A kind of liquid preparation equipment for preparing chloroprostol sodium bulk drug

Abstract

This invention provides a solution preparation device for sodium cloprostenol raw material preparation, relating to the field of sodium cloprostenol raw material preparation technology. It includes a solution preparation tank with a discharge port at its lower end, a sealing cap with several feeding hoppers, and a conveying pipe extending into a mixing tank. A first stirring shaft is rotatably mounted inside the mixing tank, with a second stirring shaft fixedly connected to its lower end. Several liquid outlet holes are opened at the bottom of the mixing tank. An electric push rod is installed on the sealing cap, with several flow guides connected to its bottom. This invention employs a graded mixing mode: initial pre-mixing with the first stirring shaft, uniform flow guidance with a conical block, and secondary fusion with the second stirring shaft. First, a small dose of the drug is pre-mixed evenly in the mixing tank, then guided evenly to the base solution by the conical block, and finally deeply mixed by the second stirring shaft. This completely solves the problem of easy aggregation and uneven mixing of small doses of the drug when directly introduced into the base solution.

Description

Technical Field

[0001] This utility model relates to the field of preparation technology of sodium cloprostenol raw material, and more specifically, to a solution preparation device for sodium cloprostenol raw material preparation. Background Technology

[0002] Cloprostol sodium raw material, also known as cloprostol sodium chemical raw material, is the core active substance for producing various cloprostol sodium preparations. It has a specific chemical structure and activity and cannot be directly administered. It is only used as a key raw material for preparation production. Solution preparation is the core step in drug preparation. Drug solution preparation equipment mixes the base solution with various drug raw materials in a preset ratio to form a uniform and clean drug solution.

[0003] In the prior art, patent CN218590297U discloses a pharmaceutical preparation container, which relates to the field of pharmaceutical technology. It includes a base, a preparation tank, a stirring structure, a feeding assembly, and a circulation assembly. The container facilitates control of the amount of pharmaceutical solution added to the tank through the combined use of a flow meter, a discharge valve, a feeding pipe, and a control block. This allows for automatic and precise addition of liquid pharmaceutical solutions, achieving accurate preparation, improving work efficiency, and reducing operating costs. The combined use of a circulation pump, a suction pipe, a guide pipe, and a circulation head facilitates the introduction of pharmaceutical solution from the bottom of the tank's inner cavity to the top, achieving internal liquid circulation, improving mixing, saving preparation time, and increasing work efficiency.

[0004] Existing pharmaceutical preparation equipment typically requires small doses of active pharmaceutical ingredients (APIs) to be directly added to a preparation tank containing a large volume of base solution. However, for some APIs with small feed amounts, direct addition to a large volume of solvent can easily lead to high concentration accumulation zones in the base solution due to delayed dispersion. It is difficult to quickly and thoroughly disperse these high concentration zones, resulting in long mixing times and the risk of uneven mixing, which directly affects the uniformity of the drug solution content. Utility Model Content

[0005] The main objective of this invention is to provide a solution preparation device for sodium chloroprostol raw material preparation, which can effectively solve the problems mentioned in the background art.

[0006] To achieve the above objectives, the technical solution adopted by this utility model is as follows:

[0007] A solution preparation device for sodium cloprostenol raw material includes a solution preparation tank, a discharge port at the lower end of the solution preparation tank, a sealing cover at the upper end of the solution preparation tank, a plurality of feeding hoppers on the sealing cover, a conveying pipe at the bottom of the feeding hoppers, a mixing tank inside the solution preparation tank, the lower end of the conveying pipe extending into the mixing tank, a first stirring shaft rotatably arranged inside the mixing tank, the upper end of the first stirring shaft being connected to the output end of a stirring motor, a second stirring shaft being fixedly connected to the lower end of the first stirring shaft, a plurality of liquid outlet holes at the bottom of the mixing tank, an electric push rod installed on the sealing cover, a plurality of flow guides connected to the bottom of the electric push rod, and the plurality of flow guides being sealed and inserted into the liquid outlet holes through the electric push rod.

[0008] Preferably, the lower end of the liquid preparation tank is fixedly installed in a fixing frame, and a plurality of mounting frames are arranged around the upper surface of the sealing cover, and a plurality of the feeding hoppers are respectively fixedly installed in the mounting frames.

[0009] Preferably, the stirring motor is fixedly installed in the middle of the upper surface of the sealing cover, the upper end of the mixing tank is fixedly installed in the mounting ring, and a plurality of connecting blocks are arranged around the upper surface of the mounting ring.

[0010] Preferably, the upper end of the connecting block is fixedly connected to the lower surface of the sealing cover, and the lower ends of the plurality of conveying pipes are fixed inside the connecting block.

[0011] Preferably, a plurality of guide rods are slidably provided on the mounting ring, and the output end of the electric push rod is fixedly connected to the upper end of one of the guide rods.

[0012] Preferably, a movable frame is fixedly connected to the lower end of the guide rod, and a plurality of connecting rods are arranged circumferentially on the movable frame, with a conical sleeve fixedly connected to one end of each connecting rod.

[0013] Preferably, the flow guide consists of two parts: a sealing plug and a conical block. The upper end of the sealing plug is sealed and inserted into the liquid outlet hole, and the conical block is fixedly connected to the lower end of the sealing plug.

[0014] Preferably, the conical sleeve is fixedly fitted onto the sealing plug, and the outer surface of the conical sleeve is flush with the outer surface of the conical block.

[0015] Compared with the prior art, the present invention has the following beneficial effects:

[0016] (1) This equipment adopts a graded mixing mode of initial premixing by the first stirring shaft, uniform flow guidance by the conical block, and secondary fusion by the second stirring shaft. First, the small dose of medicine is premixed evenly in the mixing tank, then guided evenly to the base solution by the conical block, and finally deeply mixed by the second stirring shaft, which completely solves the problem of easy aggregation and uneven mixing of small dose of medicine after it directly enters the base solution.

[0017] (2) By setting a conical block at the bottom of the sealing plug, after the initial mixing is completed, the sealing plug is pulled out from the liquid outlet hole, and the initially mixed agent flows out through the liquid outlet hole. The sealing plug and the conical block move vertically to directly below the liquid outlet hole, and the agent flows to the surface of the conical block and is evenly dispersed into the base solution along the surface of the conical block. This can effectively shorten the mixing time and improve the final mixing effect. Attached Figure Description

[0018] Figure 1 This is a three-dimensional schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a top view of the structure of this utility model;

[0020] Figure 3 This utility model Figure 2 3D schematic diagram of the cross-sectional structure of the middle AA section;

[0021] Figure 4 This utility model Figure 3 Enlarged view of the structure at point B in the middle;

[0022] Figure 5 This is a first-view perspective three-dimensional schematic diagram of a partial structure in this utility model;

[0023] Figure 6 This is a second-view perspective three-dimensional schematic diagram of a partial structure in this utility model.

[0024] In the diagram: 1. Liquid mixing tank; 11. Sealing cap; 12. Discharge port; 13. Fixing frame; 14. Mounting frame; 15. Feeding hopper; 16. Feeding pipe; 2. Stirring motor; 21. First stirring shaft; 22. Second stirring shaft; 3. Electric push rod; 31. Guide rod; 32. Movable frame; 33. Connecting rod; 34. Conical sleeve; 4. Mixing tank; 41. Mounting ring; 42. Connecting block; 43. Liquid outlet; 5. Flow guide; 51. Sealing plug; 52. Conical block. Detailed Implementation

[0025] The technical solutions of this utility model will be clearly and completely described below with reference to the embodiments of this utility model. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of this utility model.

[0026] like Figures 1-4As shown in the figure, this utility model embodiment proposes a liquid preparation device for preparing sodium cloprostenol raw material, including a liquid preparation tank 1, a discharge port 12 at the lower end of the liquid preparation tank 1, a sealing cover 11 at the upper end of the liquid preparation tank 1, a plurality of feeding hoppers 15 on the sealing cover 11, a conveying pipe 16 at the bottom of the feeding hoppers 15, a mixing tank 4 inside the liquid preparation tank 1, the lower end of the conveying pipe 16 extending into the mixing tank 4, a first stirring shaft 21 rotatably arranged inside the mixing tank 4, the upper end of the first stirring shaft 21 being connected to the output end of the stirring motor 2, a second stirring shaft 22 being fixedly connected to the lower end of the first stirring shaft 21, a plurality of liquid outlet holes 43 being opened at the bottom of the mixing tank 4, an electric push rod 3 being installed on the sealing cover 11, a plurality of flow guides 5 being connected to the bottom of the electric push rod 3, and the plurality of flow guides 5 being sealed and inserted into the liquid outlet holes 43 through the electric push rod 3.

[0027] like Figure 1 As shown, the lower end of the liquid preparation tank 1 is fixedly installed in the fixing frame 13, and several mounting frames 14 are arranged around the upper surface of the sealing cover 11, and several feeding hoppers 15 are respectively fixedly installed in the mounting frames 14.

[0028] Several mounting brackets 14 are fixedly installed on the edge of the upper surface of the sealing cover 11 to fix the feeding hopper 15. The feeding hopper 15 is used to transport various agents for preparing sodium cloprostenol raw material to the mixing tank 4. The first stirring shaft 21 is driven to rotate by the stirring motor 2 to perform preliminary mixing of the agents in the mixing tank 4, thereby improving the initial dispersion of small doses of agents and reducing local concentration.

[0029] like Figure 1 , Figure 3 , Figure 5 As shown, the stirring motor 2 is fixedly installed in the middle of the upper surface of the sealing cover 11, the upper end of the mixing tank 4 is fixedly installed in the mounting ring 41, and a number of connecting blocks 42 are arranged around the upper surface of the mounting ring 41. The upper end of the connecting blocks 42 is fixedly connected to the lower surface of the sealing cover 11, and the lower ends of a number of conveying pipes 16 are fixed in the connecting blocks 42.

[0030] The upper and lower ends of the connecting block 42 are fixedly connected to the lower surface of the sealing cover 11 and the upper surface of the mounting ring 41, respectively. The connecting block 42 fixes the mixing tank 4 through the mounting ring 41 on the one hand, and fixes the conveying pipe 16 on the other hand, to ensure the stable operation of each component.

[0031] like Figure 1 , Figures 3-6 As shown, a number of guide rods 31 are slidably arranged through the mounting ring 41. The output end of the electric push rod 3 is fixedly connected to the upper end of one of the guide rods 31. A movable frame 32 is fixedly connected to the lower end of the guide rod 31. A number of connecting rods 33 are arranged around the circumference of the movable frame 32. A conical sleeve 34 is fixedly connected to one end of the connecting rod 33.

[0032] The guide rod 31 slides through the mounting ring 41, and the bottom is fixed to the guide component 5 by the movable frame 32, the connecting rod 33, and the conical sleeve 34, which can effectively ensure the precise connection between the upper end of the guide component 5 and the liquid outlet 43. When the mixing of the agent in the mixing tank 4 is finished, the electric push rod 3 is activated to drive the guide rod 31 and the movable frame 32 to move downward. The movable frame 32 drives the guide component 5 to move downward synchronously through the connecting rod 33 and the conical sleeve 34, so that the guide component 5 is removed from the liquid outlet 43, which facilitates the flow of the agent into the solvent in the liquid preparation tank 1. The mixed base solution is stirred again by the second stirring shaft 22 to gradually resolve the concentration difference, avoid the high concentration gradient formed by concentrated feeding, and ensure the uniformity and efficiency of mixing.

[0033] like Figure 3 , Figure 4 , Figure 6 As shown, the flow guide 5 consists of two parts: a sealing plug 51 and a conical block 52. The upper end of the sealing plug 51 is sealed and inserted into the liquid outlet hole 43. The conical block 52 is fixedly connected to the lower end of the sealing plug 51. The conical sleeve 34 is fixedly sleeved on the sealing plug 51. The outer surface of the conical sleeve 34 is flush with the outer surface of the conical block 52.

[0034] During the initial mixing stage, the sealing plug 51 is inserted into the liquid outlet 43 to block the communication between the agent in the mixing tank 4 and the base solution in the liquid preparation tank 1. After the initial mixing is completed, the sealing plug 51 is pulled out from the liquid outlet 43, and the initially mixed agent flows out through the liquid outlet 43. The sealing plug 51 and the conical block 52 move vertically to directly below the liquid outlet 43, and the agent flows to the surface of the conical block 52 and is evenly dispersed along the surface of the conical block 52 into the base solution, thereby improving the final mixing effect.

[0035] The working principle of a solution preparation device for sodium cloprostenol raw material preparation:

[0036] A preset amount of base solution is injected into the preparation tank 1. Various pharmaceutical raw materials are transported to the mixing tank 4 through the feeding hopper 15 and the conveying pipe 16. The stirring motor 2 is started to drive the first stirring shaft 21 to rotate in the mixing tank 4 to perform preliminary stirring and premixing of the pharmaceuticals. After the preliminary mixing is completed, the electric push rod 3 is started to drive the guide rod 31 to slide along the mounting ring 41. The sealing plug 51 is pulled out from the liquid outlet 43 through the conical sleeve 34. The premixed pharmaceuticals are guided by the circumferentially distributed conical blocks 52 and flow evenly into the solvent in the preparation tank 1. The second stirring shaft 22 rotates to perform secondary deep stirring of the premixed pharmaceuticals and base solution. After the mixing is completed, the pharmaceuticals are discharged from the discharge port 12.

[0037] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating this utility model, and are not intended to limit the implementation of this utility model. For those skilled in the art, other variations or modifications can be made based on the above description. It is impossible to exhaustively list all the implementation methods here. Any obvious variations or modifications derived from the technical solutions of this utility model are still within the protection scope of this utility model.

Claims

1. A solution preparation device for sodium chloroprostol raw material, comprising a solution preparation tank (1), characterized in that: The mixing tank (1) has a discharge port (12) at its lower end and a sealing cover (11) at its upper end. Several feeding hoppers (15) are provided on the sealing cover (11), and a conveying pipe (16) is provided at the bottom of each feeding hopper (15). A mixing tank (4) is provided inside the mixing tank (1), and the lower end of the conveying pipe (16) extends into the mixing tank (4). A first stirring shaft (21) is rotatably installed inside the mixing tank (4). The upper end of the first stirring shaft (21) is connected to the output end of the stirring motor (2), and the lower end of the first stirring shaft (21) is fixedly connected to the second stirring shaft (22). The bottom of the mixing tank (4) is provided with several liquid outlet holes (43). An electric push rod (3) is installed on the sealing cover (11). Several flow guides (5) are connected to the bottom of the electric push rod (3). Several flow guides (5) are sealed and inserted into the liquid outlet holes (43) through the electric push rod (3).

2. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 1, characterized in that: The lower end of the liquid preparation tank (1) is fixedly installed in the fixing frame (13), and a number of mounting frames (14) are arranged around the upper surface of the sealing cover (11), and a number of feeding hoppers (15) are fixedly installed in the mounting frames (14).

3. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 1, characterized in that: The stirring motor (2) is fixedly installed in the middle of the upper surface of the sealing cover (11), and the upper end of the mixing tank (4) is fixedly installed in the mounting ring (41). Several connecting blocks (42) are arranged around the upper surface of the mounting ring (41).

4. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 3, characterized in that: The upper end of the connecting block (42) is fixedly connected to the lower surface of the sealing cover (11), and the lower ends of several conveying pipes (16) are fixed inside the connecting block (42).

5. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 3, characterized in that: A plurality of guide rods (31) are slidably provided on the mounting ring (41), and the output end of the electric push rod (3) is fixedly connected to the upper end of one of the guide rods (31).

6. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 5, characterized in that: The lower end of the guide rod (31) is fixedly connected to a movable frame (32), and a plurality of connecting rods (33) are arranged around the circumference of the movable frame (32). One end of the connecting rod (33) is fixedly connected to a conical sleeve (34).

7. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 6, characterized in that: The flow guide (5) consists of two parts: a sealing plug (51) and a conical block (52). The upper end of the sealing plug (51) is sealed and inserted into the liquid outlet (43), and the conical block (52) is fixedly connected to the lower end of the sealing plug (51).

8. The solution preparation equipment for sodium chloroprostol raw material preparation according to claim 7, characterized in that: The conical sleeve (34) is fixedly fitted onto the sealing plug (51), and the outer surface of the conical sleeve (34) is flush with the outer surface of the conical block (52).

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