Continuous production method for elastic hydrogel patch

Abstract

A continuous production method for an elastic hydrogel patch. The elastic hydrogel patch is a multi-layer material formed by compounding base cloth, a hydrogel and a bottom film. The hydrogel is formed by mixing and stirring oil-phase raw materials and water-phase raw materials, wherein the oil-phase raw materials comprise a high-molecular skeleton polymer, a solvent, a cross-linking agent, a chelating agent, an oil-soluble additive, a surfactant, a filler and a preservative; and the water-phase raw materials comprise water, a tackifier, a pH regulator and a water-soluble additive. The continuous production method comprises the steps of pretreatment, continuous stirring and kneading, coating, first curing, die cutting, sorting, packaging and second curing. An existing batch operation process for hydrogels is changed, and a continuous production process including continuous mixing, defoaming, coating, first curing, die cutting, second curing, etc., of a hydrogel is provided; and the product quality is also improved while the production efficiency is improved.

Description

A continuous production method of elastic hydrogel patch Technical Field

[0001] The present invention relates to the technical field of hydrogel patches, in particular to a continuous production method of elastic hydrogel patches. Background Art

[0002] Hydrogel is a material with a three-dimensional hydrophilic polymer network structure that contains pure water as a dispersion medium. It is highly absorbent, capable of absorbing large amounts of water, resulting in flexibility similar to that of natural tissue. In recent years, by leveraging hydrogel's elasticity, close contact with the skin, and soft touch, facial mask packs with improved wettability, nutrient-supply properties, or dead skin cell removal have been developed. Hydrogels immersed in cosmetics or pharmaceuticals are used as the base of these mask packs.

[0003] A Chinese invention patent (CN115554278A) discloses a flurbiprofen gel patch and its preparation method. The patch involves stirring an oil phase and an aqueous phase in a mixing tank to produce a hydrogel paste, which is a thick, semi-solid preparation. The gel is then removed and applied to the surface. The preparation method is intermittent, requiring cleaning of the mixing tank after each gel removal. Gel residue on the stirring mechanism is difficult to remove and can easily remain, impacting product quality, resulting in low production efficiency and significant losses.

[0004] For example, Chinese invention patent (CN 113694207 A) discloses a method for preparing a hydrogel patch, 1) weighing a polymer gel skeleton, a moisturizing agent, a tackifier, a cross-linking agent, and water according to the formula ratio, mixing them evenly, and stirring for 1-35 minutes; 2) under stirring, adding pigments, flavors, and preservatives to step 1) in sequence, continuing to stir for 1-35 minutes, and preparing a hydrogel mixture; 3) coating, shaping, and cutting the hydrogel mixture obtained in step 2). The method is an intermittent preparation method, which is also a commonly used method in the industry. The intermittent preparation method is to add the raw materials for preparing the hydrogel to a stirred tank in a certain proportion and order, stir evenly to obtain a hydrogel mixture, and then coat, shape, and cut the hydrogel mixture to obtain the final product.

[0005] However, the above preparation method has several disadvantages: 1) Since the hydrogel contains many different materials and some functional materials (such as cross-linking agents, flavors, preservatives, etc.) are added in relatively small amounts, it is easy to cause instability between batches; 2) When the materials are mixed, the cross-linking reaction occurs, causing the viscosity of the hydrogel to increase during the coating process. The different degrees of cross-linking before and after coating will also cause inconsistencies in the weight, thickness, shrinkage rate, and performance of the products before and after preparation within the batch; 3) After the hydrogel is mixed, the viscosity is high and it cannot be completely removed from the stirring tank, resulting in large losses of raw materials; a large amount of gel adheres to the wall, which is difficult to clean, increases the difficulty of workers' operation, and generates a large amount of cleaning wastewater.

[0006] Summary of the Invention

[0007] In view of the shortcomings of the existing technology, the purpose of the present invention is to provide a continuous production method for elastic hydrogel patches, change the existing intermittent operation process of hydrogels, and provide a continuous production process for hydrogels including continuous mixing, degassing, coating, primary curing, die cutting, and secondary curing; while improving production efficiency, it also enhances product quality.

[0008] The technical solution adopted by the present invention to solve the technical problem is: a continuous production method of an elastic hydrogel patch, wherein the hydrogel patch is a multilayer material composed of a base fabric, a hydrogel, and a base film; the hydrogel is prepared by mixing and stirring oil-phase raw materials and water-phase raw materials; the oil-phase raw materials include a high-molecular-weight skeleton polymer, a solvent, a cross-linking agent, a chelating agent, an oil-soluble additive, a surfactant, a filler, and a preservative; the water-phase raw materials include water, a viscosity enhancer, a pH regulator, and a water-soluble additive; the continuous production method includes pretreatment, continuous stirring and kneading, coating, primary curing, die-cutting, sorting, packaging, and secondary curing.

[0009] Furthermore, the base fabric is knitted fabric, woven fabric, or non-woven fabric; the elongation at break of the base fabric is greater than 150%; before gel coating, the coated surface undergoes an online hydrophilic treatment to enhance adhesion between the base fabric and the gel; the online hydrophilic treatment of the base fabric includes plasma purging, corona discharge treatment, and UV-ozone treatment; the base fabric after the online hydrophilic treatment is directly subjected to the coating process; and the base film is a polymer film that does not adhere to the finished hydrogel.

[0010] Furthermore, the high molecular skeleton polymer is polyacrylic acid and its sodium salt, and the addition amount is 4 to 10 parts by mass; the solvent is one or more of propylene glycol, glycerol, isopropyl alcohol, butylene glycol, hexylene glycol, octanediol, mineral oil, sorbitol, and vegetable oil, and the addition amount is 10 to 30 parts by mass; the cross-linking agent is a polyvalent metal salt, including one or more of aluminum salt, magnesium salt, silicate, and calcium salt, specifically aluminum glycinate, aluminum hydroxide, magnesium aluminum silicate, magnesium hydroxide, calcium hydroxide, etc., and the addition amount is 0.05 to 0.5 parts by mass; the chelating agent is ethylenediaminetetraacetic acid and its sodium salt, and the addition amount is 0.05 to 0.5 parts by mass; the oil-soluble additive is menthol, lidocaine, methyl salicylate, capsaicin, ketoprofen, flurbiprofen , loxoprofen sodium, felbinac, diclofenac epolamide, shea butter, avocado oil, moringa seed oil, resveratrol, vitamin E, lutein, retinol, vanillyl butyl ether, squalane, lecithin, jojoba seed oil, one or more of the addition amount is 0.025 to 6 parts by mass; the surfactant is a polyoxyethylene ether surfactant, including Tween, ethoxylated fatty alcohol AEO, alkylphenol polyoxyethylene ether APE, and the addition amount is 0.5 to 5 parts by mass; the filler is one or more of kaolin, titanium dioxide, diatomaceous earth, silicon dioxide, and talc, and the addition amount is 0.2 to 2 parts by mass; the preservative is one or more of parahydroxyacetophenone, phenoxyethanol, and parahydroxybenzoic acid esters, and the addition amount is 0.1 to 1 part by mass. Furthermore, the water is deionized water, and the addition amount is 35 to 82 parts by mass; the viscosity enhancer is a water-soluble high molecular polymer, including one or more of sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, polyacrylic acid, povidone, polyvinyl alcohol, polyethylene glycol, and polysaccharide polymers, and the addition amount is 0.5 to 5 parts by mass; the pH adjuster is one or more of tartaric acid and citric acid, and the addition amount is 0.05 to 0.5 parts by mass; the water-soluble additives include amino acids, polypeptides, proteins, algae extracts, plant extracts, biological fermentations, and functional substances, and the addition amount is 0.01 to 10 parts by mass.

[0011] Furthermore, in the pretreatment process, the oil phase raw materials and the water phase raw materials are stirred and mixed in proportion and then placed in corresponding raw material storage tanks for standby use; in the continuous stirring and kneading process, the raw materials in the raw material storage tanks are automatically and continuously transported online to the spiral mixer through a precise metering system, and after the mixing, dispersion, grinding and vacuuming operations are completed in the spiral mixer, a hydrogel is formed, and the hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0012] Furthermore, in the coating process, the hydrogel in the gel storage tank enters the coating machine through the discharge valve and enters the gap between the rollers. The thickness and gram weight of the coated hydrogel are adjusted by adjusting the gap width; after the hydrogel passes through the rollers, it is coated between the base cloth and the bottom film to form a multi-layer structured gel sheet; after the coating is completed, the gel sheet is continuously transported by a conveyor belt and enters the curing process.

[0013] Furthermore, in the primary curing process, the gel sheet after coating is cured in a curing device; the curing is carried out in an inert gas atmosphere at a certain temperature to carry out a cross-linking reaction so that the gel is fixed; the inert gas is nitrogen, carbon dioxide, or argon; the time of the primary curing is 10 to 60 minutes, and the temperature of the primary curing is 20 to 50°C; during the primary curing process, the internal oxygen concentration is less than 1%.

[0014] Furthermore, in the die-cutting process, the gel sheet after the primary curing is die-cut by a cutter; the die-cut shapes include square, rectangle, circle, oval, long strip, and special shape; the die-cutting cutter includes a roller cutter, a flat press cutter, and a combination thereof.

[0015] Furthermore, in the secondary curing process, after the sorted qualified products are packaged, secondary curing is continued inside the packaging; the temperature of the secondary curing is 20 to 40° C., and the time of the secondary curing is 10 to 24 hours.

[0016] The beneficial effects of the present invention are as follows: compared with the prior art, the continuous production method of the elastic hydrogel patch provided by the present invention has the following advantages:

[0017] (1) This production method can realize the fully automated continuous production of elastic hydrogel patches, and concentrates the basic operations such as continuous raw material feeding, pre-mixing and kneading, fine dispersion and degassing in a single device. It only needs to add the raw materials into the raw material storage tank to achieve continuous multiple production, without the need for batch loading, avoiding gel contamination, reducing production losses, and requiring no human participation, thereby saving production time and improving production efficiency; the production continuity is strong.

[0018] (2) High production efficiency. The continuous mixing process can replace multiple batch intermittent mixers with a continuous production line, which can significantly reduce the investment in equipment and the area occupied.

[0019] (3) High-intensity screw mixing makes the dispersed flow field in the cavity more intense, increases the shear force on the material, makes the oil phase and the water phase mixed and dispersed more evenly, improves the uniformity of the material, and ensures the stable quality of the product.

[0020] (4) The cross-linking method of the hydrogel adopted by the present invention is an ionic cross-linking reaction between multivalent ions and carboxyl groups on the high molecular skeleton polymer, and the curing time is slow. After coating, the colloid is highly viscous and has a certain fluidity. During die-cutting, the colloid will adhere to the cutting tool, reducing product quality and production efficiency. At the same time, the hydrogel will shrink in volume during the cross-linking process, generating internal stress, causing the elastic base fabric to shrink irregularly, resulting in wrinkles, warping, etc. Therefore, the present invention adopts a secondary curing process to solve the above problems. The hydrogel patch after coating is cured in one step, which is initially cured, reduces the fluidity of the colloid, eliminates internal stress, and is conducive to die-cutting. It is particularly suitable for die-cutting of special-shaped patches or gel patches with rounded corners. Gel patches with rounded corners can significantly improve the adhesion between the patch and the skin and prevent the edges from falling off during use. The primary curing process is carried out under nitrogen sealing, effectively avoiding the influence of impurity gases on the hydrogel, thereby improving the quality of the gel. The secondary curing is carried out in the packaging bag, reducing the volatilization of moisture and volatile components.

[0021] (5) In the present invention, before the base fabric is coated with gel, the coated surface is subjected to an online hydrophilic treatment, thereby improving the adhesion between the base fabric and the gel. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] FIG1 is a rectangular gel patch with rounded corners obtained in Example 1 of the present invention.

[0023] FIG2 is a special-shaped gel patch obtained in Example 2 of the present invention.

[0024] FIG3 is a long strip of gel patch with rounded corners obtained in Example 3 of the present invention.

[0025] FIG4 is a crescent-shaped gel patch obtained in Example 4 of the present invention.

[0026] FIG5 is a special-shaped gel patch obtained in Example 5 of the present invention. DETAILED DESCRIPTION

[0027] The present invention will be further described below by way of specific examples, which are only intended to illustrate the present invention and are not intended to limit the scope of the present invention.

[0028] Example 1

[0029] Step 1: 6 parts of sodium polyacrylate, 0.15 parts of aluminum glycinate, 0.15 parts of disodium edetate, 0.5 parts of kaolin, 0.5 parts of titanium dioxide, 5 parts of menthol, 2 parts of Tween 80, 4 parts of propylene glycol, 0.5 parts of phenoxyethanol and 20 parts of glycerol are mixed uniformly to prepare an oil phase;

[0030] 10 parts of polyacrylic acid solution (concentration 20%), 1 part of sodium carboxymethyl cellulose, 1 part of lavender extract, 0.2 parts of tartaric acid, and the balance water (to 100 parts) are mixed uniformly to prepare an aqueous phase.

[0031] Step 2: The water phase and the oil phase are continuously transported to a spiral mixer in a certain proportion through a precise metering system, and the mixing is completed in the spiral mixer with a rotation speed of 60 rpm and a vacuum degree of -0.08 MPa. The hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0032] Step 3: Ensure the ambient temperature is 20-25°C and the humidity is 45-65% RH. Install the required base film, base fabric, feed port bottom plate, and baffle. The base fabric is a knitted fabric with an air layer, and the coated surface has been treated with an in-line corona treatment. Adjust the coating thickness to 1.0-1.2mm, the coating width to 250-270mm, and the coating speed to 8 meters / minute. The coated gel sheet is continuously transported by a conveyor belt to the curing process.

[0033] Step 4: Nitrogen was introduced into the curing chamber, and the curing temperature was controlled at 25°C and the curing time was 20 minutes.

[0034] Step 5: After the primary curing is completed, use a flat knife to die-cut the gel into rectangular patches with rounded corners (as shown in Figure 1).

[0035] Step 6: Place the gel patch in an aluminum foil bag, seal it, and place it in an environment of about 35°C for secondary curing.

[0036] Example 2

[0037] Step 1: 5 parts of sodium polyacrylate, 0.15 parts of disodium edetate, 0.5 parts of jojoba seed oil, 0.3 parts of aluminum glycinate, 2 parts of acetylated fatty alcohol, 4 parts of butylene glycol, 0.5 parts of phenoxyethanol and 20 parts of glycerol are mixed uniformly to prepare an oil phase;

[0038] Mix 0.1 parts of acetyl hexapeptide-8, 2 parts of gelatin, 1 part of aloe extract, 0.15 parts of tartaric acid, and the remainder of water (to 100 parts) to prepare an aqueous phase.

[0039] Step 2: The water phase and the oil phase are continuously transported to a spiral mixer in a certain proportion through a precise metering system. The mixing is completed in the spiral mixer at a speed of 60 rpm and a vacuum degree of -0.08 MPa. The hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0040] Step 3: Ensure the ambient temperature is 20-25°C and the humidity is 45-65% RH. Install the required base film and fabric, as well as the feed port bottom plate and baffle. The fabric is a water-repellent elastic woven fabric, and the adhesive surface is treated with an in-line corona treatment. Adjust the coating thickness to 1.0-1.2mm, the coating width to 500-510mm, and the coating speed to 8 meters / minute. The coated gel sheet is continuously transported via a conveyor belt to the curing process.

[0041] Step 4: Nitrogen was introduced into the curing chamber, and the curing temperature was controlled at 25°C and the curing time was 20 minutes.

[0042] Step 5: After the primary curing is completed, the gel patch is die-cut into special-shaped gel patches using a flat knife (as shown in Figure 2).

[0043] Step 6: Place the gel patch in an aluminum foil bag, seal it, and place it in an environment of about 35°C for secondary curing.

[0044] Example 3

[0045] Step 1: 5 parts of sodium polyacrylate, 0.15 parts of aluminum glycinate, 0.15 parts of disodium edetate, 0.1 parts of kaolin, 0.1 parts of titanium dioxide, 6 parts of menthol, 1.8 parts of Tween 80, 7 parts of propylene glycol, 0.5 parts of phenoxyethanol, 3 parts of liquid paraffin and 20 parts of glycerin are mixed and prepared into an oil phase;

[0046] Mix 20 parts of polyacrylic acid solution (concentration 20%), 1.2 parts of polyvidone (PVP), 0.1 part of aloe extract, 0.1 part of camellia extract, 0.1 part of arnica montana flower extract, 0.1 part of frankincense resin extract, 0.2 part of tartaric acid, and the balance water (to 100 parts) to prepare an aqueous phase.

[0047] Step 2: The water phase and the oil phase are continuously transported to a spiral mixer in a certain proportion through a precise metering system, and the mixing is completed in the spiral mixer at a speed of 60 to 80 rpm and a vacuum degree of -0.08 MPa. The hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0048] Step 3: Ensure the ambient temperature is 20-25°C and the humidity is 45-65% RH. Install the required base film and fabric, as well as the feed port bottom plate and baffle. The fabric is a stretch knitted fabric, and the coated surface has been treated with an in-line corona treatment. Adjust the coating thickness to 1.0-1.2mm, the coating width to 250-270mm, and the coating speed to 8m / min. The coated gel sheet is continuously transported via a conveyor belt to the curing process.

[0049] Step 4: Nitrogen was introduced into the curing chamber, and the curing temperature was controlled at 40°C and the curing time was 10 minutes.

[0050] Step 5: After the primary curing is completed, use a flat knife to die-cut the gel patch into a long strip with rounded corners (as shown in Figure 3).

[0051] Step 6: Place the gel patch in an aluminum foil bag, seal it, and place it in an environment of about 25°C for secondary curing.

[0052] Example 4

[0053] Step 1: Mix 5 parts of sodium polyacrylate, 0.17 parts of aluminum glycinate, 0.2 parts of disodium edetate, 0.5 parts of kaolin, 3 parts of propylene glycol, 0.5 parts of phenoxyethanol and 15 parts of glycerin to prepare the oil phase;

[0054] 2 parts of polyacrylic acid solution (concentration 20%), 2 parts of polyvinyl alcohol, 0.3 parts of tartaric acid, and the balance of water (to 100 parts) were mixed uniformly to prepare an aqueous phase.

[0055] Step 2: The water phase and the oil phase are continuously transported to a spiral mixer in a certain proportion through a precise metering system, and the mixing is completed in the spiral mixer at a speed of 60 to 80 rpm and a vacuum degree of -0.08 MPa. The hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0056] Step 3: Ensure the ambient temperature is 20-25°C and the humidity is 45-65% RH. Install the required base film, base fabric, feed port bottom plate, and baffle. The base fabric is an elastic nonwoven fabric, and the coated surface has been corona treated online. Adjust the coating thickness to 1.3-1.5mm, the coating width to 500-510mm, and the coating speed to 8 meters / minute. The coated gel sheet is continuously transported by a conveyor belt to the curing process.

[0057] Step 4: Nitrogen was introduced into the curing chamber, and the curing temperature was controlled at 40°C and the curing time was 10 minutes.

[0058] Step 5: After the primary curing is completed, use a flat pressing knife to die-cut the gel patch into a crescent-shaped gel patch with an arc (as shown in Figure 4).

[0059] Step 6: Place the gel patch in an aluminum foil bag, seal it, and place it in an environment of about 20°C for secondary curing.

[0060] Example 5

[0061] Step 1: 7 parts of sodium polyacrylate, 0.15 parts of disodium edetate, 0.2 parts of jojoba seed oil, 0.2 parts of aluminum glycinate, 0.5 parts of acetylated fatty alcohol, 4 parts of butylene glycol, 0.4 parts of p-hydroxyacetophenone and 20 parts of glycerol are mixed uniformly to prepare an oil phase;

[0062] 0.1 part of carnosine, 0.01 part of Pseudoalteromonas fermentation product extract, 0.1 part of hydrolyzed royal jelly protein, 0.1 part of ceramide, 0.1 part of palmitoyl tripeptide-5, 0.01 part of xanthan gum, 0.1 part of collagen, 0.15 part of tartaric acid, and the remainder (to 100 parts) of water are mixed uniformly to prepare an aqueous phase.

[0063] Step 2: The water phase and the oil phase are continuously transported to a spiral mixer in a certain proportion through a precise metering system. The mixing is completed in the spiral mixer at a speed of 60 rpm and a vacuum degree of -0.08 MPa. The hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0064] Step 3: Ensure the ambient temperature is 20-25°C and the humidity is 45-65% RH. Install the required membrane cloth, feed port base plate, and baffle. The cloth is elastic non-woven, and the coated surface has been treated with an in-line corona treatment. Adjust the coating thickness to 1.2-1.3mm, the coating width to 500-510mm, and the coating speed to 8 meters / minute. The coated gel sheet is continuously transported via a conveyor belt and enters the curing process.

[0065] Step 4: Nitrogen was introduced into the curing chamber, and the curing temperature was controlled at 50°C and the curing time was 10 minutes.

[0066] Step 5: After the primary curing is completed, the gel patch is die-cut into special-shaped gel patches using a flat pressing knife (as shown in Figure 5).

[0067] Step 6: Place the gel patch in an aluminum foil bag, seal it, and place it in an environment of about 20°C for secondary curing.

[0068] Comparative Example 1

[0069] Step 1: 6 parts of sodium polyacrylate, 0.15 parts of aluminum glycinate, 0.15 parts of disodium edetate, 0.5 parts of kaolin, 0.5 parts of titanium dioxide, 5 parts of menthol, 2 parts of Tween 80, 4 parts of propylene glycol, 0.5 parts of phenoxyethanol and 20 parts of glycerin were mixed uniformly to prepare an oil phase;

[0070] 10 parts of polyacrylic acid solution (concentration 20%), 1 part of sodium carboxymethyl cellulose, 1 part of lavender extract, 0.2 parts of tartaric acid, and the balance water (to 100 parts) are mixed uniformly to prepare an aqueous phase.

[0071] Step 2: The water phase and the oil phase are continuously transported to a spiral mixer in a certain proportion through a precise metering system, and the mixing is completed in the spiral mixer at a speed of 60 to 80 rpm and a vacuum degree of -0.08 MPa. The hydrogel is continuously transported from the spiral mixer to the gel storage tank.

[0072] Step 3: Ensure the ambient temperature is 20-25°C and the humidity is 45-65% RH. Install the required film, cloth, feed port base, and baffle. The cloth should be elastic knitted, and the coated surface should be corona treated. Adjust the coating thickness to 1.0-1.2mm, the coating width to 250-270mm, and the coating speed to 8 meters / minute. The coated gel sheet is continuously transported by a conveyor belt to the curing process.

[0073] Step 4: The gel sheet is cured at a temperature of 20-25°C and for 24 hours.

[0074] Step 5: After curing, use a flat knife to die-cut the gel into rectangular patches with rounded corners.

[0075] Step 6: Place the gel patch into the aluminum foil bag and seal it.

[0076] Comparative Example 2

[0077] Preparation of oil phase: 6 parts of sodium polyacrylate, 0.15 parts of aluminum glycinate, 0.15 parts of disodium edetate, 0.5 parts of kaolin, 0.5 parts of titanium dioxide, 5 parts of menthol, 0.3 parts of aluminum glycinate, 2 parts of Tween 80, 4 parts of propylene glycol, 0.5 parts of phenoxyethanol and 20 parts of glycerin were mixed and uniformly prepared to prepare the oil phase;

[0078] Preparation of the aqueous phase: Mix 10 parts of polyacrylic acid solution (concentration 20%), 1 part of sodium carboxymethyl cellulose, 1 part of lavender extract, 0.2 parts of tartaric acid, and the remainder of water (to 100 parts) to prepare the aqueous phase.

[0079] Add the oil phase to the water phase and stir in a double planetary stirred tank under vacuum for 10 min;

[0080] The hydrogel is transferred to a coating machine, coated on a non-woven fabric, covered with a release film, edge pressed, cut, and packaged into aluminum foil bags.

[0081] Table 1. Performance test results of Examples 1 to 5 and Comparative Examples 1 to 2

[0082] Moisture volatilization rate:

[0083] The Karl Fischer tester was used to test the change in moisture content in the patch and convert it into moisture volatilization rate.

[0084] 180 degree peel strength test:

[0085] Cut the patch into strips with a width of 25mm and a length of 130mm. Glue the end of the strip to a stainless steel plate. Fix the stainless steel plate to the fixture of a tensile testing machine. The other fixture of the testing machine clamps the other end of the sample at an angle of 180° to the stainless steel plate. Test the average peel force at a displacement speed of 200mm / min.

[0086] Skin adhesion test:

[0087] The gel patch was applied to the skin under a specified pressure and equilibrated at a specified temperature and time. The adhesion of the gel patch to the skin was then recorded and scored as follows:

[0088] Adhesion Scale

[0089] The above embodiments are only used to illustrate the present invention, and are not intended to limit the present invention. Ordinary technicians in the relevant technical field may make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, all equivalent technical solutions also fall within the scope of the present invention. The scope of patent protection of the present invention should be defined by the claims.

Claims

1. A continuous production method of an elastic hydrogel patch, characterized in that: The hydrogel patch is a multilayer material composed of a base fabric, a hydrogel and a base film; the hydrogel is formed by mixing and stirring an oil phase raw material and an aqueous phase raw material; the oil phase raw material includes a high molecular skeleton polymer, a solvent, a cross-linking agent, a chelating agent, an oil-soluble additive, a surfactant, a filler and a preservative; the aqueous phase raw material includes water, a thickener, a pH regulator and a water-soluble additive; the continuous production method includes pretreatment, continuous stirring and kneading, coating, primary curing, die cutting, sorting, packaging and secondary curing.

2. The continuous production method of an elastic hydrogel patch according to claim 1, characterized in that: The base fabric is knitted fabric, woven fabric or non-woven fabric; the elongation at break of the base fabric is greater than 150%; before gel coating, the coated surface of the base fabric is subjected to online hydrophilic treatment to improve the adhesion between the base fabric and the gel; the online hydrophilic treatment of the base fabric includes plasma purging, corona discharge treatment and ultraviolet-ozone treatment; the base fabric after the online hydrophilic treatment is directly subjected to the coating process; the base film is a polymer film that does not adhere to the finished hydrogel.

3. The continuous production method of an elastic hydrogel patch according to claim 1, characterized in that: The polymer backbone polymer is polyacrylic acid and its sodium salt, and the addition amount is 4 to 10 parts by weight; the solvent is one or more of propylene glycol, glycerol, isopropanol, butylene glycol, hexylene glycol, octanediol, mineral oil, sorbitol, and vegetable oil, and the addition amount is 10 to 30 parts by weight; the cross-linking agent is a multivalent metal salt, including one or more of aluminum salt, magnesium salt, silicate, and calcium salt, and the addition amount is 0.05 to 0.5 parts by weight; the chelating agent is ethylenediaminetetraacetic acid and its sodium salt, and the addition amount is 0.05 to 0.5 parts by weight; the oil-soluble additive is menthol, lidocaine, methyl salicylate, capsaicin, ketoprofen, flurbiprofen, loxoprofen sodium, felbinac, diclofenac epol The invention discloses a novel novel novel nanostructured carbon foam comprising one or more of amine, shea butter, avocado oil, moringa seed oil, resveratrol, vitamin E, lutein, retinol, vanillyl butyl ether, squalane, lecithin, and jojoba seed oil, with the addition amount being 0.025 to 6 parts by weight; the surfactant is a polyoxyethylene ether surfactant, including Tween, ethoxylated fatty alcohol AEO, and alkylphenol polyoxyethylene ether APE, with the addition amount being 0.5 to 5 parts by weight; the filler is one or more of kaolin, titanium dioxide, diatomaceous earth, silicon dioxide, and talc, with the addition amount being 0.2 to 2 parts by weight; the preservative is one or more of p-hydroxyacetophenone, phenoxyethanol, and p-hydroxybenzoic acid ester, with the addition amount being 0.1 to 1 parts by weight.

4. The continuous production method of an elastic hydrogel patch according to claim 1, characterized in that: The water is deionized water, and the addition amount is 35 to 82 parts by weight; the viscosity enhancer is a water-soluble high molecular polymer, including one or more of sodium carboxymethyl cellulose, sodium hydroxyethyl cellulose, polyacrylic acid, povidone, polyvinyl alcohol, polyethylene glycol, and polysaccharide polymers, and the addition amount is 0.5 to 5 parts by weight; the pH adjuster is one or more of tartaric acid and citric acid, and the addition amount is 0.05 to 0.5 parts by weight; the water-soluble additives include amino acids, polypeptides, proteins, algae extracts, plant extracts, biological fermentations, and functional substances, and the addition amount is 0.01 to 10 parts by weight.

5. The continuous production method of an elastic hydrogel patch according to claim 1, characterized in that: In the pretreatment process, the oil phase raw materials and the water phase raw materials are stirred and mixed uniformly according to proportion, and then placed in corresponding raw material storage tanks for standby; in the continuous stirring and kneading process, the raw materials in the raw material storage tanks are automatically and continuously transported online to the spiral mixer through a precise metering system, and hydrogel is formed after mixing, dispersing, grinding and vacuuming operations are completed in the spiral mixer, and the hydrogel is continuously transported from the spiral mixer to the gel storage tank.

6. The method for continuously producing an elastic hydrogel patch according to claim 5, characterized in that: In the coating process, the hydrogel in the gel storage tank enters the coating machine through the discharge valve, and the thickness and gram weight of the coated hydrogel are adjusted by adjusting the width of the gap in the rollers; after the hydrogel passes through the rollers, it is coated between the base cloth and the base film to form a multi-layer structured gel sheet; after the coating is completed, the gel sheet is continuously transported by a conveyor belt and enters the curing process.

7. A method for continuously producing an elastic hydrogel patch according to claim 1 or 6, characterized in that: In the one-time curing process, the gel sheet after coating is cured in a curing device; the curing is carried out in an inert gas atmosphere at a certain temperature to carry out a cross-linking reaction so that the gel is fixed; the inert gas is nitrogen, carbon dioxide, and argon; the time of the one-time curing is 10 to 60 minutes, and the temperature of the one-time curing is 20 to 50°C; during the one-time curing process, the internal oxygen concentration is less than 1%.

8. The method for continuously producing an elastic hydrogel patch according to claim 1, characterized in that: In the die-cutting process, the gel sheet after primary curing is die-cut by a cutter; the die-cutting shapes include square, rectangle, circle, oval, strip, and special shape; the die-cutting cutter includes a rolling cutter, a flat pressing cutter, and a combination thereof.

9. The method for continuously producing an elastic hydrogel patch according to claim 1, characterized in that: In the secondary curing process, after the sorted qualified products are packaged, secondary curing is continued inside the package; the temperature of the secondary curing is 20 to 40° C., and the time of the secondary curing is 10 to 24 hours.

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