Keratotic plug removal composition

Abstract

To provide a keratotic plug removal composition that exhibits high performance in removing keratotic plugs and makeup, while ensuring non-irritation.SOLUTION: A keratotic plug removal composition contains following components (a) and (b): (a) an oil solution with an HSP distance Ra of 5.0 or less relative to δd=14.0, δp=1.0, and δh=1.0 and (b) an oil solution with an HSP distance Ra of 5.0 or less relative to δd=18.5, δp=4.0, and δh=4.0. At 25°C, the HSP distance Ra between the composition's Hansen solubility parameters and δd=15.6, δp=4.7, and δh=5.1 satisfies 4.0 or less. The composition is substantially free of organic acids and organic bases.SELECTED DRAWING: None

Description

[Technical field]

[0001] The present invention relates to a composition for removing keratin plugs. [Background technology]

[0002] Keratin plugs are formed in the pores of the nose and cheeks, and are formed when sebum secreted from the sebaceous glands and waste products from the stratum corneum accumulate and solidify inside the pores. They are known to be substances mainly composed of lipids and proteins. Keratin plugs feel rough and bumpy to the touch, and when they turn black, they can lead to a loss of aesthetic appearance. They can also enlarge and push the pores open, which is one of the causes of pores becoming larger and more noticeable. For this reason, many people, mainly young people, both men and women, have problems with pores. As a countermeasure, various techniques have been developed to remove keratin plugs. In particular, means for removing keratin plugs using cosmetics and miscellaneous goods have been proposed, and methods have been devised in which keratin plugs are removed by washing with water after cleansing (e.g., Patent Document 1), and methods of removing keratin plugs by attaching them to cosmetic sheets for removing keratin plugs (e.g., Patent Document 2). Further methods that have been devised include a method of removing keratin plugs using a composition for removing keratin plugs that combines liquid oil with an organic base such as an ethylenediamine derivative (e.g., Patent Document 3), a method of removing keratin plugs using a specific organic base such as 2-amino-2-hydroxymethyl-1,3-propanediol and a composition adjusted to a specific pH range (e.g., Patent Document 4), and a method that relies on the promotion of the activity of enzymes such as proteases by bottle gourd extract (e.g., Patent Document 5). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] JP 2007-119394 A [Patent Document 2] JP 2007-55933 A [Patent Document 3] JP 2006-225266 A [Patent Document 4] JP 2019-89857 A [Patent Document 5] JP 2017-128560 A Summary of the Invention [Problem to be solved by the invention]

[0004] While these are aimed at removing keratin plugs, the methods of removing keratin plugs using adhesive sheets that have been developed so far are difficult to apply only to keratin plugs, and since they also remove the surrounding stratum corneum, there is concern that they may put a strain on the skin and cause irritation or roughness. In comparison, the method of removing keratin plugs using cosmetics can be said to be a relatively less irritating method, but the incorporation of high concentrations of bases or the use of enzyme activity may damage the surrounding stratum corneum, causing inflammation or irritation, and thus the problem has not been completely solved. Furthermore, since these preparations are used on a daily basis, it is desirable for them to be easy and hassle-free for consumers to use, and as one solution to this problem, preparations that have both the functions of removing keratin plugs and removing makeup (cleansing) have been developed. Meanwhile, in recent years, the functionality of makeup products has improved remarkably, and many high-performance cosmetics aimed at increasing the durability of the makeup film have been launched on the market.Specifically, there are foundations, concealers, eye colors, etc. that contain multiple resins, waxes, thickeners, surface-coating powders, etc., and high performance is required for cleansing products to remove high-performance cosmetics efficiently and effectively.

[0005] Therefore, an object of the present invention is to provide a composition for removing keratin plugs which is excellent in terms of non-irritation to the skin and also has excellent performance in removing keratin plugs and makeup. [Means for solving the problem]

[0006] As a result of intensive research, the inventors have completed a keratin plug removing composition which contains an oil agent having an HSP distance Ra of 5.0 or less between δd=14.0, δp=1.0, δh=1.0 and an oil agent having an HSP distance Ra of 5.0 or less between δd=18.5, δp=4.0, δh=4.0, and which satisfies the Hansen solubility parameter at 25°C of the keratin plug removing composition and the HSP distance Ra of 4.0 or less between δd=15.6, δp=4.7, δh=5.1, and which is substantially free of organic acids or organic bases.

[0007] That is, the present invention provides the following [1] to [6]. [1] The following components (a) and (b); (a) Oil with HSP distance Ra of 5.0 or less with δd=14.0, δp=1.0, and δh=1.0 (b) Oil with HSP distance Ra of 5.0 or less with δd=18.5, δp=4.0, and δh=4.0 A composition for removing keratin plugs comprising: The Hansen solubility parameter of the composition at 25°C; The HSP distance Ra with δd = 15.6, δp = 4.7, and δh = 5.1 is 4.0 or less. The composition for removing keratin plugs is substantially free of organic acids and organic bases. [2] The composition for removing keratin plugs according to [1], wherein the component (a) is silicone oil. [3] The composition for removing keratin plugs according to [1] or [2] above, wherein the content of the component (a) is 10 to 60 mass %. [4] The composition for removing keratin plugs according to [2], wherein the component (a) is a dimethylpolysiloxane having a kinetic viscosity of 2 to 10 CS. [5] The composition for removing keratin plugs according to [1] or [2] further contains a surfactant as component (c). [6] The composition for removing keratin plugs according to [1] or [2] is a cleansing agent. Effect of the Invention

[0008] According to the present invention, it is possible to provide a composition for removing keratin plugs which has high removal performance for keratin plugs and makeup and is excellent in non-irritation. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0009] The present invention will be described in detail below, focusing on its preferred embodiments. In this specification, the symbol "to" means a range including the numerical values ​​before and after the symbol. In this specification, percentages are expressed by mass unless otherwise specified.

[0010] The Hansen solubility parameter (hereinafter, also referred to as HSP) in this invention is a value used to predict the solubility of a substance, which was announced by Charles M. Hansen in 1967, and is a parameter based on the idea that "two substances with similar intermolecular interactions are likely to dissolve in each other." HSP is calculated by the following three parameters (unit: MPa 1 / 2 ) δd: Energy due to intermolecular dispersion forces δp: Energy due to dipole interactions between molecules δh: Energy due to hydrogen bonds between molecules These three parameters can be regarded as coordinates in a three-dimensional space (Hansen space), and when the HSPs of two substances are placed in Hansen space, the closer the distance between the two points, the easier it is for them to dissolve in each other. In other words, as the saying goes, "similar things dissolve well in each other," HSPs can be used as an index of affinity. A detailed explanation is given in the March 2010 issue of Kagaku Kogyo (Kagaku Kogyosha), and the HSPs of various substances can be obtained by using the computer software "HSPiP: Hansen Solubility Parameters in Practice" and the like. In this disclosure, unless otherwise specified, the HSPs obtained using this computer software "HSPiP: Hansen Solubility Parameters in Practice" ver.5.3.02 are used. Hereinafter, the HSP of component X will be indicated as δd=δdx, δp=δpx, δh=δhx), or [δdx, δpx, δhx] (hereinafter, this notation method will be used).

[0011] Furthermore, the HSP distance Ra (hereinafter, also referred to as Ra) refers to the HSP distance that can be calculated using the Ra calculation function of "HSPiP: Hansen Solubility Parameters in Practice". It can also be expressed as follows. That is, when the HSP of component X is [δdX, δpX, δhX], the difference between the HSP of component Y [δdY, δpY, δhY] and Ra (unit: MPa 1 / 2 ) may satisfy the following formula: Ra = [4 × (δdX - δdY) 2 +(δpX - δpY) 2 +(δhX - δhY) 2 ] 1 / 2 In other words, when the HSP of component (a) is [δda, δpa, δha], the HSP of component (a) satisfies the following formula: δd=14.0, δp=1.0, δh=1.0, and Ra=[4×(14.0 - δda) 2 +(1.0 - δpa) 2 +(1.0 - δha) 2 ] 1 / 2 <= 5.0

[0012] The Ra of the component (b) and other components can be defined in a similar manner.

[0013] As mentioned above, human keratin plugs are complex structures composed of lipids and proteins, and there have been no reports of their solubility being measured using solubility parameters. As a result of extensive research, the inventors have discovered that the Hansen solubility parameters of human keratin plugs are in the vicinity of δd = 15.6, δp = 4.7, and δh = 5.1, and have reported this (Yoshikawa et al. (2022), Oral Presentation and Abstracts at the 53rd Autumn Meeting of the Society of Chemical Engineers, Japan).

[0014] Abbott(Abbott, S. (2012). An integrated According to "approach to optimizing skin delivery of cosmetic and pharmaceutical actives. Int J Cosmet Sci, 34(3), 217-222.," the HSP of human skin is said to be approximately δd = 17.0, δp = 8.0, and δh = 8.0, and it is thought that the HSP of the stratum corneum, which is located at the outermost surface of the skin, has values ​​similar to these.

[0015] On the other hand, sebum is thought to contain a lot of lipid compounds such as squalene and oleic acid. These HSPs are squalene [17.0, 0.9, 3.1] and oleic acid [16.0, 2.8, 6.2], so it is thought that the lipids in sebum also have similar HSPs.

[0016] Considering all of this together, it can be said that the result that the HSP of keratin plugs composed of lipids and proteins was calculated to be δd = 15.6, δp = 4.7, δh = 5.1, which is approximately the intermediate value between the two, is a highly convincing result, and it is thought that a composition with high affinity for keratin plugs can be obtained by setting the HSP distance Ra between the HSP of the keratin plug removal composition and δd = 15.6, δp = 4.7, δh = 5.1 (the HSP of keratin plugs) to 4.0 or less.

[0017] This value is not included in the region of component (a) or component (b), but δd is intermediate between components (a) and (b), and δp and δh are in a region of higher polarity than component (b). While maintaining a balance between these, it is necessary to bring the HSP of the entire composition for removing keratin plugs closer to δd = 15.6, δp = 4.7, and δh = 5.1 (HSP of keratin plugs). If necessary, components other than components (a) and (b) may be added.

[0018] In addition, in the case of a keratin plug removing composition in which the components are compatible, the HSP of the keratin plug removing composition can be calculated by simple linear interpolation based on the volume ratio of the HSP of the constituent compounds. In other words, it shows that the HSP of the keratin plug removing composition can be estimated from the HSP and volume ratio of the constituent components. Specifically, it is calculated based on the following formula. HSP of mixture [δdm,δpm,δhm] = [(a×δd1+b×δd2) / (a+b),(a×δp1+b×δp2) / (a+b),(a×δh1+b×δh2) / (a+b)] Component 1 = [δd1, δp1, δh1] a = volume fraction of component 1 Component 2 = [δd2, δp2, h2] b = volume fraction of component 2 This also applies when the mixture consists of three or more compounds. Hereafter, the distance Ra between the HSP of the composition and the HSP of the keratin plug [15.6, 4.7, 5.1] calculated by this method is referred to as the "Ra with the keratin plug" of the composition.

[0019] The composition of the present invention has a Ra of 4.0 or less with respect to keratin plugs at 25° C., preferably a Ra of 3.5 or less, and more preferably a Ra of 3.0 or less. By satisfying this requirement, a composition having high removal performance for keratin plugs and makeup and excellent non-irritation can be provided, however, the present invention need not be interpreted as being limited to this mechanism.

[0020] The oil agent used in the present invention, which has an HSP distance Ra of 5.0 or less with respect to component (a): δd=14.0, δp=1.0, δh=1.0, also affects the makeup removing performance. In addition, because it is an oil agent, it also affects the removal performance of dirt derived from sebum, and also affects the lack of irritation during use. As long as the oil falls within this range, any oil may be used without any restrictions on its properties, origin, or other physical properties, and for example, one or more oils selected from the group consisting of silicone oils, hydrocarbon oils, ether oils, ester oils, glyceride oils, natural animal and vegetable oils, and semi-synthetic oils may be used. The numbers in brackets following the component names indicate the HSP [δd, δp, δh] of each component. Examples of silicone oils include dimethylpolysiloxane with a dynamic viscosity of 1CS [11.73, 0.82, 0.28] to 100CS [14.41, 0.1, 4.26], phenyltrimethicone [12.93, 0.96, 0.42], methylhydrogenpolysiloxane [12.8, 1.4, 0.1], methyltrimethicone [11.97, 0.99, 0.45], octamethylcyclotetrasiloxane [12, 0.9, 0.9], decamethylcyclopentasiloxane [11.76, 0.67, 0.79], dodecamethylcyclohexasiloxane [11.7, 0.5, 0.8], and diphenylsiloxyphenyltrimethicone [15.1, 1.7, 4.8]. Examples of the hydrocarbon oil include linear, branched, and volatile hydrocarbon oils. Specific examples of the hydrocarbon oil include decane [15.62, 0.1, 0.1], dodecane [15.75, 0.1, 0.1], isododecane [15.55, 0.1, 0.1], undecane [15.68, 0.1, 0.1], tridecane [15.81, 0.1, 0.1], tetradecane [15.81, 0.1, 0.1], pentadecane [15.85, 0.1, 0.1], hexadecane [15.88, 0.1, 0.1], and isohexadecane [15.72, 0.1, 0.1]. ], squalane [15.86, 0.1, 0.1], synthetic squalane [15.86, 0.1, 0.1], vegetable squalane [15.86, 0.1, 0.1], hydrogenated farnesene (hemisqualane) [15.55, 0.1, 0.1], mineral oil (liquid paraffin) (average molecular weight 300-500) [16.0-17.0, 0.1, 0.1], (C13-16) isoparaffin [15.68, 0.1, 0.1], hydrogenated polyisobutene (average molecular weight 170-1000) [14.6-16.0, 0.1, 0.1], etc. Examples of ether oils include ethyl perfluoroisobutyl ether [12.88, 2.87, 1.79] and ethyl perfluorobutyl ether [13.12, 2.75, 2.07]. Ester oils include isobutyl isostearate [15.9, 1.66, 2.29], decyl isostearate [15.91, 1.39, 1.96], methylheptyl isostearate [15.95, 1.3, 2.04], tricyclodecane methyl isononanoate [16.19, 1.48, 1.99], heptyl undecylenate [16.01, 2.34, 2.86], behenyl erucate [16.12, 0.9, 1.57], cetyl octanoate [16, 1.46, 2.09], stearyl caprylate [16.01, 1.81, 2.26], and diisostearyl Polyglyceryl-3 phosphate [15.92, 4.11, 1.39], polyglyceryl-2 diisostearate [15.86, 3.21, 1.89], neopentyl glycol diisononanoate [15.47, 1.12, 2.43], neopentyl glycol diethylhexanoate [15.99, 2.07, 3.13], glyceryl distearate [16.14, 2.36, 2.72], octyl stearate [16.05, 1.41, 2.16], octyldodecyl stearate [16.19, 0.87, 1.48], cetyl stearate [16.03, 1. 13,1.7], diethylhexyl sebacate [16.16,2.08,2.98], dibutyloctyl sebacate [16.4,1.6,2.13], glyceryl tribehenate [16.12,0.9,1.57], ethylhexyl palmitate [16.01,1.72,2.31], methylheptyl palmitate [16.06,1.74,2.35], dipentaerythrityl hexaisononanoate [16.23,1.25,1.96], myreth-3 myristate [15.89,2.36,3.18], methylheptyl myristate [16.09,1.68 ,2.52], caprylyl laurate [16.03,2.16,2.66], decyl laurate [16.03,2.1,2.58], myristyl laurate [16.01,1.81,2.26], methylheptyl laurate [16.07,2.05,2.72], trioleyl phosphate [15.92,2.93,2.37], tricetyl phosphate [16.01,3.2,2.31], diethylhexyl carbonate [15.67,3.21,2.8], oleyl erucate [16.14,1.05,1.68], stearyl stearate [16.03,1.13,1.7], isostearyl isostearate [15.81, 0.92, 1.29], hexyldecyl isostearate [16.05, 0.92, 1.64], oleyl oleate [16.18, 1.21, 1.85], isocetyl stearate [15.92, 1.02, 1.56], isostearyl palmitate [15.86, 1.27, 1.65], cetyl palmitate [15.98, 1.39, 1.8], octyldodecyl myristate [16.17, 1.03, 1.65], isostearyl myristate [15.91, 1.19, 1.74], myristyl Isocetyl phosphate [15.91, 1.2, 1.75], cetyl myristate [16.04, 1.31, 1.9], isodecyl oleate [16.01, 1.58, 2.1], decyl oleate [16.14, 1.7, 2.26], octyldodecyl stearoyloxystearate [16.49, 0.86, 1.26], myristyl myristate [16.04, 1.5, 2.12], cetearyl isononanoate [15.87, 1.43, 1.95], cetyl caprate [16.04, 1.53, 2.15], ethylhexyl stearate [16.05, 1.41 ,2.16], stearyl heptanoate [16.03,1.75,2.33], cetyl ethylhexanoate [16,1.46,2.09], hexyldecyl ethylhexanoate [16.09,1.33,2.02], octyldodecyl neopentanoate [15.85,1.06,1.83], octyl palmitate [16.01,1.72,2.31], butyl stearate [16.06,1.79,2.46], isostearyl neopentanoate [15.6,1.26,1.65], isopropyl isostearate [15.75,1.63,1.97], isostearyl Ethyl phosphate [15.79, 1.91, 2.32], isotridecyl isononanoate [15.66, 1.12, 1.88], propylene glycol distearate [16.22, 1.45, 2.22], isocetyl stearoyloxystearate [16.16, 0.97, 1.48], ethyl oleate [16.13, 2.28, 2.86], propylene glycol diisostearate [15.92, 1.26, 1.77], propylene glycol dioleate [16.32, 1.7, 2.55], glycol dioleate [16.22, 1.99, 2.65], glycol distearate [16.15, 1.74,2.31], pentaerythrityl tetraisostearate [16.21,0.55,1], trimethylolpropane triisostearate [16.06,0.65,1.18], isopropyl palmitate [15.88,3.88,2.52], polyglyceryl-2 tetraisostearate [16.13,1.17,1.33], hexyl laurate [16.05,2.47,3.01], cetyl acetate [16.02,2.15,2.85], isodecyl isononanoate [15.52,1.43,2.23], ethylhexyl isononanoate [1 5.62, 1.43, 2.63], PEG-3 trimethylolpropane tristearate [16.46, 1.39, 1.46], tridecyl neopentanoate [15.72, 1.69, 2.44], isopropyl myristate [15.91, 2.12, 2.76], isoamyl laurate [15.87, 2.36, 2.95], PEG-3 trimethylolpropane triisostearate [16.01, 1.17, 1.93], isononyl isononanoate [15.35, 0.97, 2.06], PEG-3 glyceryl triisostearate [15.89 ,1.59,2.2], isodecyl neopentanoate [15.46,1.9,2.42], PEG-2 distearate [16.1,1.97,2.55], PEG-4 glyceryl tristearate [16.32,1.96,1.69], cetyl ricinoleate [16.13,2.22,3.03], dicaprylyl carbonate [15.75,3.52,2.81], PEG-2 diisostearate [15.81,1.78,2.17], PEG-2 dioleate [16.16,2.19,3.08], neopentyl glycol dicaprate [16.12,2 .15, 3.07], dioctyldodecyl stearoyl glutamate [16.28, 2.27, 1.93], polyglyceryl-2 triisostearate [15.91, 1.97, 0.95], diisostearyl malate [15.8, 2.17, 1.82], glyceryl diisostearate [15.87, 2.17, 3.34], ceteth-3 stearate [15.89, 1.95, 2.69], PEG-4 sorbitan triisostearate [16.19, 2.32, 2.31], PEG-5 glyceryl tristearate [16.3, 2.09, 1.62], PEG-5 glyceryl triisostearate [15.86, 1.87, 2.69], PEG-3 distearate [16.06, 2.18, 2.74], PEG-3 diisostearate [15.78, 1.99, 2.47], PEG-6 glyceryl tristearate [16.29, 2.21, 1.53], PEG-5 trimyristate Examples include methylolpropane [16.36, 2.08, 1.84], steareth-4 stearate [15.86, 2.13, 2.84], PEG-3 dipalmitate [15.95, 2.56, 3.01], PEG-4 distearate [16.02, 2.36, 2.88], and methylheptyl laurate [15.87, 2.03, 2.48]. Examples of glyceride oils include triisostearin PEG-6 [15.85, 1.99, 2.92], triisopalmitin [15.89, 1.5, 1.68], tristearin [16.42, 1.33, 1.63], tribehenin [16.48, 0.98, 1.23], triisostearin [15.94, 1.09, 1.44], and tripalmitin [16.38, 1.75, 1.88]. Examples of natural animal and vegetable oils and semi-synthetic oils include rapeseed oil (High Elsevier) [16.3, 1.3, 2.7], meadowfoam oil [16.2, 1.1, 2.4], and jojoba seed oil [16.2, 1.03, 1.8]. Among them, it is preferable that the oil is liquid at 25° C., since it is compatible with resins and provides high makeup removal performance. Silicone oil is more preferable. Specifically, dimethylpolysiloxane with a dynamic viscosity of 1CS [11.73, 0.82, 0.28] to 100CS [14.41, 0.1, 4.26], phenyltrimethicone [12.93, 0.96, 0.42], methylhydrogenpolysiloxane [12.8, 1.4, 0.1], methyltrimethicone [11.97, 0.99, 0.45], octamethylcyclotetrasiloxane [12, 0.9, 0.9], decamethylcyclopentasiloxane [11.76, 0.67, 0.79], dodecamethylcyclohexasiloxane [11.7, 0.5, 0.8], diphenylsiloxyphenyltrimethicone [15.1, 1.7, 4.8], etc. are listed. Furthermore, low viscosity dimethylpolysiloxane is even more preferred since it provides particularly high makeup removal performance. Specifically, examples include dimethylpolysiloxanes with a kinematic viscosity of 2CS [11.73, 0.82, 0.28] to 10CS [13.51, 0.16, 3.19].

[0021] The content of component (a) used in the present invention is not particularly limited, but from the viewpoint of makeup removal performance, it is preferably 10 to 60 mass % (hereinafter simply referred to as "%"), more preferably 12 to 50%, and even more preferably 15 to 40%.

[0022] The oil agent used in the present invention, which has an HSP distance Ra of 5.0 or less with respect to component (b): δd=18.5, δp=4.0, δh=4.0, is contained as a base of the composition, and also affects the makeup removing performance. It also affects the lack of irritation during use. As long as the oil falls within this range, any oil may be used without being limited in terms of properties, origin, or other physical properties. For example, one or more oils selected from the group consisting of ester oils, glyceride oils, natural animal and vegetable oils, and semi-synthetic oils may be used. Ester oils include diisopropyl dilinoleate [16.56, 5.87, 1.52], dihydrocholesteryl oleate [17.25, 1.08, 1.38], cholesteryl stearate [17.16, 0.85, 1.61], alkyl benzoate (C12-15) [16.78, 3.67, 2.62], PEG-3 glyceryl trioleate [16.38, 1.92, 4.15], tocopherol acetate [16.75, 1.38, 2.01], dihydrocholesteryl butyrate [17.11, 1.38, 1.46], and PG dicaprate [16.26, 2.43]. ,3.57], Octocrylene [17.75,3.96,3.91], Ethylhexyl Methoxycinnamate [17.46,3.67,4.69], Glyceryl Dioleate [16.28,2.59,3.39], Propylene Glycol Dinonanoate [16.25,2.54,3.61], Dioctyldodecyl Lauroyl Glutamate [16.83,3.34,1.53], Di(Phytosteryl / Octyldodecyl) Lauroyl Glutamate [17.65,3.82,1.89], PEG-5 Glyceryl Trioleate [16.31,2.12,5.23], Sorbic Acid Trioleate Tan [16.67, 2.21, 2.82], diisostearyl lauroyl glutamate [16.17, 3.67, 2.34], PG dicaprylate [16.24, 3.16, 4.17], dihexyldecyl lauroyl glutamate [16.8, 3.8, 1.9], dihydrocholesterol [17.14, 2.08, 3.33], pyridoxine dipalmitate [16.71, 2.36, 1.72], PG stearate [16.15, 3.07, 4.87], hexyldecyl myristoyl methylaminopropionate [16.48, 3.89, 2.43], hydroxy Phytosteryl cystearate [17.15, 1.43, 2.06], Phytosterols [17.15, 1.83, 3.4], Behenamidopropyl dimethylamine [16.2, 5.34, 4.14], Homosalate [17.69, 5.21, 5.62], PPG-3 benzyl ether myristate [16.64, 2.9, 3.64], Ethyl linoleate [16.4, 2.39, 3.29], Retinyl linoleate [17.04, 0.96, 1.95], Diethylhexyl malate [16.33, 3.96, 5.89], Tocopheryl retinoate [17.3,1.05,1.43], ethylhexyl benzoate [16.9,4.17,3.14], phenethyl benzoate [18.48,4.72,3.68], octyldodecyl lactate [16.19,2.66,4.59], cetyl lactate [16.14,3.23,5.13], myristyl lactate [16.2,3.63,5.87], diethylhexyl adipate [16.15,2.4,3.44], phenoxyethyl caprylate [17.09,3.85,5.01], dilauryl citrate [16.52,3.3,5.4], triethylhexyl citrate [16.65,2 .58, 4.65], diethylhexyl succinate [16.15, 2.7, 3.84], diheptyl succinate [16.22, 3.63, 4.4], diethylhexyl succinate [16.15, 2.7, 3.84], ethylhexyl salicylate [17.15, 5.47, 5.78], di(caprylic / capric) PG [16.3, 2.5, 3.6], polyglyceryl-5 dioleate [16.42, 5.44, 3.19], pyridoxine dicaprylate [17.06, 3.72, 3.31], bisethoxydiglycol cyclohexane-1,4-dicarboxylate [16 .47, 5.06, 6.6], Propylene glycol dinonanoate [16.25, 2.54, 3.61], Neopentyl glycol diheptanoate [16.09, 2.84, 3.87], Ethylhexyl dimethyl PABA [17.42, 4.26, 4.3], Polyglyceryl-3 dicocoate [16.25, 5.45, 4.43], Propylene glycol dibenzoate [18.37, 6.52, 3.7], Stearamidopropyl dimethylamine [16.26, 5.87, 4.54], Butylene glycol stearate [16.11, 3.02, 4.61], Propylene glycol stearate [16.15, 3.07, 4.87] , Pentaerythrityl Tetra(caprylate / caprate) [16.66, 2.13, 2.01], Pentaerythrityl Tetraethylhexanoate [16.77, 1.6, 1.69], Tri(C12-15) Pareth-2 Phosphate [16.98, 6.61, 4.02], Tri(C12-15) Pareth-8 Phosphate [16.51, 6.42, 3.27], Trimethylolpropane Triethylhexanoate [16.55, 1.6, 2.56], Polyglyceryl-5 Trioleate [16.54, 4.33, 2.9], Triethylhexyl Trimellitate [16.89, 5.01, 1.79], diethylhexyl naphthalene dicarboxylate [16.4, 3.67, 3.06], etc. Glyceride oils include tricaprylin [16.38, 3.15, 3.66], triethylhexanoin [16.43, 2.3, 3.1], triolein [16.51, 1.54, 2.64], triolein [16.51, 1.54, 2.64], tri(caprylic / capric)glyceryl [16.4, 2.5, 3], and triheptanoin [16.46, 3.32, 4.06]. Natural animal and vegetable oils and semi-synthetic oils include cholesterol [17.18, 2.09, 3.85], phytosterol [17.2, 1.8, 3.4], linseed oil [16.27, 1.75, 4.38], safflower oil [16.45, 1.51, 2.72], sunflower oil [16.47, 1.52, 2.65], rapeseed oil (low-l-sick) [16.41, 1.54, 3.03], olive oil [16.46, 1.54, 2.60], palm kernel oil [16.38, 2.01, 2.49], and coconut oil. [16.37, 2.10, 2.50], castor oil [16.58, 3.00, 2.97], avocado oil [16.47, 1.57, 2.68], apricot kernel oil [16.43, 1.48, 2.82], almond oil [16.44, 1.52, 2.78], hazelnut oil [16.43, 1.59, 2.84], macadamia seed oil [16.48, 1.63, 2.66], camellia oil [16.48, 1.54, 2.59], and cottonseed oil [16.28, 1.84, 4.54]. Among these, it is preferable that the cosmetic be liquid at 25°C, as this has excellent makeup removing performance. The content of component (b) used in the present invention is not particularly limited, but from the viewpoints of makeup removing performance, non-stickiness after rinsing, etc., it is preferably 5 to 75%, more preferably 10 to 70%, and even more preferably 10 to 55%.

[0023] The appearance and properties of the composition of the present invention are not particularly limited as long as they satisfy the above ranges, but it is preferable that each component is uniformly dissolved at 25° C. However, even if the composition is in a two-phase state such as separation, clouding, emulsification, etc., so long as it can be homogenized by simple mixing such as rubbing on the skin or shaking, this does not pose any problem in terms of exhibiting the performance of removing keratin plugs and makeup.

[0024] The composition of the present invention is substantially free of organic acids and organic bases, and thus can improve the lack of irritation during and after use. The organic acids and organic bases referred to here can be classified in the following stages. First, organic acids generally refer to organic compounds containing a carboxyl group, and a carboxyl group is a functional group in which one carbonyl group and one hydroxyl group are bonded, and is an important structural element that indicates the acidity of organic acids. There are various types of organic acids, including aliphatic carboxylic acids, aromatic carboxylic acids, and acidic amino acids. In the present invention, the organic base refers to an organic compound that exhibits basicity, and examples of the organic base include aliphatic amines, aromatic amines, and basic amino acids. In the present invention, "substantially free" specifically means that the content is 0.1% or less. From the viewpoint of non-irritation, the content is preferably 0.05% or less, and more preferably zero.

[0025] Furthermore, the composition of the present invention preferably contains a surfactant as component (c) from the viewpoint of makeup removal performance, etc. The surfactant referred to here is one that has an IOB of 0.40 or more and has the function of forming a water-in-oil or oil-in-water emulsion. The IOB in the present invention is a value calculated based on the organic concept diagram (Fujita Atsushi, Prediction of Organic Compounds and Organic Concept Diagram, Chemistry Area VOL. 11, No. 10 (1957) 719-715). More specifically, in this organic concept diagram, the physicochemical properties of a compound are expressed by defining the degree of properties mainly due to Van Der Waals forces as "organic" and the degree of properties mainly due to electrical affinity as "inorganic". The IOB value is an index showing the balance between inorganic and organic properties, and is expressed as IOB=inorganic value / organic value. It can be said that the larger this value is, the more hydrophilic and polar the compound is.

[0026] The composition of the present invention may be used alone or as a part of a multi-layer composition. For example, the oil layer of a two-layer composition consisting of an aqueous layer and an oil layer may comprise the composition of the present invention, or the internal oil phase of an oil-in-water emulsion composition may comprise the composition of the present invention.

[0027] In the composition for removing keratin plugs of the present invention, various components that can be contained as necessary can be appropriately used.Examples of such components include oils other than component (a) or component (b), powders, aqueous components, alcohols, water-soluble polymers, ultraviolet absorbers, moisturizers, gelling agents and thickeners, anti-fading agents, antioxidants, defoamers, beauty ingredients (whitening agents, cell activators, anti-inflammatory agents, blood circulation promoters, skin astringents, antiseborrheic agents, etc.), preservatives, antibacterial agents, fragrances, vitamins, hormones, etc. The keratin plug removing composition of the present invention can be used as a remover for cosmetics of various formulations.For example, liquid, milky, creamy, balm, solid, paste, gel, powder, press, multi-layer, mousse, spray, or stick, etc. can be mentioned, and it can be used as a remover for these cosmetics.In addition, the keratin plug removing composition of the present invention can be used as a remover for cosmetics that are intended for various application sites.For example, it can be made up cosmetics, skin care cosmetics, hair cosmetics, antiperspirants, or UV protection cosmetics, etc., and it can be used as a remover for these cosmetics.

[0028] Furthermore, the composition for removing keratin plugs of the present invention is suitably used in cleansing products such as cleansing oil, cleansing cream and mascara remover, although it is not particularly limited thereto, and is more suitably used in cleansing oil. The method of using the composition of the present invention is not particularly limited, and it may be used by rinsing or wiping, but rinsing is preferred from the viewpoint of leaving no stickiness after use and providing a refreshing feeling.

[0029] The present invention can also employ the following configuration. [1] The following components (a) and (b); (a) Oil with HSP distance Ra of 5.0 or less with δd=14.0, δp=1.0, and δh=1.0 (b) Oil with HSP distance Ra of 5.0 or less with δd=18.5, δp=4.0, and δh=4.0 A composition for removing keratin plugs comprising: The Hansen solubility parameter of the composition at 25°C; The HSP distance Ra with δd = 15.6, δp = 4.7, and δh = 5.1 is 4.0 or less. A composition for removing keratin plugs, which is substantially free of organic acids and organic bases. [2] The composition for removing keratin plugs according to [1], wherein the component (a) is silicone oil. [3] The composition for removing keratin plugs according to [1] or [2] above, wherein the content of the component (a) is 10 to 60 mass %. [4] The composition for removing keratin plugs according to [2], wherein the component (a) is a dimethylpolysiloxane having a kinetic viscosity of 2 to 10 CS. [5] The composition for removing keratin plugs according to any one of [1] to [4] further contains a surfactant as component (c). [6] The composition according to any one of [1] to [5] above is a cleansing agent. EXAMPLES

[0030] The present invention will now be further described with reference to examples, which should not be construed as limiting the present invention in any way. Examples 1-13 and Comparative Examples 1-5: Compositions for removing keratin plugs (cleansing oils) Compositions for removing keratin plugs were prepared according to the formulations shown in Tables 1 and 2 and the manufacturing methods described below, and were evaluated and judged for the following evaluation items according to the following evaluation methods and criteria. Tables 1 and 2 also show the Hansen solubility parameters (δd, δp, δh) of each composition and Ra with respect to keratin plugs. <Evaluation items> A. Removal of keratin plugs B. Make-up removal performance C. Lack of stimulation [Table 1] [Table 2] *1 Sansoft Q-102H-C (manufactured by Taiyo Kagaku Co., Ltd.) *2 Sansoft Q-172Y-C (manufactured by Taiyo Kagaku Co., Ltd.) *3 Neosolue-Aqulio (manufactured by Nippon Fine Chemicals) *4 Nikkor PDD (manufactured by Nikko Chemicals) *5 CROPURE MACADAMIA-LQ-(JP) (manufactured by Croda Japan) (Manufacturing method) A: Heat (1) to (3) to 60°C. B: Add A to (10)~(20) and stir until uniform. C: (4) to (9) were added to B and stirred at room temperature with a paddle mixer at 200 rpm for 5 minutes to mix uniformly to obtain a cleansing oil. (Evaluation method) A. Removal of keratin plugs The artificial keratin plugs prepared according to the following recipe 1 were melt-filled into a punched sheet with a total of 64 holes, each with a diameter of Φ2.0 mm and a depth of 1.0 mm, and attached to the front and back of the paddle part of a paddle mixer. 200 g of each sample was weighed out into a 500 mL beaker, and the paddle part to which the punched sheet containing the artificial keratin plugs was attached was immersed and stirred at 150 rpm at room temperature for 15 minutes. After 15 minutes, the paddle was removed, the punched sheet was carefully peeled off, and the number of artificial keratin plugs that had fallen off was counted. The cleaning rate (%) was then calculated and judged using the following formula (1). Cleansing rate (%) = {(number of artificial keratin plugs removed) / 64} × 100 (1) <Judgment criteria> [Cleaning rate]:[Judgment] Over 80%: ◎ 60% or more but less than 80%: 〇 Less than 60%: ×

[0031] (Formulation 1) Artificial keratin plug (Component) (%) (1) Cholesterol: 20.0 (2) Rosa canina fruit oil 25.0 (3) Oleic acid 9.0 (4) Fatty acid (C12-18) cetyl *6 6.0 (5) Keratin powder *7 39.99 (6) Iron oxide (red) 0.01 *6: Synthetic Gairo S (manufactured by Yuka Sangyo Co., Ltd.) *7: Keratin (derived from wool) (manufactured by Tokyo Chemical Industry Co., Ltd.) (Manufacturing method) A: Heat ingredients (1) to (4) to approximately 90°C and mix uniformly. B: Cool A to 50°C. C: Add (5) and (6) to B and mix and knead uniformly.

[0032] (Evaluation method) B. Make-up removal performance A non-aqueous concealer prepared according to the following formula 2 was applied to the eyes and cheeks, and a powder foundation prepared according to formula 3 was used to apply makeup to the entire face in a usage test conducted by 10 professional cosmetic evaluators. Approximately 4.5 mL of each sample was taken in the hand, applied to the face, and after thorough absorption, the product was washed off with water and dried with a towel. The makeup removal performance was then evaluated on a 5-point scale according to the following evaluation criteria. The average score of all the evaluators was then judged according to the following judgment criteria. Tests were conducted for formula 2 and formula 3, and if the scores for both were the same, the score was indicated, and if they were different, the lower score was indicated. <Evaluation criteria> [Evaluation result]:[Score] No makeup left: 5 points A small amount of makeup remains but it doesn't bother me: 4 points Feels like makeup is still on the skin: 3 points It feels like most of the makeup is still there: 2 points Makeup completely remaining: 1 point <Judgment criteria> [Average score]:[Judgment] 4.0 or higher: ◎ 3.0 or more and less than 4.0: ○ Less than 3.0: ×

[0033] (Evaluation method) C. Lack of stimulation A use test was conducted by 10 cosmetic expert evaluators who applied makeup using a non-aqueous concealer prepared according to formula 2 and a powder foundation prepared according to formula 3. Approximately 4.5 mL of each sample was taken in the hand, and while applying it to a wet face (during use), and after thoroughly blending it in and rinsing it off and wiping off the moisture with a towel (after use), whether or not the "lack of irritation" was felt was evaluated on a 5-point scale according to the following evaluation criteria. The average score of all the evaluators was then judged according to the following judgment criteria. Evaluations were made during and after use, and if the scores for both were the same, the score was indicated, and if they were different, the lower score was indicated. <Evaluation criteria> [Evaluation result]:[Score] No irritation felt: 5 points Slight irritation felt but not bothersome: 4 points I felt stimulated: 3 points I felt quite stimulated: 2 points Very strong stimulation / unable to continue study: 1 point <Judgment criteria>: [Average score]:[Judgment] 4.0 or higher: ◎ Over 3.0 and under 4.0: Yes 3.0 or below: ×

[0034] (Formulation 2) Non-aqueous concealer (Component) (%) (1) Hydrogenated rosin acid, pentaerythrityl *8 3.0 (2) Triethylhexanoin 20.0 (3) Hydrogenated polyisobutene *9 5.0 (4) Decamethylcyclopentasiloxane 29.0 (5) Vaseline 3.0 (6) Microcrystalline wax 3.8 (7) Polyhydroxystearic acid 2.0 (8) Silicone 2% treated titanium dioxide 20.0 (9) Silicone 2% treated iron oxide (red) 0.5 (10) Silicone 2% treated iron oxide (yellow) 3.5 (11) Silicone 2% treated iron oxide (yellow) 0.2 (12) Polylactic acid 10.0 *8: Estergum HP (manufactured by Arakawa Chemical Industries) *9: IP Solvent 1620MU (Idemitsu Kosan Co., Ltd.) (Manufacturing method) A. Heat ingredients (1) to (6) to approximately 110°C and mix uniformly. B. Add components (7) to (12) and knead uniformly. Add B to CA and stir until homogenous. The DC was heated to 90°C and filled into a jar to give a non-aqueous concealer.

[0035] (Formulation 3) Powder foundation (Component) (%) (1) Titanium oxide-coated synthetic phlogopite iron *10 5.0 (2) Phospholipid-coated titanium dioxide *11 10.0 (3) Dimethylpolysiloxane-coated zinc oxide *12 5.0 (4) Boron nitride 8.0 (5) Bismuth oxychloride 5.0 (6) Iron oxide (red) 0.5 (7) Iron oxide (yellow) 1.7 (8) Iron oxide (black) 0.2 (9) Talc remaining (10) Spherical silica (average particle size 8 μm) 10.0 (11) Lauroyl Lysine 4.0 (12) Spherical cellulose 10.0 (13) Dimethylpolysiloxane (dynamic viscosity: 10CS) 2.5 (14) Diphenylsiloxyphenyl trimethicone 8.0 (15) Isotridecyl isononanoate 5.0 (16) Chlorphenesin 0.2 *10 HELIOS R10R (manufactured by Topy Industries) *11 MP-40 (manufactured by Teika) 0.3% processed product *12 MZY-505M (manufactured by Teika) (Manufacturing method) A. Mix ingredients (1) to (12) uniformly using a super mixer. Add a uniform mixture of components (13) to (16) to BA, disperse uniformly, and pulverize. The CB was filled into a container and compression molded to obtain a powder foundation.

[0036] As is clear from the results in Tables 1 and 2, Examples 1 to 13 were evaluated as excellent in all of the evaluation items. Comparative Example 1, which did not contain component (a), did not have excellent makeup removing performance. Comparative Example 2, which did not contain component (b), did not have excellent makeup removing performance. Comparative Example 3, in which Δd=15.6, Δp=4.7, and Δh=5.1 were such that Ra exceeded 4.0, did not have excellent performance in removing keratin plugs. Comparative Example 4, which contained triethanolamine, an organic base, and Comparative Example 5, which contained a large amount of isostearic acid, an organic acid, were inferior in terms of non-irritation.

[0037] Example 15: Cleansing Oil ([δd, δp, δh] = [16.26, 4.85, 4.80], Ra with keratin plug = 1.4) (Component) (%) (1) Polyglyceryl-6 dicaprate *1 13.0 (2) Polyglyceryl-10 dioleate *2 4.0 (3) Phenoxyethanol 0.1 (4) Jojoba seed oil 1.0 (5) Propylene glycol dicaprylate *4 24.0 (6) Ethylhexyl palmitate 29.9 (7) Dimethylpolysiloxane (dynamic viscosity: 6CS) 21.0 (8) Macadamia nut oil *5 7.0 (Manufacturing method) A: Heat ingredients (1) to (3) to 60°C. B: Add A to ingredient (5) and stir until homogenous. C: (4), (6) to (8) were added to B, and the mixture was stirred at room temperature with an anchor mixer at 200 rpm for 5 minutes to obtain a cleansing oil. The cleansing oil obtained in this manner had high removal performance for keratin plugs and makeup, and was excellent in the lack of irritation.

[0038] Example 16: Oil facial cleanser for wiping ([δd, δp, δh] = [16.4, 2.3, 2.5], Ra with keratin plug = 3.8) (Component) (%) (1) Mineral oil 5.0 (2) Jojoba seed oil 5.0 (3) Triethylhexanoin 40.0 (4) Alkyl benzoate (C12-15) 10.0 (5) Methylheptyl laurate *12 30.0 (6) Phytosteryl / Octyldodecyl Lauroyl Glutamate*13 10.0 *12NIKKOL GS-MHL (manufactured by Nikko Chemicals) *13 Eldew PS-203 (Ajinomoto Co., Ltd.) (Manufacturing method) A. Mix ingredients (1) to (6) at room temperature using a Satake paddle mixer until uniform. The BA was filled into a bottle container equipped with a dispenser to obtain a wipe-off oil facial cleanser. Example 16 obtained as described above had high removal performance for keratin plugs and makeup, and was excellent in terms of non-irritation.

[0039] Example 17: Cleansing balm ([δd, δp, δh] = [16.2, 2.5, 2.3], Ra with keratin plug = 3.8) (Component) (%) (1) PEG-10 glyceryl triisostearate *14 15.0 (2) Mineral oil 10.0 (3) Ethylhexyl palmitate 10.0 (4) Triethylhexanoin 39.0 (5) Propylene glycol dicaprylate 20.0 (6) Rice bran wax *15 6.0 *14 EMALEX GWIS-310EX (manufactured by Nippon Emulsion Co., Ltd.) *15 Refined rice wax S-100 (manufactured by Yokoseki Oil Industries Co., Ltd.) (Manufacturing method) A. Heat ingredients (1) to (6) to 85°C or higher and mix uniformly using a dispersing mixer. The BA is cooled to 40°C, removed and stored at room temperature overnight. The CB was heated to 85°C, filled into a jar, and allowed to cool to room temperature to obtain a cleansing balm. Example 17 obtained as described above had high removal performance for keratin plugs and makeup, and was excellent in that it was non-irritating.

Claims

1. The following components (a) and (b): (a) An oil having an HSP distance Ra of 5.0 or less with respect to δd = 14.0, δp = 1.0, and δh = 1.0 (b) An oil having an HSP distance Ra of 5.0 or less with respect to δd = 18.5, δp = 4.0, and δh = 4.0 A composition for removing keratin plugs comprising: The Hansen solubility parameter of the composition at 25° C.; The HSP distance Ra with δd = 15.6, δp = 4.7, and δh = 5.1 is 4.0 or less, A composition for removing keratin plugs, which is substantially free of organic acids and organic bases.

2. 2. The composition for removing keratin plugs according to claim 1, wherein the component (a) is a silicone oil.

3. The composition for removing keratin plugs according to claim 1 or 2, wherein the content of the component (a) is 10 to 60% by mass.

4. The keratin plug removal composition according to claim 2, wherein the component (a) is a dimethylpolysiloxane having a dynamic viscosity of 2 to 10 CS.

5. The composition for removing keratin plugs according to claim 1 or 2, further comprising a surfactant as component (c).

6. The composition for removing keratin plugs according to claim 1 or 2, which is a cleansing agent.

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