Connecting device for improving detection sensitivity based on ion chromatography transformation

Abstract

The utility model discloses a connecting device for improving detection sensitivity based on ion chromatography transformation, which comprises a chromatographic column, a column oven, a suppressor and a detector, the chromatographic column is arranged in the column oven; the suppressor is provided with a leacheate inlet, and the leacheate inlet is connected with the outlet of the chromatographic column; the suppressor is provided with a leacheate outlet, and the leacheate outlet is connected with an inlet of the detector; the suppressor is provided with a regenerated liquid inlet, and the regenerated liquid inlet is connected with an outlet of the detector; and the suppressor is powered by a direct-current stabilized power supply. According to the device, the column oven and the suppressor are additionally arranged, compared with original old equipment, the suppressor improves sensitivity, the column oven optimizes the separation degree, and efficient analysis of complex samples can be achieved through combination of the suppressor and the column oven.

Description

Technical Field

[0001] This utility model relates to the field of ion chromatography analysis and detection technology, specifically to a connection device based on ion chromatography modification to improve detection sensitivity. Background Technology

[0002] Ion chromatography (IC) instruments are well-established methods for detecting inorganic anions (such as fluoride, chloride, nitrate, and sulfate ions), alkali metals (such as lithium, sodium, and potassium ions), and alkaline earth metals (magnesium and calcium ions) in aqueous solutions. These methods are widely used in key technological fields such as environmental protection, food safety, and the pharmaceutical industry. However, with the development of ion chromatography instruments, the requirements for detection limits and sensitivity of test samples are becoming increasingly stringent. Older instruments lack the necessary sensitivity and low detection limits, necessitating the purchase of the latest models and software upgrades to meet the analytical requirements for low-concentration samples and achieve analytical objectives. This places a significant financial burden on ion chromatography users. Utility Model Content

[0003] The purpose of this invention is to overcome the shortcomings of the prior art and provide a connection device based on ion chromatography modification to improve detection sensitivity.

[0004] To achieve the above objectives, the technical solution of this utility model is as follows:

[0005] A connection device for improving detection sensitivity based on ion chromatography modification includes a chromatographic column, a column oven, a suppressor, and a detector; the chromatographic column is disposed inside the column oven; the suppressor has an eluent inlet connected to the outlet of the chromatographic column; the suppressor has an eluent outlet connected to the inlet of the detector; the suppressor has a regeneration inlet connected to the outlet of the detector; the suppressor is powered by a DC regulated power supply.

[0006] Optionally, the suppressor is provided with a waste liquid outlet, which is connected to a waste liquid tank.

[0007] Optionally, the column oven includes a heating plate, with the temperature controlled by a digital switch in real time.

[0008] Optionally, the outer shell of the column temperature chamber is made of stainless steel, and the cover of the column temperature chamber is made of sponge or insulating degreased cotton.

[0009] Optionally, the column oven is equipped with chromatographic clamps for fixing the chromatographic column.

[0010] Compared with the prior art, the advantages of this utility model are as follows:

[0011] (1) By adding a suppressor, this utility model can reduce the background conductivity and improve the sensitivity compared with the original instrument. It can reduce the detection limit of the test group by 1-2 orders of magnitude, improve the peak shape, and enhance the anti-interference ability.

[0012] (2) Compared with the prior art, the progress of this utility model is that the addition of a column oven can control the temperature of the chromatographic column, optimize the separation process, improve the resolution by 20%-30%, and greatly shorten the analysis time.

[0013] (3) Compared with the original old equipment, the implementation of this utility model improves the sensitivity of the suppressor and optimizes the separation of the column oven. The combination of the two can realize the efficient analysis of complex samples. Attached Figure Description

[0014] Figure 1 A schematic diagram of the connection device for improving detection sensitivity based on ion chromatography modification provided in the embodiments of this application;

[0015] Figure 2 This is a schematic diagram of the suppressor piping connection;

[0016] Figure 3 This is a schematic diagram of the column oven structure;

[0017] In the diagram: 1. Chromatographic column; 2. Column oven; 3. Suppressor; 31. Eluent inlet; 32. Eluent outlet; 33. Regeneration inlet; 34. Waste outlet; 4. Detector; 5. Eluent; 6. Tandem pump; 7. Injection valve. Detailed Implementation

[0018] Example:

[0019] To make the above-mentioned objectives, features, and advantages of this application more apparent and understandable, the specific embodiments of this application are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a thorough understanding of this application. However, this application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this application. Therefore, this application is not limited to the specific embodiments disclosed below.

[0020] In the description of this application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, these terms indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0021] Furthermore, where the terms "first" and "second" appear, these terms are for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, where the term "multiple" appears, "multiple" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0022] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "joining," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can be a mechanical connection or an electrical connection; they can be a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0023] In this application, unless otherwise expressly specified and limited, the use of descriptions such as "above" or "below" the second feature indicates that the first and second features are in direct contact, or indirect contact via an intermediate medium. Furthermore, "above," "on top of," and "over" the second feature can mean that the first feature is directly above or diagonally above the second feature, or simply that the first feature is at a higher horizontal level than the second feature. Similarly, "below," "below," and "under" the second feature can mean that the first feature is directly below or diagonally below the second feature, or simply that the first feature is at a lower horizontal level than the second feature.

[0024] It should be noted that if an element is referred to as being "fixed to" or "set on" another element, it can be directly on the other element or there may be an intervening element. If an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intervening element. If so, the terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used in this application are for illustrative purposes only and do not represent the only possible implementation.

[0025] See Figure 1 As shown in the figure, this embodiment provides a connection device for improving detection sensitivity based on ion chromatography modification, including a chromatographic column 1, a column oven 2, a suppressor 3, and a detector 4. The eluent 5 is connected to a series pump 6 via an acid- and alkali-resistant hose, which is then connected to an injection valve 7 and a PEEK tube to the ion chromatography column 1. The column 1 is placed inside the column oven 2, whose temperature range is controlled between room temperature and above, and 80°C. The temperature accuracy is within 0.1°C, the stabilization time is less than 5 minutes, and the heating power is between 100 and 120 W, ensuring that the eluent carries the sample into the column 1. Separation can be achieved by changing the column temperature through the column oven. Thus, by adding a column oven 2 and placing the chromatographic column 1 inside it, the column temperature can be controlled, the separation process optimized, and the resolution improved by 20%-30%, while the analysis time is significantly shortened.

[0026] The eluent inlet 31 of the suppressor 3 is connected to the outlet of the chromatographic column 1, the eluent outlet 32 ​​of the suppressor 3 is connected to the inlet of the detector 4, and the regeneration inlet 33 of the suppressor is connected to the outlet of the detector 4. The suppressor is powered by a DC regulated power supply, which can regulate both current and voltage, thus better controlling the conductivity of the instrument's detector. This reduces the background conductivity of the sample, and the analyte ultimately reaches the detector 4 through the PEE tube to achieve the separation and detection of different components in different samples. By adding the suppressor 3, compared with the original instrument, the background conductivity can be reduced, the sensitivity can be improved, the detection limit of the analyte can be reduced by 1-2 orders of magnitude, the peak shape is improved, and the anti-interference ability is enhanced.

[0027] Therefore, it can be seen that by adding a column oven and a suppressor, this device can achieve efficient analysis of complex samples compared with the original old equipment. The suppressor improves sensitivity and the column oven optimizes resolution. The combination of the two can achieve efficient analysis of complex samples.

[0028] In one specific embodiment, the suppressor 3 is provided with a waste liquid outlet 34, which is connected to a waste liquid tank. That is to say, the suppressor 3 has a total of four interfaces, which can realize the connection between PEEK pipes and PEEK connectors. The connection between connectors of different sizes can be realized through two small tubes, so that PEEK connectors of different sizes can be connected to each other.

[0029] In one specific embodiment, the column oven 2 includes a heating plate, and the temperature is controlled in real-time by a digitally controlled switch. That is, the temperature inside the oven can be displayed in real time using a digitally controlled temperature display, and the temperature can be adjusted. Furthermore, the outer shell of the column oven is made of stainless steel, and the oven lid is made of sponge or insulating cotton, which helps to prevent heat loss and achieve a heat insulation effect. Additionally, the column oven is equipped with chromatographic clamps for fixing the chromatographic column, thereby enabling column fixation.

[0030] In one specific embodiment, the components of the chromatographic column 1, column oven 2, suppressor 3, and detector are connected by acid and alkali resistant tubing, including 1 / 16 Teflon tubing or 1 / 16 polytetrafluoroethylene tubing.

[0031] The above embodiments are merely illustrative of the technical concept and features of this utility model, and are intended to enable those skilled in the art to understand the content of this utility model and implement it accordingly. They should not be construed as limiting the scope of protection of this utility model. All equivalent changes or modifications made based on the substance of the content of this utility model should be covered within the scope of protection of this utility model.

Claims

1. A connection device for improving detection sensitivity based on ion chromatography modification, comprising a chromatographic column, characterized in that, It also includes a column oven, a suppressor, and a detector; the chromatographic column is disposed inside the column oven; the suppressor is provided with an eluent inlet, which is connected to the outlet of the chromatographic column; the suppressor is provided with an eluent outlet, which is connected to the inlet of the detector; the suppressor is provided with a regenerator inlet, which is connected to the outlet of the detector; the suppressor is powered by a DC regulated power supply.

2. The connection device for improving the detection sensitivity based on the ion chromatography modification according to claim 1, characterized in that, The suppressor is provided with a waste liquid outlet, which is connected to a waste liquid tank.

3. The connection device for improving detection sensitivity based on ion chromatography modification as described in claim 1, characterized in that, The column temperature chamber contains a heating plate, and the temperature is controlled by a digital switch in real time.

4. The connection device for improving the detection sensitivity based on the ion chromatography according to claim 3, wherein The outer shell of the column temperature chamber is made of stainless steel, and the cover of the column temperature chamber is made of sponge or heat-insulating degreased cotton.

5. The connection device for improving the detection sensitivity based on the ion chromatography modification according to claim 3 or 4, characterized in that, The column oven is equipped with chromatographic clamps for fixing the chromatographic column.

Images