Stabilizer or stabilizer composition for stabilizing dihydroavenanthramide d

Abstract

The present invention relates to the use of a stabilizer or a stabilizer composition for stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroavenanthramide D and to a mixture comprising Dihydroavenanthramide D and a stabilizer, as well as to a cosmetic preparation comprising such a mixture.

Description

[0001] Munich,14 June 2024 Our Ref.: SM 6693-02WO SOE / DREApplicant:Symrise AGSerial Number:Subsequent Application based on PCT / EP2023 / 066131 Symrise AG Mühlenfeldstraße 1, 37603 Holzminden, Germany Stabilizer or stabilizer composition for stabilizing Dihydroavenanthramide D The present invention relates to the use of a stabilizer or a stabilizer composition for stabi- lizing Dihydroavenanthramide D in a mixture comprising Dihydroavenanthramide D and to a mixture comprising Dihydroavenanthramide D and a stabilizer, as well as to a cosmetic preparation comprising such a mixture. Dihydroavenanthramide D is a compound with particular importance in the cosmetic indus- try. Dihydroavenanthramide D belongs to the family of Avenanthramides, i.e. anthranilic acid amides, and is also described as hydroxyphenyl propamidobenzoic acid. Dihydroav- enanthramide D is described by the CAS number 697235-49-7 (as listed by the European Chemicals Agency) and corresponds to the following chemical structure: Dihydroavenanthramide D * *2022400321541500*315150* Dihydroavenanthramide D has been described for several cosmetic applications. For ex- ample, WO 2006 / 134013 A1 describes an application of Dihydroavenanthramide D for al- leviating itching and / or for reducing skin reddening. US 2006 / 089413 A1 describes that Dihydroavenanthramide D can be used for the inhibition of the substance P-induced release of histamine from mast cells. In this way, pruritus, skin reddening, weal development or allergic skin reactions may be prevented. Typically, Dihydroavenanthramide D is formulated in a cosmetic composition including fur- ther substances. One challenge for using Dihydroavenanthramide D is to provide and main- tain its colour stability in a cosmetic composition. If no or only insufficient colour stability of Dihydroavenanthramide D in a cosmetic composition is provided, it starts to cause a dis- coloration of the cosmetic composition. In such cases, the cosmetic compositions will change to a yellow to brownish colour, which increases with decreased colour stabilization of Dihydroavenanthramide D. Compositions with such discoloration are not accepted by the consumers of cosmetic com- positions, irrespective of the functionality of such a composition. Thus, Dihydroavenanthramide D is typically stabilized in cosmetic compositions. The sta- bilizer ascorbyl palmitate ascorbyl palmitate is widely used in such compositions. Ascorbyl palmitate is frequently added as a colour stabilizer for Dihydroavenanthramide in a cosmetic composition. It was found that ascorbyl palmitate is able to stabilize Dihydroavenanthramide D in cosmetic compositions. However, it was found that this function of ascorbyl palmitate is limited, since a reduced colour sta- bility of Dihydroavenanthramide D was observed after long-term storage of cosmetic com- positions comprising Dihydroavenanthramide D. Even though the stabilizer ascorbyl palmi- tate was added, the compositions showed a discoloration, often yellow to brownish discol- oration, after storage for some months and / or under conditions promoting the instability of compounds in a composition, such as increased temperature (e.g.40 °C or higher or 50 °C or higher). Thus, a need for further, preferably improved, colour stabilizers for Dihydroavenanthramide D in cosmetic compositions remains. Furthermore, discussions regarding the stabilizer ascorbyl palmitate have recently started. It is (controversially) discussed that ascorbyl palmitate provides a comedogenic activity, i.e. promotes the formation of comedones. Comedones are clogged hair follicles in the skin, which occur as a result of increased oil production in the sebaceous glands. Comedones are visible as darkened spots on the skin and occur mostly on the face, neck, upper chest, shoulders, and back of a subject, wherein they represent an exclusively cosmetic condition. Frequently, those areas treated with cosmetic compositions are visible in daily life and rep- resent those areas which shall provide a groomed appearance. Thus, comedones need to be prevented in these areas. Consequently, there is a need for further colour stabilizers for Dihydroavenanthramide D in cosmetic compositions, which preferably show an improved colour stabilizing ability. The primary object of the present invention was thus to provide stabilizers for Dihydroav- enanthramide D, preferably with improved colour stabilization compared to ascorbyl palmi- tate. The primary object of the present invention is solved by the use of a stabilizer or a stabilizer composition, wherein the stabilizer or, respectively, the or one or all stabilizer(s) of the stabilizer composition is / are selected from the group consisting of diethylhexyl syringyli- dene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mix- tures thereof, for stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroavenanthramide D, wherein stabilizing Dihydroavenanthramide D refers to the prevention or reduction of dis- coloration of the mixture and / or to the prevention or reduction of malodour formation, and wherein the weight ratio of the stabilizer(s) to Dihydroavenanthramide D is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1. It was surprisingly found that the stabilizer(s) used according to the invention provide a particular advantageous colour stabilization of Dihydroavenanthramide D. It was surpris- ingly found that a particularly low discoloration is observed when such a stabilizer or stabi- lizer composition is used, compared to the typically used stabilizer for Dihydroavenan- thramde D, i.e. ascorbyl palmitate, or tocopherol acetate, which is another frequently used stabilizer. Moreover, it was surprisingly found that a particularly low malodour formation occurs when such a stabilizer or stabilizer composition is used, compared to the typically used stabilizer for Dihydroavenanthramde D, i.e. ascorbyl palmitate, or tocopherol acetate, which is an- other frequently used stabilizer. It was further surprisingly found that the best outcome was observed when the weight ratio of Diethylhexyl Syringyldenemalonate to Dihydroavenanthramide D was higher than 0.01 and lower than 0.2, as also shown in Example 3 and Fig.1. Diethylhexyl syringylidene malonate is also known as Oxynex ST (and thus preferably is or includes Diethylhexyl Syringyldenemalonate, Caprylic / Capric Triglyceride) and is prefera- bly described by the CAS number 444811-29-4 (as listed by the European Chemicals Agency) and is preferably described as Propanedioic acid, 2-[(4-hydroxy-3,5-dimethoxy- phenyl)methylene]-, 1,3-bis(2-ethylhexyl) ester. Tocopheryl acetate, preferably alpha-tocopherol acetate, is preferably described by the CAS number 52225-20-4 (as listed by the European Chemicals Agency) and is preferably described as [2R*(4R*,8R*)]-(±)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl- tridecyl)-2H-benzopyran-6-yl acetate. Sodium metabisulfite is preferably described by the CAS number 7681-57-4 (as listed by the European Chemicals Agency) and is preferably described as Disodium disulphite. Tris(tetramethylhydroxypiperidinol) citrate is preferably described by the CAS number 220410-74-2 (as listed by the European Chemicals Agency) and is preferably described as 1,4-dihydroxy-2,2,6,6-tetramethyl piperidinium-2-hydroxy-1,2,3-propanetricarboxylate. Advantageously, no comedogenic activity is described for diethylhexyl syringylidene malo- nate, sodium metabisulfite or Tris(tetramethylhydroxypiperidinol) citrate. The term “stabilizer composition” as used herein describes a composition comprising one or more stabilizer(s). In case the composition comprises more than one stabilizer, two, three or more or all stabilizers may be mixed. Preferably for stabilizing Dihydroavenanthramide D, the stabilizer or, respectively, stabilizer composition is mixed with Dihydroavenanthramide D. In case of a stabilizer composition, the respective stabilizers, in case more than one stabilizer is present in the stabilizer com- position, may be mixed with Dihydroavenanthramide D separately. In case of a stabilizer composition, the respective stabilizers, in case more than one stabilizer is present in the stabilizer composition, may be mixed with each other first and then be mixed with Dihy- droavenanthramide. In case of a stabilizer composition, two, three or more of the respective stabilizers, in case more than one stabilizer is present in the stabilizer composition, may be mixed with each other first and then be mixed with Dihydroavenanthramide D and one, two, three or more of the of the respective stabilizers, in case more than one stabilizer is present in the stabilizer composition, may be mixed with Dihydroavenanthramide D separately. Typically, before mixing a or the stabilizer(s) with Dihydroavenanthramide D, the, one or more or all stabilizer(s) are dissolved in a solvent. Additionally or alternatively, before mix- ing a or the stabilizer(s) with Dihydroavenanthramide D, Dihydroavenanthramide D is typi- cally dissolved in a solvent. Preferably, the term “stabilizer”, as used herein, refers to a compound reducing or prevent- ing the discoloration and / or malodour formation of Dihydroavenanthramide D or, respec- tively, a mixture comprising Dihydroavenanthramide D. The term “stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroavenan- thramide D” preferably refers to the prevention or reduction of discoloration of the mixture. The discoloration may be measured by comparing the CIE L*a*b* Coordinates of two sam- ples, which is well known to a skilled person. Additionally or alternatively, the term “stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroavenanthramide D” preferably refers to the prevention or reduction of malodour formation. The formation of malodour may be tested by sensorical evaluation, e.g. by panellists. Preferably, the term “reduction of discoloration” or “reduction of malodour formation”, as used herein, describes a comparison of a mixture comprising a stabilizer with the same mixture but without the stabilizer. Preferably, the discoloration may be measured by determining the ΔL* value, preferably wherein a ΔL* value (i.e. the absolute value) of higher than 1.5, preferably higher than 1.75, particularly preferably higher than 2, further preferably higher than 2.25, more preferably higher than 2.5, even further preferably higher than 2.75, most preferably higher than 3 is considered as a discoloration. Preferably, the discoloration may be measured by determining the Δa* value, preferably wherein a Δa* value (i.e. the absolute value) of higher than 1.5, preferably higher than 1.75, particularly preferably higher than 2, further preferably higher than 2.25, more preferably higher than 2.5, even further preferably higher than 2.75, most preferably higher than 3 is considered as a discoloration. Preferably, the discoloration may be measured by determining the Δb* value, preferably wherein a Δb* value (i.e. the absolute value) of higher than 1.5, preferably higher than 1.75, particularly preferably higher than 2, further preferably higher than 2.25, more preferably higher than 2.5, even further preferably higher than 2.75, most preferably higher than 3 is considered as a discoloration. Preferably, the discoloration may be measured by determining the ΔE* value, preferably wherein a ΔE* value (i.e. the absolute value) of higher than 1.5, preferably higher than 1.75, particularly preferably higher than 2, further preferably higher than 2.25, more preferably higher than 2.5, even further preferably higher than 2.75, most preferably higher than 3 is considered as a discoloration. Preferably, the ΔE* is determined according to the following formula: Preferably, the stabilizer or, respectively, the or one or all stabilizer(s) of the stabilizer com- position is / are selected from the group consisting of diethylhexyl syringylidene malonate, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is diethylhexyl syringylidene malonate. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is sodium metabisulfite. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is Tris(tetramethylhydroxypiperidinol) citrate. It is preferred that the weight ratio of the summed weight of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate to Dihydroavenanthramide D in the (stabilized) mixture is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1. In case one or more of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhy- droxypiperidinol) citrate is not present in the (stabilized) mixture, its weight is considered as 0 for calculating the summed weight. Preferably, the mixture comprising Dihydroavenanthramide D comprises i) Dihydroavenanthramide D, and ii) one or more alkane diol(s). Preferably the, one, two, three or more or all alkane diol(s) is / are selected from the group consisting of 1,2-alkane diols, 1,3-alkane diols, 2,3-alkane diols, and mixtures thereof. Preferably the, one, two, three or more or all alkane diol(s) is / are selected from the group consisting of 1,2-propane diol, 1,2-butane diol, 1,2-pentane diol, 1,2-hexane diol, 1,2-hep- tane diol, 1,2-octane diol, 1,2-nonane diol, 1,2-decane diol, 1,2-undecane diol, 1,2-dodec- ane diol and 1,2-tridecane diol, 1,3-propane diol, 1,3-butane diol, 1,3-pentane diol, 1,3- hexane diol, 1,3-heptane diol, 1,3-octane diol, 1,3-nonane diol, 1,3-decane diol, 1,3-un- decane diol, 1,3-dodecane diol and 1,3-tridecane diol, 2-methyl-2,4-pentan diol, 2,3-butane diol, 2,3-pentane diol, 2,3-hexane diol, 2,3-heptane diol, 2,3-octane diol, 2,3-nonane diol, 2,3-decane diol, 2,3-undecane diol, 2,3-dodecane diol, 2,3-tridecane diol, and mixtures thereof. Preferably, the, one or two alkane diols is / are selected from the group consisting of 1,3- butylene glycol, 1,2-pentylene glycol, and mixtures thereof. Thus, it is preferred that the mixture comprising Dihydroavenanthramide D comprises i) Dihydroavenanthramide D, ii.a) 1,3-butylene glycol, and ii.b) pentylene glycol. It is preferred that the stabilizer or, respectively, stabilizer composition is mixed with the mixture comprising Dihydroavenanthramide D to obtain a stabilized mixture, wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of diethylhexyl syringylidene malo- nate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of sodium metabisulfite, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of Tris(tetramethylhydroxypiperidi- nol) citrate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of a mixture comprising two or all of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhy- droxypiperidinol) citrate. Preferably, the term “stabilized mixture” refers to a mixture comprising the stabilizer or, respectively, stabilizer composition and Dihydroavenanthramide D and optionally further components, as described herein, preferably one or more solvents. The term “stabilized” refers to the stabilization of Dihydroavenanthramide D, as described herein, i.e. to reduced discoloration and / or malodour formation. Preferably, the obtained stabilized mixture comprises 0.1 to 20 wt.-%, preferably 0.5 to 15 wt.-%, preferably 1 to 10 wt.-%, preferably 2.5 to 7.5 wt.-% of Dihydroavenanthramide D, based on the total weight of the stabilized mixture. It is preferred that the weight ratio of Dihydroavenanthramide D to sodium metabisulfite in the (stabilized) mixture is in range of from 1.000:1 to 1:1.000, preferably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. It is preferred that the weight ratio of Dihydroavenanthramide D to Tris(tetramethylhydrox- ypiperidinol) citrate in the (stabilized) mixture is in a range of from 1.000:1 to 1:1.000, pref- erably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. It is preferred that the weight ratio of Dihydroavenanthramide D to the summed weight of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypi- peridinol) citrate in the (stabilized) mixture is in a range of from 1.000:1 to 1:1.000, prefer- ably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. In case one or more of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate is not present in the (stabilized) mixture, its weight is considered as 0 for calculating the summed weight. The present invention further relates to a method for stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroavenanthramide D, comprising the steps a) providing a mixture comprising Dihydroavenanthramide D, b) providing a stabilizer or a stabilizer composition, wherein the stabilizer or, respec- tively, the or one or all stabilizer(s) of the stabilizer composition is / are selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof, c) mixing the components provided in step a) and in step b) (to obtain a stabilized mix- ture), wherein stabilizing Dihydroavenanthramide D refers to the prevention or reduction of dis- coloration of the mixture and / or to the prevention or reduction of malodour formation, and wherein the weight ratio of the stabilizer(s) to Dihydroavenanthramide D in the mixture obtained in step c) is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1. Preferably, providing the stabilizer or stabilizer composition in step b) includes dissolving the stabilizer or stabilizer composition or the, one, two, three or more or all stabilizer(s) of a stabilizer composition in a solvent. What was said above with regard to the use according to the invention applies accordingly. Particularly, what was said above with regard to the stabilizer or stabilizer composition or with regard to a stabilization applies accordingly. Preferably, the stabilizer or, respectively, the or one or all stabilizer(s) of the stabilizer com- position is / are selected from the group consisting of diethylhexyl syringylidene malonate, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is diethylhexyl syringylidene malonate. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is sodium metabisulfite. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is Tris(tetramethylhydroxypiperidinol) citrate. It is preferred that the weight ratio of the summed weight of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate to Dihydroavenanthramide D in the (stabilized) mixture obtained in step c) is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1. In case one or more of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate is not present in the (stabilized) mixture, its weight is considered as 0 for calculating the summed weight. Preferably, the mixture provided in step a) comprises i) Dihydroavenanthramide D, ii) one or more alkane diol(s). What was said above with regard to the alkane diol(s) applies accordingly. Particularly preferably, the mixture provided in step a) comprises i) Dihydroavenanthramide D, ii.a) 1,3-butylene glycol, and ii.b) pentylene glycol. Furthermore, it is preferred that after the mixing in step c), a stabilized mixture is obtained, wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of diethylhexyl syringylidene malo- nate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of sodium metabisulfite, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of Tris(tetramethylhydroxypiperidi- nol) citrate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of a mixture comprising two or all of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhy- droxypiperidinol) citrate. Preferably, the term “stabilized mixture” refers to a mixture comprising the stabilizer or, respectively, stabilizer composition and Dihydroavenanthramide D and optionally further components, as described herein, preferably one or more solvents. The term “stabilized” refers to the stabilization of Dihydroavenanthramide D, as described herein, i.e. to reduced discoloration and / or malodour formation. Preferably, the obtained stabilized mixture comprises 0.1 to 20 wt.-%, preferably 0.5 to 15 wt.-%, preferably 1 to 10 wt.-%, preferably 2.5 to 7.5 wt.-% of Dihydroavenanthramide D, based on the total weight of the (stabilized) mixture. It is preferred that the weight ratio of Dihydroavenanthramide D to sodium metabisulfite in the (stabilized) mixture is in range of from 1.000:1 to 1:1.000, preferably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. It is preferred that the weight ratio of Dihydroavenanthramide D to Tris(tetramethylhydrox- ypiperidinol) citrate in the (stabilized) mixture is in a range of from 1.000:1 to 1:1.000, pref- erably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. It is preferred that the weight ratio of Dihydroavenanthramide D to the summed weight of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypi- peridinol) citrate in the stabilized mixture is in a range of from 1.000:1 to 1:1.000, preferably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. In case one or more of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate is not present in the (stabilized) mixture, its weight is considered as 0 for calculating the summed weight. The present invention further relates to a mixture comprising i) Dihydroavenanthramide D, ii) one or more alkane diol(s), and iii) a stabilizer selected from the group consisting of diethylhexyl syringylidene malo- nate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof, wherein the weight ratio of the stabilizer(s) iii) to Dihydroavenanthramide D i) in the mixture is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1. What was said above with regard to the use and / or method according to the invention ap- plies accordingly. Preferably, the mixture according to the invention is a stabilized mixture, wherein Dihy- droavenanthramide D is stabilized in the mixture. Preferably, the mixture according to the invention is a stabilized mixture as described herein, wherein Dihydroavenanthramide D is stabilized in the mixture. Particularly, what was said above with regard to the stabilizer or stabilizer composition or with regard to a stabilization applies accordingly. Preferably, the stabilizer or, respectively, the or one or all stabilizer(s) of the stabilizer com- position is / are selected from the group consisting of diethylhexyl syringylidene malonate, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is diethylhexyl syringylidene malonate. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is sodium metabisulfite. Preferably, the stabilizer or, respectively, the or one stabilizer of the stabilizer composition is Tris(tetramethylhydroxypiperidinol) citrate. It is preferred that the weight ratio of the summed weight of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate to Dihydroavenanthramide D in the mixture is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1. In case one or more of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypi- peridinol) citrate is not present in the mixture, its weight is considered as 0 for calculating the summed weight. Particularly, what was said above with regard to the alkane diol(s) applies accordingly. It is thus preferred that the mixture comprises i) Dihydroavenanthramide D, ii.a) 1,3-butylene glycol, ii.b) pentylene glycol, and iii) a stabilizer selected from the group consisting of diethylhexyl syringylidene malo- nate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof. Preferably, the mixture comprises - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of di- ethylhexyl syringylidene malonate, based on the total weight of the stabilized mix- ture, and / or - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of so- dium metabisulfite, based on the total weight of the stabilized mixture, and / or - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of Tris(tetramethylhydroxypiperidinol) citrate, based on the total weight of the stabilized mixture, and / or - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of a mixture comprising two or all of diethylhexyl syringylidene malonate, sodium meta- bisulfite and Tris(tetramethylhydroxypiperidinol) citrate. Preferably, the mixture comprises 0.1 to 20 wt.-%, preferably 0.5 to 15 wt.-%, preferably 1 to 10 wt.-%, preferably 2.5 to 7.5 wt.-% of Dihydroavenanthramide D, based on the total weight of the mixture. It is preferred that the weight ratio of Dihydroavenanthramide D to sodium metabisulfite in the mixture is in range of from 1.000:1 to 1:1.000, preferably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more prefer- ably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. It is preferred that the weight ratio of Dihydroavenanthramide D to Tris(tetramethylhydrox- ypiperidinol) citrate in the mixture is in a range of from 1.000:1 to 1:1.000, preferably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. It is preferred that the weight ratio of Dihydroavenanthramide D to the summed weight of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypi- peridinol) citrate in the mixture is in a range of from 1.000:1 to 1:1.000, preferably in a range of from 500:1 to 1:250, further preferably in a range of from 400:1 to 1:100, especially preferably in a range of from 300:1 to 1:25, even further preferably in a range of from 200:1 to 1:1, more preferably in a range of from 175:1 to 2:1, particularly preferably in a range of from 150:1 to 5:1. In case one or more of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate is not present in the mixture, its weight is considered as 0 for calculating the summed weight. The present invention further relates to a cosmetic preparation comprising a mixture ac- cording to the invention. Cosmetic preparations, as described herein, are in particular preparations, which are suit- able for topical application to the skin of a human, in particular to achieve a cosmetic effect. Cosmetic preparations, as described herein, may further comprise one, two, three or more or all substances selected from the group consisting of odoriferous substances, perfume oils, fatty oils, fatty acids, ceramides, pseudoceramides, sterols, hydrocarbons phytoster- ols, anti-acne active ingredients, antidandruff active ingredients, antimicrobial active ingre- dients, preservatives, antiperspirants, anti-irritants, pruritus-relieving active ingredients, cooling active ingredients, antiaging active ingredients, skin-lightening and skin-tanning ac- tive ingredients, skin moisture regulators, osmolytes, enzyme inhibitors, odour absorbers, dyes, abrasives, anti-acne agents, anti-cellulitis agents, antidandruff agents, anti-inflam- matory agents, irritation-preventing agents, irritation-inhibiting agents, antioxidants, astrin- gents, perspiration-inhibiting agents, antiseptic agents, ant-statics, binders, buffers, carrier materials, chelating agents, cell stimulants, cleansing agents, care agents, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, softeners, emulsi- fiers, enzymes, essential oils, fibres, film-forming agents, fixatives, foam-forming agents, foam stabilizers, substances for preventing foaming, foam boosters, gelling agents, gel- forming agents, hair care agents, hair-setting agents, hair-straightening agents, moisture- donating agents, moisturizing substances moisture-retaining substances, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impreg- nating agents, dirtrepellent agents, friction-reducing agents, lubricants, moisturizing creams, ointments, opacifying agents, plasticizing agents, covering agents, polish, gloss agents, polymers, powders, proteins, re-oiling agents, abrading agents, silicones, skin- soothing agents, skin-cleansing agents, skin care agents, skin-healing agents, skin-light- ening agents, skin-protecting agents, skin-softening agents, hair promotion agents, cooling agents, skin-cooling agents, warming agents, skin-warming agents, stabilizers, UV- absorbing agents, UV filters, detergents, fabric conditioning agents, suspending agents, skin-tanning agents, thickeners, vitamins, oils, waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, a-hydroxy acids, polyhydroxyfatty acids, lique- fiers, dyestuffs, colour-protecting agents, pigments, anticorrosives, aromas, flavouring sub- stances, odoriferous substances, polyols, surfactants, electrolytes, organic solvents, and silicone derivatives. Preferably, the amount of Dihydroavenanthramide D in the preparation according to the invention is in the range of from 0.000005 to 2.5 wt.-%, preferably in the range of from 0.0000075 to 2 wt.-%, further preferably in the range of from 0.00001 to 1.5 wt.-%, espe- cially preferably in the range of from 0.000025 to 1.25 wt.-%, even further preferably in the range of from 0.00005 to 1 wt.-%, more preferably in the range of from 0.000075 to 0.75 wt.-%, particularly preferably in the range of from 0.0001 to 0.5 wt.-%, even more preferably in the range of from 0.00025 to 0.25 wt.-%, most preferably in the range of from 0.0005 to 0.1 wt.-%, based on the total weight of the preparation. Preferably, the summed weight of Dihydroavenanthramide D and the stabilizer selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof in the preparation is in a range of from 0.01 to 4 wt.-%, preferably in a range of from 0.05 to 3 wt.-%, further prefer- ably in a range of from 0.1 to 2 wt.%, based on the total weight of the cosmetic preparation. In case one or more of the above compounds is not present in the mixture, its weight is considered as 0 for calculating the summed weight. Preferably, the summed weight of Dihydroavenanthramide D and the stabilizer selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof, and alkane diol(s) in the preparation is in a range of from 0.01 to 4 wt.-%, preferably in a range of from 0.05 to 3 wt.- %, further preferably in a range of from 0.1 to 2 wt.%, based on the total weight of the cosmetic preparation. In case one or more of the above compounds is not present in the mixture, its weight is considered as 0 for calculating the summed weight. Preferably, the cosmetic preparation according to the invention is a rinse-off preparation. Preferably, the cosmetic preparation according to the invention is a leave-on preparation. What was said above with regard to the use and / or method and / or mixture according to the invention applies accordingly. Particularly, what was said above with regard to the stabilizer or stabilizer composition or with regard to a stabilization applies accordingly. Particularly, what was said above with regard to the alkane diol(s) applies accordingly. Fig.1 shows the results of Example 1 with the percentage b* values of mixtures 2 to 12 compared to mixture 1. Further aspects and advantages of the invention result from the subsequent description of preferred examples.

[0002] Examples Example 1: Comparing different stabilizers - discoloration Compositions A-M were prepared as described below and stored at 40°C and 50°C for 1 month. Composition A serves as a comparative sample. The color of all samples were measured by using chromametry (L*a*b* values) at test-start and after 1 month storage at the different temperatures. Based on this numbers, the overall discoloration (ΔE) was calculated. The following stabilizing ingredients were used: - Ascorbyl palmitate (Composition B) - Oxynex ST liquid (INCI: Diethylhexyl Syringylidene Malonate, Caprylic / Capric / Tri- glycerides, 90% AS) (Compositions C and D) - Tinogard TT (INCI Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate) (Compo- sitions E and F) - Tocopherol Acetate (Compositions G and H) - Covastyle MBS (INCI Sodium Metabisulfite) (Compositions I and K) - Tinogard Q (INCI Tris(Tetramethylhydroxypiperidinol) Citrate) (Compositions L and M) Table 1 Ingredient INCI A B C D E F Dihydroavenan- Hydroxyphenyl Pro- 5.0 5.0 5.0 5.0 5.0 5.0 thramide D pamidobenzoic Acid Hydrolite-5 green Pentylene Glycol 47.5 47.5 47.5 47.5 47.5 47.5 1,2-Butylenglycol Butylene Glycol 47.4 47.4 47.2 47.0 47.4 47.4 5 Ascorbylpalmitate Ascorbylpalmitate 0.1 - - - Oxynex ST Liquid Diethylhexyl Sy- - - 0.3 0.5 - - ex Merck ringyldenemalonate, Caprylic / Capric Tri- glyceride Tinogard TT Pentaerythrityl Tetra- - - - - 0.05 0.1 di-t-butyl Hydroxyhy- drocinnamate w / w% 100 100 100 100 100 100 Table 1 (continued) Ingredient INCIG H I K L MDihydroavenan- Hydroxyphenyl Pro- 5.0 5.0 5.0 5.0 5.0 5.0 thramide D pamidobenzoic Acid Hydrolite-5 green Pentylene Glycol 47.5 47.5 47.5 47.5 47.5 47.5 1,2-Butylenglycol) Butylene Glycol 47.2 47.0 47.4 47.4 47.4 47.3 5 Tocopherol ace- Tocopherolacetate 0.3 0.5 - - - - tate Covastyle MBS Sodium Metabisulfite - - 0.05 0.1 - - Tinogard Q Tris(Tetramethylhy- - - - - 0.1 0.2 droxypiperidinol) Cit- rate w / w% 100 100 100 100 100 100 Production Method (compositions A to M) Heat Butylene Glycol and Pentylene Glycol up to maximum 70°C and blend both ingredi- ents by stirring. Add respective stabilizer at 65 °C – 80°C and stir for 5 minutes at this temperature. Add Dihydroavenanthramide D at 60°C, stir for 30 min. Color determination (Lico 690 ex Hach Lange) The color of the samples were measured by using chromametry (L*a*b* values) at test- start and after 1 month storage at the different temperatures. Bases on this numbers the overall discoloration (ΔE) was calculated according to the fol- lowing formula: Color determination of samples E and F (containing Pentaerythrityl Tetra-di-t-butyl Hydrox- yhydrocinnamate) was not possible due to recrystallization directly after production. These samples were not stored, no further evaluation was performed. The following results were obtained: 40 °C A B C D G H I K L M L* value (brightness) Start 99.6 99.8 98.8 99.3 99.1 99.5 99.6 99.3 99.1 98.8 1 month 100.1 99.2 99.4 99.3 97.9 98.7 99.6 99.7 99.4 99.3 ΔL* 0.5 -0.6 0.6 0 -1.2 -0.8 0 0.4 0.3 0.5 a* value (red / green) Start -0.2 -0.8 -1.3 -1.9 -0.2 -0.3 -0.3 -0.3 -0.3 -0.2 1month-0.8 -2.6 -1.5 -2 -1.6 -0.9 -0.4 -0.5 -0.4 -0.5 Δa* -0.6 -1.8 -0.2 -0.1 -1.4 -0.6 -0.1 -0.2 -0.1 -0.3 b* value (blue / yellow) Start 1.5 1.5 3.5 4.4 2 1.8 1.5 1.9 2.2 2.8 1 month 4.3 8.1 4.5 5.4 8.3 5.1 1.8 2.1 2.5 3.2 Δb* 2.8 6.6 1 1 6.3 3.3 0.3 0.2 0.3 0.4 ΔE value ΔE2.9 5.5 1.2 1 6.6 3.5 0.3 0.5 0.4 0.7 50°C A B C D G H I K L M L* value (brightness) Start 99.6 99.8 98.8 99.3 99.1 99.5 99.6 99.3 99.1 98.8 1 month 97.2 96.7 97.7 98.2 94.4 95.8 99.3 99.2 99 98.5 ΔL* -2.4 -3.1 -1.1 -1.1 -4.7 -3.7 -0.3 -0.1 -0.1 -0.3 a* value (red / green) Start -0.2 -0.8 -1.3 -1.9 -0.2 -0.3 -0.3 -0.3 -0.3 -0.2 1 month -4.4 -4.4 -2.1 -2.6 -4.9 -3.6 -0.6 -0.7 -0.8 -0.9 Δa* -4.2 -3.6 -0.8 -0.7 -4.7 -3.3 -0.3 -0.4 -0.5 -0.7 b* value (blue / yellow) Start 1.5 1.5 3.5 4.4 2 1.8 1.5 1.9 2.2 2.8 1 month 19.3 18.3 9.2 9.6 26.5 17.1 2.2 2.6 4.3 5.7 Δb* 17.8 16.8 5.7 5.2 24.5 15.3 0.7 0.7 2.1 2.9 ΔE value ΔE 18.4 16.1 5.9 5.4 25.4 16.1 0.8 0.8 2.2 3 The above data reveal that compositions C and D (including diethylhexyl syringylidene ma- lonate), I and K (including sodium metabisulfite), and L and M (including Tris(tetramethylhy- droxypiperidinol) citrate) provided much lower discoloration after 1 month of storage, indi- cating much more stable compositions than composition B (including ascorbyl palmitate), composition G and H (including tocopherol acetate) or composition A (including no stabi- lizer). Example 2: Comparing different stabilizers – malodour formation Compositions A, B, C, G, I, and L were prepared as described in Example 1. The compositions were stored at 22 °C for 1 month. Subsequently, the malodour intensity was evaluated by a trained panel of 4 panellists (P1 to P4), using a scale from 0 to 10 with 0 = no malodour and 10 = intense malodour. The following results were obtained: PanellistA B C G I LP1 5 5 2 2 4 1 P2 3 3 2 3 2 1 P3 4 3 4 4 4 3 P4 4 4 2 3 3 2 Average 4.0 3.75 2.5 3.0 3.25 1.75 The above data reveal that compositions C (including diethylhexyl syringylidene malonate), I (including sodium metabisulfite), and L (including Tris(tetramethylhydroxypiperidinol) cit- rate) provided much lower malodour formation after 1 month of storage, indicating much more stable compositions than composition B (including ascorbyl palmitate), composition G and H (including tocopherol acetate) or composition A (including no stabilizer). A particularly low malodour formation was observed for compositions C (including dieth- ylhexyl syringylidene malonate), and L (including Tris(tetramethylhydroxypiperidinol) cit- rate). Example 3: Optimum ratio of stabilizer and Dihydroavenanthramide D wt.-% INCI 1 2 3 4 5 6 Dihydroavenanthramide D 5 5 5 5 5 5 Pentylene Glycol 47.5 47.5 47.5 47.5 47.5 47.5 1,3-butylene glycol 47.5 47.49 47.45 47.4 47.3 47.2 Diethylhexyl Syringyldenemalonate 0 0.01 0.05 0.1 0.2 0.3 Weight ratio of Diethylhexyl Sy- ringyldenemalonate to Dihy- 0 0.002 0.01 0.02 0.04 0.06 droavenanthramide D Sum 100 100 100 100 100 100 wt.-% INCI 7 8 9 10 11 12 Dihydroavenanthramide D 5 5 5 5 5 5 Pentylene Glycol 47.5 47.5 47.5 47.5 47.5 47.5 1,3-butylene glycol 47.1 47 46.5 46 45.5 45 Diethylhexyl Syringyldenemalonate 0.4 0.5 1 1.5 2 2.5 Weight ratio of Diethylhexyl Sy- ringyldenemalonate to Dihy- 0.08 0.1 0.2 0.3 0.4 0.5 droavenanthramide D Sum 100 100 100 100 100 100 The mixtures 1 to 14 above were prepared by providing the 1,3-butylene glycol and heating it up to 70 °C. Pentylene glycol was then added while stirring. The diethylhexyl sy- ringyldenemalonate was added at 65 °C and stirred for 5 min at this temperature. The Di- hydroavenanthrmaide D was then added at 60 °C and it was stirred for 30 min. The mixtures were then stored at 50 °C for 1 month. After 1 month, the b* values were measured. It was surprisingly found that the best outcome was observed when the weight ratio of Diethylhexyl Syringyldenemalonate to Dihydroavenanthramide D was higher than 0.01 and lower than 0.2, as also shown in Fig.1: 1 2 3 4 5 6 Weight ratio 0 0.002 0.01 0.02 0.04 0.06 b* value 12,5 12,3 11,5 7,4 6,7 7,1 Δb* value#--- -0,2 -1 -5,1 -5,8 -5,4 % of mixture 1 --- 98,4% 92,0% 59,2% 53,6% 56,8% # compared to mixture 1 7 8 9 10 11 12 Weight ratio 0.08 0.1 0.2 0.3 0.4 0.5 b* value 7,3 5,9 9,5 10,5 11,3 12,1 Δb* value#-5,2 -6,6 -3 -2 -1,2 -0,4 % of mixture 1 58,4% 47,2% 76,0% 84,0% 90,4% 96,8% # compared to mixture 1 Application Examples: PERFUME OILS Table 2: Composition of perfume oil 1 (PO1, Amounts in ‰ b.w.) Ingredients Amount ALDEHYDE C14 SO-CALLED 2 ALLYL AMYL GLYCOLATE 10% DPG 5 ANISIC ALDEHYDE PURE 5 APPLE OLIFFAC TYPE 10 BENZYLACETATE 50 BERGAMOT IDENTOIL® COLOURLESS 15 CANTHOXAL 5 CETALOX 10% IPM 3 CITRONELLOL 950 40 DAMASCENONE TOTAL 1% DPG 5 DAMASCONE ALPHA 10% DPG 5 DAMASCONE DELTA 10% DPG 2 DIMETHYL BENZYL CARBINYL BUTYRATE 2 DIPROPYLENE GLYCOL 178 EBANOL 2 ETHYL DECADIENOATE TRANS CIS-2,410% IPM 2 FLOROSA 5 FRAMBINON® 10% DPG 7 GALAXOLIDE 50% IN IPM 100 GALBEX TYPE BASE 1 GERANYL ACETATE PURE 2 HEDIONE 30 HELIOTROPIN 10 HEXENYL ACETATE CIS-310% DPG 1 HEXENYL SALICYLATE CIS-3 5 HEXYL CINNAMIC ALDEHYDE ALPHA 70 HEXYL SALICYLATE 50 HYDROXY CITRONELLAL 10 ISO E SUPER 15 ISORALDEINE 70 20 LEAFOVERT® 1 LILIAL 60 LINALOOL 60 LINALYL ACETATE 20 LYRAL 7 MANZANATE 2 PHENOXANOL 7 PHENYLETHYL ALCOHOL 120 SANDAL MYSORE CORE 2 SANDRANOL® 7 STYRALYL ACETATE 3 TAGETES RCO 10% TEC 2 TERPINEOL PURE 20 TETRAHYDROGERANIOL 10% DPG 5 TONALIDE 7 VERTOCITRAL 10% DPG 5 VERTOFIX 15 Total 1000 Table 3: Composition of perfume oil 2 (PO2, Amounts in ‰ b.w.) Ingredients Amount Acetophenone, 10% in DPG 10 n-Undecanal 5 Aldehyde C14, so-called (peach aldehyde) 15 Allylamyl glycolate, 10% in DPG 20 Amyl salicylate 25 Benzyl acetate 60 Citronellol 80 d-Limonene 50 Decenol trans-9 15 Dihydromyrcenol 50 Dimethylbenzylcarbinyl acetate 30 Diphenyloxide 5 Eucalyptol 10 Geraniol 40 Nerol 20 Geranium oil 15 Hexenol cis-3, 10% in DPG 5 Hexenyl salicylate cis-3 20 Indole, 10% in DPG 10 Alpha-ionone 15 Beta-ionone 5 Lilial®(2-methyl-3-(4-tert-butyl-phenyl)propanal) 60 Linalool 40 Methylphenyl acetate 10 Phenylethyl alcohol 275 Styrolyl acetate 20 Terpineol 30 Tetrahydrolinalool 50 Cinnamyl alcohol 10 Total: 1000 Table 4: Composition of perfume oil 3 (PO3, Amounts in ‰ b.w.) Ingredients Amount Benzyl acetate 60 Citronellyl acetate 60 Cyclamenaldehyde (2-methyl-3-(4-isopropylphenyl)propanal 20 Dipropylene glycol (DPG) 60 Ethyllinalool 40 Florol (2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol) 30 Globanone®[(E / Z)-8-cyclohexadecen-1-one] 180 Hedione®(methyldihydrojasmonate) 140 Hexenyl salicylate, cis-3 10 Vertocitral (2,4-dimethyl-3-cyclohexenecarboxaldehyde) 5 Hydratropaldehyde, 10% in DPG 5 Isodamascone (1-(2,4,4-trimethyl-2-cyclohexen-1-yl)-2-buten-1- 5 one, 10% in DPG Isomuscone (cyclohexadecanone) 40 Jacinthaflor (2-methyl-4-phenyl-1,3-dioxolane) 10 Cis-jasmone, 10% in DPG 20 Linalool 50 Linalyl acetate 30 Methyl benzoate, 10% in DPG 25 para-Methyl cresol, 10% in DPG 10 Nerol 20 Phenylpropylaldehyde 5 2-Phenylethyl alcohol 82 Tetrahydrogeraniol 13 2,2-Dimethyl-3-cyclohexyl-1-propanol 80 Total: 1000 Table 5: Composition of perfume oil 4 (PO4, Amounts in ‰ b.w.) Ingredients Amount AMBRETTOLIDE (MACRO) 10 AMBROXIDE 10% in IPM 10 BENZYL ACETATE 20 BENZYL SALICYLATE 15 BERGAMOT OIL. bergapten-free 60 CALONE®195110% in DPG 15 COUMARIN 5 CYCLOGALBANATE®10% in DPG 10 ALPHA -DAMASCONE 1% in DPG 20 DIHYDROMYRCENOL 10 ETHYL LINALOOL 75 ETHYL LINALYLACETATE 50 ETHYL MALTOL 1% in DEP 10 ETHYLENE BRASSYLATE (MACRO) 80 FLOROSA 40 GERANYLACETATE 10 HEDIONE®HC / 30 35 HEDIONE®210 HELIONAL®15 HELVETOLIDE®(ALICYC) 30 HEXENYLSALICYLATE CIS-3 20 ISO E SUPER®40 LEAFOVERT®10% in DEP 10 LILIAL®80 LYRAL®20 MANDARIN OIL 10 STYRALYL ACETATE 5 SYMROSE®15 VANILLIN 10% in DEP 20 DIPROPYLENE GLYCOL (DPG) 50 TOTAL 1000 Table 6: Composition of perfume oil 5 (PO5, Amounts in ‰ b.w.) Ingredients Amount AMAROCITE®10 AMBROCENIDE®10% in DPG 5 AMBROXIDE 15 AURELIONE®(7 / 8-Cyclohexadecenone) (MACRO) 70 BERGAMOT OIL. bergapten-free 90 CALONE®195110% in DPG 20 CARAWAY OIL 10 CITRAL 20 COUMARIN 10 ALPHA-DAMASCONE 1% in DPG 15 DIHYDROMYRCENOL 70 ESTRAGON OIL 10 ETHYL LINALOOL 100 ETHYL LINALYLACETATE 90 EUGENOL 10 EVERNYL®5 FRUCTATE®5 GERANIUM OIL 5 HEDIONE®HC / 30 100 HELIONAL®10 INDOLE 10% in DPG 5 ISO E SUPER®100 KEPHALIS®5 LAVENDER OIL 40 CITRUS OIL 80 LILIAL®30 MANDARIN OIL 20 MUSCENONE (MACRO) 5 SANDRANOL®10 VANILLIN 10% in DPG 5 DIPROPYLENE GLYCOL 30 TOTAL 1000 The perfume oils PO1, PO2, PO3, PO4, or PO5 from the above examples were separately added into the formulations as presented below. Cosmetic formulations (compositions) - amounts are indicated as % by weight for all formulations. Energy Concentrate Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 Sodium Metabisulfite Sodium Metabisulfite 0.01 Pemulen™ TR-2 Polymeric Emul- Acrylates / C10-30Alkyl Acrylate Crosspoly- sifier mer 0.5 Glycerin 99.5% Glycerin 2.0 SymVital®AR 3040 Zinbiber officinale (ginger) root extract 0.1 SymFinity®1298 Echinacea purpurea extract 0.5 Aqua,Glycerin, Citrus aurantium dulcis Extrapone®Orange (Organic) GW juice 1.0 Aqua, Coffea Arabica Seed Extract, Actipone®Black Coffee GW Coffea Robusta Seed Extract 0.5 Aqua, Pentylene Glycol, Sodium Lauryl Sulfoacetate, Sodium Oleoyl Sarcosinate, 3.0 SymSol®PF-3 Sodium Chloride, Sodium Oleate Hexyldecanol, Bisabolol, Cethylhydroxy- proline Palmitamide, Stearic acid, Bras- 0.2 SymRepair®100 sica Campestris (Rapeseed) sterols Tocopherol Alpha DL Tocopherol 0.2 Pentylene Glycol, Butylene Glycol, Hy- droxyphenyl Propamidobenzoic Acid, Di- Blend 1 with Hydroxyphenyl Pro- ethylhexyl Syringylidenemalonate, 1.0 pamidobenzoic Acid Caprylic / Capric Triglyceride Hydrolite®5 green Pentylene Glycol 5.0 Perfume oil PO1, Parfum 0.1 Sodium Hydroxide, 10% solution Aqua, Sodium hydroxide 1.5 Natural Beauty Enhancer (Solid concentrate) Ingredients EU INCI Amount Mango Butter Mangifera indica Seed Butter Ad 100 Beeswax White Cera Alba 14.0 Carnauba Wax LC Organic Copernicia Cerifera (Carnuba) Wax 6.0 Rice Bran Wax Oryza Sativa (Rice) Bran Wax 6.0 ImerCare®Pharma 00T Talc 2.0 Hydrolite®5 green Pentylene Glycol 2.0 Pentylene Glycol, Butylene Glycol, Hy- droxyphenyl Propamidobenzoic Acid, Blend 2 with Hydroxyphenyl Pro- Tris(Tetramethylhydroxypiperidinol) Cit- 0.5 pamidobenzoic Acid rate, Aqua, Alcohol Benzyl Alcohol Benzyl Alcohol 0.5 SymReboot™ L19 Maltodextrin, Lactobacillus Ferment 0.5 Prunus Amygdalus Dulcis (Sweet Almond) Sweet Almond Oil (Organic) oil 26.0 SymVital®AR 3040 Zingiber officinale (Ginger) Root Extract 0.2 Tocopherol Alpha DL Tocopherol 0.5 SymLite®G8 Glyceryl Caprylate 0.5 Argan Oil Argania Spinosa Kernel Oil 1.0 Perfume oil PO2 Parfum 0.5 Solid Body Oil Ingredients EU INCI Amount Glyceryl Isostearate Caprylic / Capric Gly- Ethox 4075 cerides 27.8 Sodium Stearate Sodium Stearate 2.8 SymMollient®S green Cetearyl Nonanoate 3.0 SymMollient®PDCC Propanediol Dicaprylate / Caprate 10.0 PCL-Liquid®100 Cetearyl Ethylhexanoate 7.5 Isodragol Triisononanoin 5.0 Caprylic / Capric Trigylceride Caprylic / Capric Triglyceride Ad 100 Caprylic / Capric Triglyceride, Hy- SymDecanox™ HA droxymethoxyphenyl Decanone 0.5 Tocopherol Alpha DL Tocopherol 0.1 Pentylene Glycol, Butylene Glycol, Hy- droxyphenyl Propamidobenzoic Acid, Blend 2 with Hydroxyphenyl Pro- Tris(Tetramethylhydroxypiperidinol) Cit- 1.3 pamidobenzoic Acid rate, Aqua, Alcohol Hydrolite®5 green Pentylene Glycol 1.0 SymSave®H Hydroxyacetophenone 0.1 SymFit®1617 Trimethylcyclohexyl Butylcarbamate 0.2 Perfume oil PO4 Parfum 0.3 Sensi-SCALP (Green Solid Shampoo) Ingredients EU INCI Amount AMISOFT®MS-11 Sodium Myristoyl Glutamate 30.0 ELFAN®AT 84 Sodium cocoyl Isethionate 15.0 ImerCare®02K-S Kaolin 18.8 Hydrolite®5 green Pentylene Glycol 1.5 Dragosantol®100 Bisabolol 0.1 Potassium Sorbate Potassium Sorbate 0.3 Aqua / Water Aqua Ad 100 Caprylic / Capric Triglyceride, Hy- SymDecanox™ HA droxymethoxyphenyl decanone 1.5 Alpha Tocopherol DL Tocopherol 0.5 Cetiol®SB45 Butyrospermum parkii butter 13.0 Aqua, Glycerin, Aspalathus Linearis leaf Extrapone®Rooibus GW extract 1.0 SymReboot™ L19 Maltodextrin, Lactobacillus Ferment 0.5 Pentylene Glycol, Butylene Glycol, Hy- droxyphenyl Propamidobenzoic Acid, Blend 2 with Hydroxyphenyl Pro- Tris(Tetramethylhydroxypiperidinol) Cit- 1.8 pamidobenzoic Acid rate, Aqua, Alcohol Glycine soja oil, Gossypium herbaceum seed oil, mangifera idica seed butter, olea europaea fruitoil, persea gratissima oil, 1.0 prununs amygdalus dulcis (sweet almond) SymOleo®Vita7 oil, Theobroma cacao seed butter Perfume oil PO1 Parfum 1.2 Advanced Lifting serum Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 SymSave®H Hydroxyacetophenone 0.5 Dragosine®Carnosine 0.1 Sodium Metabisulftie Sodium Metabisulfite 0.025 Aqua, Glycerin, Hydrolyzed Pearl, Xan- Extrapone®Pearl GW than Gum 0.5 Ammonium Acryloyoldimethyltaurate / VP Aristoflex®AVC Copolymer 0.6 PCL-Solid Stearyl Heptanote, Stearyl Caprylate 3.5 Brazilian Nut Oil, refined Bertholletia Excelsa Seed Oil 1.0 Isodragol®Triisononanoin 3.0 PCL-Liquid®100 Cetearyl Ethylhexanoate 5.0 Xiameter PMC-200 Silicone Fluid 350 CS Dimethicone 1.0 Frescolat®X-Cool Menthyl Ethylamido Oxalate 1.0 Caprylic / Capric Trigylceride, Hy- SymDecanox™ HA droxymethoxyphenyl Decanone 1.0 Pentylene Glycol, Butylene Glycol, Hy- droxyphenyl Propamidobenzoic Acid, Di- Blend 1 with Hydroxyphenyl Pro- ethylhexyl Syringylidenemalonate, 1.6 pamidobenzoic Acid Caprylic / Capric Triglyceride Glyceryl Oleate Citrate, Caprylic / Capric Dracorin®GOC Trigylceride 1.0 SunPURO®Pearl Silver C80- 1608 Titanium Dioxide, Mica 0.5 Perfume oil PO5 Parfum 0.3 Perfect Hand with exp. SPF 15, UVA / UVB Balanced Raw material INCI Amount Emulsiphos®Potassium cetyl phosphate 1.5 Hydrogenated palm glycerides Lanette®O Cetearyl alcohol 1.0 Tegosoft®MM Myristyl myristate 0.5 Neo Heliopan®OS Ethylhexyl salicylate 5.0 Edeta®BD Disodium EDTA 0.1 Dragoxat®89 Ethylhexyl isononanoate 2.0 Isoadipate Diisopropyl adipate 6.0 PCL-Liquid®100 Cetearyl ethylhexanoate 3.0 Corapan®TQ Diethylhexyl 2,6-naphthalate 2.0 Cetiol®SB 45 Butyrospermum parkii butter 1.5 SymBright™ 2036 Sclareolide 0.2 SymDecanox™ HA Caprylic / capric triglyceride, Hydroxymeth- 1.0 oxyphenyl decanone SymCare®O Hexyldecanol, Pentylene glycol, 4-t-butyl- 2.0 cyclohexanol, Bisabolol, Cetylhydroxypro- line palmitamide, Hydroxyphenyl pro- pamidobenzoic acid, Stearic acid, Bras- sica campestris (rapeseed) sterols, Zingi- ber officinale (ginger) root extract SymDetox®3,3,5-trimethylcyclohexyl succinate dime- 0.5 thylamide Pentylene Glycol, Butylene Glycol, Hy- 0.3 droxyphenyl Propamidobenzoic Acid, Di- Blend 1 with Hydroxyphenyl Pro- ethylhexyl Syringylidenemalonate, pamidobenzoic Acid Caprylic / Capric Triglyceride Alpha Tocopherol DL Tocopherol 0.2 Genuvisco®Carrageenan CG- Carrageenan 0.4 131 Keltrol®CG-SFT Xanthan gum 0.2 Aqua / Water Aqua Ad 100 Neo Heliopan®Hydro Phenylbenzimidazole sulfonic acid 2.5 Biotive®L-Arginine Arginine 1.0 Sodium Hydroxide 10% solution Aqua 1.3 Sodium hydroxide Glycerin Glycerin 2.0 SymSave®H Hydroxyacetophenone 0.5 SymDiol®68 1,2-hexanediol, Caprylyl glycol 0.5 RonaFlair®Flawless Silica 1.5 CI 77892 CI 77491 Extrapone®Moroccan Rose GW Aqua, Glycerin, Peg-40 hydrogenated 1.0 castor oil, Rosa damascena flower extract Tego®Feel C10 Cellulose 1.5 Perfume oil PO2 Parfum 0.5 Warming Mineral Mask Ingredients EU INCI Amount Glycerin Glycerin 3.0 Keltrol®CG-SFT Xanthan Gum 0.3 Aqua / Water Aqua Ad 100 Sodium Gluconate Sodium Gluconate 0.2 Sodium Metabisulfite Sodium Metabisulfite 0.05 Perfume Oil PO3 Fragrance 0.1 Kaolin Kaolin 10.0 Bentonite Bentonite 5.0 Dracorin®CE Glyceryl Stearate Citrate 2.0 Lanette®O Cetearyl Alcohol 1.7 Brij™ 72 Steareth-2 0.8 SymMollient®S green Cetearyl Nonanoate 1.0 Mango Butter Mangifera Indica Seed Butter 0.8 Alpha Tocopherol DL Tocopherol 0.2 Caprylic / Capric Trigylceride, Hy- SymDecanox™HA droxymethoxyphenyl Decanone 0.1 SymClariol®Decylene Glycol 0.25 SymSave®H Hydroxyacetophenone 0.5 Hydrolite®5 green Pentylene Glycol 4.0 Citric Acid, 30% solution Aqua, Citric Acid 0.07 SymVital®AR 3040 Zingiber officinale (Ginger) Root Extract 0.15 Vanillyl Butyl Ether, 1,2-Hexanediol, Thermolat®Capryly Glycol 0.3 Perfume oil PO1 Parfum 0.3 Extrapone Charcol®G CA Glycerin, Charcoal Powder 5.0 Extrapone®Coconut Water GW Aqua, Glycerin, Cocos Nucifera fruit Juice 10.0 Pentylene Glycol, Butylene Glycol, Hy- Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- 0.8 rate, Aqua, Alcohol Colour I 0.8 Colour II 4.0 Sheet mask Ingredients EU INCI Amount EDTA NA2 Disodium EDTA 0.1 Aqua / Water Aqua Ad 100 SymSave®H Hydroxyacetophenone 0.5 Glycerin Glycerin 5.0 Sepimax™ZEN Polyacrylate crosspolymer-6 0.4 Hydrolite®5 green Pentylene Glycol 3.0 Dragosine®Carnosine 0.2 Aqua, Glycerin, 1,2-Hexanediol, Caprylyl SymGlucan®Glycol, Beta-Glucan 4.0 Pentylene Glycol, Butylene Glycol, Hy- Blend 1 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, Di- pamidobenzoic Acid ethylhexyl Syringylidenemalonate, 2.0 Caprylic / Capric Triglyceride Extrapone®Glacier Water GW Glycerin, Aqua 1.0 Perfume oil PO3 Parfum 0.15 Alpha Tocopherol DL Tocopherol 0.1 Hydrolite®7 green 1,2 Heptanediol 0.7 Dragosantol®100 Bisabolol 0.05 PEG-40 Hydrogenated castor oil, Tride- Solubilizer ceth-9, Aqua 1.0 Citric acid 50% sol Aqua, Citric acid 0.12 After Shave Tonic Ingredients INCI Amount Water (Aqua), Pentylene Glycol, Sodium SymSol®PF-3 Lauryl Sulfoacetate, Sodium Oleoyl Sar- cosinate, Sodium Chloride, Disodium Sul- 3.0 foacetate, SodiumOleate, Sodium Sulfate SymSitive®1609 Pentylene Glycol, 4-t-Butylcyclohexanol 1.0 Sodium Metabisulfite Sodium Metabisulfite 0.04 Frescolat®ML Menthyl Lactate 0.3 Glycerol 99,5%. Glycerol 5.0 Water Water (Aqua) ad 100 Extrapone®Glacier Water GW Glycerol, Water (Aqua) 1.0 Pentylene Glycol, Butylene Glycol, Hy- Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- 0.5 rate, Aqua, Alcohol Dragosine®Carnosine 0.1 Hydrolite®5 green Pentylene Glycol 5.0 Ethanol 96 % Alcohol Denat. 5.0 Colour Pigment Colour Pigment 0.05 Perfume oil PO3 Parfum 0.15 Alpha Tocopherol DL Tocopherol 0.2 After Sun Refreshing Gel Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 Hydrolite®5 green Pentylene Glycol 2.5 SymSave®H Hydroxyacetophenone 0.5 Panthenol 75W Panthenol 0.5 1,3 Butylene Glycol Butylene Glycol 3.0 Glycerin 99,5% Glycerin 2.0 DragoCalm®Aqua, Glycerin, Avena sativa kernel extract 1.5 SymGlucan®Aqua,Glycerin, 1,2-Hexanediol, Caprylyl 5.0 Glycol, Beta-Glucan Dragosine®Carnosine 0.1 Acrylates / C10-30 Alkyl Acrylate Crosspol- Carbopol®Ultrez 21 Polymer ymer 0.4 PEG-40 Hydrogenated castor oil, Tride- Solubilizer ceth-9, Propylene Glycol, Aqua 1.5 SymMollient®W / S Trideceth-9, PEG-5 Isononanoate, Aqua 1.0 SymBright®2036 Sclareolide 0.1 SymSitive®1609 Pentylene Glycol, 4-t-Butylcyclohexanol 1.0 SymUrban®Benzylidene Dimethoxydimethylidanone 0.15 Pentylene Glycol, Butylene Glycol, Hy- Blend 1 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, Di- pamidobenzoic Acid ethylhexyl Syringylidenemalonate, 1.0 Caprylic / Capric Triglyceride Frescolat®ML Cryst Menthyl Lactate 0.3 Perfume oil PO2 Parfum 0.05 Sodium Hydroxide 10% solution Aqua, Sodium hydroxide 0.8 Colour 0.4 Aqua, Propylene Glycol, cucumis sativus Extrapone®Cucumber CL (Cucumber) Juice 1.0 SymFinity®1298 Echinacea Purpurea Extract 0.06 Flash SOS Aloe Gelée Ingredients EU INCI Amount Dracorin®GOC Glyeryl Oleate Citrate, Caprylic / Capric Tri- 0.6 glyceride SymMollient®PDCC Propanediol Dicaprylate / Caprate 6.0 Dragoxat®89 Ethylhexyl Isononanoate 5.0 Pentylene Glycol, Butylene Glycol, Hy- 2.0 Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- rate, Aqua, Alcohol PCL-Liquid®100 Cetearyl Ethylhexanoate 1.5 Frescolat®X-Cool Menthyl Ethylamido Oxalate 1.0 SymRelief®100 Bisabolol, Zingiber Officinale Root Extract 0.1 SymDecanox™HA Caprylic / Capric Triglyceride, Hy- 0.8 droxymethoxyphenyl Decanone Alpha Tocopherol DL Tocopherol 0.1 Carbopol®Ultrez 20 Polymer Acrylates / C10-30 Alkyl Acrylate Crosspol- 0.4 ymer Aqua / Water Aqua Ad 100 Glycerin Glycerin 3.0 Sodium Metabisulfite Sodium Metabisulfite 0.01 SymMollient®W / S Trideceth-9, PEG-5 Isononanoate, Aqua 1.0 SymDiol®68 1,2-Hexanediol, Caprylyl Glycol 0.5 SymSave®H Hydroxyacetophenone 0.5 Aloe Vera Gel Concentrate Aloe Barbadensis Leaf Juice 1.5 Sodium Hydroxide 10% solution Aqua, Sodium hydroxide 0.7 Perfume oil PO1 Parfum0.5Color 0.03 Intimate Sensi-Gel Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 Sodium Benzoate Sodium benzoate0.3Keltrol®CG-T Xanthan Gum0.2Cyamopsis Tetragonolobus Gum Cyamopsis Tetragonolobus Gum0.1Glycerin Glycerin 4.0 Tego®Betain F50 Cocamidopropyl betaine14.0PEG-40 Hydrogenated castor oil, Tride- ® 3.0 Solubilizer ceth-9, Propylene Glycol, Aqua Hydrolite®7 green 1,2 Heptanediol0.5Hydrolite®6 1,2 Hexanediol1.0Phenylpropanol, o-cymen-5-ol, Decylene SymGuard®CD Glycol 0.3 SymRelief®100 Bisabolol, Zingiber officinale root extract0.1Perfume oil PO2 Parfum0.2Frescolat®X-cool Menthyl ethylamido oxalate 0.4 Frescolat®Plus Menthol, Menthyl Lactate 0.3 Plantacare 2000 UP Decyl Glucoside 2.0 Pentylene Glycol, Butylene Glycol, Hy- Blend 1 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, Di- pamidobenzoic Acid ethylhexyl Syringylidenemalonate, 1.2 Caprylic / Capric Triglyceride Lactic acid 90% Nat. Lactic Acid, Aqua0.3Mild feminine wash Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 SymSave®H Hydroxyacetophenone 0.5 Keltrol CG-T Xanthan Gum 0.5 Sodium Metabisulfite Sodium Metabisulfite 0.02 Glycerin Glycerin 2.0 Propylene Glycol Propylene Glycol 3.0 Tego Betain F50 Cocamidopropyl betaine 14.0 Phenylpropanol, o-cymen-5-ol, Decylene SymGuard®CD Glycol 0.3 Frescolat®ML nat Menthyl Lactate 0.2 Plantacare®2000 UP Decyl Glucoside 2.0 Glycerin, Aqua, Hamamelis Virginiana Extrapone®Witch Hazel GW Bark / -Leaf / Twig Extract 1.0 PEG-40 Hydrogenated castor oil, Tride- Solubilizer ceth-9, Propylene Glycol, Aqua 1.5 Perfume oil PO4 Parfum 0.2 Blend 1 with Pentylene Glycol, Butylene Glycol, Hy- Hydroxyphenyl Propamidobenzoic droxyphenyl Propamidobenzoic Acid, Di- Acid ethylhexyl Syringylidenemalonate, Caprylic / Capric Triglyceride 1.0 Lactic acid 90% Nat. Lactic Acid, Aqua 0.32 Intimate Rescue Gel Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 SymSave®H Hydroxyacetophenone 0.3 Keltrol CG-T Xanthan Gum 0.3 Genuvisco®CG-131 Carrageenan 0.2 Glycerin Glycerin 4.0 Tego®Betain F50 Cocamidopropyl betaine 14.0 Sodium Hydroxide 10% solution Aqua, Sodium hydroxide 1.0 PEG-40 Hydrogenated castor oil, Tride- Solubilizer ceth-9, Propylene Glycol, Aqua 3.0 Hydrolite®6 1,2-Hexanediol 1.0 Phenylpropanol, o-cymen-5-ol, Decylene SymGuard®CD Glycol 0.3 Pentylene Glycol, Butylene Glycol, Hy- Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- 1.0 rate, Aqua, Alcohol Perfume oil PO1, PO2, PO3, PO4, or PO5 Parfum 0.2 Frescolat®MGA Plus Menthone Glycerin Acetal, Menthol 0.5 Plantacare 2000 UP Decyl Glucoside 2.0 Men After Shave Fluid Ingredients EU INCI Amount Water demin Aqua Ad 100 Glycerin Glycerin 3.00 Dermosoft®1388 Water, Glycerin, Sodium Levulinate, 3.00 Sodium Anisate Tego®Care CG90 Cetearyl Glucoside 1.00 Covathick 2009 Microcrystalline Cellulose, Cellulose Gum 0.50 Cutina®GMS V Glyceryl Stearate 1.00 Coconut Oil refined, organic Cocos Nucifera (Coconut) Oil 10.00 Dermofeel®BGC Butylene Glycol Dicaprylate / Dicarate 5.00 Keltrol®CG-SFT Xanthan Gum 0.30 Genuvisco®CG-131 Carrageenan 0.30 Citric acid solution 10% Water, citric acid 1.70 Ethanol Alcohol 5.00 Perfume oil PO3 Parfum 0.50 Dragosantol®100 Bisabolol 0.2 Frescolat®X-cool Menthyl Ethylamido oxalate 1.0 Pentylene Glycol, Butylene Glycol, Hy- 2.0 Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- rate, Aqua, Alcohol Anti-Wrinkle Night Emulsion Raw material INCI Amount Emulsiphos®Potassium cetyl phosphate 2.5 Hydrogenated palm glycerides Dragoxat®89 Ethylhexyl isononanoate 2.0 PCL-Liquid®100 Cetearyl Ethylhexanoate 2.0 Hexyldecanol, Bisabolo, Cetylhydroxypro- 2.5 SymRepair®100 line Palmitade, Stearic Acid, Brassica Campestris (Rapeseed) Sterols Caprylic / Capric Triglyceride Caprylic / Capric Triglyceride 3.0 SymMollient®S green Cetearyl Nonanoate 2.0 Isoadipate Diisopropyl Adipate 2.0 SymDecanox™HA Caprylic / Capric Triglyceride, Hy- 2.0 droxymethdoxyphenyl Decanone Alpha Tocopherol DL Tocopherol 0.5 SymRenew™HPR Diisopropyl Adipate, Hydroxypinacolone 2.0 Retinoate, Tocopherol Argan Oil Argania Spinosa Kernel Oil 1.0 Jojoba Oil Simmondsia Chinensis Seed Oil 1.0 Avocado Oil CA Persea Gratissima Oil 1.0 SymUrban®Benzylidene Dimethoxydimethylindanone 0.5 Food Color Iron Oxide RED E172 CI77491 0.005 Keltrol®CG-BT Xanthan Gum 0.2 Cosmedia®SP Sodium Polyacrylate 0.5 Aqua / Water Aqua Ad 100 Glycerin Glycerin 3.0 Sodium Metabisulfite Sodium Metabisulfite 0.04 Edeta®BD Disodium EDTA 0.1 SymSave®H Hydroxyacetophenone 0.5 SymDiol®68 1,2 Hexanediol, Caprylyl Glycol 0.5 Actipone®Laminaria Saccharina Glycerin, Aqua, Laminaria Saccharina Ex- 1.0 GW CA tract Macadamia Oil Macadamia Integrifolia Seed Oil 2.0 SymGlucan®Aqua, Glycerin, 1,2-Hexanediol, Caprylyl 2.0 Glycol, Beta-Glucan Pentylene Glycol, Butylene Glycol, Hydro- 1.0 Blend 1 with Hydroxyphenyl Pro- xyphenyl Propamidobenzoic Acid, Diethy- pamidobenzoic Acid lhexyl Syringylidenemalonate, Ca- prylic / Capric Triglyceride Ethanol 96% Alcohol Denat. 3.0 Sodium hydroxide 10% solution Aqua, Sodium Hydroxide 0.7 Perfume oil PO1; PO2; PO3; Parfum 0.3 PO4; or PO5 Essential Care Face& Body Cream Raw material INCI Amount Emulsiphos®Potassium Cetyl Phosphate, Hydrogen- 2.0 ated Palm Glycerides Dracorin®GOC Glyceryl Oleate Citrate, Caprylic / Capric 0.5 Triglyceride Lanette®O Cetearyl Alcohol 3.0 PCL-Liquid®100 Cetearyl Ethylhexanoate 4.0 SymMollient®S green Ceterayl Nonanoate 4.0 Oxynex St Liquid Diethylhexyl Syringylidenemalonate, 0,1 Caprylic / Capric Triglyceride Murumuru Butter Refined Astrocaryum Murumuru Seed Butter, Heli- 2.0 anthus Annuus Seed Oil, Tocopherol Aqua / Water Aqua Ad 100 Dragosine®Carosine 0.2 Carbopol®Ultrez 21 Polymer Acryltes / C10-30 Alkyl Acrylate Crosspoly- 0.2 mer Glyceirn Glycerin 3.0 Keltrol®CG-T Xanthan Gum 0.1 SymSave®H Hydroxyacetophenone 0.6 Pentylene Glycol, Butylene Glycol, Hy- 1.6 Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- rate, Aqua, Alcohol SymGlucan®Aqua, Glycerin, 1,2 Hexanediol, Caprylyl 5.0 Glycol, Beta Glucan Alpha Tocopherol DL Tocopherol 0.1 Perfume oil PO1; PO2; PO3; Parfum 0.4 PO4; or PO5 Blend with Hydroxyphenyl Pro- Pentylene Glycol, Butylene Glycol, Hy- 2.0 pamidobenzoic Acid®droxyphenyl Propamidobenzoic acid Sodium Hydroxide 10% solution 0.4 Natural Night Cream Aloe Raw material INCI Amount Deionised Water Aqua Ad 100 Glycerin 99.5% Glycerin 2.0 Dermofeel PA-3 Sodium Phytate; Aqua; Alcohol 0.1 Dermosoft 1388 eco Glycerin, Aqua, Sodium Levulinate, So- 3.0 dium Anisate Veegum Ultra Granules Magnesium Aluminium Silicate 0.5 Keltrol CG-RD Xanthan Gum 0.5 Dermofeel SL Sodium Stearoyl Lactylate 2.0 Dermofeel PS Polyglyceryl-3 Stearate 3.0 Dermosoft decalact MB Sodium Caproyl / Lauroyl Lactylate 0.8 Phytosqualan, veg. grade Squalane 4.0 Cegesoft®SBE Butyrospermum Parkii (Shea) Butter 2.0 Pentylene Glycol, Butylene Glycol, Hy- 1.1 Blend 1 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, Di- pamidobenzoic Acid ethylhexyl Syringylidenemalonate, Caprylic / Capric Triglyceride Cutina GMS Glyceryl Stearate 2.0 Lanette O Cetearyl Alcohol 1.0 Sunflower oil Helianthus Annuus Seed Oil 4.0 Dermofeel sensolv Isoamyl Laurate 5.0 Aloe Vera Gel Concentrate 10 / 1 Aloe Barbadensis Leaf Juice 0.3 Perfume oil PO5 Parfum 0.3 Revitalizing CONDITIONER Ingredients EU INCI Amount Aqua Aqua Ad 100 EDETA BD Disodium EDTA 0.05 Glycerin 99.5% Glycerin 1.00 Lactic Acid Lactic acid 0.85 Genamin®KDMP Behentrimonium chloride 2.50 SymSave®H Hydroxyacetophenone 0.50 Hydrolite®CG Caprylyl Glycol 0.50 Tego®Amid S18 Stearamidopropyl Dimethylamine 3.00 Distearoylethyl Dimonium chloride (and) VARISOFT®EQ65 ceterayl alcohol 4.00 SymMollient®S green Ceteraryl Nonanoate 2.00 Cetiol®SB 45 Butyrospermum parkii butter 3.00 Lanette®16 Cetyl alcohol 4.75 Lanette®18 Stearyl alcohol 4.25 Beeswax Beeswax 0.80 Glycine soja oil, Gossypium herbaceum seed oil, 40angifera idica seed butter, olea SymOleo®Vita7 europaea fruitoil, persea gratissima oil, 3.00 prununs amygdalus dulcis (sweet almond) oil, Theobroma cacao seed butter Alpha Tocopherol DL Tocopherol 0.65 Eumulgin®B2 Ceteareth-20 1.00 Perfume oil PO1, PO2, PO3, PO4, or PO5 Parfum 1.00 SymHair®Restore Glycerin, Triticum vulgare protein, Aqua 1.00 Pentylene Glycol, Butylene Glycol, Blend 1 with Hydroxyphenyl Pro- Hydroxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Diethylhexyl Syringylidenemalonate, Ca- 1.00 prylic / Capric Triglyceride Lactic acid Lactic acid 0.50 Refreshing Conditioning Foam Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 Edeta BD Disodium EDTA 0.05 SymSave®H Hydroxyacetophenone 0.50 PEG-40 Hydrogenated castor oil, Tride- Solubilizer ceth-9, Propylene Glycol, Aqua 1.50 Hydrolite®5 green Pentylene Glycol 1.50 Frescolat®ML Menthyl Lactate 0.50 Aqua, Pentylene Glycol, Sodium Lauryl SymSol®PF-3 Sulfoacetate, Sodium Oleoyl Sarcosinate, 5.00 Sodium Chloride, Sodium Oleate Perfume oil PO1, PO2, PO3, PO4, or PO5 Parfum 1.00 Pentylene Glycol, Butylene Glycol, Hy- Blend 2 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, pamidobenzoic Acid Tris(Tetramethylhydroxypiperidinol) Cit- 2.00 rate, Aqua, Alcohol Citric Acid 50% Sol Aqua, Citric Acid 0.05 Dandruff Control Shampoo Ingredients EU INCI Amount Texapon®NSO UP Sodium Laureth Sulfate 30.0 Phenoxyethanol, Climbazole, Decylene Crinipan®ADS Glycol,1,2-Hexanediol 1.5 Crinipan PMC green Propanediol Caprylate 0.5 Frescolat®Plus Menthol, Menthyl Lactate 0.5 Sodium Benzotriazolyl Butylphenol Sul- Cibafast H Liquid fonate, Buteth-3, Tributyl Citrate 0.05 Perfume oil PO1, PO2, PO3, PO4, or PO5 Parfum 0.6 Pentylene Glycol, Butylene Glycol, Hy- Blend 1 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, Di- pamidobenzoic Acid ethylhexyl Syringylidenemalonate, 1.0 Caprylic / Capric Triglyceride Aqua / Water Aqua Ad 100 Glycerin Glycerin 3.0 Glycerin, Triticum vulgare (Wheat) Gluten, Dragoderm Aqua 1.0 Dehyton®K Cocamidopropyl Betaine 12.0 Sodium Chloride Sodium Chloride 0.7 Colour I 0.062 Colour II 0.053 Citric Acid 50% Sol. Aqua, Citric Acid 1.26 Extrapone®Lemon (Organic) GW Aqua, Glycerin, Citrus Limon Juice 0.1 Aqua, Glycerin, Thymus vulgaris Extrapone®Thyme GW flower / leaf extract 0.1 Shampoo Sulfate-Free Ingredients EU INCI Amount Aqua / Water Aqua Ad 100 Akypo®Foam RL 40 Sodium Laureth-5 Carboxylate 15.0 Plantacare®2000 UP Decyl Glucoside 5.0 EDTA NA2 Disodium EDTA 0.1 Phenoxyethanol, Hydroxyacetophenone, SymOcide®PH Caprylyl Glycol, Aqua 1.45 Aqua / Water Aqua 10.0 Acrylates / Beheneth-25 Methacrylate Co- Novethix™ L-10 Polymer polymer 7.0 Dehyton®PK-45 Cocamidopropyl Betaine 10.0 SymMollient®W / S Trideceth-9, PEG-5 Isononanoate, Aqua 0.5 Blend 2 with Hydroxyphenyl Pro- Pentylene Glycol, Butylene Glycol, Hy- pamidobenzoic Acid droxyphenyl Propamidobenzoic Acid, 1.0 Tris(Tetramethylhydroxypiperidinol) Cit- rate, Aqua, Alcohol Propylene Glycol, PEG-55 Propylene Gly- Antil 141 Liquid col Oleate 2.0 Acusol OP 301 Styrene / Acrylates Copolymer 1.0 SymHair®Restore Glycerin, Triticum vulgare protein, Aqua 1.0 Fragrance Parfum 1.0 Mild Conditioning Shampoo for Kids / Babies Ingredients EU INCI Amount Perfume Parfume 0.2 Texapon®NSO UP Sodium Laureth Sulfate 8.0 Methoxy PEG / PPG-7 / 3 Aminopropyl Di- ABIL Soft AF 100 methicone 0.7 Water Water Ad 100 Ucare Polymer JR 400 Polyquaternium-10 0.2 Disodium PEG-5 Laurylcitrate Sulfosuc- REWOPOL SB CS 50 B MB cinate; Sodium Laureth Sulfate 10.5 REWOTERIC AM C MB Sodium Cocoamphoacetate 11.0 Citric Acid 30% sol Aqua, Citric Acid 1.7 VARISOFT PATC MB Pamitamidopropyltrimonium Chloride 1.5 Pentylene Glycol, Butylene Glycol, Hy- Blend 1 with Hydroxyphenyl Pro- droxyphenyl Propamidobenzoic Acid, Di- pamidobenzoic Acid ethylhexyl Syringylidenemalonate, 1.5 Caprylic / Capric Triglyceride PEG-200 Hydrogenated Glyceryl Palmate; ANTIL 200 PEG-7 Glyceryl Cocoate 1.5

Claims

Claims 1. Use of a stabilizer or a stabilizer composition, wherein the stabilizer or, respectively, the or one or all stabilizer(s) of the stabilizer composition is / are selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof, for stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroavenan- thramide D, wherein stabilizing Dihydroavenanthramide D refers to the prevention or reduction of discoloration of the mixture and / or to the prevention or reduction of malodour for- mation, and wherein the weight ratio of the stabilizer(s) to Dihydroavenanthramide D is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly prefera- bly of from 0.02 to 0.

1.

2. Use according to claim 1, wherein the mixture comprising Dihydroavenanthramide D comprises i) Dihydroavenanthramide D, and ii) one or more alkane diol(s).

3. Use according to any one of the preceding claims, wherein the mixture comprising Dihydroavenanthramide D comprises i) Dihydroavenanthramide D, ii.a) 1,3-butylene glycol, and ii.b) pentylene glycol.

4. Use according to any one of the preceding claims, wherein the stabilizer or, respec- tively, stabilizer composition is mixed with the mixture comprising Dihydroavenan- thramide D to obtain a stabilized mixture,wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of diethylhexyl syringyli- dene malonate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of sodium metabisulfite, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of Tris(tetramethylhydrox- ypiperidinol) citrate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of a mixture comprising two or all of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate.

5. Method for stabilizing Dihydroavenanthramide D in a mixture comprising Dihydroav- enanthramide D, comprising the steps a) providing a mixture comprising Dihydroavenanthramide D, b) providing a stabilizer or a stabilizer composition, wherein the stabilizer or, re- spectively, the or one or all stabilizer(s) of the stabilizer composition is / are selected from the group consisting of diethylhexyl syringylidene malonate, so- dium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof, c) mixing the components provided in step a) and in step b), wherein stabilizing Dihydroavenanthramide D refers to the prevention or reduction of discoloration of the mixture and / or to the prevention or reduction of malodour for- mation, and wherein the weight ratio of the stabilizer(s) to Dihydroavenanthramide D in the mixture obtained in step c) is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, particularly preferably of from 0.02 to 0.1.

6. Method according to claim 5, wherein the mixture provided in step a) comprises i) Dihydroavenanthramide D, ii) one or more alkane diol(s).

7. Method according to claim 5 or 6, wherein the mixture provided in step a) comprises i) Dihydroavenanthramide D, ii.a) 1,3-butylene glycol, and ii.b) pentylene glycol.

8. Method according to any one of claims 5 to 7, wherein after the mixing in step c), a stabilized mixture is obtained, wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of diethylhexyl syringyli- dene malonate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of sodium metabisulfite, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of Tris(tetramethylhydrox- ypiperidinol) citrate, based on the total weight of the stabilized mixture, and / or wherein the obtained stabilized mixture comprises 0.06 to 0.9 wt.-%, prefera- bly 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of a mixture comprising two or all of diethylhexyl syringylidene malonate, sodium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate.

9. Mixture comprising i) Dihydroavenanthramide D,ii) one or more alkane diol(s), and iii) a stabilizer selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof, wherein the weight ratio of the stabilizer(s) iii) to Dihydroavenanthramide D i) in the mixture is in a range of from 0.0125 to 0.175, preferably of from 0.015 to 0.15, par- ticularly preferably of from 0.02 to 0.

1.

10. Mixture according to claim 9, comprising i) Dihydroavenanthramide D, ii.a) 1,3-butylene glycol, ii.b) pentylene glycol, and iii) a stabilizer selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiperidinol) citrate, and mixtures thereof.

11. Mixture according to claim 9 or 10, wherein the mixture comprises - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of diethylhexyl syringylidene malonate, based on the total weight of the stabi- lized mixture, and / or - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of sodium metabisulfite, based on the total weight of the stabilized mixture, and / or - 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of Tris(tetramethylhydroxypiperidinol) citrate, based on the total weight of the stabilized mixture, and / or- 0.06 to 0.9 wt.-%, preferably 0.075 to 0.75 wt.-%, preferably 0.1 to 0.5 wt.-% of a mixture comprising two or all of diethylhexyl syringylidene malonate, so- dium metabisulfite and Tris(tetramethylhydroxypiperidinol) citrate.

12. Cosmetic preparation comprising a mixture according to any one of claims 9 to 11.

13. Cosmetic preparation according to claim 12, wherein the summed weight of Dihy- droavenanthramide D and the stabilizer selected from the group consisting of dieth- ylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxypiper- idinol) citrate, and mixtures thereof in the preparation is in a range of from 0.01 to 4 wt.-%, preferably in a range of from 0.05 to 3 wt.-%, further preferably in a range of from 0.1 to 2 wt.%, based on the total weight of the cosmetic preparation.

14. Cosmetic preparation according to claims 12 or 13, wherein the summed weight of Dihydroavenanthramide D and the stabilizer selected from the group consisting of diethylhexyl syringylidene malonate, sodium metabisulfite, Tris(tetramethylhydroxy- piperidinol) citrate, and mixtures thereof, and alkane diol(s) in the preparation is in a range of from 0.01 to 4 wt.-%, preferably in a range of from 0.05 to 3 wt.-%, further preferably in a range of from 0.1 to 2 wt.%, based on the total weight of the cosmetic preparation.

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