Oral composition

Abstract

To provide an oral composition that contains 3-hydroxy-3-methylbutyric acid or a salt thereof, and has high dispersibility and suppressed formation of lumps.SOLUTION: An oral composition contains 3-hydroxy-3-methylbutyric acid or a salt thereof, and hesperidin.SELECTED DRAWING: Figure 1

Description

[Technical field]

[0001] The present invention relates to oral compositions containing 3-hydroxy-3-methylbutyric acid or a salt thereof. [Background technology]

[0002] 3-Hydroxy-3-methylbutyric acid (HMB) is a metabolic product of the essential amino acid leucine, and is known to be involved in promoting muscle synthesis and inhibiting muscle breakdown. However, since the amount of HMB produced in the body is very small, attempts have been made to ingest this HMB as a supplement, etc. (see, for example, Patent Documents 1 and 2). [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Special Publication No. 2015-533509 [Patent Document 2] JP 2009-159983 A Summary of the Invention [Problem to be solved by the invention]

[0004] Calcium 3-hydroxy-3-methylbutyrate, which is commonly used as a supplement, is a powder, but due to its high viscosity, it tends to clump, which results in a poor texture. When the powder is dissolved and consumed, it is difficult to dissolve because it tends to clump, and the texture is also poor. Furthermore, in the manufacturing process of the product, there are problems such as difficulty in mixing uniformly because it tends to clump, and especially when processing into granules or tablets, there are problems in that the high viscosity causes the product to adhere to the machine or deteriorates tableting properties, resulting in reduced manufacturing efficiency.

[0005] An object of the present invention is to provide an oral composition which contains 3-hydroxy-3-methylbutyric acid or a salt thereof and has high dispersibility and is inhibited from forming lumps. [Means for solving the problem]

[0006] As a result of intensive research aimed at solving the above-mentioned problems, the inventors have found that by using at least one material selected from long pepper and hesperidin together with 3-hydroxy-3-methylbutyric acid or a salt thereof, the formation of lumps is suppressed, thereby improving the texture and increasing production efficiency, and have thus completed the present invention.

[0007] That is, the present invention is as follows. [1] An oral composition comprising 3-hydroxy-3-methylbutyric acid or a salt thereof and at least one material selected from the group consisting of pepper and hesperidin. [2] The oral composition according to [1] above, further comprising at least one material selected from grapes and chili peppers. Effect of the Invention

[0008] According to the present invention, it is possible to provide an oral composition having high dispersibility and in which the formation of lumps due to the high viscosity of 3-hydroxy-3-methylbutyric acid is suppressed. [Brief description of the drawings]

[0009] [Figure 1] FIG. 2 is a diagram showing the amount of powder (amount of powder with a particle size of less than 150 μm) recovered in a receiver in particle size measurement of the composition (powder) of the present invention. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0010] The oral composition of the present invention is characterized by containing 3-hydroxy-3-methylbutyric acid or a salt thereof, and at least one material selected from pepper and hesperidin.

[0011] By using at least one material selected from long pepper and hesperidin together with 3-hydroxy-3-methylbutyric acid or a salt thereof, the formation of lumps (aggregation) can be suppressed. Therefore, even when ingested as a powder, the texture is good. Also, even when dissolved in liquid such as water or hot water and ingested, it is easily dissolved in the liquid, can be easily mixed, and has a good texture. Furthermore, in the manufacturing process of the product, adhesion between powders is suppressed in the powder mixing process, and the formation of lumps is suppressed, enabling uniform mixing. That is, the oral composition of the present invention can be prepared simply by mixing, and is easy to prepare. For example, when mixing raw materials that are highly aggregative and prone to forming lumps, it is known that the raw materials are pretreated, such as crushed using a grinder, to ensure the flowability of the raw materials before being charged, and further, after charging, it is necessary to supply air as quickly as possible to prevent re-aggregation and start flow, but such complicated operations are not required. Also, when producing granules or tablets, the raw materials do not adhere to the machine, and the deterioration of tableting can be suppressed, so that the decrease in manufacturing efficiency can be suppressed.

[0012] Furthermore, since the composition of the present invention has high dispersibility, even when materials other than the components of the present invention are mixed to prepare the oral composition of the present invention, there is no need to carry out the complicated operations described above, and the composition can be prepared simply by mixing.

[0013] [3-Hydroxy-3-methylbutyric acid or its salts] 3-Hydroxy-3-methylbutyric acid (HMB) is a metabolic product of the essential amino acid leucine, and is synthesized in the human body. In the present invention, HMB or a salt thereof can be used. HMB salts are not particularly limited, but include calcium salt, sodium salt, potassium salt, and magnesium salt, and calcium salt (HMBCa) is preferred from the viewpoint of muscle building and diet effects. HMB or a salt thereof in the oral composition of the present invention can be synthesized by a known method or a commercially available product. There is no limitation on the commercially available product as long as it is applicable to food. In the present invention, only one type of HMB or a salt thereof can be used, or two or more types can be used.

[0014] The content of 3-hydroxy-3-methylbutyric acid or a salt thereof is not particularly limited as long as it is an amount that has a muscle-building effect and / or a diet effect, and is, for example, 0.1 to 99% by mass, preferably 1 to 98% by mass, and more preferably 5 to 97% by mass, relative to the total amount of the composition.

[0015] [Peppermint] Long pepper is a plant of the genus Piper in the family Piperaceae, scientific name Piper longum L., and is also known by the alias Indian long pepper. The long pepper used in the present invention includes mature or immature fruit heads (fruits), leaves, petioles, branches, roots, etc., and mature or immature fruit heads are preferred. As the long pepper, a processed product of long pepper may be used, for example, a product obtained by drying and crushing harvested long pepper into powder, an extract (extract powder) extracted with water, a lower alcohol, or a mixed solvent thereof, or a fermented product (fermented powder) can be used, and it is preferable to use the extract powder. As the long pepper used in the present invention, from the viewpoint of swelling suppression effect, swelling improvement effect, and body chill improvement effect, it is preferable to use an extract powder of mature or immature fruit heads.

[0016] [Hesperidin] The hesperidin used in the present invention may be hesperidin or a food material rich in hesperidin (for example, extracts (extract powder) of the peel, juice, or seeds of citrus fruits such as mandarin oranges and grapefruits). Hesperidin derivatives such as methyl hesperidin, enzyme-treated hesperidin, and glycosyl hesperidin may also be used, with glycosyl hesperidin being preferred from the viewpoints of swelling suppression and improvement effects, blood vessel strengthening effects, and blood flow improvement effects.

[0017] The oral composition of the present invention preferably contains at least one material selected from grapes and red pepper together with 3-hydroxy-3-methylbutyric acid or a salt thereof, and at least one material selected from long pepper and hesperidin, which can further suppress the formation of lumps.

[0018] [Grapes] Grapes are plants belonging to the Vitaceae family, and the grapes used in the present invention may be fruit, skin, seeds, leaves, etc., and are not particularly limited, but are preferably fruit, seeds, or leaves. In addition, the grapes are not particularly limited, and any variety may be used, such as European and American varieties (scientific name: Vitis. vinifera) and American varieties (scientific name: Vitis. labrusca), but are preferably European and American varieties. In particular, red grapes, which are European and American varieties with red, purple, blue, dark blue, or black skin and red flesh, are preferred. As the grapes, processed products of grapes may be used, for example, harvested grapes dried, crushed, and powdered, extracts (extract powders) extracted with water, lower alcohol, or a mixed solvent thereof, and fermented products (fermented powders) can be used, and it is preferable to use extract powders. As the grapes used in the present invention, from the viewpoints of swelling suppression effect, swelling improvement effect, platelet aggregation effect, and anti-inflammatory effect, grape fruit, seed, or leaf extract powder is preferred, and red grape leaf extract powder is particularly preferred. Furthermore, by adding an extract powder of grapes, particularly grape fruits, seeds, or leaves, and more preferably an extract powder of red grape leaves, to an oral composition containing 3-hydroxy-3-methylbutyric acid or a salt thereof and at least one material selected from long pepper and hesperidin, it is expected that the swelling suppressing effect and swelling improving effect can be improved.

[0019] [Chili pepper] Capsicum annuum is a plant of the Capsicum genus of the Solanaceae family. The capsicum used in the present invention may be fruit or leaves, and is not particularly limited, but is preferably fruit. Capsicum may be any of a variety of peppers, such as red peppers with ripe, red fruit, and green peppers with immature, green fruit, but is preferably green peppers. Capsicum may be processed into a powder, such as dried, crushed, and powdered harvested peppers, or an extract (extract powder) extracted with water, lower alcohol, or a mixed solvent thereof, or a fermented product (fermented powder), and is preferably fermented powder.

[0020] Examples of the fermented powder include a powder obtained by fermenting harvested chili peppers, drying them, and fermenting the extract from the harvested chili peppers, and fermenting the fermented product. As the fungus used for fermentation, a fungus usually used for fermentation such as koji mold, yeast fungus, lactic acid bacteria, acetic acid bacteria, and Bacillus subtilis can be used, but it is preferable to use lactic acid bacteria. As the chili pepper used in the present invention, a fermented product of green chili pepper is preferable from the viewpoint of swelling suppression effect, swelling improvement effect, blood flow improvement effect, and metabolism promotion effect. In addition, by adding a chili pepper, particularly a fermented product of green chili pepper, to an oral composition containing 3-hydroxy-3-methylbutyric acid or a salt thereof and at least one material selected from long pepper and hesperidin, it is expected that the swelling suppression effect and swelling improvement effect can be improved.

[0021] The oral composition of the present invention can be used, for example, as a medicine (including quasi-drugs), so-called health foods such as functional foods whose efficacy has been approved by a designated organization, such as foods for specified health uses, foods with nutritional functions, and foods with functional claims, as well as general foods, food additives, feed, etc.

[0022] The oral composition of the present invention can be used as a muscle-building composition for muscle building. Such a muscle-building composition is not particularly limited as long as it contains HMB or a salt thereof, and long pepper and / or hesperidin, and can be distinguished from other products in terms of being used for muscle building and muscle fatigue recovery. The scope of the present invention includes, for example, those that indicate on the main body, packaging, instructions, or advertising materials of the product of the present invention that the product has functions such as muscle building, enhancement of muscle synthesis, inhibition of muscle breakdown, inhibition, maintenance, and increase of muscle mass (muscle weight, muscle cross-sectional area, muscle density) decline, inhibition, maintenance, and increase of muscle quality, inhibition, maintenance, and increase of muscle strength (power, endurance), inhibition, maintenance, and increase of exercise ability decline, inhibition, maintenance, and increase of metabolism (basal metabolism, resting and exercise metabolism), inhibition, maintenance, and increase of lean body mass decline, prevention and improvement of muscle fatigue, metabolic improvement effect by muscle building, prevention and improvement effect of locomotive syndrome, and prevention and improvement effect of sarcopenia.

[0023] The muscle-building composition of the present invention is not limited to those labeled with the components of the present invention (HMB or a salt thereof, and long pepper and / or hesperidin) as active ingredients for muscle building on the product packaging, etc. For example, the active ingredient may not be specified, and only HMB or a salt thereof may be labeled as an active ingredient.

[0024] Specifically, the muscle-building composition of the present invention includes pharmaceuticals (including quasi-drugs) and so-called health foods. Examples of so-called health foods include those labeled with the following claims: "supports muscle-building power," "suppresses muscle breakdown," "strengthens muscle strength," "suppresses, maintains, improves, or enhances the decline in walking ability," "improves metabolism by strengthening muscles," "suppresses metabolic decline," "prevents and recovers muscle fatigue," "suppresses and maintains the decline in balance ability," "shapes up," "muscular," "slim and muscular," "beautiful body," "prevents bedriddenness," "prevents falls," "improves metabolism by strengthening muscles," and "maintains muscle mass and strength." Subjects who take the oral composition of the present invention are usually people who need to strengthen their muscles, and preferred examples of such subjects include people who want to shape up, athletes, and elderly people with weak legs and hips.

[0025] In addition, the oral composition of the present invention can be used as a diet composition used for dieting. Such a diet composition is not particularly limited as long as it contains HMB or its salt, and long pepper and / or hesperidin, and can be distinguished from other products in terms of being used for dieting (obesity suppression, obesity improvement), and for example, the scope of the present invention includes a product that displays the function of dieting (including body fat reduction, body fat accumulation suppression, metabolic syndrome improvement, slimming, etc.) on the main body, packaging, instructions, or advertising material of the product of the present invention. Note that the diet composition of the present invention is not limited to a product that displays the components of the present invention (HMB or its salt, and long pepper and / or hesperidin) as the active ingredient of dieting on the product packaging, etc. For example, it may be a product that does not specify the active ingredient, and may display only HMB or its salt as the active ingredient.

[0026] Specifically, the diet composition of the present invention includes medicines (including quasi-drugs) and so-called health foods. Examples of so-called health foods include those labeled "for those concerned about body fat," "for those who are prone to obesity," "for those concerned about weight (BMI)," "reduces weight and abdominal fat (visceral fat and subcutaneous fat)," "reduces waist circumference," etc.

[0027] The muscle-building effect and diet effect of the oral composition of the present invention can be obtained by taking the composition of the present invention in daily life, but more excellent effects can be obtained by combining it with exercise. Examples of exercise include aerobic exercise and resistance exercise (strength training, weight training). In particular, when obtaining muscle-building effects, it is preferable to combine it with resistance exercise, and the amount of exercise is preferably 10 minutes or more per day, more preferably 20 minutes or more, and even more preferably 30 minutes or more.

[0028] In addition, the oral composition of the present invention can be used as a swelling-suppressing composition used to suppress swelling, or a swelling-improving composition used to improve swelling. Such a swelling-suppressing and / or improving composition is not particularly limited as long as it contains HMB or a salt thereof, and long pepper and / or hesperidin, and can be distinguished from other products as a product in terms of being used to suppress and / or improve swelling. For example, the scope of the present invention includes a product that displays, on the main body, packaging, instruction manual, or advertising material of the product of the present invention, the function of suppressing swelling, improving swelling, preventing swelling, reducing swelling, eliminating swelling, reducing the circumference, area, or volume of legs such as ankles, calves, lower legs, thighs, and thighs, and arms such as upper arms and forearms, and reducing the area and volume of the face. The dietary composition of the present invention is not limited to those labeled on the product packaging, etc. with the components of the present invention (HMB or a salt thereof, and long pepper and / or hesperidin) as the active ingredient for suppressing and / or eliminating swelling. For example, the active ingredient may not be specified, or may be labeled with long pepper and / or hesperidin as the active ingredient.

[0029] Specifically, examples of the composition of the present invention for suppressing and / or improving swelling include pharmaceuticals (including quasi-drugs) and so-called health foods. Examples of so-called health foods include those labeled with claims such as "For those concerned about swelling," "Prevents swelling," "Reduces swelling," "Eliminates swelling," "Reduces ankle circumference," "Reduces calf circumference," "Reduces thigh circumference," "Reduces upper arm circumference," and "Reduces forearm circumference."

[0030] Examples of the form of the composition of the present invention include tablets, capsules (hard capsules, soft capsules, etc.), powders, granules, liquids, grains, rods, plates, blocks, solids, rounds, pastes, creams, caplets, gels, chewable tablets, sticks, etc. Among these, tablets, hard capsules, powders, granules, rounds, and chewable tablets are preferred.

[0031] When the composition of the present invention is made into a tablet, pill, or chewable tablet, it is preferable to add at least one of an excipient, a lubricant, and a flow agent, since this enhances moldability and improves the storage stability of the obtained tablet, pill, or chewable tablet. In particular, the storage stability can be further improved by using an excipient and a lubricant.

[0032] An excipient is added to improve the handling or molding of a composition or to make it easier to take. There is no particular limitation on the excipient that can be used in the present invention, and examples thereof include starch or its derivatives such as starch, pregelatinized starch, partially pregelatinized starch, and starch hydrolyzates, crystalline cellulose, sugar alcohol, lactose, brewer's yeast, low-substituted hydroxypropyl cellulose, hydroxypropyl cellulose, refined white sugar, light anhydrous silicic acid, calcium silicate, titanium oxide, precipitated calcium carbonate, etc. These may be used alone or in combination of two or more.

[0033] A lubricant is used to reduce friction between the punch and die of a tablet press and the tablet when compressing powder for tablets, and to prevent tableting problems such as sticking. The lubricant that can be used in the present invention is not particularly limited as long as it is a component that can achieve the above-mentioned purpose, and examples thereof include stearic acid or its salts such as stearic acid, calcium stearate, and magnesium stearate, sodium stearyl fumarate, sucrose fatty acid esters, talc, polyethylene glycol, vegetable oils and fats, and hardened oils. These may be used alone or in combination of two or more.

[0034] A fluidizer is used to improve the fluidity of mixed powders or granules. Fluidizers that can be used in the present invention are not particularly limited, and examples thereof include silicon dioxide, aluminum silicate, magnesium aluminosilicate, calcium phosphate, magnesium carbonate, magnesium oxide, etc. These may be used alone or in combination of two or more. In the present invention, commercially available excipients, lubricants, and fluidizers can all be used.

[0035] The content of the components of the present invention (HMB or a salt thereof, and pepper and / or hesperidin) may be appropriately determined within the range in which the effects are exhibited.

[0036] Specifically, when the oral composition of the present invention is a tablet, pill, or capsule-shaped supplement or pharmaceutical, the component of the present invention is preferably contained in an amount of 5 to 99% by mass, more preferably 8 to 98% by mass, and particularly preferably 10 to 97% by mass, calculated as a dry mass. When the oral composition of the present invention is a chewable tablet-shaped supplement or pharmaceutical, the component of the present invention is preferably contained in an amount of 0.1 to 70% by mass, more preferably 0.5 to 60% by mass, and particularly preferably 1 to 50% by mass, calculated as a dry mass. In the case of powdered or granular supplements or pharmaceuticals, the component of the present invention is preferably contained in an amount of 0.1 to 90% by mass, more preferably 0.5 to 80% by mass, and particularly preferably 1 to 70% by mass, calculated as a dry mass. In the case of liquid supplements or pharmaceuticals, the component of the present invention is preferably contained in an amount of 5 to 99% by mass, more preferably 8 to 98% by mass, and particularly preferably 10 to 97% by mass, calculated as a dry mass.

[0037] The intake amount of the oral composition of the present invention is not particularly limited, but from the viewpoint of more significantly exerting the effects of the present invention, it is preferable that the intake amount of HMB or a salt thereof per day for an adult is 100 mg / day or more, more preferably 200 mg / day or more, and particularly preferably 300 mg / day or more. The upper limit is, for example, 10000 mg / day, preferably 8000 mg / day, and more preferably 5000 mg / day. The oral composition of the present invention may be appropriately designed so that the daily intake amount is the above-mentioned intake amount, and may be taken once or in multiple divided doses. For example, in the case of tablets, capsules, powders, granules, pills, or chewable tablets, the number of intakes per day is 1 to 4 times, and the total amount of the intake amount may be taken as described above, and in the case of beverages, the daily intake amount may be blended with the above-mentioned intake amount. The oral composition of the present invention can be stored as a daily amount in one container or, for example, divided into multiple containers, so that the daily intake amount is the above-mentioned intake amount.

[0038] The blending mass ratio of HMB or a salt thereof to the total amount of pepper and hesperidin is preferably in the range of 1:0.00001-10, more preferably 1:0.00005-5, and particularly preferably 1:0.0001-1, calculated on a dry mass basis.

[0039] The oral composition of the present invention can be prepared by a known method by adding other ingredients than the ingredients of the present invention as necessary. Examples of other ingredients than the ingredients of the present invention include vitamins such as water-soluble vitamins (vitamin B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, PABA, vitamin C, vitamin P) and oil-soluble vitamins (vitamins A, D, E, K); minerals such as magnesium, phosphorus, zinc, and iron; sulfur-containing compounds contained in taurine and garlic; flavonoids or flavonoids such as hesperidin and quercetin; proteins such as collagen; peptides; amino acids; animal fats and oils; vegetable fats and oils; crushed or extracted animals and plants. In particular, ingredients that enhance the secretion of glucagon-like peptide-1 (GLP-1) hormone, which can transport carbohydrates to muscles, are preferred, and examples thereof include spirulina, sweet potato stems and leaves, marjoram, and artemisia capillaris. EXAMPLES

[0040] The present invention will be described below based on examples, but the present invention is not limited to these examples.

[0041] (Sample preparation) As 3-hydroxy-3-methylbutyric acid or a salt thereof, HMBCa (powder) was used. The long pepper extract used was made by extracting the long pepper fruit heads with hot water, drying them, and pulverizing them to obtain an extract powder. Glycosylated hesperidin was used as the hesperidin. For the grape extract, red grape leaves were extracted with 30% ethanol aqueous solution, dried, and crushed to obtain an extract powder. The chili pepper used was a fermented extract (powder) made by fermenting green chili peppers using lactic acid bacteria, obtaining a liquid by solid-liquid separation, adding and mixing dextrin, and spray-drying to obtain a powder.

[0042] Each sample was thoroughly mixed in the amount shown in Table 1 (unit: g). 10 g of the mixture was used to measure the particle size.

[0043] [Table 1]

[0044] Specifically, the particle size was measured using a micro-type electromagnetic vibration sieve M-2 model (manufactured by Tsutsui Rikagaku Kikai Co., Ltd.). The measurement conditions were 10 g of each sample, the vibration scale was set to 5, and the vibration time was 5 minutes. Two types of sieves with openings of 150 and 106 μm were used, and the larger sieves were stacked on top of the receiver in ascending order of opening size from the bottom. After 5 minutes of vibration, the powder remaining in each sieve and receiver was collected and the weight of the powder was measured. The results are shown in Table 2 and FIG.

[0045] [Table 2]

[0046] As shown in Table 2 and Figure 1, the recovery amount of powder with a small particle size of less than 150 μm in the mixtures using HMB together with pepper or hesperidin (Examples 1 to 3) was greater than that in the case of HMB alone (Comparative Example 1), indicating that the formation of lumps (aggregation) was suppressed. Furthermore, the powder recovery amount in Examples 1 to 3 was greater than that in the cases of HMB, pepper, or hesperidin alone (Comparative Examples 1 to 3), indicating a synergistic aggregation-inhibiting effect of the combination. Furthermore, as shown in Examples 4 to 10, the aggregation-inhibiting effect was even more remarkable by adding grapes and / or chili peppers.

[0047] <Production Examples 1 to 6> Granules containing HMB or a salt thereof, and long pepper and / or hesperidin were manufactured according to the formulation in Table 3 below.

[0048] [Table 3]

[0049] <Production Examples 7 to 12> Granules containing HMB or a salt thereof, and long pepper and / or hesperidin were manufactured according to the formulation in Table 4 below.

[0050] [Table 4]

[0051] <Production Examples 13-18> A powdered beverage containing HMB or a salt thereof, and long pepper and / or hesperidin was produced according to the formulation in Table 5 below.

[0052] [Table 5]

[0053] <Examples 19-24> Soft capsules containing HMB or a salt thereof, and long pepper and / or hesperidin were manufactured according to the formulation in Table 6 below.

[0054] [Table 6]

[0055] <Examples 25-30> Hard capsules containing HMB or a salt thereof, and long pepper and / or hesperidin were manufactured according to the formulation in Table 7 below.

[0056] [Table 7]

[0057] <Production Examples 31 to 36> A liquid beverage containing HMB or a salt thereof, and long pepper and / or hesperidin was produced according to the formulation in Table 8 below.

[0058] [Table 8]

[0059] <Production Examples 37-42> Tablets containing HMB or a salt thereof, and peppermint and / or hesperidin were manufactured according to the formulation in Table 9 below.

[0060] [Table 9] [Industrial Applicability]

[0061] The oral composition of the present invention is industrially useful since it can be used as so-called health foods, etc. In particular, health foods in the form of tablets, hard capsules, powders, granules, pills, and chewable tablets are useful.

Claims

1. An oral composition comprising 3-hydroxy-3-methylbutyric acid or a salt thereof and Peppermint.

2. 2. The oral composition according to claim 1, further comprising at least one material selected from grapes and chili peppers.

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