External composition

Abstract

To provide a novel external composition containing naturally derived nanofibers with improved unpleasant odor.SOLUTION: Provided is an external composition containing (A) naturally derived nanofibers, (B) an oily component, and (C) one or more selected from the group consisting of glycosaminoglycans, glycosides, and acrylic acid-based polymer compounds.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to topical compositions. [Background technology]

[0002] Known technologies relating to naturally occurring nanofibers include, for example, those described below.

[0003] Patent Document 1 describes a technology relating to cellulose fibers having aldehyde groups and carboxyl groups, which are obtained by oxidizing natural cellulose with 2,2,6,6-tetramethylpiperidinooxyl (TEMPO) and sodium hypochlorite. Patent Document 2 describes a technology relating to fine cellulose fibers having phosphate groups. [Prior art documents] [Patent documents]

[0004] [Patent Document 1] Japanese Patent Application Laid-Open No. 2010-37348 [Patent Document 2] International Publication No. 2016 / 002689 Summary of the Invention [Problem to be solved by the invention]

[0005] The present inventors have discovered a new problem: when a specific compound is blended into a composition containing naturally-derived nanofibers, an unpleasant odor is generated. An object of the present invention is to provide a novel topical composition containing naturally-derived nanofibers that has an improved unpleasant odor.

[0006] Furthermore, compositions containing naturally-derived nanofibers have the problem that the generated foam rises slowly, resulting in the foam being difficult to dissipate. The present invention aims to provide a novel topical composition containing naturally-derived nanofibers that has an improved foam rising speed. [Means for solving the problem]

[0007] The present inventors have discovered that adding an oily component to a topical composition containing naturally derived nanofibers and a specific compound reduces unpleasant odors. The present inventors have also discovered that adding a specific component to a topical composition containing naturally derived nanofibers quickly dissipates any foam generated in the topical composition. The present invention is based on these findings and provides the following inventions.

[0008] [1] (A) Naturally derived nanofibers, (B) oily components, and (C) one or more selected from the group consisting of glycosaminoglycans, glycosides, and acrylic acid-based polymer compounds; A topical composition comprising: [2] The topical composition according to [1], wherein component (B) is one or more selected from the group consisting of ester oil, vegetable oil, silicone oil, hydrocarbon oil, and fat-soluble vitamin. [3] The composition for external use according to [1] or [2], wherein the content of component (B) is 0.01 to 40% by mass based on the total amount of the composition for external use. [4] The topical composition according to any one of [1] to [3], wherein component (C) is one or more selected from the group consisting of hyaluronate, decomposed hyaluronic acid, acetylated hyaluronate, polyoxypropylene methyl glucoside, arbutin, and carboxyvinyl polymer. [5] The topical composition according to [4], wherein component (C) is three or more selected from the group consisting of hyaluronate, decomposed hyaluronic acid, acetylated hyaluronate, polyoxypropylene methyl glucoside, arbutin, and carboxyvinyl polymer. [6] The topical composition according to [5], wherein the three or more (C) components contain two or more selected from the group consisting of sodium hyaluronate, decomposed hyaluronic acid, and acetylated sodium hyaluronate. [7] (A') cellulose nanofibers, and (D) one or more selected from the group consisting of tranexamic acids, ascorbic acids, glycosaminoglycans, glycosides, nicotinic acids, cyclohexane-1,4-dicarboxylic acid derivatives, cinnamic acid derivatives, and metal oxides; The content of component (A') is 0.01 to 7.0% by mass based on the total amount of the topical composition. [8] The topical composition according to [7], wherein component (D) is one or more selected from the group consisting of tranexamic acid, ascorbic acid derivatives, hyaluronate, polyoxypropylene methyl glucoside, nicotinamide, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, ethylhexyl methoxycinnamate, and titanium oxide. [Effects of the Invention]

[0009] According to the present invention, it is possible to provide a novel topical composition containing naturally-derived nanofibers, which has an improved unpleasant odor. Also, according to the present invention, it is possible to provide a novel topical composition containing naturally-derived nanofibers, which has an improved foam rising speed. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, embodiments of the present invention will be described in detail, but the present invention is not limited to the following embodiments.

[0011] [1. External composition (1)] The topical composition (1) according to this embodiment contains (A) naturally derived nanofibers (also referred to simply as "component (A)"), (B) an oily component (also referred to simply as "component (B)"), and (C) one or more members selected from the group consisting of glycosaminoglycans, glycosides, and acrylic acid-based polymer compounds.

[0012] <Component (A)> The naturally occurring nanofibers that are component (A) are made from naturally occurring substances and have an average fiber diameter of 1 to 2000 nm.

[0013] Examples of natural products that can be used as materials for naturally derived nanofibers include plants (trees such as coniferous trees and broad-leaved trees; herbaceous plants such as bamboo; citrus peel; cotton, hemp, wheat, rice, sugar beet, sugar cane, etc.), animals (arthropods, crustaceans, marine animals, etc.), fungi (mushrooms, etc.), and algae. Furthermore, all or part of these natural products may be used, or natural products that have been further processed may also be used. Examples of further processed natural products include wood pulp obtained by bleaching and pulverizing trees such as coniferous trees and broad-leaved trees, and sugar obtained by refining extracts from sugar beet, sugar cane, etc.

[0014] Examples of naturally occurring substances derived from natural products include plant-derived cellulose, animal-derived chitin, silk, etc. Also included in the naturally occurring substances referred to here are cellulose derivatives (e.g., carboxymethyl cellulose) obtained by introducing a substituent such as an anionic group into cellulose, and chitosan obtained by deacetylating chitin.

[0015] The naturally occurring nanofibers may be commercially available products, or may be obtained by chemically and / or mechanically treating natural materials to defibrate them, or by microbial fermentation of natural materials.

[0016] Methods for chemically treating natural products to defibrate them include, for example, the introduction of anionic groups such as carboxyl groups (TEMPO oxidation, etc.), phosphate groups, sulfonate groups, or carboxymethyl groups; hydrolysis; enzymatic degradation; etc. The surface of the obtained naturally occurring nanofibers can also be further modified with various modifying groups to change their hydrophilicity, hydrophobicity, ionicity, etc. The modifying groups are not limited as long as they change the surface properties of the naturally occurring nanofibers. Metal ions or metal nanoparticles may also be attached to the surface of the obtained naturally occurring nanofibers.

[0017] Examples of methods for mechanically treating and defibrating natural substances include underwater head-on collision, hydraulic penetration pulverization, water jet method, high-pressure homogenizer treatment, microfluidizer method, ball mill pulverization, grinder method, etc. In addition, water, organic solvents, etc. can be used as solvents for dispersing naturally occurring substances in mechanical treatment of naturally occurring substances.

[0018] Microorganisms that can be used in microbial fermentation of natural products include, for example, bacteria, yeast, mold, etc. Among these, it is preferable to use bacteria (e.g., Acetobacter, Agrobacterium, Rhizobium, Sarcina, Pseudomonas, Achromobacter, Alcaligenes, Aerobacter).

[0019] Examples of naturally occurring nanofibers include cellulose nanofibers made from cellulose or a cellulose derivative, chitin nanofibers made from chitin, chitosan nanofibers made from chitosan, and silk nanofibers made from silk. Of these, cellulose nanofibers and chitin nanofibers are preferred, with cellulose nanofibers being more preferred, from the viewpoint of more significantly exhibiting the effects of the present invention.

[0020] Commercially available naturally derived nanofibers may contain the naturally derived nanofibers in the form of an aqueous dispersion, gel, slurry, paste, powder, sheet, pellet, or non-aqueous dispersion. Commercially available naturally derived nanofibers are preferably in the form of an aqueous dispersion, gel, slurry, paste, or non-aqueous dispersion.

[0021] Specific examples of commercially available naturally derived nanofibers include those with carboxyl groups introduced, such as Cellenpia (registered trademark) TC-01A, Cellenpia (registered trademark) TC-02X (all manufactured by Nippon Paper Industries), Rheocrysta (registered trademark) 1-2SX, Rheocrysta (registered trademark) 1-2AX, Rheocrysta (registered trademark) 1-2AE, and Rheocrysta (registered trademark) C-2SP (all manufactured by Daiichi Kogyo Seiyaku); those with carboxymethyl groups introduced, such as Cellenpia (registered trademark) CS-01 and Cellenpia (registered trademark) CS-01C (all manufactured by Nippon Paper Industries); and those with hydrolyzates, such as Examples of such nanofibers include cellulose nanocrystals (Filler Bank); those produced by mechanical processing include nanoforest-S (Chuetsu Pulp Industry), ELLEX-S (Daioh Paper), BiNFi-s (Sugino Machine), Celish KY100G, Celish FD200L (all from Daicel FineChem), chitin nanofiber, partially hydrolyzed chitin nanofiber (all from Marine Nanofiber), citrus nanofiber (Kami Shoji), and FibriMa (registered trademark) (Masuko Sangyo); and those produced by microbial fermentation include Fibnano (Kusano Sakuko).

[0022] The naturally-derived nanofibers may be crystalline. From the viewpoint of more significantly achieving the effects of the present invention, the crystallinity of the naturally-derived nanofibers may be 30% or more, 35% or more, 40% or more, or 45% or more, and may be 95% or less, 90% or less, 85% or less, or 80% or less. Note that "crystallinity" refers to the proportion of crystalline regions in the entire naturally-derived substance. The crystallinity of the naturally-derived nanofibers can be calculated by the Segal method from the diffraction intensity value obtained by X-ray diffraction. For example, when the naturally-derived nanofibers are cellulose nanofibers, the crystallinity can be calculated by the method described in JP 2019-112493 A.

[0023] From the viewpoint of more significantly exhibiting the effects of the present invention, the average fiber diameter of naturally occurring nanofibers may be 1 nm or more, 2 nm or more, 2.5 nm or more, or 3 nm or more, or 2000 nm or less, 1500 nm or less, 1000 nm or less, 500 nm or less, 200 nm or less, 100 nm or less, 50 nm or less, 20 nm or less, 10 nm or less, or 5 nm or less. The average fiber diameter can be calculated using an atomic force microscope (AFM) by the method described in JP 2019-112493 A.

[0024] From the viewpoint of more significantly exhibiting the effects of the present invention, the average aspect ratio (average fiber length / average fiber diameter) of naturally occurring nanofibers may be 10 or more, 20 or more, 30 or more, or 40 or more, and may be 1000 or less, 500 or less, 400 or less, and more preferably 350 or less. The aspect ratio can be calculated using an atomic force microscope (AFM) by the method described in JP 2019-112493 A.

[0025] When the naturally occurring nanofiber contains anionic groups, the anionic group content of the naturally occurring nanofiber may be 0.1 mmol / g or more, more preferably 0.4 mmol / g or more, 0.6 mmol / g or more, or 0.8 mmol / g or more, from the viewpoint of more significantly achieving the effects of the present invention, and may be 3.0 mmol / g or less, 2.7 mmol / g or less, 2.5 mmol / g or less, or 2.0 mmol / g or less. The "anionic group content" refers to the total amount of anionic groups in the naturally occurring material constituting the nanofiber. The anionic group content can be adjusted to fall within this range by, for example, performing a reduction treatment or further performing an oxidation treatment. The anionic group content can be calculated using the method described in JP 2019-112493 A.

[0026] The content of component (A) in the topical composition (1) according to this embodiment is not particularly limited and is set appropriately depending on the type and content of other ingredients, the intended use of the topical composition, the formulation, etc. To more significantly exhibit the effects of the present invention, the content of component (A) may be, for example, 0.01% by mass or more, 0.05% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 0.7% by mass or more, or 1.0% by mass or more, or 5.0% by mass or less, 4.5% by mass or less, 4.0% by mass or less, 3.5% by mass or less, 3.0% by mass or less, or 2.5% by mass or less, based on the total amount of the topical composition.

[0027] <(B) component> The oily component (B) is a hydrophobic component that undergoes phase separation from water at room temperature and may be any component that is medicamentally, pharmacologically (pharmaceutical), or physiologically acceptable. Examples of oily components include ester oils, vegetable oils, silicone oils, hydrocarbon oils, fat-soluble vitamins, and monoterpenes.

[0028] Examples of ester oils that can be used include synthetic esters and esters of higher alcohols and higher fatty acids, such as diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, isostearyl isostearate, trimethylolpropane triisostearate, cetyl 2-ethylhexanoate (cetyl ethylhexanoate), neopentyl glycol di-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate (pentaerythritol tetra-2-ethylhexanoate), octyldodecyl neopentanoate, cetyl octanoate, caprylic / caprylic triglyceride, neopentyl glycol dicaprate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate, cetyl lactate, tetralactic acid Tradecyl, octyldodecyl lactate, isopropyl myristate, octyldodecyl myristate, cetyl myristate, myristyl myristate, octyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearate, diisostearyl malate, pentaerythrityl tetrarosinate, dimer dilinoleyl diisostearate, Examples of the dimer dilinoleate include di(isostearyl / phytosteryl) dimer dilinoleate, dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleate (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl bis(phytosteryl / behenyl / isostearyl) dimer dilinoleate, and (polyglyceryl-2 isostearate / dimer dilinoleate) copolymer.Preferred ester oils are cetyl 2-ethylhexanoate (cetyl ethylhexanoate), glyceryl tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate (pentaerythritol tetra-2-ethylhexanoate), octyldodecyl neopentanoate, caprylic / caprylic triglyceride, diisostearyl malate, dimer dilinoleyl dimer dilinoleate, and polyglyceryl-2 isostearate / dimer dilinoleate copolymer.

[0029] Examples of vegetable oils include drying oils such as soybean oil, safflower oil, grape seed oil, rosehip oil, sunflower oil, and evening primrose seed oil; semi-drying oils such as cottonseed oil, sesame oil, wheat germ oil, and almond oil; non-drying oils such as olive oil, camellia oil, camellia oil, castor oil, peanut oil, avocado oil, macadamia nut oil, hazelnut oil, and meadowfoam oil; vegetable liquid waxes such as jojoba oil; and essential oils such as eucalyptus oil, peppermint oil, Roman chamomile oil, lavender oil, and bergamot oil.

[0030] Examples of silicone oils include higher alkoxy-modified silicones such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclohexasiloxane, and stearoxysilicone; amino-modified silicones such as amodimethicone and aminoethylaminopropyldimethicone; alkyl-modified silicones; and higher fatty acid ester-modified silicones.

[0031] Examples of hydrocarbon oils that can be used include paraffinic hydrocarbons and olefinic hydrocarbons, such as hydrogenated lanolin, squalane, ceresin, paraffin, pristane, microcrystalline wax, liquid paraffin, petrolatum, hydrogenated polyisobutene, light liquid paraffin, etc. Preferred hydrocarbon oils are microcrystalline wax, liquid paraffin, petrolatum, hydrogenated polyisobutene, and light liquid paraffin.

[0032] Examples of fat-soluble vitamins include tocopherols and their derivatives, retinols and their derivatives, and ubiquinones and their derivatives. Examples of tocopherols include α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, α-tocotrienol, β-tocotrienol, γ-tocotrienol, and δ-tocotrienol. Examples of tocopherol derivatives include tocopherol acetate, tocopherol linoleate, tocopherol nicotinate, and tocopherol (linoleate / oleate). Examples of retinols include retinol, retinal, retinoic acid, 3-dehydroretinol, 3-dehydroretinal, 3-dehydroretinoic acid, and hydrogenated retinol. Examples of retinol derivatives include retinol palmitate, retinol propionate, retinol linoleate, and retinol acetate. Provitamins A such as α-carotene, β-carotene, γ-carotene, and cryptoxanthin are also included in retinols. Ubiquinone is the general term for 2,3-dimethoxy-5-methyl-6-polyprenyl-1,4-benzoquinone, also known as coenzyme Q. Ubiquinones typically have 1 to 20 isoprene units in their side chains, and are represented by the names coenzyme Q1 to 20, respectively.

[0033] Examples of monoterpenes include monocyclic monoterpenes such as menthol, eugenol, thymol, limonene, anethole, cymene, and terpineol; bicyclic monoterpenes such as camphor, borneol, cineole, pinene, camphene, isoborneol, and fengchen; and acyclic monoterpenes such as geraniol, nerol, myrcene, myrcenol, linalool, linalool acetate, and lavandulol.

[0034] The component (B) may be a commercially available product. The oil component may be used alone or in combination of two or more.

[0035] The component (B) is preferably an ester oil, a vegetable oil, a silicone oil, a hydrocarbon oil, or a fat-soluble vitamin, and more preferably an ester oil, a vegetable oil, or a fat-soluble vitamin.

[0036] The content of component (B) in the topical composition (1) according to this embodiment is not particularly limited and is set appropriately depending on the type of component (B), the types and contents of other ingredients, the intended use of the topical composition, the formulation, etc. To more significantly exhibit the effects of the present invention, the content of component (B) may be, for example, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, or 40% by mass or less, 30% by mass or less, 25% by mass or less, or 20% by mass or less, based on the total amount of the topical composition.

[0037] When component (B) is an ester oil, vegetable oil, silicone oil, or hydrocarbon oil, the content thereof may be, for example, 0.01% by mass or more, 0.05% by mass or more, or 0.08% by mass or more, based on the total amount of the topical composition, and may be 40% by mass or less, 35% by mass or less, 30% by mass or less, or 25% by mass or less, in order to more significantly exhibit the effects of the present invention.

[0038] When component (B) is a fat-soluble vitamin or monoterpene, the content thereof may be, for example, based on the total amount of the topical composition, 0.001% by mass or more, 0.005% by mass or more, or 0.01% by mass or more, or 2% by mass or less, 1% by mass or less, 0.8% by mass or less, or 0.6% by mass or less, in order to more significantly exhibit the effects of the present invention.

[0039] The content ratio of component (B) to component (A) in the topical composition (1) according to this embodiment is not particularly limited and is set appropriately depending on the type of component (B), the types and contents of other ingredients, the intended use of the topical composition, the formulation, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, the content ratio of component (B) to component (A) may be, for example, 0.01 parts by mass or more, 0.05 parts by mass or more, 0.1 parts by mass or more, or 0.5 parts by mass or more of the total content of component (B) per 1 part by mass of the total content of component (A) contained in the topical composition according to this embodiment, or 400 parts by mass or less, 300 parts by mass or less, 200 parts by mass or less, or 100 parts by mass or less.

[0040] <(C) component> Specific examples of glycosaminoglycans as component (C) include hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, keratan sulfate, proteoglycan, Aphanothece sacrum polysaccharides, and salts thereof, as well as derivatives thereof. Preferred glycosaminoglycans include hyaluronates (sodium hyaluronate, hydroxypropyltrimonium hyaluronate, zinc hyaluronate), degraded hyaluronic acid (hyaluronic acid with a weight-average molecular weight of 50,000 or less, hyaluronic acid oligosaccharides), and acetylated hyaluronates (acetylated sodium hyaluronate).

[0041] The glycosides of component (C) are compounds having a glycosidic bond in the molecule. Specific examples of glycosides include polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, and arbutin. From the viewpoint of more significantly achieving the effects of the present invention, the polyoxyethylene methyl glucoside preferably has an added molar number of polyoxyethylene of 5 to 35, more preferably 10 to 30, and even more preferably 10 to 20. From the viewpoint of more significantly achieving the effects of the present invention, the polyoxypropylene methyl glucoside preferably has an added molar number of polyoxypropylene of 5 to 35, more preferably 10 to 30, and even more preferably 10 to 20.

[0042] Specific examples of the acrylic acid-based polymer compound of component (C) include carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, polyacrylamide, copolymers containing acrylamide and / or acryloyldimethyltaurine as structural units, etc. Carboxyvinyl polymer is preferred as the acrylic acid-based polymer compound.

[0043] Component (C) may be a commercially available product, such as hyaluronic acid FCH-200 (average molecular weight 1.8 million to 2.2 million; Kikkoman Biochemifa Corporation), hyaluronic acid FCH-120 (average molecular weight 1 million to 1.4 million; Kikkoman Biochemifa Corporation), hyaluronic acid FCH-60 (average molecular weight 500,000 to 700,000; Kikkoman Biochemifa Corporation), biosodium hyaluronate HA20 (average molecular weight 1.9 million to 2.7 million; Shiseido Co., Ltd.), or bio Sodium hyaluronate HA9 (average molecular weight 800,000 to 1.2 million; Shiseido Co., Ltd.), Hyaluronsan HA-LQH (average molecular weight 1.2 million to 2.2 million; Kewpie Corporation), Hyaluronsan HA-LQ (average molecular weight 850,000 to 1.6 million; Kewpie Corporation), sodium hyaluronate (average molecular weight 1.8 million to 2.2 million; Food Chemifa Co., Ltd.), microhyaluronic acid FCH (average molecular weight 5000; Kikkoman Biochemifa Co., Ltd.) ), acetylated hyaluronic acid sodium (molecular weight around 100,000; Shiseido Co., Ltd.), hydrolyzed hyaluronic acid sodium (molecular weight less than 10,000; Kewpie Corporation), Hyalooligo (average molecular weight less than 10,000; Kewpie Corporation), hyaluronic acid (L) (average molecular weight less than 50,000; FAP Japan Co., Ltd.), hyaluronic acid (SL) (average molecular weight less than 10,000; FAP Japan Co., Ltd.), hyaluronic acid oligosaccharide tetrasaccharide (Cosmo Bio Co., Ltd.), hyaluronic acid Commercially available products such as 12-disaccharide oligosaccharide (Cosmobio Co., Ltd.), Macbiobride MG-10E (NOF Corporation), Macbiobride MG-20E (NOF Corporation), Glucam E-10 (Noveon), Glucam E-10 (Noveon), Macbiobride MG-10P (NOF Corporation), Macbiobride MG-20P (NOF Corporation), Glucam P-10 (Noveon), and Glucam P-20 (Noveon) can also be used. One type of component (C) may be used alone, or two or more types may be used in combination.

[0044] The component (C) is preferably one or more selected from the group consisting of hyaluronate, decomposed hyaluronic acid, acetylated hyaluronate, polyoxyethylene methyl glucoside, arbutin, and carboxyvinyl polymer, more preferably three or more selected from the group consisting of, and more preferably the three or more components (C) are two or more selected from the group consisting of sodium hyaluronate, decomposed hyaluronic acid, and acetylated sodium hyaluronate.

[0045] The content of component (C) in the topical composition (1) according to this embodiment is not particularly limited and is set appropriately depending on the type of component (C), the types and contents of other ingredients, the intended use of the topical composition, the formulation, etc. To more significantly exhibit the effects of the present invention, the content of component (C) may be, for example, 0.001% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, or 5% by mass or less, 3% by mass or less, 2% by mass or less, or 1% by mass or less, based on the total amount of the topical composition.

[0046] The content ratio of component (C) relative to component (A) in the topical composition (1) according to this embodiment is not particularly limited and is set appropriately depending on the type of component (C), the types and contents of other blended components, the intended use of the topical composition, the formulation, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, the content ratio of component (C) relative to component (A) may be, for example, 0.001 parts by mass or more, 0.01 parts by mass or more, 0.05 parts by mass or more, 0.1 parts by mass or more, or 0.5 parts by mass or more relative to 1 part by mass of the total content of component (A) contained in the topical composition according to this embodiment, or may be 100 parts by mass or less, 50 parts by mass or less, 30 parts by mass or less, 25 parts by mass or less, or 15 parts by mass or less.

[0047] The topical composition (1) according to this embodiment may further contain additives such as thickeners, stabilizers, gelling agents, colorants, antioxidants, preservatives, antibacterial agents, pH adjusters, buffers, chelating agents, fragrances, amino acids or salts thereof, sugars, moisturizers, organic acids or salts thereof, etc. These may be appropriately selected from known substances and may be prepared using conventional methods.

[0048] When the topical composition (1) of this embodiment contains water, the total water content may be 30% by mass or more, 40% by mass or more, or 50% by mass or more, based on the total amount of the topical composition, and may be 90% by mass or less, 80% by mass or less, or 70% by mass or less.

[0049] The water used in the topical composition (1) according to this embodiment may be any water that is medicamentally, pharmacologically (pharmaceutical), or physiologically acceptable. Examples of such water include distilled water, tap water, purified water, sterile purified water, water for injection, and distilled water for injection. These definitions are based on the 17th edition of the Japanese Pharmacopoeia.

[0050] The topical composition (1) of this embodiment can be prepared by adding and mixing the desired amounts of components (A), (B), and (C), and, if necessary, other components, to the desired concentration.

[0051] The topical composition (1) according to this embodiment can be in various formulations depending on the purpose. Examples of formulations include liquids, gels, semisolids (ointments, etc.), suspensions, emulsions, creams, liniments, lotions, and aerosols. Furthermore, the topical composition (1) according to this embodiment is preferably transparent. In this specification, "transparent" refers to a composition having a light transmittance of 70% or more at 600 nm, including colored compositions. Light transmittance can be measured using a UV spectrophotometer UV-2450 (Shimadzu Corporation).

[0052] The topical composition (1) according to this embodiment can be used in pharmaceuticals, cosmetics (preferably cosmetics for use on the skin, hair, and nails), etc. The application method may be application, dripping, spraying, or the like, depending on the dosage form. When applying the topical composition to the human body, an applicator may also be used.

[0053] [2. External composition (2)] The topical composition (2) of this embodiment contains (A') cellulose nanofibers (also referred to simply as "component (A')") and (D) one or more members selected from the group consisting of tranexamic acids, ascorbic acids, glycosaminoglycans, glycosides, nicotinic acids, cyclohexane-1,4-dicarboxylic acid derivatives, cinnamic acid derivatives, and metal oxides (also referred to simply as "component (D)"), and the content of component (A') is 0.01 to 7 mass% based on the total amount of the topical composition.

[0054] <Component (A')> The cellulose nanofibers (component A') are nanofibers made from cellulose or a cellulose derivative and have an average fiber diameter of 1 to 2000 nm. Here, the cellulose derivative refers to a derivative obtained by introducing a substituent such as an anionic group into cellulose (e.g., carboxymethyl cellulose).

[0055] Examples of natural products that can be used as raw materials for cellulose nanofibers include plants (trees such as coniferous trees and broad-leaved trees; herbaceous plants such as bamboo; citrus peel; cotton, hemp, wheat, rice, sugar beet, sugar cane, etc.). All or part of these natural products may be used, or natural products that have been further processed may also be used. Examples of further processed natural products include wood pulp obtained by bleaching and pulverizing trees such as coniferous trees and broad-leaved trees, and sugar obtained by refining extracts from sugar beet, sugar cane, etc.

[0056] The cellulose nanofibers used may be commercially available products, or may be those obtained by chemically and / or mechanically treating natural products to defibrate them, or those obtained by microbial fermentation of natural products.

[0057] Methods for chemically treating natural products to defibrate them include, for example, the introduction of anionic groups such as carboxyl groups (e.g., TEMPO oxidation), phosphate groups, and sulfonic acid groups, or carboxymethyl groups; hydrolysis; and enzymatic degradation. The surface of the obtained naturally-derived nanofibers can also be further modified with various modifying groups to change their hydrophilicity, hydrophobicity, or ionicity. This can change the wettability and three-dimensional structure of the naturally-derived nanofibers, thereby controlling the dispersibility of the cellulose nanofibers in topical compositions and their interaction with other components. There are no particular limitations on the modifying groups, as long as they change the surface properties of the cellulose nanofibers. Metal ions or metal nanoparticles may also be attached to the surface of the obtained cellulose nanofibers.

[0058] Examples of methods for mechanically treating and defibrating natural substances include underwater head-on collision, hydraulic penetration pulverization, water jet method, high-pressure homogenizer treatment, microfluidizer method, ball mill pulverization, grinder method, etc. In addition, water, organic solvents, etc. can be used as solvents for dispersing naturally occurring substances in mechanical treatment of naturally occurring substances.

[0059] Microorganisms that can be used in microbial fermentation of natural products include, for example, bacteria, yeast, mold, etc. Among these, it is preferable to use bacteria (e.g., Acetobacter, Agrobacterium, Rhizobium, Sarcina, Pseudomonas, Achromobacter, Alcaligenes, Aerobacter).

[0060] Commercially available cellulose nanofiber products may contain cellulose nanofibers in the form of an aqueous dispersion, gel, slurry, paste, powder, sheet, pellet, or non-aqueous dispersion. Commercially available cellulose nanofiber products are preferably those containing cellulose nanofibers in the form of an aqueous dispersion, gel, slurry, paste, or non-aqueous dispersion.

[0061] Specific examples of commercially available cellulose nanofibers include those with carboxyl groups introduced, such as Cellenpia (registered trademark) TC-01A and Cellenpia (registered trademark) TC-02X (all manufactured by Nippon Paper Industries Co., Ltd.), Rheocrysta (registered trademark) 1-2SX, Rheocrysta (registered trademark) 1-2AX, Rheocrysta (registered trademark) 1-2AE, and Rheocrysta (registered trademark) C-2SP (all manufactured by Daiichi Kogyo Seiyaku Co., Ltd.), and those with carboxymethyl groups introduced, such as Cellenpia (registered trademark) CS-01 and Cellenpia (registered trademark) CS -01C (all Nippon Paper Industries); as a hydrolyzate, cellulose nanocrystal (Filler Bank); as a mechanically processed product, nanoforest-S (Chuetsu Pulp Industries), ELLEX-S (Daioh Paper), BiNFi-s (Sugino Machine), Celish KY100G, Celish FD200L (all Daicel FineChem), Citrus Nanofiber (Kami Shoji), FibriMa (registered trademark) (Masuko Sangyo); as a microbial fermentation product, Fibnano (Kusano Sakuko), etc.

[0062] The cellulose nanofibers may be crystalline. From the viewpoint of more significantly achieving the effects of the present invention, the crystallinity of the cellulose nanofibers may be 30% or more, 35% or more, 40% or more, or 45% or more, and may be 95% or less, 90% or less, 85% or less, or 80% or less. The term "crystallinity" refers to the proportion of crystalline regions in the entire cellulose. The crystallinity of the cellulose nanofibers can be calculated by the Segal method from the diffraction intensity value obtained by X-ray diffraction. For example, the crystallinity can be calculated by the method described in JP 2019-112493 A.

[0063] From the viewpoint of more significantly exhibiting the effects of the present invention, the average fiber diameter of the cellulose nanofibers may be 1 nm or more, 2 nm or more, 2.5 nm or more, or 3 nm or more, or may be 2000 nm or less, 1500 nm or less, 1000 nm or less, 500 nm or less, 200 nm or less, 100 nm or less, 50 nm or less, 20 nm or less, 10 nm or less, or 5 nm or less. The average fiber diameter can be calculated using an atomic force microscope (AFM) by the method described in JP 2019-112493 A.

[0064] From the viewpoint of more significantly exhibiting the effects of the present invention, the average aspect ratio of the cellulose nanofibers (average fiber length / average fiber diameter) may be 10 or more, 20 or more, 30 or more, or 40 or more, and may be 1000 or less, 500 or less, 400 or less, and more preferably 350 or less. The aspect ratio can be calculated using an atomic force microscope (AFM) by the method described in JP 2019-112493 A.

[0065] When cellulose nanofibers contain anionic groups, the anionic group content of the cellulose nanofibers may be 0.1 mmol / g or more, more preferably 0.4 mmol / g or more, 0.6 mmol / g or more, or 0.8 mmol / g or more, from the viewpoint of more significantly achieving the effects of the present invention, and may be 3.0 mmol / g or less, 2.7 mmol / g or less, 2.5 mmol / g or less, or 2.0 mmol / g or less. The "anionic group content" refers to the total amount of anionic groups in the cellulose constituting the nanofibers. The anionic group content can be adjusted to fall within this range by, for example, performing a reduction treatment or further performing an oxidation treatment. The anionic group content can be calculated using the method described in JP 2019-112493 A.

[0066] The content of component (A') in the topical composition (2) according to this embodiment is not particularly limited as long as it is within the range of 0.01 to 7.0% by mass based on the total amount of the topical composition, and is appropriately set depending on the type and content of other ingredients, the intended use of the topical composition, the formulation, etc. To more significantly exhibit the effects of the present invention, the content of component (A') may be, for example, 0.05% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 0.7% by mass or more, or 1.0% by mass or more, or 5.0% by mass or less, 4.5% by mass or less, 4.0% by mass or less, 3.5% by mass or less, 3.0% by mass or less, or 2.5% by mass or less, based on the total amount of the topical composition.

[0067] <(D) component> Examples of tranexamic acids as component (D) include tranexamic acid, tranexamic acid derivatives, and salts thereof. Tranexamic acid is synonymous with trans-4-aminomethylcyclohexane-1-carboxylic acid. Examples of tranexamic acid derivatives include tranexamic acid amide, tranexamic acid alkylamide, and tranexamic acid alkyl ester. Examples of salts of tranexamic acid or tranexamic acid derivatives include sodium salt, potassium salt, magnesium salt, hydrochloride, phosphate, and sulfate. Tranexamic acid is preferred as the tranexamic acid.

[0068] Examples of ascorbic acids used as component (D) include ascorbic acid, ascorbic acid derivatives, and salts thereof. Examples of ascorbic acid derivatives include L-ascorbic acid monoesters such as ethyl ascorbic acid, ascorbic acid 2-glucoside, ascorbic acid 2-phosphate, ascorbic acid 3-phosphate, ascorbic acid 6-phosphate, ascorbic acid 2-polyphosphate, and ascorbic acid 2-sulfate. Examples of ascorbic acid salts include sodium salt, potassium salt, magnesium salt, calcium salt, barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, monoisopropanolamine salt, and triisopropanolamine salt. Examples of ascorbic acid derivative salts include sodium salt, potassium salt, magnesium salt, calcium salt, barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt, monoisopropanolamine salt, and triisopropanolamine salt. Ascorbic acids, ascorbic acid, ethyl ascorbic acid, ascorbic acid 2-glucoside, ascorbyl palmitate, and magnesium ascorbyl phosphate are preferred, and ethyl ascorbic acid is more preferred. Furthermore, as ascorbic acid, L-ascorbic acid and its derivatives are preferred. Specific examples of glycosaminoglycans as component (D) include hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, keratan sulfate, proteoglycan, Aphanothece sacrum polysaccharides, and salts thereof, as well as derivatives thereof. Preferred glycosaminoglycans include hyaluronates (sodium hyaluronate, hydroxypropyltrimonium hyaluronate, zinc hyaluronate), degraded hyaluronic acid (hyaluronic acid with a weight-average molecular weight of 50,000 or less, hyaluronic acid oligosaccharides), and acetylated hyaluronates (acetylated sodium hyaluronate).

[0069] The glycosides of component (D) are compounds having a glycosidic bond in the molecule. Specific examples of glycosides include polyoxyethylene methyl glucoside, polyoxypropylene methyl glucoside, and arbutin. From the viewpoint of more significantly achieving the effects of the present invention, the polyoxyethylene methyl glucoside preferably has an added molar number of polyoxyethylene of 5 to 35, more preferably 10 to 30, and even more preferably 10 to 20. From the viewpoint of more significantly achieving the effects of the present invention, the polyoxypropylene methyl glucoside preferably has an added molar number of polyoxypropylene of 5 to 35, more preferably 10 to 30, and even more preferably 10 to 20.

[0070] Examples of nicotinic acids as component (D) include nicotinic acid, nicotinamide, DL-α-tocopherol nicotinate, benzyl nicotinate, etc. Of the nicotinic acids, nicotinamide is preferred.

[0071] Examples of cyclohexane-1,4-dicarboxylic acid, component (D), include bisethoxydiglycol cyclohexane-1,4-dicarboxylate.

[0072] Examples of cinnamic acid derivatives as component (D) include ethylhexyl methoxycinnamate (Uvinal MC80, Uvinal MC80N, BASF Japan; Parsol MCX, DSM Nutrition Japan, etc.), isoamyl methoxycinnamate (Neohelipan T, Herman & Reimer, etc.), 2-ethylhexyl α-cyano-β-phenylcinnamate (also known as Octocrylene, Parsol 340, DSM Nutrition Japan, etc.), isopropyl methoxycinnamate, cinoxate, DEA methoxycinnamate, diisopropyl methylcinnamate, methyl trimethoxycinnamate bis(trimethylcimexy)silylisopentyl, methyl 2,5-diisopropylcinnamate, glyceryl di-para-methoxycinnamate mono-2-ethylhexanoate, and hydroxycinnamic acid derivatives (e.g., resveratrol, caffeic acid, ferulic acid, p-coumaric acid, etc.). The cinnamic acid derivative is preferably ethylhexyl methoxycinnamate.

[0073] The metal oxide of component (D) includes metal oxides that have an ultraviolet ray scattering effect, and specific examples include zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, etc. Titanium oxide is preferred as the metal oxide.

[0074] The component (D) may be a commercially available product. The component (D) may be used alone or in combination of two or more.

[0075] The component (D) is preferably one or more selected from the group consisting of tranexamic acid, ascorbic acid derivatives, hyaluronate, polyoxypropylene methyl glucoside, nicotinamide, cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, ethylhexyl methoxycinnamate, and titanium oxide, and more preferably one or more selected from the group consisting of tranexamic acid, ascorbic acid derivatives, and hyaluronate.

[0076] The content of component (D) in the topical composition (2) according to this embodiment is not particularly limited and is set appropriately depending on the type of component (D), the types and contents of other ingredients, the intended use of the topical composition, the formulation, etc. To more significantly exhibit the effects of the present invention, the content of component (D) may be, for example, 0.001% by mass or more, 0.005% by mass or more, 0.01% by mass or more, 0.05% by mass or more, or 0.1% by mass or more, or 10% by mass or less, 5% by mass or less, 3% by mass or less, 2% by mass or less, or 1% by mass or less, based on the total amount of the topical composition.

[0077] The content ratio of component (D) relative to component (A') in the topical composition (2) according to this embodiment is not particularly limited and is set appropriately depending on the type of component (D), the types and contents of other ingredients, the intended use of the topical composition, the formulation, etc. From the viewpoint of more significantly exhibiting the effects of the present invention, the content ratio of component (D) relative to component (A') may be, for example, 0.001 parts by mass or more, 0.01 parts by mass or more, 0.05 parts by mass or more, 0.1 parts by mass or more, or 0.5 parts by mass or more relative to 1 part by mass of the total content of component (A') contained in the topical composition according to this embodiment, or may be 100 parts by mass or less, 50 parts by mass or less, 30 parts by mass or less, 25 parts by mass or less, or 15 parts by mass or less.

[0078] The topical composition (2) according to this embodiment may further contain additives such as thickeners, stabilizers, gelling agents, colorants, antioxidants, preservatives, antibacterial agents, pH adjusters, buffers, chelating agents, fragrances, amino acids or salts thereof, sugars, moisturizers, organic acids or salts thereof, etc. These may be appropriately selected from known substances and may be produced using conventional methods.

[0079] When the topical composition (2) of this embodiment contains water, the total water content may be 30% by mass or more, 40% by mass or more, or 50% by mass or more, based on the total amount of the topical composition, and may be 90% by mass or less, 80% by mass or less, or 70% by mass or less.

[0080] The water used in the topical composition (2) according to this embodiment may be any water that is medicamentally, pharmacologically (pharmaceutical), or physiologically acceptable. Examples of such water include distilled water, tap water, purified water, sterile purified water, water for injection, and distilled water for injection. These definitions are based on the 17th edition of the Japanese Pharmacopoeia.

[0081] The topical composition (2) according to this embodiment can be prepared by adding and mixing the desired amounts of component (A'), component (D), and, if necessary, other components to the desired concentration.

[0082] The topical composition (2) according to this embodiment can be in various formulations depending on the purpose. Examples of formulations include liquids, gels, semisolids (ointments, etc.), suspensions, emulsions, creams, liniments, lotions, and aerosols. The topical composition (1) according to this embodiment is preferably transparent. In this specification, "transparent" refers to a composition having a light transmittance of 70% or more at 600 nm, including colored compositions. Light transmittance can be measured using a UV spectrophotometer UV-2450 (Shimadzu Corporation).

[0083] The topical composition (2) according to this embodiment can be used in pharmaceuticals, cosmetics (preferably cosmetics for use on the skin, hair, and nails), etc. The application method may be painting, dripping, spraying, etc., depending on the dosage form. When applying the topical composition to the human body, an applicator may also be used. [Example]

[0084] The present invention will be specifically explained below based on test examples, but the present invention is not limited to these.

[0085] [Test Example 1: Odor Evaluation] The topical compositions for each of the Test Examples and Examples shown in Tables 1 to 3 were prepared by conventional methods. The unit of the amount of each component in Tables 1 to 3 is % by mass. The following raw materials were used. Cellulose nanofiber (1): Rheocrysta C-2SP (average fiber diameter approximately 3 nm; Daiichi Kogyo Seiyaku) Cellulose nanofiber (2): AuroVisco CS (average fiber diameter 3–4 nm; Oji Holdings) Cellulose nanofiber (3): ELLEX (average fiber diameter 3-4 nm; Daio Paper Co., Ltd.) Sodium hyaluronate: Weight average molecular weight 800,000 to 1,200,000 Decomposed hyaluronic acid: weight average molecular weight of 10,000 or less Acetylated sodium hyaluronate: Weight average molecular weight 90,000 to 110,000 Carboxyvinyl polymer: Carbopol 980 (LUBRIZOL) Four subjects, who understood the following evaluation criteria, applied 0.1 g of each topical composition to the arm, and smelled the applied area to evaluate the odor using a VAS (visual analog scale). That is, subjects were asked to indicate the point on a 10 cm line at both ends, where 10 cm indicates no odor at all and 0 cm indicates a strong odor. The average distance (cm) from the 0 cm point for the four subjects was calculated and used as the odor evaluation score. Next, using the odor evaluation score of the corresponding test example as the standard, the change in the odor evaluation score for each example was calculated using the following formula, which was used as the odor improvement value. Odor improvement score = (Odor evaluation score of each test example or example) - (Odor evaluation score of the corresponding test example) The corresponding test example is Test Example 1. The results are shown in Tables 1 to 3.

[0086] [Table 1]

[0087] [Table 2]

[0088] [Table 3]

[0089] The compositions of Test Examples 2 to 5, which contained cellulose nanofibers combined with sodium hyaluronate, decomposed hyaluronic acid, acetylated sodium hyaluronate, or arbutin, showed a lower odor improvement score compared to the composition of Test Example 1, which contained only cellulose nanofibers, demonstrating the generation of an unpleasant odor (Table 1). On the other hand, the compositions of Examples 1 to 10, which contained compositions containing cellulose nanofibers and sodium hyaluronate, or compositions containing cellulose nanofibers, sodium hyaluronate, decomposed hyaluronic acid, and acetylated sodium hyaluronate, and further blended with various oily components, showed increased odor improvement scores compared to compositions containing no oily components, demonstrating the improvement of unpleasant odor (Table 2). Furthermore, the compositions of Examples 11 to 14 and 16, which contained compositions containing cellulose nanofibers and sodium hyaluronate, compositions containing cellulose nanofibers and polyoxypropylene methyl glucoside, or compositions containing cellulose nanofibers and carboxyvinyl polymer, and further blended with various oily components, also showed increased odor improvement scores compared to compositions containing no oily components, demonstrating the improvement of unpleasant odor (Table 3). When the compositions of Examples 1 to 14 and 16 were applied to the arm, they caused no irritation and had a moisturizing effect. Furthermore, the compositions of Examples 1 to 14 and 16 remained homogeneous and stable even after being stored at 40°C for two weeks. In other words, the compositions of Examples 1 to 14 and 16 were compositions that could stably contain oily ingredients without the coexistence of surfactants that irritate the skin.

[0090] [Test Example 2: Foam Evaluation] The topical compositions for each of the Test Examples and Examples shown in Table 4 were prepared by conventional methods. The unit of the amount of each component in Table 4 is % by mass. The following raw materials were used. Cellulose nanofiber (1): Rheocrysta C-2SP (average fiber diameter approximately 3 nm; Daiichi Kogyo Seiyaku) Sodium hyaluronate: Weight average molecular weight 1.1 million to 1.6 million Each topical composition was placed in a 50 mL transparent polyethylene terephthalate container to a height of 5 cm from the bottom and sealed. The containers containing each topical composition were simultaneously shaken up and down 10 times, and the movement of bubbles generated in the topical composition was immediately observed. The bubbles generated at a height of 2 cm from the bottom of the container were compared with those in Test Example 6 and each of the topical compositions in each Example. If the speed at which the bubbles rose toward the water surface was faster than that in Test Example 6, it was evaluated as A; if the speed was the same, it was evaluated as B; and if the speed was slower, it was evaluated as C. The results are shown in Table 4.

[0091] [Table 4]

[0092] It was confirmed that the compositions of Examples 17 to 19, in which cellulose nanofibers were blended with tranexamic acid, ethyl ascorbic acid, or sodium hyaluronate as component (D), had a faster foam rising rate and were more likely to disappear than the composition of Test Example 6, which did not contain component (D).

[0093] [Test Example 3: Evaluation of Usability] The topical compositions for each of the Test Examples and Examples shown in Table 5 were prepared by conventional methods. The unit of the amount of each component in Table 5 is % by mass. The following raw materials were used. Cellulose nanofiber (1): Rheocrysta C-2SP (average fiber diameter approximately 3 nm; Daiichi Kogyo Seiyaku) Three subjects, who understood the following evaluation criteria, applied 0.1 g of each topical composition to the arm, and evaluated the ease of spreading evenly in comparison with Test Example 7. The three subjects rated the composition on a 5-point scale according to the following criteria, and the average score for the three subjects was calculated. The results are shown in Table 5. (Evaluation criteria) 5: Feels much better than Test Example 7 4: I feel it is better than Test Example 7 3: No difference from Test Example 7 2: Feels worse than Test Example 7 1: Feels much worse than Test Example 7

[0094] [Table 5]

[0095] The compositions of Examples 20 to 24, in which cellulose nanofibers were blended with nicotinamide, polyoxypropylene methyl glucoside, bisethoxydiglycol cyclohexane-1,4-dicarboxylate, ethylhexyl methoxycinnamate, or titanium oxide as component (D), were confirmed to be easier to apply evenly and to have an improved feel when used, compared to the composition of Test Example 7, which did not contain component (D). The comments made by three subjects regarding the feel when used with each of the compositions of Examples 20 to 24 were as follows: Example 20: Skin feels soft and plump. Wrinkles are less noticeable. Example 21: Light feeling after application. Example 22: The product feels bouncy and sticks to the skin. The highly moisturizing feeling lasts. The skin becomes firm. Example 23: When makeup was applied after application, the makeup was less likely to come off. Example 24: A film forms on the skin, creating a barrier feeling against the outside air. It feels dry and comfortable to use, without being sticky.

[0096] An external composition having the following composition was prepared by a conventional method.

[0097] Formulation Example 1 (clear gel-like composition for external use) Component Content (mass%) Glycerin 5.0 1,3-butylene glycol 5.0 Diglycerin 5.0 Triethylhexanoin 1.0 Diethoxyethyl succinate 0.5 Dimethicone 0.5 Carbomer 0.5 Glyceryl glucoside 0.5 Phenoxyethanol 0.3 Sodium hyaluronate 0.2 Squalane 0.2 Potassium hydroxide 0.2 Cellulose nanofiber (average fiber diameter approximately 3 nm) 0.2 Succinic acid 0.1 Sodium edetate 0.1 Olive fruit oil 0.01 Hydrolyzed Hyaluronic Acid 0.01 Aphanothece sacrum polysaccharides 0.01 Hyaluronic acid hydroxypropyltrimonium 0.01 Sodium Hyaluronic Acid Crosspolymer 0.01 Pentylene glycol 0.01 Remaining purified water

[0098] Formulation Example 2 (Sunscreen Composition for External Use) Component Content (mass%) Ethylhexyl methoxycinnamate 10.0 1,3-butylene glycol 8.0 Triethylhexyl trimellitate 2.0 Diethylaminohydroxybenzoylhexyl benzoate 2.0 BisPEG-18 methyl ether dimethyl silane 2.0 Bis-ethylhexyloxyphenol methoxyphenyl triazine 1.0 (Acrylates / C10-30 alkyl acrylate) crosspolymer 0.5 Polyglyceryl-10 Pentaisostearate 0.5 PEG-12 Dimethicone 0.5 Methylparaben 0.2 Sodium edetate 0.1 Cellulose nanofiber (average fiber diameter approximately 3 nm) 0.5 Ethanol 10.0 Remaining purified water

[0099] The topical composition of Formulation Example 1 was easy to spread on the arm and absorbed well into the skin. When a sheet of nonwoven fabric soaked in the topical composition of Formulation Example 1 was applied to the face and removed after 5 minutes, the skin felt very moisturized and the moisturizing effect lasted.

Claims

1. (A) cellulose nanofibers, (B) an oily component, and (C) one or more selected from the group consisting of hyaluronate, decomposed hyaluronic acid, acetylated hyaluronate, polyoxypropylene methyl glucoside, and carboxyvinyl polymer; The content of component (A) is 0.01 to 5.0% by mass based on the total amount of the topical composition, the content of component (B) is 5 to 20% by mass based on the total amount of the topical composition, and the content of component (C) is 0.01 to 5% by mass based on the total amount of the topical composition, The cellulose nanofibers are obtained by introducing carboxyl groups, sulfonic acid groups, or carboxymethyl groups into natural products; hydrolysis; enzymatic degradation, and / or mechanical treatment to defibrate the natural products, or by microbial fermentation of the natural products.

2. The topical composition according to claim 1, wherein component (B) is one or more selected from the group consisting of ester oils, vegetable oils, silicone oils, hydrocarbon oils, and fat-soluble vitamins.

3. 3. The topical composition according to claim 1, wherein component (C) is three or more selected from the group consisting of hyaluronate, decomposed hyaluronic acid, acetylated hyaluronate, polyoxypropylene methyl glucoside, arbutin, and carboxyvinyl polymer.

4. The topical composition according to claim 3, wherein the three or more components (C) contain two or more selected from the group consisting of sodium hyaluronate, decomposed hyaluronic acid, and acetylated sodium hyaluronate.

5. The topical composition according to any one of claims 1 to 4, wherein the total content of component (B) is 0.01 to 400 parts by mass per 1 part by mass of the total content of component (A).

6. The topical composition according to any one of claims 1 to 5, wherein the total content of the (C) component is 0.001 to 100 parts by mass per 1 part by mass of the total content of the (A) component.

7. (A') cellulose nanofibers, and (D) one or more selected from the group consisting of tranexamic acid and ascorbic acid derivatives, The content of the component (A') is 0.01 to 7.0% by mass based on the total amount of the topical composition, and the content of the component (D) is 0.01 to 10% by mass based on the total amount of the topical composition, The cellulose nanofibers are obtained by introducing carboxyl groups, sulfonic acid groups, or carboxymethyl groups into natural products; hydrolysis; enzymatic degradation, and / or mechanical treatment to defibrate the natural products, or by microbial fermentation of the natural products.

8. The topical composition according to claim 7, wherein the total content of the (D) component is 0.001 to 100 parts by mass per 1 part by mass of the total content of the (A') component.

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