Cosmetic composition comprising biodegradable polymer particles

Abstract

The present application relates to a cosmetic composition comprising a biodegradable polymer resin containing a PHA resin and having a particle diameter adjusted to a specific range. The cosmetic composition of the present application can be used in the manufacture of various products, such as basic cosmetics, color cosmetics, sunscreen cosmetics, and hair care cosmetics.

Description

Cosmetic composition comprising biodegradable polymer particles

[0001] The present invention relates to a cosmetic composition comprising biodegradable polymer particles. More specifically, the present invention relates to a cosmetic composition using biodegradable polymer particles comprising polyhydroxyalkanoate (PHA).

[0002] Microplastics, a major contributor to environmental pollution, are a major issue in the cosmetics industry. Globally, regulations have been enacted banning the distribution of cosmetics containing solid plastic particles (microplastics) 5 mm or less, used for cleansing and exfoliating purposes, limited to wash-off products. A grace period has also been granted for non-wash-off products (basic cosmetics, sunscreen, makeup), and the ban is expected to be implemented soon.

[0003] When applying sunscreen products and entering the ocean, harmful ingredients can be washed away, causing serious harm to coral and fish, and significantly negatively impacting the marine ecosystem. The banned ingredients are octinoxate (ethylhexyl methoxycinnamate) and oxybenzone (benzophenone-3), which are known to cause coral bleaching and damage coral DNA. Furthermore, they are known to be highly toxic, causing allergies and affecting the respiratory and digestive systems, and the Environmental Working Group (EWG), a non-profit organization in the United States, has rated them as hazardous. Coral reefs, which play a key role in the ecosystem, are essential for the survival of countless marine species. Furthermore, the ocean covers 70% of the Earth's surface, making the protection of the marine ecosystem crucial. Therefore, banned ingredients have been designated for sunscreen products to protect the marine ecosystem, and regulations on the use of microplastics are being strengthened.

[0004] In this way, the cosmetics industry is increasingly considering the environment and using safe raw materials to protect health.

[0005] [Prior Art Literature]

[0006] (Patent Document 1) Japanese Patent Publication No. 2015-522065

[0007]

[0008] Polyhydroxyalkanoate (PHA), a biodegradable polymer, is biocompatible, non-cytotoxic, and promotes the regeneration of human dermal fibroblasts, helping to repair damaged skin. Therefore, it is safe for skin use and offers numerous benefits, making it ideal for general personal care applications, including foundation and color cosmetics, UV protection, and hair care.

[0009] The present inventors studied a cosmetic composition using polyhydroxyalkanoate (PHA) particles and confirmed that a cosmetic composition including a copolymerized PHA resin and a biodegradable polymer resin with a particle size controlled within a specific range is excellent in terms of usability, sensory properties, UV protection, hiding properties, non-toxicity, and formulation stability.

[0010] Accordingly, the task of the present invention is to provide a cosmetic composition having excellent characteristics as a cosmetic while being biodegradable and not polluting the environment.

[0011]

[0012] The present invention provides a cosmetic composition comprising biodegradable polymer particles, wherein the biodegradable polymer particles comprise a copolymerized polyhydroxyalkanoate (PHA), wherein the copolymerized polyhydroxyalkanoate (PHA) comprises 1 to 20 wt% of a repeating unit derived from 4-hydroxybutyrate (4-HB) based on the total weight of the copolymerized polyhydroxyalkanoate (PHA), and wherein the average particle diameter of the biodegradable polymer particles is 20 μm or less.

[0013] In one embodiment, the copolymerized polyhydroxyalkanoate (PHA) is selected from the group consisting of 2-hydroxybutyrate (2-HB), 3-hydroxybutyrate (3-HB), 3-hydroxypropionate (3-HP), 3-hydroxyvalerate (3-HV), 3-hydroxyhexanoate (3-HH), 3-hydroxyheptanoate (3-Hhep), 3-hydroxyoctanoate (3-HO), 3-hydroxynonanoate (3-HN), 3-hydroxydecanoate (3-HD), 3-hydroxydodecanoate (3-HDd), 4-hydroxyvalerate (4-HV), 5-hydroxyvalerate (5-HV), and 6-hydroxyhexanoate (6-HH). It may further include repeating units derived from one or more selected monomers.

[0014] In another embodiment, the copolymerized polyhydroxyalkanoate (PHA) may comprise poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3HB-co-4HB).

[0015] In another embodiment, the copolymerized polyhydroxyalkanoate (PHA) may contain repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 3 wt% to 15 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).

[0016] In another embodiment, the copolymerized polyhydroxyalkanoate (PHA) may be included in an amount of 0.1 wt% to 30 wt% based on the total weight of the cosmetic composition.

[0017] In another embodiment, the cosmetic composition may further comprise at least one selected from the group consisting of a sunscreen, an oil, a surfactant, and a polyol.

[0018] In another embodiment, the sunscreen comprises titanium dioxide (TiO2), zinc oxide (ZnO), drometrizole, drometrizole trisiloxane, digalloyl trioleate, disodium phenyl dibenzimidazole tetrasulfonate, diethylamino hydroxybenzoyl hexyl benzoate, diethylhexyl butamido triazone, methylene bis-benzotriazolyl tetramethylbutylphenol, methyl anthranilate, benzophenone-4, It may be at least one selected from the group consisting of benzophenone-8, bis-ethylhexyloxyphenol methoxyphenyl triazine, ethylhexyl dimethyl PABA, ethylhexyl salicylate, ethylhexyl triazone, isoamyl p-methoxycinnamate, terephthalylidene dicamphor sulfonic acid, phenylbenzimidazole sulfonic acid, and polysilicone-15.

[0019] In another embodiment, the oil may be at least one selected from the group consisting of natural oils, vegetable oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, and silicone oils.

[0020] In another embodiment, the surfactant may be at least one selected from the group consisting of anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, polymeric surfactants, natural surfactants, and silicone surfactants.

[0021] In another embodiment, the content of the surfactant may be 0.1 wt% to 30 wt% based on the total weight of the cosmetic composition.

[0022] In another embodiment, the content of the sunscreen may be from 5 wt% to 35 wt% based on the total weight of the cosmetic composition.

[0023] In another embodiment, the content of the oil may be from 0.1 wt% to 70 wt% based on the total weight of the cosmetic composition.

[0024] In another embodiment, the cosmetic composition may have an SPF (Sun Protection Factor) of 30 or more and a PA (Protection Factor of UVA) of 8 or more.

[0025] In another embodiment, the cosmetic composition may have the formulation of a sun stick, sun lotion, sunscreen, sun balm, sun spray, emollient toner, nourishing toner, lotion, nourishing cream, massage cream, essence, ampoule, eye cream, makeup base cream, primer, foundation, pact, shampoo, treatment, scalp ampoule, pack, spray, body wash, cleansing foam, cleansing lotion, cleansing oil, or powder.

[0026] In another embodiment, the cosmetic composition can be used in the manufacture of a base cosmetic, a color cosmetic, a sunscreen cosmetic, or a hair care cosmetic.

[0027] In addition, the present invention provides a cosmetic composition for blocking ultraviolet rays, which comprises biodegradable polymer particles, wherein the biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), wherein the copolymerized polyhydroxyalkanoate (PHA) comprises repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 1 wt% to 20 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA), and has an SPF (Sun Protection Factor) of 30 or more and a PA (Protection Factor of UVA) of 8 or more.

[0028] In addition, the present invention provides a cosmetic composition for skin regeneration, which comprises biodegradable polymer particles, wherein the biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), and wherein the copolymerized polyhydroxyalkanoate (PHA) comprises repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 1 wt% to 20 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).

[0029]

[0030] The cosmetic composition according to the present invention comprises a copolymerized PHA resin and a biodegradable polymer resin having a particle size controlled within a specific range, and is excellent in all aspects of usability, sensory properties, UV protection, hiding properties, non-toxicity, and formulation stability.

[0031] Specifically, the cosmetic composition exhibits excellent UVB and UVA blocking booster effects, reducing the amount of UV filters that cause irritation in the formulation and helping to protect the skin from UV damage. Furthermore, the spherical PHA particles provide a smooth feel, improving spreadability, and provide a soft-focusing effect on the skin, helping to smooth skin texture. Furthermore, PHA has a high melting point, so its particles and shape remain stable even at low and high temperatures, allowing it to be applied to high-temperature emulsified formulations such as lotions and creams.

[0032] In particular, the cosmetic composition can be applied to various cosmetics such as cosmetics using inorganic or organic UV filters or basic and color cosmetics, and can be easily biodegraded in both soil and the ocean, so it can effectively contribute to environmental conservation.

[0033] As such, the cosmetic composition of the present invention is excellent in terms of usability, UV protection booster effect, cell proliferation rate, etc., and can be used in the manufacture of various products such as basic cosmetics, color cosmetics, sunscreen cosmetics, and hair care cosmetics.

[0034]

[0035] The invention is described in detail below through examples. The examples are not limited to the content disclosed below and may be modified in various ways as long as the spirit of the invention remains intact.

[0036] The word "comprising" or "including" in this specification is intended to specify particular features, regions, steps, processes, elements and / or components, and does not exclude the presence or addition of other features, regions, steps, processes, elements and / or components, unless specifically stated to the contrary.

[0037] In addition, all numerical ranges indicating the physical properties, dimensions, etc. of the components described in this specification should be understood to be modified by the term “about” in all cases unless otherwise specified.

[0038] In the numerical ranges that limit the size, physical properties, etc. of the components described in this specification, if a numerical range limited only to the upper limit and a numerical range limited only to the lower limit are separately exemplified, it should be understood that a numerical range in which these upper and lower limits are combined is also included in the exemplary range.

[0039]

[0040] biodegradable polymer particles

[0041] A cosmetic composition according to the present invention comprises biodegradable polymer particles.

[0042] Specifically, the biodegradable polymer particles include polyhydroxyalkanoate (PHA).

[0043] The above polyhydroxyalkanoate (PHA) can have similar properties to synthetic polymers such as polybutylene adipate terephthalate (PBAT), polybutylene succinate (PBS), polybutylene succinate terephthalate (PBST), and polybutylene succinate adipate (PBSA) derived from conventional petroleum, and exhibits excellent biodegradability and also excellent biocompatibility.

[0044] Specifically, the PHA is a natural polyester polymer that accumulates within microbial cells and can be completely decomposed into carbon dioxide, water, organic waste, etc. in soil and / or the ocean, thereby exhibiting excellent biodegradability without generating microplastics. Therefore, the cosmetic composition according to the present invention can exhibit excellent biodegradability and environmental friendliness by including such PHA.

[0045] In particular, the PHA particles themselves are processed to have a round shape and small particle size, and when applied to base or color cosmetics, they can provide a soft focusing effect and help improve the feeling of use.

[0046] In addition, PHA has the function of an SPF booster, so when making a UV protection product together with a sunscreen (TiO2, ZnO, etc.), it can increase the spreadability and show a higher UV protection effect. UVA (long wavelength 320-400 nm) has only 1 / 1000 of the energy of UVB (short wavelength 280-320 nm), but the amount of light that reaches the ground is 100 times that of UVB, and is known to be the main cause of skin pigmentation and aging. PHA has an excellent UVA protection booster effect in addition to UVB blocking, so it has the advantage of blocking a wider range of UV rays than organic absorbents.

[0047] The above PHA can be obtained through cell disruption of microorganisms using mechanical or physical methods, or through cell disruption of microorganisms using non-mechanical or chemical methods. Specifically, the above PHA can be a copolymer obtained through an enzyme-catalyzed polymerization process of one or more monomers within living microbial cells.

[0048] More specifically, the biodegradable polymer particles include copolymerized polyhydroxyalkanoate (PHA).

[0049] The above copolymerized polyhydroxyalkanoate (PHA) may include a copolymer containing two or more different repeating units in which the different repeating units are randomly distributed in the polymer chain.

[0050] In one embodiment, the copolymerized polyhydroxyalkanoate (PHA) comprises repeating units derived from 4-hydroxybutyrate (4-HB).

[0051] Since the above copolymer PHA includes a repeating unit derived from the above 4-hydroxybutyrate (4-HB), the physical properties and effects of the cosmetic composition can be improved, thereby providing a cosmetic composition that can be used for various purposes.

[0052] In the present invention, it is important to control the content of the 4-HB repeating unit in the copolymer PHA. That is, in order to realize the physical properties desired in the present invention, particularly to enhance biodegradability and realize excellent mechanical properties, the content of the 4-HB repeating unit in the copolymer PHA may be important.

[0053] The content of the repeating unit derived from the 4-hydroxybutyrate (4-HB) based on the total weight of the copolymerized polyhydroxyalkanoate (PHA) may be 0.1 wt% or more, 1 wt% or more, 3 wt% or more, 5 wt% or more, 7 wt% or more, 8 wt% or more, 10 wt% or more, 12 wt% or more, 13 wt% or more, 15 wt% or more, 17 wt% or more, 18 wt% or more, 20 wt% or more, or 25 wt% or more, and may be 50 wt% or less, 45 wt% or less, 43 wt% or less, 42 wt% or less, 40 wt% or less, 35 wt% or less, 30 wt% or less, 25 wt% or less, or 20 wt% or less.

[0054] In one embodiment, the copolymerized polyhydroxyalkanoate (PHA) comprises 1 to 20 wt% of repeating units derived from 4-hydroxybutyrate (4-HB) based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).

[0055] For example, the content of the repeating unit derived from 4-hydroxybutyrate (4-HB) based on the total weight of the copolymerized polyhydroxyalkanoate (PHA) may be, but is not limited to, 1 wt% to 20 wt%, 2 wt% to 20 wt%, 3 wt% to 15 wt%, 5 wt% to 15 wt%, or 5 wt% to 10 wt%.

[0056] As a specific example, the copolymerized polyhydroxyalkanoate (PHA) may contain repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 3 wt% to 15 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).

[0057] When the content of 4-HB repeating units in the above copolymerized polyhydroxyalkanoate (PHA) satisfies the above range, biodegradability in soil and the ocean can be improved, and stability and excellent physical properties can be maintained as a cosmetic raw material.

[0058] In this way, the copolymer PHA includes at least one 4-HB repeating unit, and the crystallinity of the copolymer PHA can be controlled by controlling the content of the 4-HB repeating unit. In other words, the copolymer PHA can be a polymer with controlled crystallinity.

[0059] The above-mentioned copolymer PHA with controlled crystallinity may have controlled crystallinity and amorphousness by increasing irregularity in the molecular structure, and specifically, may be one in which the type of monomer, the ratio of monomers, or the type and / or content of isomers is controlled.

[0060] In addition, the above copolymer PHA may be a PHA copolymer that includes a 4-HB repeating unit, additionally includes one repeating unit different from the 4-HB, or additionally includes two, three, four, five, six or more repeating units that are different from each other.

[0061] For example, the above copolymerized polyhydroxyalkanoate (PHA) is selected from the group consisting of 2-hydroxybutyrate (2-HB), 3-hydroxybutyrate (3-HB), 3-hydroxypropionate (3-HP), 3-hydroxyvalerate (3-HV), 3-hydroxyhexanoate (3-HH), 3-hydroxyheptanoate (3-Hhep), 3-hydroxyoctanoate (3-HO), 3-hydroxynonanoate (3-HN), 3-hydroxydecanoate (3-HD), 3-hydroxydodecanoate (3-HDd), 4-hydroxyvalerate (4-HV), 5-hydroxyvalerate (5-HV), and 6-hydroxyhexanoate (6-HH). It may further include repeating units derived from one or more monomers.

[0062] Specifically, the copolymerized polyhydroxyalkanoate (PHA) may further include one or more repeating units selected from the group consisting of 3-hydroxybutyrate (3-HB), 3-hydroxypropionate (3-HP), 3-hydroxyvalerate (3-HV), 3-hydroxyhexanoate (3-HH), 4-hydroxyvalerate (4-HV), 5-hydroxyvalerate (5-HV), and 6-hydroxyhexanoate (6-HH).

[0063] More specifically, the copolymer PHA may include a copolymer comprising repeating units derived from 3-HB and repeating units derived from 4-HB. For example, the copolymer PHA may include poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (3HB-co-4HB).

[0064] For example, the content of the repeating unit derived from the 3-HB based on the total weight of the copolymer PHA may be 50 wt% or more, 55 wt% or more, 60 wt% or more, 64 wt% or more, 70 wt% or more, 75 wt% or more, or 80 wt% or more, and may also be 99.9 wt% or less, 99 wt% or less, 95 wt% or less, 90 wt% or less, 85 wt% or less, 80 wt% or less, or 75 wt% or less.

[0065] Additionally, the copolymer PHA may include isomers. For example, the copolymer PHA may include structural isomers, enantiomers, or geometric isomers. Specifically, the PHA may include structural isomers.

[0066] The above copolymer PHA may have a glass transition temperature (Tg) of, for example, -45°C to 80°C, -35°C to 80°C, -30°C to 80°C, -25°C to 75°C, -20°C to 70°C, -35°C to 5°C, -25°C to 5°C, -35°C to 0°C, -25°C to 0°C, -30°C to -10°C, -35°C to -15°C, -35°C to -20°C, -20°C to 0°C, -15°C to 0°C, or -15°C to -5°C.

[0067] The above copolymer PHA may have a crystallization temperature (Tc) that may not be measured, for example, or may be, for example, from 70°C to 120°C, from 75°C to 120°C, from 75°C to 115°C, from 75°C to 110°C, or from 90°C to 110°C.

[0068] The above copolymer PHA may have a melting temperature (Tm) that may not be measured, for example, or may be from 100°C to 170°C, from 110°C to 150°C, or from 120°C to 140°C.

[0069] The above copolymer PHA may have a weight average molecular weight (Mw) of, for example, 10,000 g / mol to 1,200,000 g / mol. For example, the weight average molecular weight of the PHA is 50,000 g / mol to 1,200,000 g / mol, 100,000 g / mol to 1,200,000 g / mol, 50,000 g / mol to 1,000,000 g / mol, 100,000 g / mol to 1,000,000 g / mol, 100,000 g / mol to 900,000 g / mol, 200,000 g / mol to 1,200,000 g / mol, 250,000 g / mol to 1,150,000 g / mol, 300,000 g / mol to 1,100,000 g / mol, 350,000 g / mol to 1,000,000 g / mol, 350,000 g / mol to 950,000 g / mol, 100,000 g / mol to 900,000 g / mol, 200,000 g / mol to 800,000 g / mol, 200,000 g / mol to 700,000 g / mol, 250,000 g / mol to 650,000 g / mol, 200,000 g / mol to 400,000 g / mol, 300,000 g / mol to 800,000 g / mol, 300,000 g / mol to 600,000 g / mol, 400,000 g / mol to 800,000 g / mol, 500,000 g / mol to 1,200,000 g / mol, It may be 500,000 g / mol to 1,000,000 g / mol, 550,000 g / mol to 1,050,000 g / mol, 550,000 g / mol to 900,000 g / mol, or 600,000 g / mol to 900,000 g / mol.

[0070] In one specific example, the copolymer PHA may be a crystalline or semi-crystalline PHA. For example, the crystalline or semi-crystalline PHA may contain, for example, 1 wt% to 25 wt%, or 3 wt% to 20 wt%, of the 4-HB repeating unit based on the total weight of the copolymer PHA. In addition, the glass transition temperature (Tg) of the crystalline or semi-crystalline PHA may be, for example, -20°C to 0°C, the crystallization temperature (Tc) may be, for example, 75°C to 115°C, and the melting temperature (Tm) may be, for example, 110°C to 160°C.

[0071] In another embodiment, the biodegradable polymer particles may further comprise other PHA polymers, for example, one or more polymers selected from the group consisting of poly(3-hydroxybutyrate) (P3HB), poly(4-hydroxybutyrate) (P4HB), poly(3-hydroxyhexanoate) (P3HH), poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (P3HB-3HH), poly(3-hydroxyoctanoate) (P3HO), and poly(3-hydroxybutyrate-co-3-hydroxyoctanoate) (P3HB-3HO).

[0072] In another embodiment, the biodegradable polymer particles may be one or a mixture of two or more selected from synthetic biodegradable polymers and natural biodegradable polymers other than polyhydroxyalkanoate (PHA). Examples of the synthetic biodegradable polymers may include polylactic acid (PLA), polycaprolactone (PCL), polyglycolic acid (PGA), poly(lactic acid-co-caprolactone) (PLCL), poly(lactic acid-co-glycolic acid) (PLGA), polybutylene succinate (PBS), and poly(butylene adipate-co-terephthalate) (PBAT). In addition, examples of the natural biodegradable polymers may include starch, silk fibroin, chitosan, chitin, cellulose, collagen, and gelatin.

[0073] The particle size of the above biodegradable polymer particles can be controlled within a specific range.

[0074] In one embodiment, the average particle diameter of the biodegradable polymer particles is 20 μm or less.

[0075] The above average particle size may be, for example, the particle size corresponding to a cumulative percentage of 50% in the particle size distribution, i.e., D50.

[0076] Within the above particle size range, it is suitable for use in basic cosmetics, color cosmetics, UV protection products, etc., but if it goes beyond this range, it may not feel good to use and may feel like a foreign body.

[0077] Specifically, the average particle diameter of the biodegradable polymer particles may be 1 ㎛ to 10 ㎛, and more specifically, 2 ㎛ to 8 ㎛.

[0078] The biodegradable polymer particles can be ground into small particles using a food mixer or an atomizer to obtain a size suitable for cosmetic formulations. Furthermore, the grinding process can be repeated once, twice, or three times to obtain a suitable particle size. In addition to the grinding equipment described above, various fine particle grinders (jet mills, air jet mills, etc.) can also be used. Furthermore, biodegradable polymer particles can be fed into a circular vibration sorter for screening to obtain particles of a desired particle size.

[0079]

[0080] cosmetic composition

[0081] The cosmetic composition of the present invention is manufactured using biodegradable polymer particles containing copolymerized polyhydroxyalkanoate (PHA), as described above.

[0082] The content of the biodegradable polymer particles may be 0.1 wt% or more, 0.5 wt% or more, 1 wt% or more, 2 wt% or more, 3 wt% or more, 5 wt% or more, 7 wt% or more, 8 wt% or more, 10 wt% or more, 15 wt% or more, 20 wt% or more, or 25 wt% or more, based on the total weight of the cosmetic composition, and may also be 50 wt% or less, 40 wt% or less, 30 wt% or less, 25 wt% or less, 20 wt% or less, or 15 wt% or less.

[0083] Specifically, the content of the biodegradable polymer particles may be 0.1 wt% to 50 wt%, 0.1 wt% to 30 wt%, 1 wt% to 30 wt%, 1 wt% to 25 wt%, 1 wt% to 20 wt%, 1 wt% to 15 wt%, 1.5 wt% to 10 wt%, 2 wt% to 10 wt%, 2.5 wt% to 10 wt%, 3 wt% to 50 wt%, 3 wt% to 30 wt%, 3 wt% to 20 wt%, 3 wt% to 10 wt%, 4 wt% to 10 wt%, or 5 wt% to 10 wt%, based on the total weight of the cosmetic composition.

[0084] In addition, the content of the copolymerized polyhydroxyalkanoate (PHA) may be 0.1 wt% or more, 0.2 wt% or more, 0.5 wt% or more, 1 wt% or more, 1.5 wt% or more, 2 wt% or more, 2.5 wt% or more, 3 wt% or more, 5 wt% or more, 10 wt% or more, 15 wt% or more, or 20 wt% or more, and may also be 50 wt% or less, 40 wt% or less, 30 wt% or less, 25 wt% or less, 20 wt% or less, 15 wt% or less, or 10 wt% or less, based on the total weight of the cosmetic composition.

[0085] In one embodiment, the copolymerized polyhydroxyalkanoate (PHA) may be included in an amount of 0.1 wt% to 30 wt% based on the total weight of the cosmetic composition. Specifically, the copolymerized polyhydroxyalkanoate (PHA) may be present in an amount of 1 wt% to 20 wt%, 1 wt% to 15 wt%, 2 wt% to 10 wt%, 2.5 wt% to 10 wt%, 3 wt% to 30 wt%, 3 wt% to 20 wt%, 3 wt% to 10 wt%, or 5 wt% to 10 wt% based on the total weight of the cosmetic composition.

[0086] Within the above preferred range, biodegradability and cell proliferation effects can be further improved, and other cosmetic properties can also be more advantageous.

[0087] The above cosmetic composition may further comprise at least one selected from the group consisting of a sunscreen, an oil, a surfactant, and a polyol.

[0088] The cosmetic composition according to the present invention may include a sunscreen. The sunscreen blocks UVA (long wavelength 320-400 nm) and UVB (short wavelength 280-320 nm) rays from reaching the skin, thereby preventing pigmentation and aging.

[0089] The above sunscreen may be, for example, at least one selected from the group consisting of an inorganic sunscreen, an organic sunscreen, and an organic / inorganic composite sunscreen.

[0090] The above UV blocker specifically includes titanium dioxide (TiO2), zinc oxide (ZnO), drometrizole, drometrizole trisiloxane, digalloyl trioleate, disodium phenyl dibenzimidazole tetrasulfonate, diethylamino hydroxybenzoyl hexyl benzoate, diethylhexyl butamido triazone, methylene bis-benzotriazolyl tetramethylbutylphenol, methyl anthranilate, benzophenone-4, benzophenone-8, It may be at least one selected from the group consisting of Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Ethylhexyl Dimethyl PABA, Ethylhexyl Salicylate, Ethylhexyl Triazone, Isoamyl p-Methoxycinnamate, Terephthalylidene Dicamphor Sulfonic Acid, Phenylbenzimidazole Sulfonic Acid, and Polysilicone-15.

[0091] In one embodiment, the UV blocking agent may be at least one selected from titanium dioxide (TiO2) and zinc oxide (ZnO).

[0092] Based on the total weight of the cosmetic composition of the present invention, the content of the sunscreen may be 0.1 wt% or more, 1 wt% or more, 3 wt% or more, 5 wt% or more, 10 wt% or more, or 20 wt% or more, and may also be 50 wt% or less, 40 wt% or less, 30 wt% or less, or 25 wt% or less.

[0093] As a specific example, the content of the sunscreen may be 5 wt% to 35 wt% based on the total weight of the cosmetic composition.

[0094] Additionally, the cosmetic composition may contain the sunscreen in an amount of 1 to 6 parts by weight, 1.5 to 6 parts by weight, or 2 to 4 parts by weight based on 1 part by weight of the copolymerized polyhydroxyalkanoate (PHA).

[0095] The cosmetic composition according to the present invention may include oil. The oil functions as a moisturizer to protect the skin and also functions as an emollient to soften the cosmetic composition, thereby improving spreadability.

[0096] The above oil may be, for example, one or more selected from the group consisting of natural oils, vegetable oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, and silicone oils.

[0097] In one embodiment, the oil may be at least one selected from the group consisting of dimethicone, cyclomethicone, cyclopentasiloxane, neopentyl glycol dicaprate, ethylhexyl palmitate, C12-15 alkyl benzoate, dicaprylyl carbonate, hexyl laurate, caprylic / capric triglyceride, propylene glycol dicaprylate / dicaprate, and coco-caprylate / caprate.

[0098] Based on the total weight of the cosmetic composition of the present invention, the content of the oil may be 0.1 wt% or more, 1 wt% or more, 3 wt% or more, 5 wt% or more, 10 wt% or more, or 15 wt% or more, and may also be 70 wt% or less, 50 wt% or less, 30 wt% or less, or 20 wt% or less, but is not limited thereto. As a specific example, based on the total weight of the cosmetic composition, the content of the oil may be 0.1 wt% to 70 wt%.

[0099] Additionally, the cosmetic composition may contain the oil in an amount of 0.1 to 7 parts by weight, 0.5 to 6 parts by weight, or 1 to 5 parts by weight based on 1 part by weight of the copolymerized polyhydroxyalkanoate (PHA).

[0100] The cosmetic composition according to the present invention may include a surfactant. The surfactant uniformly disperses powdered ingredients or cosmetic compositions into a liquid medium, allowing them to spread evenly throughout the product. It also prevents the powdered ingredients from separating or settling in the liquid medium, thereby maintaining product stability. Surfactants can also be used as dispersants, emulsifiers, and detergents, depending on their function.

[0101] The above surfactant may be at least one selected from the group consisting of, for example, anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, polymeric surfactants, natural surfactants, and silicone surfactants.

[0102] In one embodiment, the surfactant is Cetearyl Olivate, Sorbitan Olivate, Cetearyl Alcohol, Glyceryl Monostearate, Glyceryl Stearate, PEG-100 Stearate, C14-22 Alcohols, C12-20 Alkyl Glucoside, Polyglyceryl-6 Polyricinoleate, Polyglyceryl-3 Polyricinoleate, Polyglyceryl-10 Myristate, Potassium Cetyl Phosphate It may contain one or more (two or more, three or more, or four or more) selected from the group consisting of Cetyl Phosphate, Cetyl PEG / PPG-10 / 1 Dimethicone, PEG-10 dimethicone, and Stearic Acid.

[0103] Based on the total weight of the cosmetic composition of the present invention, the content of the surfactant may be 0.1 wt% or more, 1 wt% or more, 3 wt% or more, 5 wt% or more, 10 wt% or more, or 15 wt% or more, and may also be 40 wt% or less, 30 wt% or less, 25 wt% or less, or 20 wt% or less, but is not limited thereto. As a specific example, based on the total weight of the cosmetic composition, the content of the surfactant may be 0.1 wt% to 30 wt%.

[0104] In addition, the cosmetic composition may contain the surfactant in an amount of 0.05 to 3 parts by weight, or 0.1 to 1.5 parts by weight, based on 1 part by weight of the copolymerized polyhydroxyalkanoate (PHA).

[0105] The cosmetic composition according to the present invention may include a polyol. The polyol is a component that ensures the formulation stability of the cosmetic composition while enhancing skin moisturizing power.

[0106] These polyols are not particularly limited, but may include at least one selected from the group consisting of glycerin, 1,3-butylene glycol, dipropylene glycol, propylene glycol, polyethylene glycol, and 1,2-hexanediol. Specifically, the polyol may include glycerin, which is economical and has excellent moisturizing properties.

[0107] Based on the total weight of the cosmetic composition of the present invention, the content of the polyol may be 0.1 wt% or more, 1 wt% or more, 3 wt% or more, 5 wt% or more, 10 wt% or more, or 15 wt% or more, and may also be 40 wt% or less, 30 wt% or less, 25 wt% or less, or 20 wt% or less, but is not limited thereto. As a specific example, based on the total weight of the cosmetic composition, the content of the polyol may be 0.1 wt% to 30 wt%.

[0108] Additionally, the cosmetic composition may contain the polyol in an amount of 0.05 to 3 parts by weight, 0.1 to 2 parts by weight, or 0.2 to 1 part by weight based on 1 part by weight of the copolymerized polyhydroxyalkanoate (PHA).

[0109] The cosmetic composition according to the present invention may further include purified water to control viscosity and ensure formulation stability. The purified water is not particularly limited, as long as it is any commonly known purified water (e.g., distilled water, deionized water, pure water, etc.).

[0110] The cosmetic composition according to the present invention may further include one or more additives selected from the group consisting of a moisturizer, a softener, a thickener, a preservative, a neutralizer, an acidity regulator, and a fragrance, as needed.

[0111] The moisturizer further included in the cosmetic composition according to the present invention is an ingredient capable of supplying moisture to the skin.

[0112] The emollient further included in the cosmetic composition according to the present invention is an ingredient capable of soothing the skin and providing softness. The emollient is not particularly limited, but may include one or more selected from the group consisting of natural vegetable oils, ester oils, hydrocarbon oils, higher alcohols, and silicone oils.

[0113] A thickener further included in the cosmetic composition according to the present invention is a component that increases the viscosity of the cosmetic composition. Such thickener is not particularly limited, but may include at least one selected from the group consisting of polyquaternium-10, carbomer, sodium chloride, methylcellulose, carboxymethylcellulose, carboxymethylhydroxyguanine, hydroxymethylcellulose, hydroxyethylcellulose, sodium acryloyldimethyltaurate / VP crosspolymer, ammonium acryloyldimethyltaurate / VP copolymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer-6, stearic acid, carrageenan, xanthan gum, gellan gum, cellulose gum, and bentonite.

[0114] The preservative further included in the cosmetic composition according to the present invention is a component that enhances the storage stability of the cosmetic composition. Such preservative is not particularly limited, but may include at least one selected from the group consisting of ethanol, phenoxyethanol, ethylhexylglycerin, caprylyl glycol, chlorphenesin, and sodium benzoate.

[0115] The neutralizing agent further included in the cosmetic composition according to the present invention is a component that interacts with the preservative included in the cosmetic composition to enhance the stability of the cosmetic composition during use. This neutralizing agent is not particularly limited, but may include at least one selected from the group consisting of potassium hydroxide, sodium hydroxide, calcium hydroxide, triethanolamine, trolamine, and aminomethylpropanol.

[0116] An acidity regulator further included in the cosmetic composition according to the present invention is a component that regulates the pH of the cosmetic composition. This acidity regulator is not particularly limited, but may include at least one selected from the group consisting of citric acid, acetic acid, propionic acid, oxalic acid, glycolic acid, malonic acid, lactic acid, succinic acid, tartaric acid, aspartic acid, maleic acid, glutaric acid, glutamic acid, gluconic acid, sorbic acid, benzoic acid, ascorbic acid, and salicylic acid.

[0117] The fragrance further included in the cosmetic composition according to the present invention is a component that imparts fragrance to the cosmetic composition.

[0118] The content of these additives can be appropriately adjusted within a range that does not deteriorate the physical properties that the cosmetic composition should have.

[0119] The cosmetic composition according to the present invention can be prepared in various formulations.

[0120] For example, the cosmetic composition may have the formulation of a sun stick, sun lotion, sunscreen, sun balm, sun spray, flexible toner, nourishing toner, lotion, nourishing cream, massage cream, essence, ampoule, eye cream, makeup base cream, primer, foundation, pact, shampoo, treatment, scalp ampoule, pack, spray, body wash, cleansing foam, cleansing lotion, cleansing oil, or powder.

[0121] The above cosmetic composition has excellent UV protection properties. For example, the SPF (Sun Protection Factor) of the cosmetic composition may be 20 or more, 25 or more, 30 or more, 35 or more, 40 or more, or 45 or more, and specifically may be 20 to 60, 30 to 55, or 30 to 50. In addition, the PA (Protection Factor of UVA) of the cosmetic composition may be 5 or more, 8 or more, 10 or more, or 15 or more, and specifically may be 5 to 30, 8 to 25, 10 to 25, or 10 to 20.

[0122] As a specific example, the cosmetic composition may have an SPF (Sun Protection Factor) of 30 or more and a PA (Protection Factor of UVA) of 8 or more.

[0123] The cosmetic composition according to the present invention, by including the aforementioned ingredients, can ensure excellent biodegradability and UV protection properties while ensuring formulation stability. In particular, the cosmetic composition according to the present invention can be environmentally friendly by being biodegradable and exhibiting minimal skin irritation, excellent usability, and low skin barrier properties due to the inclusion of the aforementioned biodegradable polymer particles.

[0124] Therefore, the cosmetic composition according to the present invention can be used for cosmetic purposes in various fields.

[0125] For example, the cosmetic composition can be used in the manufacture of a base cosmetic, a color cosmetic, a sunscreen cosmetic, or a hair care cosmetic.

[0126] Accordingly, the present invention also provides a cosmetic composition for blocking ultraviolet rays, which comprises biodegradable polymer particles, wherein the biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), wherein the copolymerized polyhydroxyalkanoate (PHA) comprises 1 to 20 wt% of repeating units derived from 4-hydroxybutyrate (4-HB) based on the total weight of the copolymerized polyhydroxyalkanoate (PHA), and has an SPF (Sun Protection Factor) of 30 or more and a PA (Protection Factor of UVA) of 8 or more.

[0127] Specific examples of the composition and content of biodegradable polymer particles and copolymer PHA included in the above UV-blocking cosmetic composition may be applied to the contents described above.

[0128] The SPF (Sun Protection Factor) of the above-described cosmetic composition for blocking ultraviolet rays may be 20 or more, 25 or more, 30 or more, 35 or more, 40 or more, or 45 or more, and specifically may be 20 to 60, 30 to 55, or 30 to 50. In addition, the PA (Protection Factor of UVA) of the above-described cosmetic composition may be 5 or more, 8 or more, 10 or more, or 15 or more, and specifically may be 5 to 30, 8 to 25, 10 to 25, or 10 to 20.

[0129] The above-mentioned UV-blocking cosmetic composition exhibits excellent UVB and UVA blocking booster effects, reducing the amount of UV filters that cause irritation in the formulation and helping to protect the skin from UV damage. Furthermore, the round PHA particles provide a smooth feel, improving spreadability, and provide a soft-focusing effect on the skin, helping to smooth skin texture. Furthermore, PHA has a high melting point, so its particles and shape remain stable even at low and high temperatures, allowing it to be applied to high-temperature emulsified formulations such as lotions and creams.

[0130] In addition, the present invention provides a cosmetic composition for skin regeneration, which comprises biodegradable polymer particles, wherein the biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), and wherein the copolymerized polyhydroxyalkanoate (PHA) comprises repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 1 wt% to 20 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).

[0131] Specific examples of the composition and content of biodegradable polymer particles and copolymer PHA included in the above skin regeneration cosmetic composition may be applied as described above.

[0132]

[0133] The present invention is further described in detail with reference to the following examples. However, the following examples are intended only to illustrate the present invention and the scope of the examples is not limited to these examples.

[0134]

[0135]

[0136] Experimental Example 1: Preparation and Usability Evaluation of O / W Sunscreen

[0137] Inorganic UV blocking agent (inorganic sunscreen) sunscreens of Examples 1 and 2 and Comparative Examples 1 and 2 were manufactured according to the manufacturing method below with the compositions described in Table 1 below.

[0138] The aqueous raw materials were placed in a beaker at room temperature, heated to 80℃, and mixed with a homogenizer (Premix, Japan) to check whether the thickener was transparently dissolved. After that, the oily raw materials that had been heated to 80℃ and dissolved were slowly added, and mixed for 10 minutes to completely disperse and homogenize. After cooling the beaker to 60℃, the inorganic blocking agent was slowly added while mixing, and the mixture was dispersed and homogenized for 10 minutes. PHA was slowly added while mixing at 60℃, and the mixture was dispersed and homogenized for 10 minutes. After cooling the beaker to 45℃, the preservative was added, and mixing was completed to manufacture. The PHA used was ground twice with an atomizer, and the average particle size (D50) was approximately 8㎛.

[0139] Classification Raw Material Name (INCI) Example 1 Example 2 Comparative Example 1 Comparative Example 2 1 Water to 100 to 100 to 100 to 100 2 Glycerin (polyol) 5.0 5.0 5.0 5.0 3 1,2-Hexanediol (polyol) 2.0 2.0 2.0 2.0 4 Hydroxyethyl Acrylate / Sodium Acryloyldimethyltaurate Copolymer (thickener) 0.5 0.5 0.5 0.5 5 Ammonium Acryloyldimetyltaurate / VP Copolymer (thickener) 0.2 0.2 0.2 0.2 6 Cetearyl Olivate, Sorbitan Olivate (surfactant) 3.0 3.0 3.0 3.0 7 Cetearyl Alcohol (surfactant) 2.0 2.0 2.0 2.0 8 Glyceryl Monostearate (Surfactant) 0.5 0.5 0.5 0.5 9 Dimethicone (Softener) 3.0 3.0 3.0 3.0 10 Titanium Dioxide (Sunscreen), Aluminum Hydroxide (Dispersant), Stearic Acid (Surfactant) 25.0 25.0 25.0 25.0 11 PHA (4HB repeating unit content 0%)--10.0-12 PHA (4HB repeating unit content 4%)-10.0--13 PHA (4HB repeating unit content 12%) 10.0---14 Ethylhexylglycerin (Preservative) 0.5 0.5 0.5 0.5 Total (parts by weight) 100 100 100 100

[0140]

[0141] The usability and satisfaction of the above Examples 1 and 2 and Comparative Examples 1 and 2 were evaluated.

[0142] The evaluation was conducted on 20 subjects in total, 10 women and 10 men in their 30s and 40s. 2 g of each of the cosmetic compositions of Examples 1 and 2 and Comparative Examples 1 and 2 was applied to the arms, gently rolled, and gently absorbed. Usability and satisfaction were evaluated, and the results are shown in Table 2 below. The usability scores for rolling sensation (spreadability), whitening sensation, and finishing sensation were evaluated based on the criteria of 1.0 (very poor), 2.0 (poor), 3.0 (average), 4.0 (good), and 5.0 (very good), and the less whitening sensation there was, the better it was evaluated. In addition, user satisfaction was evaluated from 0% (very dissatisfied) to 100% (very satisfied).

[0143] Example 1 of lost goods Example 2 of comparison Example 1 of comparison Example 2 of rolling feeling 4.5 3.8 3.5 3.5 Cloudiness 4.5 4.3 4.0 2.9 Finishing feeling 4.4 4.0 3.5 3.2 User satisfaction 95% 80% 73% 63%

[0144]

[0145] As shown in Table 2 above, the cosmetic composition of Example 1 was evaluated as excellent in all items, and specifically, it was evaluated as having a good rolling feel, less white turbidity, and a refreshing finish. In addition, the cosmetic composition of Example 2 was also evaluated as excellent overall, although lower than Example 1. In the case of the cosmetic composition of Comparative Example 1, the white turbidity was evaluated as being superior to that of Comparative Example 2, but it received lower scores than Examples 1 and 2 in the rolling feel and finish, respectively. In the case of Comparative Example 2, the white turbidity was evaluated as being the most severe, and thus it received the lowest evaluation in the satisfaction section.

[0146]

[0147] Experimental Example 2: Preparation and Usability of W / O Sunscreen, UV Protection, and Coverage Evaluation

[0148] Cosmetic compositions of Examples 3 and 4 and Comparative Examples 3 and 4 were prepared according to the manufacturing method below with the compositions described in Table 3 below.

[0149] After properly dispersing the oily ingredients, the water-based ingredients were slowly added over 5 minutes while mixing with a homogenizer (Premix, Japan) to emulsify them, and then completely dispersed and homogenized for 10 minutes. The fragrance was added and mixed to completely disperse and homogenize them, completing the manufacturing process.

[0150] The above PHA was used after being crushed twice with an atomizer, and the average particle size (D50) was approximately 8 ㎛.

[0151] Classification Raw Material Name Example 3 Example 4 Comparative Example 3 Comparative Example 4 1 Zinc Oxide (UV blocker) 10.0 10.0 10.0 10.0 10.0 2 Titanium Dioxide (UV blocker) 10.0 10.0 10.0 10.0 3 PHA (4HB repeating unit content 0%)--10.0 4 PHA (4HB repeating unit content 4%)-10.0- - 5 PHA (4HB repeating unit content 12%) 10.0--- 6 Polyglyceryl-6 polyricinoleate (surfactant) 1.0 1.0 1.0 1.0 7 C12-15 Akylbenzoate (softener) 20.0 20.0 20.0 20.0 20.0 8 Dicaprylyl Carbonate (softener) 10.0 10.0 10.0 10.0 9 Cetyl PEG / PPG-10 / 1 Dimethicone (Surfactant) 2.5 2.5 2.5 2.5 10 Water to 100 to 100 to 100 to 100 11 Sodium Chloride (Thickener) 1.0 1.0 1.0 1.0 12 1,2-Hexanediol (Polyol) 2.0 2.0 2.0 2.0 13 Butylene Glycol (Polyol) 3.0 3.0 3.0 3.0 14 Fragrance Amount Amount Amount Amount Amount Total (Parts by Weight) 100 100 100 100

[0152]

[0153] An experiment was conducted to confirm the usability evaluation satisfaction for the above examples 3 and 4 and comparative examples 3 and 4.

[0154] The evaluation was conducted on 20 subjects, 10 women and 10 men in their 30s and 40s. 2 g of each of the cosmetic compositions of Examples 3 and 4 and Comparative Examples 3 and 4 was applied to the arms, gently rolled, and gently absorbed. Usability and satisfaction were evaluated in the same manner as in Experimental Example 1, and the results are shown in Table 4 below.

[0155] Example 3 of lost goods Example 4 of comparison Example 3 of comparison Example 4 of rolling feeling 4.5 4.0 3.8 3.4 Cloudiness 4.3 4.1 3.9 2.7 Finishing feeling 4.4 3.5 3.2 3.0 User satisfaction 93% 81% 73% 58%

[0156]

[0157] As shown in Table 4 above, the cosmetic composition of Example 3 was evaluated as excellent in all items, and specifically, it was evaluated as having a good rolling feel, less white turbidity, and a smooth finish. The cosmetic composition of Example 4 was also evaluated as excellent overall, although lower than Example 3. In the case of the cosmetic composition of Comparative Example 3, the white turbidity was evaluated as above average, but it received lower scores than Examples 3 and 4 in the rolling feel and finish, respectively. The cosmetic composition of Comparative Example 4 had the most severe white turbidity and received the lowest evaluation in the satisfaction section.

[0158] Additionally, the in vitro UV protection effects of the cosmetic compositions of Examples 1 to 4 and Comparative Examples 1 to 4 were measured using an SPF-290AS (Solar light, USA) device. The UV protection test results are summarized in Table 5 below.

[0159] In addition, since turbidity is an essential factor to consider when manufacturing a UV-blocking product with an inorganic composition, the hiding index of the cosmetic compositions of Examples 1 to 4 and Comparative Examples 1 to 4 was measured to confirm the turbidity, and this was recorded in Table 5 below.

[0160] The hiding index was calculated using the mathematical formula 1 below, and the closer it is to 1, the higher the hiding rate (i.e., whiteness or coverage) is evaluated. To this end, 1 g each of the cosmetic compositions of Examples 1 to 4 and Comparative Examples 1 to 4 was applied to black and white paper using a film-forming applicator to form a film, and after drying for 1 hour, the L value was measured using a colorimeter (Coloremeter NR-60CP).

[0161] [Mathematical Formula 1]

[0162] Concealment index = L value of blank map / L value of black map

[0163] CategoryExample 1Example 2Comparative Example 1Comparative Example 2Example 3Example 4Comparative Example 3Comparative Example 4SPF (UVB)35.7231.5625.2116.9045.0832.4527.319.09PA (UVA)12.079.588.105.8816.929.918.027.88Coverage Index1.891.831.791.481.981.891.781.65

[0164]

[0165] As shown in Table 5 above, the cosmetic composition of Example 3 containing inorganic sunscreens zinc oxide, titanium dioxide, and PHA (4HB repeating unit content 12%) exhibited the highest UV blocking rate. In addition, even without zinc oxide, the cosmetic composition of Example 1 containing titanium dioxide and PHA (4HB repeating unit content 12%) also exhibited a relatively high UV blocking rate. The UV blocking rates of Examples 2 and 4 were also excellent.

[0166] On the other hand, the cosmetic compositions of Comparative Examples 2 and 4, which did not contain PHA despite containing an inorganic sunscreen, exhibited the lowest UV protection rates. Meanwhile, PHA (0% 4HB repeat unit content) in Comparative Examples 1 and 3 also appeared to contribute relatively to the UV protection effect. Thus, it was confirmed that when PHA was included, both SPF (UVB) and PA (UVA) increased.

[0167] In addition, the white turbidity usually increases when there is a lot of titanium dioxide, but it was confirmed that Examples 1 and 2 and Comparative Example 1 containing PHA had higher transparency than Comparative Example 2, and the cosmetic compositions of Examples 3 and 4 and Comparative Example 3 manufactured as W / O creams were the same. From this, it was confirmed that PHA helps disperse the inorganic blocking agent.

[0168] As described above, when usability, UV protection, and concealment rate are comprehensively considered, it can be seen that the cosmetic compositions of Examples 1 to 4 have satisfactory effects.

[0169]

[0170] Experimental Example 3: Manufacturing and Usability Evaluation of Makeup Base

[0171] Cosmetic compositions of Example 5, Comparative Examples 5 and 6 were manufactured according to the manufacturing method below with the compositions described in Table 6 below.

[0172] After properly dispersing the oily ingredients, the water-based ingredients were slowly added over 5 minutes while mixing with a homogenizer (Premix, Japan) to emulsify them, and then completely dispersed and homogenized for 10 minutes. The fragrance was added and mixed to completely disperse and homogenize them, completing the manufacturing process.

[0173] The above PHA was used after being crushed three times with an atomizer, and the average particle size (D50) was approximately 5 ㎛.

[0174] Classification Raw Material Name Example 5 Comparative Example 5 Comparative Example 6 1 Neopentyl Glycol Dicaprate (Softener) 5.0 5.0 5.0 2 Polyglyceryl-6 polyricinoleate (Surfactant) 1.0 1.0 1.0 3 Cyclomethicone (Softener) 15.0 15.0 15.0 4 Dimethicone (Softener) 2.0 2.0 2.0 5 Dimethicone / Vinyl Dimethicone Crosspolymer (Dispersant, Emulsifier) ​​4.0 4.0 4.0 6 Titanium Dioxide, Chrome Green Oxide, Talc (UV Blocker, Pigment) 7.0 7.0 7.0 7 PHA (4HB repeating unit content 12%) 3.0 0.0 0.0 8 Polymethylsilsesquioxane (Skin Conditioning Agent) 0.0 3.0 0.0 9 Water to 100 to 100 to 10010Sodium Chloride (Thickener)1.01.01.0111,2-Hexanediol (Polyol)2.02.02.012Glycerin (Polyol)3.03.03.013FragranceAmountAmountAmountAmountTotal (weight parts)100100100

[0175]

[0176] The above component (6) was uniformly mixed in a weight ratio of titanium dioxide: chromium green oxide: talc = 65:7:28, and then ground twice with an atomizer.

[0177] The usability and sensory properties of the cosmetic compositions of Example 5, Comparative Examples 5 and 6 were evaluated. The evaluation was conducted on 20 women in their 30s and 40s. 2 g of each of the cosmetic compositions of Example 5, Comparative Examples 5 and 6 was applied to the arms, gently rolled, and gently absorbed. The usability and sensory properties were evaluated, and the results are shown in Table 7 below. The scores for rolling sensation (spreadability), adhesion, durability, soft focus effect and makeup finish were evaluated on a scale of 1.0 (very poor), 2.0 (poor), 3.0 (average), 4.0 (good) and 5.0 (very good).

[0178] Example 5 of lost product Comparison Example 5 Comparison Example 6 Rolling feeling 4.5 4.2 3.6 Adhesion 4.3 4.3 3.8 Durability 4.3 4.2 3.5 Soft focus effect 4.2 4.1 3.1 Makeup finish 4.0 3.9 3.2

[0179]

[0180] As shown in Table 7 above, the cosmetic composition of Example 5 was evaluated as superior in all items, specifically, it had good rolling sensation, excellent adhesion, durability, soft focus effect, and excellent cosmetic finish. This indicates that the cosmetic composition containing PHA improved the heavy feeling of use and thick cosmetic finish of colorants (clay minerals).

[0181] In particular, it was found that a cosmetic composition containing PHA provides an excellent usability equivalent to polymethylsilsesquioxane, a general silicone powder used to improve the finish of a makeup base and for a soft focus effect.

[0182]

[0183] Experimental Example 4: Preparation of a Skin Regeneration Cream and In-Vitro Cytotoxicity Recovery Evaluation

[0184] Cosmetic compositions of Examples 6 and 7 and Comparative Example 7 were prepared according to the manufacturing method below with the compositions described in Table 8 below.

[0185] The water-based raw materials were placed in a beaker, heated to 80°C, and mixed with a homomixer (Premix, Japan). The oil-based raw materials dissolved at 80°C were slowly added to emulsify the mixture, and the mixture was completely dispersed and homogenized for 10 minutes. After cooling to 60°C, a thickener was added, and the mixture was mixed for 5 minutes to completely disperse and homogenize the mixture. After cooling to 50°C, a neutralizing agent was added, and the mixture was mixed for 5 minutes to completely disperse and homogenize the mixture, completing the manufacturing process.

[0186] The above PHA was used after being crushed three times with an atomizer, and the average particle size (D50) was approximately 5 ㎛.

[0187] Classification Raw Material Name Example 6 Example 7 Comparative Example 7 1 Water to 100 to 100 to 100 2 Glycerin (polyol) 8.0 8.0 8.0 3 Ammonium Acryloyldimethyltaurate / VP Copolymer (thickener) 0.3 0.3 0.3 4 1,2-Hexanediol (polyol) 2.0 2.0 2.0 5 PHA (4HB repeating unit content 12%) 5.0 2.5 0.0 6 Cetearyl Olivate, Sorbitan Olivate (surfactant) 2.0 2.0 2.0 7 Glyceryl Stearate, PEG-100 Stearate (surfactant) 2.5 2.5 2.5 8 C14-22 Alcohols, C12-20 Alkyl Glucoside (surfactant) 1.0 1.0 1.0 9 Propylene Glycol Dicaprylate / Dicaprate (Softener) 3.5 3.5 3.5 10 Caprylic / Capric Triglyceride (Softener) 8.0 8.0 8.0 11 Carbomer 2% Solution (Thickener) 5.0 5.0 5.0 12 Potassium hydroxide 10% Solution (Neutralizer) 1.0 1.0 1.0 Total (parts by weight) 100 100 100

[0188]

[0189] 2Х10 keratinocytes were seeded in 24-well plates 5 The cells were seeded at a density of 10 cells / well in DMEM (Dulbeco's Modified Eagle's Medium, Gibco) supplemented with 10% FBS and cultured in a humidified 37°C, 5% CO2 incubator for 1 day. After replacing with serum-free DMEM, the cells were exposed to fluorescent sunlight in the UV wavelength range of 240–360 nm for 1 minute to damage the cells. After UV exposure, the cosmetic compositions of Examples 6 and 7 and Comparative Example 7 were seeded at a certain concentration (v / v) and cultured for 3 days. After culture, the cell proliferation effect was measured by MTT assay and is shown in Table 9 below.

[0190] Sample nameConcentration (ppm)Cell proliferation effect (%) (vs. UV treatment)Example 610,000113.10 % ± 1.27Example 61,000104.34 % ± 2.01Example 710,000107.17 % ± 1.79Example 71,000101.11 % ± 1.25Comparative example 710,000-Comparative example 71,000-

[0191]

[0192] As shown in Table 9 above, the cell proliferation effect of the sample treated with 10,000 ppm of the cosmetic composition of Example 6 was evaluated to be the best, followed by the sample treated with 10,000 ppm of the cosmetic composition of Example 7.

[0193] On the other hand, in the case of the cosmetic composition of Comparative Example 7, cell proliferation did not occur, and from this, it can be seen that the cell proliferation effect of Examples 6 and 7 was due to the proliferation caused by the inclusion of PHA. Specifically, the sample treated with the cosmetic composition containing PHA had a good cell proliferation rate, and it can also be confirmed that there was no cytotoxicity as the cell proliferation occurred without any decrease.

[0194]

[0195] Experimental Example 5: Formulation Stability Evaluation

[0196] The formulation stability of the cosmetic compositions of Examples 1 to 7 and Comparative Examples 1 to 7 prepared above was evaluated.

[0197] The long-term storage stability of the above cosmetic compositions was evaluated at 4°C, 25°C, 45°C, and 50°C for 1 week, 2 weeks, 1 month, and 3 months. The evaluation criteria are summarized in Table 10, and the evaluation results are shown in Table 11.

[0198] Maintain statusO Sedimentation / separation and precipitationXDiscolorationXOdorX

[0199] Storage temperatureStorage periodExample 1Example 2Example 3Example 4Example 5Example 6 74℃1 weekOOOOOOOO2 weeksOOOOOOOO1 monthOOOOOOOO3 monthsOOOOOOOO25℃1 weekOOOOOOOO2 weeksOOOOOOOO1 monthOOOOOOOO3 monthsOOOOOOOO45℃1 weekOOOOOOOO2 weeksOOOOOOOO1 monthOOOOOOOO3 monthsOOOOOOOO50℃1 weekOOOOOOOO2 weeksOOOOOOOO1 monthOOOOOOOO3 monthsOOOOOOOO

[0200]

[0201] As shown in Table 11 above, the cosmetic compositions of Examples 1 to 7 had excellent long-term storage stability overall.

[0202] However, in the case of particles with a 0% 4HB content in PHA, such as Comparative Examples 1 and 3, it was not easy to manufacture uniform particles during grinding due to their high crystallinity and brittle nature, and when the cosmetic composition formulations of Comparative Examples 1 and 3 were spread, a foreign body sensation from the PHA particles was sometimes felt.

[0203]

[0204] Although various cosmetic compositions in various formulations were manufactured through the above examples, the scope of the present invention is not limited thereto, and the present invention can also be manufactured in the form of a flexible toner, a nourishing toner, a lotion, a nourishing cream, a massage cream, an essence, an eye cream, a BB cream, a CC cream, a primer, a foundation, a pact, a shampoo, a treatment, a scalp ampoule, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, a powder, etc.

Claims

1. Contains biodegradable polymer particles, The above biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), The above copolymerized polyhydroxyalkanoate (PHA) contains repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 1 wt% to 20 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA), A cosmetic composition wherein the average particle diameter of the biodegradable polymer particles is 20 ㎛ or less.

2. In paragraph 1, The above copolymerized polyhydroxyalkanoate (PHA) is A cosmetic composition further comprising a repeating unit derived from at least one monomer selected from the group consisting of 2-hydroxybutyrate (2-HB), 3-hydroxybutyrate (3-HB), 3-hydroxypropionate (3-HP), 3-hydroxyvalerate (3-HV), 3-hydroxyhexanoate (3-HH), 3-hydroxyheptanoate (3-Hhep), 3-hydroxyoctanoate (3-HO), 3-hydroxynonanoate (3-HN), 3-hydroxydecanoate (3-HD), 3-hydroxydodecanoate (3-HDd), 4-hydroxyvalerate (4-HV), 5-hydroxyvalerate (5-HV), and 6-hydroxyhexanoate (6-HH).

3. In paragraph 1, A cosmetic composition comprising the above copolymerized polyhydroxyalkanoate (PHA) poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P3HB-co-4HB).

4. In paragraph 1, A cosmetic composition wherein the copolymerized polyhydroxyalkanoate (PHA) comprises 3 to 15 wt% of repeating units derived from 4-hydroxybutyrate (4-HB) based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).

5. In paragraph 1, The above copolymerized polyhydroxyalkanoate (PHA) is Based on the total weight of the above cosmetic composition, A cosmetic composition, comprising 0.1% to 30% by weight.

6. In paragraph 1, The above cosmetic composition A cosmetic composition further comprising at least one selected from the group consisting of a sunscreen, an oil, a surfactant and a polyol.

7. In paragraph 6, The above surfactant A cosmetic composition comprising at least one selected from the group consisting of anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, polymeric surfactants, natural surfactants, and silicone surfactants.

8. In paragraph 6, The above sunscreen Titanium Dioxide (TiO2), Zinc Oxide (ZnO), Drometrizole, Drometrizole Trisiloxane, Digiloyl Trioleate, Disodium Phenyl Dibenzimidazole Tetrasulfonate, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Diethylhexyl Butamido Triazone, Methylene Bis-Benzotriazolyl Tetramethylbutylphenol, Methyl Anthranilate, Benzophenone-4, Benzophenone-8 A cosmetic composition comprising at least one selected from the group consisting of Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Ethylhexyl Dimethyl PABA, Ethylhexyl Salicylate, Ethylhexyl Triazone, Isoamyl p-Methoxycinnamate, Terephthalylidene Dicamphor Sulfonic Acid, Phenylbenzimidazole Sulfonic Acid, and Polysilicone-15.

9. In paragraph 6, The above oil is A cosmetic composition comprising at least one selected from the group consisting of natural oils, vegetable oils, waxes, hydrocarbons, higher fatty acids, higher alcohols, and silicone oils.

10. In paragraph 6, Based on the total weight of the above cosmetic composition, A cosmetic composition wherein the content of the surfactant is 0.1 wt% to 30 wt%.

11. In paragraph 6, Based on the total weight of the above cosmetic composition, A cosmetic composition wherein the content of the above sunscreen is 5% to 35% by weight.

12. In paragraph 6, Based on the total weight of the above cosmetic composition, A cosmetic composition wherein the content of the oil is 0.1 wt% to 70 wt%.

13. In paragraph 1, The above cosmetic composition SPF (Sun Protection Factor) is 30 or higher, A cosmetic composition having a PA (Protection Factor of UVA) of 8 or more.

14. In paragraph 1, The above cosmetic composition A cosmetic composition having the formulation of a sun stick, sun lotion, sunscreen, sun balm, sun spray, flexible toner, nourishing toner, lotion, nourishing cream, massage cream, essence, ampoule, eye cream, makeup base cream, primer, foundation, pact, shampoo, treatment, scalp ampoule, pack, spray, body wash, cleansing foam, cleansing lotion, cleansing oil, or powder.

15. In paragraph 1, The above cosmetic composition A cosmetic composition used in the manufacture of a base cosmetic, a color cosmetic, a sunscreen cosmetic, or a hair care cosmetic.

16. Contains biodegradable polymer particles, The above biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), The above copolymerized polyhydroxyalkanoate (PHA) contains repeating units derived from 4-hydroxybutyrate (4-HB) in an amount of 1 wt% to 20 wt% based on the total weight of the copolymerized polyhydroxyalkanoate (PHA), A cosmetic composition for blocking ultraviolet rays, having an SPF (Sun Protection Factor) of 30 or higher and a PA (Protection Factor of UVA) of 8 or higher.

17. Contains biodegradable polymer particles, The above biodegradable polymer particles comprise copolymerized polyhydroxyalkanoate (PHA), A cosmetic composition for skin regeneration, wherein the copolymerized polyhydroxyalkanoate (PHA) comprises a repeating unit derived from 4-hydroxybutyrate (4-HB) in an amount of 1% to 20% by weight based on the total weight of the copolymerized polyhydroxyalkanoate (PHA).