Sample bearing device for mass spectrometer and positioning target groove of mass spectrometer

Abstract

The utility model discloses a sample bearing device used for a mass spectrometer and a positioning target groove of the mass spectrometer, the sample bearing device is matched with the positioning target groove in the mass spectrometer for installation, the sample bearing device comprises a group of target point units, the target point units comprise a plurality of target points arranged at intervals along a first direction, the sample bearing device bears samples through the target points, and the target points are arranged at intervals along the first direction. The surface of the target spot is a hydrophilic surface and / or the surface of the sample bearing device around the target spot is a hydrophobic surface; only one group of target point units is arranged, and the target points on the target point units are arranged at intervals along the first direction, so that the device is suitable for users with small single detection quantity, and the ratio of the quantity of the target points containing samples on the sample bearing device to the total quantity of the target points during single-batch detection can be increased; therefore, the phenomenon that a user repeatedly scrubs the target plate due to the fact that many unused target spots are considered is avoided, the risk of cross contamination between the target spots is avoided, the influence on the detection quality of the next batch of samples is eliminated, and the accuracy of the sample detection result can be improved.

Description

Technical Field

[0001] This utility model relates to the field of mass spectrometry detection technology, and in particular to a sample carrier device for a mass spectrometer and a positioning target groove for a mass spectrometer. Background Technology

[0002] A mass spectrometer, also known as a mass spectrometer, is a device that uses a mass analyzer and an ion detector as its core components. Its purpose is to separate substances and determine their composition. The ion source ionizes sample molecules under high vacuum conditions, the mass analyzer separates ions of different masses, and the ion detector collects and amplifies the ion signals, providing data for a computer to generate a mass spectrum. The ion source moves the sample under high vacuum conditions to the detection channels of the mass analyzer and ion detector.

[0003] Mass spectrometers separate and detect substances based on the principle that charged particles can deflect in an electromagnetic field, according to the mass differences of atoms, molecules, or molecular fragments. Ions are bombarded with energy and fly upwards to the detector. The flight path does not need to move or change. Samples at different positions are sampled at different locations by moving the coordinates of the motion platform. Existing mass spectrometers all use an XY cross-motion platform as the power source for reciprocating motion. The target plate has 96 target points arrayed, each carrying a different sample. For users with small detection volumes, it is difficult to use all the target points on the target plate in one batch of detection. After each batch of detection, users often immerse the used target plate in cleaning agent to wipe it clean, considering the large number of unused target points, so that the unused target points can be used for sample carrying in the next batch of sample detection. However, frequent wiping damages the surface of unused target points, affecting the sample quality of these target points, thus affecting the detection quality. Moreover, the sequential use of target points on the target plate for multiple batches of sample detection poses a risk of cross-contamination between different target points.

[0004] Therefore, how to provide a sample carrier device and a positioning target slot for a mass spectrometer to at least partially solve the above-mentioned problems is a technical problem that needs to be solved by those skilled in the art. Utility Model Content

[0005] The purpose of this invention is to provide a sample carrier device and a target positioning slot for a mass spectrometer, which can increase the ratio of the number of target points containing samples to the total number of target points on the sample carrier device during single-batch detection, avoiding repeated cleaning of the target plate by users due to concerns about the large number of unused target points, thereby eliminating the impact on the detection quality of the next batch of samples; it can also enrich the sample within the target points, increase the concentration of the sample within the target points, and thus improve the accuracy of the sample detection results.

[0006] To achieve the above objectives, this utility model provides a sample carrier for a mass spectrometer. The sample carrier is installed in conjunction with the positioning target slot inside the mass spectrometer. The sample carrier includes a set of target units, each of which includes a plurality of target points spaced apart along a first direction. The sample carrier carries the sample through the target points. The surface of the target points is a hydrophilic surface and / or the surface of the sample carrier around the target points is a hydrophobic surface.

[0007] In one possible implementation, the sample carrier includes a target holder and a sample target plate, with the target point set on the sample target plate, and the sample target plate being installed with the positioning target groove via the target holder.

[0008] In one possible implementation, the target holder is a slot target holder, and the top of the first end of the slot target holder is provided with a left positioning part and a right positioning part;

[0009] The sample target plate is provided with several target points with long axes for sample enrichment. One end of the sample target plate is provided with a first chamfer adapted to the left positioning part and a second chamfer adapted to the right positioning part, so that the sample target plate can be detachably installed on the slot target holder.

[0010] In one possible implementation, the top of the slot target holder is provided with a bonding surface for the bottom of the sample target plate to be bonded. Both sides of the bonding surface are provided with guide grooves, and the ends of the guide grooves away from the first end are provided with guide openings for the sample target plate to enter the guide grooves, so that the sample target plate moves along the extension direction of the guide grooves until the first chamfer abuts against the left positioning part and the second chamfer abuts against the right positioning part.

[0011] In one possible implementation, the first end is provided with a clearance position located between the left positioning part and the right positioning part, which is used to suspend the end part of the sample target plate. The slot target holder also includes a second end opposite to the first end. The second end is provided with a left pick-up and right pick-up position set at an angle to the mating surface and lower than the mating surface, which are used to pick up and put down the sample target plate installed on the slot target holder along the second end.

[0012] In one possible implementation, the bottom of the slot target holder is provided with a stepped groove, which includes a first groove with a smaller cross-sectional area perpendicular to its own axis and a second groove with a larger cross-sectional area perpendicular to its own axis. The first groove is used for mounting a first magnet to magnetically attract the sample target plate, and the second groove is used for mounting a silicon wafer to seal the first groove.

[0013] In one possible implementation, the other end of the sample target plate is provided with a third chamfer on the same side as the first chamfer and a fourth chamfer on the same side as the second chamfer, and the third chamfer and the first chamfer are asymmetrical structures.

[0014] In one possible implementation, the sample target plate is also provided with a barcode area and a location marker, with the location marker corresponding to the target point one by one.

[0015] A positioning target slot for a mass spectrometer, the positioning target slot being used to carry a sample carrier device for a mass spectrometer as described in any one of the above.

[0016] The positioning target groove is provided with a third groove and a fourth groove connected to the third groove. The bottom surface of the fourth groove is provided with a second magnet, a first guide member and a second guide member whose axis is perpendicular to the bottom surface and are spaced apart.

[0017] The sample carrier device is provided with a first through hole adapted to the first guide member, a second through hole adapted to the second guide member, and a corresponding magnetic member that can be magnetically attracted to the second magnet, so that the sample carrier device can be detachably installed in the fourth groove.

[0018] In one possible implementation, the sample carrier device is provided with a first positioning groove, a second positioning groove and a third positioning groove in the bottom circumferential direction. The first positioning groove, the second positioning groove and the third positioning groove are arranged in a triangle. The bottom surface of the fourth groove is also provided with a first positioning block adapted to the first positioning groove, a second positioning block adapted to the second positioning groove and a third positioning block adapted to the third positioning groove. The positioning target groove supports the sample carrier device through the first positioning block, the second positioning block and the third positioning block.

[0019] Compared with the above-mentioned background technology, the sample carrier device for mass spectrometer provided by this utility model is installed in conjunction with the positioning target groove in the mass spectrometer. The sample carrier device includes a set of target unit, and the target unit includes a plurality of target points spaced apart along a first direction. The sample carrier device carries the sample through the target points. The surface of the target point is a hydrophilic surface and / or the surface of the sample carrier device around the target point is a hydrophobic surface.

[0020] Specifically, by setting only one set of target units on the sample carrier, and with the target points on the target units spaced apart along the first direction, the number of target points on the sample carrier is significantly reduced compared to the number of target points on sample carriers with arrayed target distribution in the prior art. This is suitable for users with small single detection volumes, and can increase the ratio of the number of target points containing samples on the sample carrier to the total number of target points during a single batch of detection. This avoids users repeatedly wiping the target plate due to concerns about the large number of unused target points, thereby avoiding the risk of cross-contamination between target points caused by repeated wiping, thus eliminating the impact on the detection quality of the next batch of samples. At the same time, by using the hydrophilic surface of the target point and / or the hydrophobic surface of the sample carrier around the target point, the sample is enriched within the target point, which can increase the concentration of the sample within the target point, thereby improving the accuracy of the sample detection results. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the provided drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the structure of the sample carrier and the positioning target groove when they are combined according to an embodiment of the present invention;

[0023] Figure 2 This is a schematic diagram of the sample target plate provided in the first embodiment of the present invention;

[0024] Figure 3 for Figure 2 A magnified view of part A in the image;

[0025] Figure 4 This is a schematic diagram of the sample target plate provided in the second embodiment of the present invention;

[0026] Figure 5 This is a schematic diagram of the sample target plate provided in the third embodiment of the present invention;

[0027] Figure 6 This is a schematic diagram of the sample target plate provided in the fourth embodiment of the present invention;

[0028] Figure 7 This is a schematic diagram of the sample target plate assembled into the slot target holder according to an embodiment of the present invention;

[0029] Figure 8 This is a schematic diagram of the slot target holder provided in an embodiment of the present utility model;

[0030] Figure 9 A schematic diagram of the bottom structure of the slot target holder provided in an embodiment of this utility model;

[0031] Figure 10 A schematic diagram of the top structure of the slot target holder provided in an embodiment of this utility model;

[0032] Figure 11 A cross-sectional view of the slot target holder provided in an embodiment of this utility model;

[0033] Figure 12 This is a schematic diagram of the structure of the slot target holder installed in the positioning target slot according to an embodiment of the present invention;

[0034] Figure 13 This is a schematic diagram of the positioning target groove provided in an embodiment of the present utility model;

[0035] Figure 14 A cross-sectional view of the positioning target groove provided in an embodiment of this utility model;

[0036] Figure 15 This is a schematic diagram of the motion mechanism provided in an embodiment of the present utility model;

[0037] Figure 16 This is a schematic diagram of the motion mechanism provided in an embodiment of the present invention from another perspective.

[0038] in:

[0039] 1-Positioning target groove, 11-Third groove, 12-Fourth groove, 121-First positioning block, 122-Second positioning block, 123-Third positioning block, 13-First guide, 14-Second guide;

[0040] 2-Slot target holder, 21-Third through hole, 22-Fourth through hole, 23-First end, 231-Left positioning part, 232-Right positioning part, 233-Avoiding position, 234-First positioning groove, 235-Second positioning groove, 236-Avoiding slope, 24-Mating surface, 25-Guide groove, 26-Guide opening, 27-Second end, 271-Left pick-up and place position, 272-Right pick-up and place position, 273-Third positioning groove, 28-Stepped groove, 281-First groove, 282-Second groove, 283-First magnet, 284-Silicon wafer, 29-Grip position;

[0041] 3-Sample target plate, 31-Target point, 311-Long axis, 32-First chamfer, 33-Second chamfer, 34-Third chamfer, 35-Fourth chamfer, 36-Barcode area, 37-Position marker, 371-Observation marker, 38-Fifth through hole, 39-Sixth through hole;

[0042] 4-Cavity cover plate;

[0043] 5-Motor mechanism. Detailed Implementation

[0044] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0045] To enable those skilled in the art to better understand the present invention, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0046] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left" and "right" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the indicated position or element must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations of this utility model.

[0047] The purpose of this invention is to provide a sample carrier device for a mass spectrometer and a positioning target slot 1 for the mass spectrometer, which can increase the ratio of the number of target points 31 containing samples to the total number of target points 31 on the sample carrier device during single-batch detection, avoid users repeatedly wiping the target plate due to concerns about the large number of unused target points 31, thereby eliminating the impact on the detection quality of the next batch of samples; it can also enrich the sample within the target points 31, increase the concentration of the sample within the target points 31, and thus improve the accuracy of the sample detection results.

[0048] Please see Figure 1 To achieve the above objectives, this utility model provides a sample carrier for a mass spectrometer. The sample carrier is installed in conjunction with the positioning target groove 1 inside the mass spectrometer. The sample carrier includes a set of target point units, each of which includes a plurality of target points 31 spaced apart along a first direction. The sample carrier carries the sample through the target points 31. The surface of the target points 31 is a hydrophilic surface and / or the surface of the sample carrier surrounding the target points 31 is a hydrophobic surface. The first direction can be referred to in the attached diagram. Figure 2 The X direction in the equation.

[0049] By setting only one set of target units on the sample carrier, and the target points 31 on the target units are spaced apart along the first direction, the number of target points 31 on the sample carrier is significantly reduced compared to the number of target points 31 on the sample carrier in the prior art where the target points 31 are arrayed. This is suitable for users with small single detection volumes, and can increase the ratio of the number of target points 31 containing samples on the sample carrier to the total number of target points 31 during a single batch of detection. This avoids users repeatedly wiping the target plate due to concerns about the large number of unused target points 31, thereby avoiding the risk of cross-contamination between target points 31 caused by repeated wiping, thus eliminating the impact on the detection quality of the next batch of samples. At the same time, by using the hydrophilic surface of the target point 31 and / or the hydrophobic surface of the sample carrier surrounding the target point 31, the sample is enriched within the target point 31, which can increase the concentration of the sample within the target point 31, thereby improving the accuracy of the sample detection results.

[0050] It should be noted that when only one set of target units is set, and all target points 31 of the set of target units are spaced apart along the first direction, after the sample carrier device is placed in the positioning target slot 1 in the mass spectrometer, at least some target points 31 can be sequentially located at the target point 31 of the mass spectrometer detection position as the positioning target slot 1 moves along the first direction. In this application, only a motion module that moves in one direction is needed as the power source for the reciprocating motion of the sample carrier device to realize that all target points 31 are sequentially the target point 31 for sample detection. Compared with the prior art, which uses a motion module that can move in two directions as the power source for the reciprocating motion of the sample carrier device, the positional accuracy of the sample carrier device during the detection process can be improved by the cooperation between the sample carrier device and the mass spectrometer provided in this application.

[0051] In one possible implementation, the sample carrying device includes a target holder and a sample target plate 3. Target points 31 are set on the sample target plate 3. The sample target plate 3 is installed with the positioning target groove 1 through the target holder. Specifically, the sample target plate 3 with target points 31 is assembled onto the target holder, and the target holder is assembled onto the positioning target groove 1, so that the sample target plate 3 is assembled into the preset position of the positioning target groove 1. The target holder is used to support and fix the sample target plate 3, and the positioning target groove 1 is used for positioning the target holder.

[0052] Please see Figures 7 to 10 In one possible implementation, the target holder is a slot target holder 2. The top of the first end 23 of the slot target holder 2 is provided with a left positioning part 231 and a right positioning part 232. The sample target plate 3 is provided with a plurality of target points 31 with long axes 311 for sample enrichment. One end of the sample target plate 3 is provided with a first chamfer 32 adapted to the left positioning part 231 and a second chamfer 33 adapted to the right positioning part 232. By providing the first chamfer 32 adapted to the left positioning part 231 and the second chamfer 33 adapted to the right positioning part 232 at the same end of the sample target plate 3, the sample target plate 3 is positioned by the left positioning part 231 and the right positioning part 232 when placed in the slot target holder 2, so that the sample target plate 3 can be detachably installed in the preset position of the slot target holder 2, thereby realizing the detachable installation of the sample target plate 3 in the slot target holder 2.

[0053] Please see Figures 2 to 6The sample target plate 3 can be made of ultra-thin silicon steel. The first direction can be the length direction of the sample target plate 3. The length direction of the sample target plate 3 can also be used as the moving direction when the sample target plate 3 is engaged with the slot target holder 2 (insertion and removal). The sample target plate 3 has a number of enrichment target points 31 arranged in the first direction. The sample can be freely applied within the enrichment target points 31. The sample target points 31 are coated with a hydrophilic coating, which can enrich the sample towards the inner side of the contour. The sample is concentrated in the direction of the long axis 311 of the target points 31. The number of target points 31 of the sample target plate 3 can be set according to the requirements. For example, the sample target plate 3 has 12 target points 31. At the same time, the long axis 311 of the target points 31, i.e. the sample enrichment direction, can also be adjusted according to actual needs. For example, the long axis 311 of the target points 31 can be parallel to the first direction, or perpendicular to it, or at a 45-degree angle. In addition, the shape of the target points 31 can be a circle as shown in Embodiment 1, a rectangle as shown in Embodiment 3, a horizontal ellipse as shown in Embodiment 4, etc.

[0054] When the target point 31 is elliptical in shape, and the major axis 311 of the ellipse extends in the direction of the first direction, the sample within the target point 31 can be concentrated in the first direction, allowing for multiple detections of different positions of the sample within the same target point 31. When the target point 31 is elliptical in shape, and the major axis 311 of the ellipse extends in the direction of the first direction, that is, the width of the elliptical target point 31 in the first direction is smaller, which can improve the detection throughput of the same sample target plate 3. There are corresponding target point 31 position observation marks 371 between the target points 31. The target points 31 can be observed in the mass spectrometer through a high-precision camera. The sample target plate 3 is also provided with a barcode area 36 and a position mark 37. The position mark 37 corresponds one-to-one with the target point 31 and is used to record the position of the target point 31. The position mark 37 is located on the right side of the target point 31 to ensure the accuracy of sample recording and collection.

[0055] In this embodiment, the top of the slot target holder 2 is provided with a fitting surface 24 for the bottom of the sample target plate 3 to fit. Both sides of the fitting surface 24 are provided with guide grooves 25, which extend along a first direction. The ends of the guide grooves 25 away from the first end 23 are provided with guide openings 26 for the sample target plate 3 to enter the guide grooves 25. The end of the sample target plate 3 with a first chamfer 32 and a second chamfer 33 first enters the guide groove 25 along the guide opening 26 and moves along the extension direction of the guide groove 25 until the first chamfer 32 abuts against the left positioning part 231 and the second chamfer 33 abuts against the right positioning part 231. Positioning part 232: After the sample target plate 3 is inserted into the guide groove 25 to a certain depth along the extension direction of the guide groove 25, the sample target plate 3 is pushed from the end of the sample target plate 3 that has not entered the guide groove 25 to complete the movement of the sample target plate 3 to the preset position on the slot target holder 2. The other end of the sample target plate 3 (the end that has not entered the guide groove 25) is provided with a third chamfer 34 on the same side as the first chamfer 32 and a fourth chamfer 35 on the same side as the second chamfer 33. The third chamfer 34 and the first chamfer 32 are asymmetrical structures to prevent misinsertion from causing a mismatch between the identification results and the target point 31 information.

[0056] Please see Figure 11 The bottom of the slot target holder 2 is provided with a stepped groove 28. The stepped groove 28 includes a first groove 281 with a smaller cross-sectional area perpendicular to its own axis and a second groove 282 with a larger cross-sectional area perpendicular to its own axis. The first groove 281 is used for the installation of the first magnet 283 to magnetically attract the sample target plate 3. The second groove 282 is used for the installation of the silicon wafer 284 to seal the first groove 281. The slot target holder 2 uses the first magnet 283 to attract the sample target plate 3 onto the mating surface 24 of the slot target holder 2. The first magnet 283 can be, but is not limited to, a neodymium iron boron magnet. The neodymium iron boron magnet is sealed inside the stepped groove 28 by the silicon wafer 284. The number of stepped grooves 28 and the corresponding neodymium iron boron magnets can be adjusted according to the actual situation. No specific limitation is made here, as long as the above purpose can be achieved.

[0057] In this embodiment, the bottom of the first end 23 is provided with a clearance position 233, which is located between the left positioning part 231 and the right positioning part 232, and is used to suspend the end part of the sample target plate 3. The slot target holder 2 also includes a second end 27 away from the first end 23. The second end 27 is provided with a left pick-up position 271 and a right pick-up position 272 that are set at an angle to the contact surface 24 and are lower than the contact surface 24, for picking up and placing the sample target plate 3 installed on the slot target holder 2 along the second end 27. When the sample target plate 3 is taken out of the slot target holder 2, it can be picked up from one side or both sides of the sample target plate 3 from the left pick-up position 271 and the right pick-up position 272. When the force resistance is felt, the sample target plate 3 located above the clearance position 233 can be pressed down with the fingers, and the sample target plate 3 can be taken out in conjunction with the operation of the left pick-up position 271 and the right pick-up position 272.

[0058] Please see Figures 12 to 14 This application also provides a positioning target groove 1 for a mass spectrometer, which is used to support the sample carrying device for the mass spectrometer. The positioning target groove 1 is provided with a third groove 11 and a fourth groove 12 connected to the third groove 11. The bottom surface of the fourth groove 12 is provided with a second magnet, a first guide 13 and a second guide 14 whose axes are perpendicular to the bottom surface and are spaced apart. The sample carrying device is provided with a first through hole adapted to the first guide 13, a second through hole adapted to the second guide 14, and a corresponding magnet that can be magnetically attracted to the second magnet, so that the sample carrying device can be detachably installed in the fourth groove 12. There are two third grooves 11, which are respectively located on both sides of the fourth groove 12. The bottom of the third groove 11 is lower than the fourth groove 12. When the sample carrying device includes a slot target holder 2 and a sample target plate 3, the two sides of the slot target holder 2 are respectively provided with gripping positions 29 located above the third groove 11. The slot target holder 2 is placed into the positioning target groove 1 through the gripping positions 29, and the slot target holder 2 is prevented from moving during movement by the magnetic force of the second magnet and the magnet.

[0059] The first guide 13 and the second guide 14, located on the bottom surface of the fourth groove 12, engage with the first and second through holes on the sample carrier device to stabilize the relative position of the sample carrier device and prevent it from shaking. Both the first guide 13 and the second guide 14 are conical. The conical free-guide structure on the bottom surface of the fourth groove 12, which engages with the first and second through holes on the sample carrier device, allows the sample carrier device to be guided and positioned without precise alignment when placed in the positioning target groove 1, guided by the conical free-guide structure.

[0060] When the sample carrier includes a slot target holder 2 and a sample target plate 3, the first through hole is formed by opening a third through hole 21 corresponding to the first guide member 13 on the slot target holder 2 and a fifth through hole 38 corresponding to the third through hole 21 on the sample target plate 3. The second through hole is formed by opening a fourth through hole 22 corresponding to the second guide member 14 on the slot target holder 2 and a sixth through hole 39 corresponding to the fourth through hole 22 on the sample target plate 3.

[0061] When the sample carrier includes a slot target holder 2 and a sample target plate 3, the bottom of the sample carrier, which is also the bottom of the slot target holder 2, has a first positioning groove 234, a second positioning groove 235, and a third positioning groove 273 arranged circumferentially on the bottom of the slot target holder 2. The first positioning groove 234, the second positioning groove 235, and the third positioning groove 273 are arranged in a triangle. The positioning target groove 1 also has a first positioning block 121 adapted to the first positioning groove 234 and a third positioning block 121 adapted to the second positioning groove 235 on the bottom surface of the fourth groove 12. The second positioning block 122 and the third positioning block 123 adapted to the third positioning groove 273 support the sample carrier device through the first positioning block 121, the second positioning block 122 and the third positioning block 123. The first positioning block 121, the second positioning block 122 and the third positioning block 123 are all horizontally set to provide a superplane for the slot target holder 2 to be placed. This allows the plane accuracy when the slot target holder 2 and the positioning target groove 1 are in contact to reach 5um, so that the slot target holder 2 can be stably fixed in the positioning target groove 1.

[0062] Please see Figures 15 to 16 In this embodiment, the mass spectrometer also includes a cavity cover plate 4 disposed above the positioning target slot 1 and a motion mechanism 5 for moving the positioning target slot 1. The first end 23 of the slot target holder 2 is provided with a clearance slope 236 adjacent to the left positioning part 231 and the right positioning part 232. Under the drive of the motion mechanism 5, the positioning target slot 1 pushes the sample away from the cavity cover plate 4 and enters the vacuum cavity for sample identification. The slot target holder 2 is provided with a clearance slope 236 at the sample inlet end, which can avoid interference with the movement of the cavity cover plate 4 during the movement of entering and exiting the target, and smoothly complete the sample inlet movement.

[0063] It should be noted that in this specification, relational terms such as first and second are used only to distinguish one entity from several other entities, and do not necessarily require or imply any such actual relationship or order between these entities.

[0064] The various embodiments in this specification are described in a progressive manner, with each embodiment focusing on the differences from other embodiments. The same or similar parts between the various embodiments can be referred to each other.

[0065] This article uses specific examples to illustrate the principles and implementation methods of this utility model. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made to this utility model without departing from the principles of this utility model, and these improvements and modifications also fall within the protection scope of this utility model.

Claims

1. A sample carrier for a mass spectrometer, the sample carrier being fitted into a positioning target groove within the mass spectrometer, characterized in that, The sample carrier device includes a set of target point units, each target point unit including a plurality of target points spaced apart along a first direction. The sample carrier device carries the sample through the target points, and the surface of the target points is a hydrophilic surface and / or the surface of the sample carrier device surrounding the target points is a hydrophobic surface.

2. The sample carrier device for a mass spectrometer according to claim 1, characterized in that, The sample carrying device includes a target holder and a sample target plate. The target point is set on the sample target plate, and the sample target plate is installed with the positioning target groove through the target holder.

3. The sample carrier device for a mass spectrometer according to claim 2, characterized in that, The target holder is a slot target holder, and the top of the first end of the slot target holder is provided with a left positioning part and a right positioning part; The sample target plate is provided with a number of target points with long axes for sample enrichment. One end of the sample target plate is provided with a first chamfer adapted to the left positioning part and a second chamfer adapted to the right positioning part, so that the sample target plate can be detachably installed on the slot target holder.

4. The sample carrier device for a mass spectrometer according to claim 3, characterized in that, The top of the slot target holder is provided with a fitting surface for the bottom of the sample target plate to fit. Both sides of the fitting surface are provided with guide grooves, and the ends of the guide grooves away from the first end are provided with guide openings for the sample target plate to enter the guide grooves, so that the sample target plate moves along the extension direction of the guide grooves until the first chamfer abuts against the left positioning part and the second chamfer abuts against the right positioning part.

5. The sample carrier device for a mass spectrometer according to claim 4, characterized in that, The first end is provided with a clearance position, which is located between the left positioning part and the right positioning part, for suspending the end part of the sample target plate. The slot target holder also includes a second end opposite to the first end. The second end is provided with a left pick-up and right pick-up position that are set at an angle to the mating surface and are lower than the mating surface, for picking up and placing the sample target plate installed on the slot target holder along the second end.

6. The sample carrier for a mass spectrometer according to claim 5, characterized in that, The bottom of the slot target holder is provided with a stepped groove, which includes a first groove with a smaller cross-sectional area perpendicular to its own axis and a second groove with a larger cross-sectional area perpendicular to its own axis. The first groove is used for the installation of a first magnet to magnetically attract the sample target plate, and the second groove is used for the installation of a silicon wafer to seal the first groove.

7. The sample carrier device for a mass spectrometer according to claim 3, characterized in that, The other end of the sample target plate is provided with a third chamfer on the same side as the first chamfer and a fourth chamfer on the same side as the second chamfer, and the third chamfer and the first chamfer are asymmetrical structures.

8. The sample carrier device for a mass spectrometer according to claim 2, characterized in that, The sample target plate is also provided with a barcode area and a location marker, and the location marker corresponds one-to-one with the target point.

9. A positioning target groove for a mass spectrometer, characterized in that, The positioning target groove is used to support the sample carrying device for a mass spectrometer as described in any one of claims 1-8; The positioning target groove is provided with a third groove and a fourth groove connected to the third groove. The bottom surface of the fourth groove is provided with a second magnet, a first guide member and a second guide member whose axis is perpendicular to the bottom surface and are spaced apart. The sample carrier is provided with a first through hole adapted to the first guide, a second through hole adapted to the second guide, and a corresponding magnetic component that can be magnetically attracted to the second magnet, so that the sample carrier can be detachably installed in the fourth groove.

10. The positioning target slot of the mass spectrometer according to claim 9, characterized in that, The sample carrier device has a first positioning groove, a second positioning groove, and a third positioning groove circumferentially arranged at its bottom. The first positioning groove, the second positioning groove, and the third positioning groove are arranged in a triangle. The bottom surface of the fourth groove is also provided with a first positioning block adapted to the first positioning groove, a second positioning block adapted to the second positioning groove, and a third positioning block adapted to the third positioning groove. The positioning target groove supports the sample carrier device through the first positioning block, the second positioning block, and the third positioning block.

Images