4. The elastic membrane 12 presses against the opening surface of the nucleic acid detection plate 4.

[0030] The isolation sealing strip 2 includes a long frame internally divided into two or more isolation chambers 21 arranged in a single row. Each isolation chamber 21 is square and of equal size. One isolation chamber 21 corresponds to one storage unit 41. The isolation sealing strip 21 is pressed between the elastic film 12 and the upper surface of the nucleic acid detection plate 4 to seal and isolate the corresponding storage unit 41. Typically, the isolation sealing strip 2 corresponds to one row or column of storage units 41 along the edge, because only one unit in each sequence has a protruding magnetic sleeve.

[0031] According to a specific embodiment of the present invention, the elastic tightening part 11 is a rectangular outer frame structure, which is consistent with the shape of the nucleic acid detection plate 4. The two are fastened together and locked by interference elastic deformation force.

[0032] According to a specific embodiment of the present invention, the elastic tightening part 11 is 1-3 cm long, so as to provide sufficient storage space for the protruding part of the magnetic sleeve.

[0033] According to a specific embodiment of the present invention, the wall of the isolation chamber 21 is a smooth structure, and both the upper and lower surfaces are planar structures, so as to facilitate use and the volatile liquid can easily flow back into the storage section 41.

[0034] According to a specific embodiment of this utility model, the nucleic acid detection plate sealing structure further includes a pressure film pad 3, which is fitted inside the isolation chamber 21 and is removable. Using the pressure film pad 3 provides greater flexibility, and the isolation sealing strip 2 can also be integrally formed with the cover 1, thereby reducing production and usage costs.

[0035] According to a specific embodiment of the present invention, the pressure film pad 3 includes a pressure film 31 and a flexible frame 32. The pressure film 31 is sealed and laid on the flexible frame 32, and the flexible frame 32 is compressibly clamped between the elastic covering film 11 and the upper surface of the nucleic acid detection plate 4.

[0036] According to a specific embodiment of the present invention, the flexible frame 32 has an outer square and inner circle structure, the outer side of the flexible frame 32 is connected to the inner side of the isolation chamber 21, and the inner side of the flexible frame 32 is connected to the storage part 41.

[0037] According to a specific embodiment of the present invention, the radius of the inner circular hole of the flexible frame 32 is less than or equal to the radius of the outer circle of the storage part 41.

[0038] According to a specific embodiment of the present invention, the flexible frame 32 is provided with a positioning protrusion (not shown in the figure) on the outer side, and the isolation chamber 21 is provided with a positioning recess (not shown in the figure) on the inner side. The positioning protrusion and the positioning recess are correspondingly matched to facilitate the snap-fit ​​between the two and facilitate assembly and disassembly.

[0039] According to a specific embodiment of the present invention, as shown in Figure 2, the nucleic acid detection plate 4 has a cuboid structure, the storage unit 41 has a total of 96 units arranged in a 12×8 array, and the isolation sealing strip 21 is set in a row or column corresponding to the outer edge, as shown in Figure 3, and the number of them is 8.

[0040] In other embodiments, the storage section 41 on the nucleic acid detection plate 4 has a square opening, and the corresponding pressure pad 3 can have a square inner hole or a circular inner hole. The magnetic sleeve has a long cylindrical structure and is a commonly used medical device, so it will not be described in detail here.

[0041] As can be seen from the above technical solution, the advantages and positive effects of the nucleic acid detection plate sealing structure of this utility model are as follows:

[0042] This invention uses an isolation sealing strip 2 to separate and seal each isolation chamber 21, which can effectively and conveniently seal the nucleic acid detection plate 4 at a low cost, prevent the extraction reagent from adhering, improve the utilization rate of the extraction plate, avoid error in the results, and improve the accuracy of the test.

[0043] Those skilled in the art to which this utility model pertains should understand that the specific structures and processes shown in the above detailed embodiments are merely exemplary and not restrictive. Furthermore, those skilled in the art can combine the various technical features described above in various possible ways to form new technical solutions or make other modifications, all of which fall within the scope of this utility model.

Claims

1. A nucleic acid detection plate sealing structure for repeatedly sealing a nucleic acid detection plate, wherein the nucleic acid detection plate is provided with an array of storage units, characterized in that, include: The cover includes an elastic membrane and an elastic tightening part. The elastic tightening part is located on the outer edge of the elastic membrane and is in an interference fit with the periphery of the nucleic acid detection plate. The elastic membrane presses against the opening surface of the nucleic acid detection plate. The isolation sealing strip includes a long frame, internally divided into two or more isolation chambers arranged in a single row. Each isolation chamber is square and of equal size. One isolation chamber corresponds to one storage part. The isolation sealing strip presses against the elastic membrane and the upper surface of the nucleic acid detection plate to seal and isolate the corresponding storage part.

2. The sealing structure of the nucleic acid detection plate according to claim 1, characterized in that: The elastic tightening part has a rectangular outer frame structure.

3. The nucleic acid detection plate sealing structure according to claim 2, characterized in that: The length of the elastic tightening part is 1-3 cm.

4. The sealing structure of the nucleic acid detection plate according to claim 1, characterized in that: The walls of the isolation chamber are smooth, and both the top and bottom surfaces are planar.

5. The nucleic acid detection plate sealing structure according to any one of claims 1-4, characterized in that: The nucleic acid detection plate sealing structure also includes a pressure film pad, which is fitted inside the isolation chamber and is removable.

6. The nucleic acid detection plate sealing structure according to claim 5, characterized in that: The pressure film pad includes a pressure film and a flexible frame. The pressure film is sealed and laid on the flexible frame, and the flexible frame is compressibly clamped between the elastic film and the upper surface of the nucleic acid detection plate.

7. The nucleic acid detection plate sealing structure according to claim 6, characterized in that: The flexible frame has an outer square and inner circle structure. The outer side of the flexible frame is connected to the inner side of the isolation chamber, and the inner side of the flexible frame corresponds to the storage section.

8. The sealing structure of the nucleic acid detection plate according to claim 7, characterized in that: The radius of the inner circular hole of the flexible frame is less than or equal to the radius of the outer circle of the storage section.

9. The sealing structure of the nucleic acid detection plate according to claim 7, characterized in that: The flexible frame has a positioning protrusion on its outer side and a positioning recess on its inner side, with the positioning protrusion and the positioning recess corresponding to each other.

10. The sealing structure of the nucleic acid detection plate according to claim 1, characterized in that: The nucleic acid detection plate has a cuboid structure, and there are 96 storage units arranged in a 12×8 array. The isolation sealing strip is set in a row or column corresponding to the outer edge of the plate.

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