Handheld medical internet of things terminal device

Abstract

A handheld medical Internet of Things terminal device, comprising a housing, a main control module, and a bearing module, the bearing module being used to accommodate a reaction tube, and being provided with a first observation hole; the terminal device further comprises an optical detection module and a display module; the display module comprises a background light connected to the main control module, at least one background light being provided; the optical detection module comprises a fluorescence sensor connected to the main control module, the fluorescence sensor being mounted at one side of the bearing module; the fluorescence sensor detects a fluorescence signal of the reaction tube quantitatively in real time by means of the first observation hole, and transmits the fluorescence signal to the main control module, the main control module processing the fluorescence signal after receiving the fluorescence signal to obtain a detection result, and simultaneously controlling and adjusting the color of the background light to display the current detection result. The display module has the characteristic of diversified functions. Different colors can be displayed by means of the display module, to show temperature, or strength of the fluorescent signal.

Description

A handheld medical Internet of Things terminal device

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This disclosure is based on the Chinese patent application with application number 202323212433.7 and application date November 27, 2023, and claims the priority of the Chinese patent application. The entire content of the Chinese patent application is hereby introduced into this disclosure as a reference. Technical Field

[0003] The present disclosure relates to the technical field of medical equipment, and in particular to a handheld medical Internet of Things terminal device. Background Art

[0004] A Chinese patent application (publication number CN115404159A) provides a portable nucleic acid detection device and method. The device includes a main body; a mounting cavity for a carrier module is provided on the main body, the carrier module is used to accommodate a reaction tube, and the reaction tube is used to accommodate a test substance; the carrier module is connected to a heating module, the heating module is used to adjust the temperature of the carrier module, and thus adjust the temperature of the reaction tube; the main body is connected to a light-emitting module, the light-emitting module is arranged at the bottom of the carrier module, and the carrier module is provided with a light hole facing the light-emitting module so that the light emitted by the light-emitting module is irradiated on the reaction tube through the light hole; the main body is also provided with an observation window, a first observation hole is provided on a first side of the carrier module, and the first observation hole is used to observe the reaction tube; when the carrier module is installed in the mounting cavity, the observation window is used to observe the reaction tube through the first observation hole. The detection device directly observes the fluorescence reaction through the observation window, and the detection result can only be determined based on the fluorescence reaction with the naked eye, which cannot eliminate the influence of individual visual differences. In addition, because the fluorescence reaction can only be viewed with the naked eye or recorded with a mobile phone, the detection result cannot be intuitively displayed on the device after the test is completed, and real-time data during the test process cannot be obtained, and objective quantitative analysis cannot be performed, which affects the user experience. In addition, although users can interact with the device in real time and obtain the reaction temperature and progress of the device during operation through the mobile terminal, the reaction progress and temperature cannot be directly reflected on the device, which also affects the user experience.

[0005] Summary of the Invention

[0006] The present disclosure provides a handheld medical Internet of Things terminal device to at least solve one of the technical problems existing in the prior art.

[0007] A handheld medical Internet of Things terminal device comprises a shell, a main control module and a carrying module, wherein the carrying module is used to accommodate a reaction tube and is provided with a first observation hole, and further comprises a status and result display module and an optical detection module; the status and result display module comprises a background light connected to the main control module, and at least one background light is provided; the optical detection module comprises a fluorescence sensor connected to the main control module, and the fluorescence sensor is mounted on one side of the carrying module; the fluorescence sensor quantitatively detects the fluorescence signal of the reaction tube in real time through the first observation hole and transmits the fluorescence signal to the main control module; the main control module processes the received fluorescence signal to obtain a detection result, and controls and adjusts the color of the background light to display the current detection result.

[0008] In one embodiment, the optical detection module further includes a fluorescence sensor mounting substrate, wherein the fluorescence sensors are provided in plurality and the number is equal to the number of the first observation holes, and the fluorescence sensors are arranged in sequence on the fluorescence sensor mounting substrate and the mounting positions of the fluorescence sensors are opposite to the positions of the first observation holes.

[0009] In one embodiment, the optical detection module also includes a filter and a filter mounting substrate, the filter is provided in plurality and the number is equal to the first observation hole, the filter is provided on the filter mounting substrate, the filter mounting substrate is provided between the fluorescence sensor mounting substrate and the carrier module and the position of the filter is opposite to the position of the first observation hole.

[0010] In one embodiment, the background light is a lamp bead with different colors, and there are 4-8 background lights, which are arranged in sequence and installed on the shell. The main control module is used to control the background light to display the reaction progress in real time during the detection process, and to control and adjust the color of the background light to display the current reaction temperature during the detection process. The main control module is used to control and adjust the color of the background light according to the concentration of the detected target after the detection is completed.

[0011] In one embodiment, the status and result display module further includes a protection screen, which covers the backlight and is connected to the housing.

[0012] In one embodiment, a server is further included, which is connected to the main control module. The main control module is used to transmit the data of the fluorescence signal acquired in real time to the server, and the server processes the data to obtain the detection result.

[0013] In one embodiment, the server is connected to a hospital information system HIS or a laboratory information system LIS, and the server transmits the acquired fluorescence signal data to the hospital information system HIS or the laboratory information system LIS, which processes the data to obtain the test results.

[0014] In one possible implementation manner, the electronic device includes a mobile phone, a pad, and a computer.

[0015] In one possible implementation, the server is connected to the electronic device, and the server transmits the detection result to the electronic device; or the server transmits data to the electronic device in real time, and the electronic device analyzes and processes the data to obtain the detection result.

[0016] In one embodiment, a button component is further included, which includes a selection button and an execution button connected to the main control module. The selection button transmits a selection signal to the main control module, and the main control module receives the selection signal to confirm the current detection item and controls the corresponding background light to light up; the execution button transmits an execution signal to the main control module, and the main control module receives the execution signal and executes the detection item.

[0017] On the other hand, the present disclosure also provides a handheld medical Internet of Things terminal device, including a shell, a main control module and a carrying module, the carrying module is used to accommodate a reaction tube and is provided with a first observation hole, and also includes a status and result display module and an optical detection module; the status and result display module includes a display screen connected to the main control module, the optical detection module includes a fluorescence sensor connected to the main control module, and the fluorescence sensor is installed on one side of the carrying module; the fluorescence sensor detects the fluorescence signal of the reaction tube in real time and quantitatively through the first observation hole and transmits the fluorescence signal to the main control module, and the main control module controls the display screen to display the current detection result in real time after processing the fluorescence signal.

[0018] In one embodiment, the display screen displays the current detection result in real time, including being used to display the fluorescence value in the reaction tube in real time;

[0019] The optical detection module further includes a fluorescence sensor mounting substrate. The fluorescence sensors are provided in plurality and the number is equal to the first observation holes. The fluorescence sensors are arranged in sequence on the fluorescence sensor mounting substrate and the mounting positions of the fluorescence sensors are opposite to the positions of the first observation holes.

[0020] In one embodiment, the display screen is further configured to display at least one of a reaction tube number, a reaction progress bar, a reaction temperature, and a reaction time in real time;

[0021] The optical detection module also includes a filter and a filter mounting substrate. There are multiple filters and the number is equal to the first observation holes. The filters are arranged on the filter mounting substrate. The filter mounting substrate is arranged between the fluorescence sensor mounting substrate and the carrier module, and the position of the filter is opposite to the position of the first observation hole.

[0022] In one possible implementation, the display screen is an OLED display, an LCD display screen, or an LED display screen;

[0023] The main control module is also connected to a printer, and the main control module prints the test results by controlling the printer;

[0024] The main control module is also connected to the sound module, and the main control module plays the detection results by controlling the sound module.

[0025] The state and result display module further includes a protection screen, which covers the top of the display screen and is connected to the housing.

[0026] In one embodiment, a server is further included, which is connected to the main control module. The main control module is used to transmit the data of the fluorescence signal acquired in real time to the server, and the server processes the data to obtain the detection result.

[0027] In one embodiment, the server is connected to a hospital information system (HIS) or a laboratory information system (LIS). The server transmits the acquired fluorescence signal data to the HIS or LIS, and the HIS or LIS processes the data to obtain the test results.

[0028] In one possible implementation, the server is connected to the electronic device, and the server transmits the detection result to the electronic device; or the server transmits data to the electronic device in real time, and the electronic device analyzes and processes the data to obtain the detection result.

[0029] In one possible implementation manner, the electronic device includes a mobile phone, a pad, and a computer.

[0030] In one embodiment, it further includes a button component, which includes a selection button and an execution button connected to the main control module. The selection button transmits a selection signal to the main control module, and the main control module receives the selection signal to confirm the current detection item and controls the display screen to display the corresponding detection item name and item information; the execution button transmits an execution signal to the main control module, and the main control module receives the execution signal and executes the detection.

[0031] Compared with the existing technology, the advantages of the handheld medical Internet of Things terminal device disclosed in this disclosure are:

[0032] 1) The disclosed handheld medical IoT terminal device incorporates a status and result display module. This display module, comprised of a translucent acrylic panel and LEDs, offers diverse functionality and can display different colors, such as temperature or the intensity of a fluorescent signal. First, during an experiment, a progress bar is formed by the on / off switching of the background light, visually displaying the operating status of the instrument and the progress of the reaction. Second, the display module can also reflect the temperature range of the instrument's heating module, providing temperature information through color changes in the background light, further optimizing experimental control and monitoring.

[0033] 2) The handheld medical Internet of Things terminal device disclosed herein selects preset programs by setting a button component: when disconnected from an electronic device (such as a mobile phone), the preset program can be selected by selecting a button, allowing the device to operate independently.

[0034] 3) The handheld medical Internet of Things terminal device disclosed herein is equipped with an optical detection module that can realize real-time quantitative analysis, and obtains the detection results after processing the data through the built-in algorithm of the main control module. Compared with the traditional endpoint detection method, the real-time quantitative analysis provides higher detection accuracy, thereby more accurately determining negative or positive results.

[0035] 4) The handheld medical Internet of Things terminal device disclosed in the present invention can have multiple result presentation methods: The device disclosed in the present invention provides two presentation methods for the test results to meet the different needs of the operators: A: The results are directly presented through the display module, and the results are directly displayed in color, so that the operator can clearly judge the test results. Compared with traditional visual detection equipment, this method reduces subjectivity and reduces dependence on operator experience. B: The test results are uploaded to the server wirelessly, and the data or results are sent to the examinee and the operator. The operator can query the previous test results at any time through the supporting application, applet or APP. This method provides a more flexible and convenient way to access results, allowing operators to obtain relevant information anytime and anywhere.

[0036] 5) The handheld medical Internet of Things terminal device disclosed in the present invention is highly portable, weighing approximately 290g. Compared with large polymerase chain reaction (PCR) instruments and nucleic acid amplification instruments, which weigh dozens of kilograms, the handheld medical Internet of Things terminal device disclosed in the present invention is highly portable and can be used in any place where disease detection is required (including but not limited to new coronavirus nucleic acid detection, and any other pathogens can also be realized, epidemic detection, animal and plant pathogen detection, genetically modified detection, etc.), and can realize on-site detection, and can be directly tested after the pathogens are collected.

[0037] 6) The disclosed handheld medical Internet of Things terminal device is more adaptable. On the one hand, it can meet laboratory needs and can set reaction parameters through the mobile app to meet its own experimental needs. On the other hand, it can simplify operations through built-in programs, which is more friendly to non-laboratory environments and non-professional laboratory personnel and can be operated with one click.

[0038] 7) The disclosed handheld medical IoT terminal device is provided with a status and result display module, which is composed of a display screen. The display screen can intuitively reflect the current quantitative test results, which is more user-friendly;

[0039] 8) The display screen provided in the handheld medical Internet of Things terminal device disclosed herein can display the current test tube number, the fluorescence value in the reaction tube, the reaction progress bar, the reaction temperature and the reaction time in real time, making the display more intuitive and avoiding misjudgment by non-professional inspectors;

[0040] 9) The handheld medical Internet of Things terminal device disclosed herein can also be connected to an external printer to print the test results through the printer. The handheld medical Internet of Things terminal device disclosed herein is also provided with a sound module to play the test results through the sound module, providing users with diverse choices.

[0041] It should be understood that the contents described in this section are not intended to identify the key or important features of the embodiments of the present disclosure, nor are they intended to limit the scope of the present disclosure. Other features of the present disclosure will become readily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] The above and other objects, features and advantages of the exemplary embodiments of the present disclosure will become readily understood by reading the detailed description below with reference to the accompanying drawings, in which several embodiments of the present disclosure are shown by way of example and not limitation, wherein:

[0043] In the drawings, the same or corresponding reference numerals denote the same or corresponding parts.

[0044] FIG1 shows a first structural diagram of a handheld medical Internet of Things terminal device according to Embodiment 1 of the present disclosure;

[0045] FIG2 shows a second structural diagram of a handheld medical Internet of Things terminal device according to Embodiment 1 of the present disclosure;

[0046] FIG3 shows a first structural diagram of the handheld medical Internet of Things terminal device when it is opened according to Example 1 of the present disclosure;

[0047] FIG4 shows a second structural diagram of the handheld medical Internet of Things terminal device when it is opened according to Example 1 of the present disclosure;

[0048] FIG5 shows a third structural diagram of the handheld medical Internet of Things terminal device according to Example 1 of the present disclosure;

[0049] FIG6 shows a schematic structural diagram of the connection between the carrier module and the optical detection module according to Example 1 of the present disclosure;

[0050] FIG7 shows a disassembly diagram 1 of FIG6 ;

[0051] FIG8 shows a second disassembly diagram of FIG6 ;

[0052] FIG9 shows a schematic structural diagram of the connection between the carrier module, the light-emitting module and the reaction tube according to Example 1 of the present disclosure;

[0053] FIG10 shows a schematic structural diagram of a carrier module according to Embodiment 1 of the present disclosure;

[0054] FIG11 shows a schematic structural diagram of the cover body of Example 1 of the present disclosure;

[0055] FIG12 shows a structural diagram 1 of a handheld medical Internet of Things terminal device according to Embodiment 2 of the present disclosure;

[0056] FIG13 shows a structural diagram 2 of a handheld medical Internet of Things terminal device according to Embodiment 2 of the present disclosure.

[0057] Explanation of the numbers in the figure: 1-main body, 11-carrying module, 111-light hole, 112-first observation hole, 113-groove, 114-mounting plate, 115-mounting hole, 12-heating module, 13-light-emitting module, 15-cover, 151-pressing plate, 152-magnetic switch, 153-cover mounting plate, 154-elastic member, 155-pressing plate groove, 16-housing, 18-power module, 2-reaction tube, 21-test object, 4-optical detection module, 41-filter mounting substrate, 42-filter, 43-fluorescence sensor, 44-fluorescence sensor mounting substrate, 5-status and result display module, 51-protective screen, 52-status and result display backlight, 6-main control module, 7-button assembly, 71-execution button, 72-select button, 8-display screen. DETAILED DESCRIPTION

[0058] To make the purposes, features, and advantages of the present disclosure more apparent and understandable, the technical solutions in the embodiments of the present disclosure will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present disclosure, not all of them. All other embodiments obtained by those skilled in the art based on the embodiments of the present disclosure without creative work shall fall within the scope of protection of the present disclosure.

[0059] Example 1

[0060] The embodiment of the present disclosure provides a handheld medical Internet of Things terminal device. The handheld medical Internet of Things terminal device further optimizes the result detection part based on the structure of the Chinese patent application (publication number CN115404159A), and uses the handheld medical Internet of Things terminal device as an Internet of Things terminal to connect to the network through a wireless connection. The detected information will be uploaded to the Weijian cloud server. After the Weijian cloud server processes the data, the results will be directly delivered to the user according to different user needs, or it will be connected to the hospital information system (HIS) or laboratory information system (LIS). The handheld medical Internet of Things terminal device of the embodiment of the present disclosure can be controlled and operated by an electronic device (such as a mobile phone), or it can be independently operated by conveying instructions through the buttons on the device itself and indicating the operating status through the background light.

[0061] As shown in Figures 1 and 7 , the handheld medical IoT terminal device of the present disclosure, based on the Chinese patent application (publication number CN115404159A), additionally includes an optical detection module 4, a status and result display module 5, and a button assembly 7. For ease of description, the status and result display module 5 will be referred to as the display module 5. The optical detection module 4 uses a photosensor to quantitatively detect the fluorescence signal from the reaction tube in real time, acting as a fluorescence sensor. The display module 5 provides feedback on the device's operating status. The display module 5's backlight turns on and off to form a progress bar, displaying the current reaction progress of the device in real time. The color of the display module 5's backlight reflects the current temperature range of the device's heating module. The main control module processes the real-time quantitative fluorescence signal fed back by the optical detection module 4 and then calculates the test result, such as negative or positive, using a built-in algorithm. Furthermore, the display module 5's backlight displays a qualitative output, such as by adjusting the backlight color based on the test result, to display the current test result. By selecting the preset program in the main control module through the button component, when the device is disconnected from the electronic device (such as a mobile phone), the preset program and signal acquisition program can be selected through the button component, allowing the device to operate independently. In addition, the electronic device can also receive data feedback from the IoT terminal device of the embodiment of the present disclosure and draw a real-time quantitative curve based on the feedback data. The specific instructions are as follows:

[0062] As shown in Figures 1-5, the display module 5 is mounted on the surface of the housing 16. Specifically, the display module 5 includes a protective screen 51 and a status and result display backlight 52. For ease of description, the status and result display backlight 52 will be referred to as the backlight 52. There are multiple backlights 52, and in this embodiment, there are eight backlights 52. Each of the multiple backlights 52 is electrically connected to the main control module 6. These backlights 52 are mounted sequentially on the housing 16. The protective screen 51 covers the backlights 52 and is flush with the surface of the housing 16. The protective screen 51 is a translucent acrylic plate, and the backlights 52 are commonly used commercially available LEDs that can display different colors.

[0063] In the embodiment of the present disclosure, the display module 5 has a multifunctional and diversified feature and can display different colors. Different colors can reflect the temperature or the strength of the fluorescent signal. Specifically, when the handheld medical Internet of Things terminal device of the embodiment of the present disclosure is running in a specific experiment, a progress bar can be formed by lighting up the background light in sequence to intuitively display the operating status and reaction progress of the device, and the background light 52 can also show the temperature range of the heating module 12. The temperature information can be reflected in real time through the color change of the background light. Specifically, in the handheld medical Internet of Things terminal device of the embodiment of the present disclosure, according to common detection items, the main control module 6 presets the reaction programs corresponding to these detection items respectively. The reaction program includes the reaction stage, the reaction temperature corresponding to each stage, and the reaction time. Among them, according to each reaction stage, the main control module 6 presets the reaction temperature value corresponding to each reaction stage, which is set to the first stage temperature value, the second stage temperature value, and the nth stage temperature value respectively. These stage temperature values ​​correspond to different background light colors. For example, when the temperature value in the first stage is 35°C, the corresponding background light color is yellow. When the temperature value in the second stage is 65°C, the corresponding background light color is red. During the transition period from the first stage temperature value to the second stage temperature value, that is, when the temperature is within 35-65°C, the corresponding background light color can be set to other colors, such as orange. The background light colors corresponding to these reaction stages can be set according to specific circumstances.

[0064] Therefore, when the handheld medical Internet of Things terminal device of the embodiment of the present disclosure is running in a specific experiment, the main control module controls the background lights 52 to light up in sequence according to the reaction time of the built-in reaction program to display the current detection progress, and the main control module 6 receives the temperature value transmitted by the heating module 12 in real time and compares it with the preset stage temperature value, and controls the background light to display the color corresponding to the temperature domain of the heating module 12.

[0065] As shown in Figures 5-10, the optical detection module 4 is mounted on the side of the carrier module 11. Specifically, the optical detection module 4 includes a filter mounting substrate 41, a filter 42, a fluorescence sensor 43, and a fluorescence sensor mounting substrate 44. The filter mounting substrate 41 is fixed to the side of the carrier module 11. A plurality of filters 42 are provided, and the number of filters 42 is equal to the number of the first observation holes 112 of the carrier module 11. Multiple filters 42 are mounted on the filter mounting substrate 41, and the positions of the filters 42 are corresponding to the positions of the first observation holes 112 on the carrier module 11. The filter 42 is used to filter out the excitation light signal in the first observation hole 112 and allow the fluorescence signal to pass through. The fluorescence sensor 43 is a miniature fluorescence sensor. There are multiple fluorescence sensors 43 and the number is equal to the number of filters. The multiple fluorescence sensors 43 are arranged in sequence and installed on the fluorescence sensor mounting substrate 44, and the installation position of the fluorescence sensor 43 is set corresponding to the position of the filter 42 (or the first observation hole 112). The fluorescence sensor mounting substrate 44 is fixedly mounted on the side of the filter mounting substrate 41, and the fluorescence sensor 43 is electrically connected to the main control module 6.

[0066] The fluorescence sensor 43 detects the fluorescence signal of the reaction tube 2 in real time and quantitatively through the filter 42 and the first observation hole 112 and transmits it to the main control module 6. The main control module 6 receives the fluorescence signal and processes it to obtain the detection result. Among them, the main control module 6 of the handheld medical Internet of Things terminal device of the present embodiment can present the detection result in any of the following ways:

[0067] First, after receiving and processing the fluorescent signal, the main control module 6 controls the backlight 52 of the display module 5 to display the test results. Specifically, the main control module 6 has preset fluorescence signal thresholds corresponding to each reaction program, namely the first fluorescence signal threshold, the second fluorescence signal threshold, and the nth fluorescence signal threshold. These fluorescence signal thresholds correspond to different test results. The main control module 6 displays the test results by presetting the background light colors corresponding to these fluorescence signal thresholds. For example, if the first fluorescence signal threshold indicates a negative result, the background light color is set to green; if the second fluorescence signal threshold indicates a weak positive result, the background light color is set to orange; and if the nth fluorescence signal threshold indicates a strong positive result, the background light color is set to red. The stronger the positive result, the redder the background light color. Of course, these settings can be adjusted according to specific circumstances. Therefore, when the main control module 6 processes the received fluorescent signal, it obtains the concentration value of the detected target and compares it with the preset fluorescent signal threshold, and then controls the background light to display the corresponding color, thereby intuitively displaying the current detection result (this is a qualitative output), that is, showing whether the detected target is negative, positive, strong positive, or weak positive; that is, after the detection is completed, the main control module 6 controls and adjusts the color of the background light according to the concentration value of the detected target, so as to intuitively show whether the detected target is negative, positive, strong positive, or weak positive.

[0068] The fluorescent signal can also display different indicator light colors according to the type of detection target and the detection results of different detection targets. For example, a positive test result of target A is displayed in red, a positive test result of target B is displayed in green, a positive test result of both targets A and B is displayed in orange, and a negative test result of both targets A and B is displayed in weak white.

[0069] Second, based on the first method, the main control module 6 can also be connected to an external server through a communication module, and the test results are uploaded to the server through the communication module, and the server feeds back the obtained test results to the user. Alternatively, the main control module 6 transmits the data of the fluorescent signal obtained in real time to the server, and the server processes the data to obtain the test results. The test results can be presented in the form of a report, and the format of the report can be, for example, PDF format or other visual formats applicable to the embodiments of the present disclosure. Among them, the communication module can be an existing well-known communication module such as a Bluetooth module, a wireless network module, etc. to realize the connection and communication between the main control module 6 and the server.

[0070] Main control module 6 can also be connected with the electronic equipment (such as mobile phone, pad, computer) of user terminal by communication module, and detection result is transferred to electronic equipment by communication module, and electronic equipment transmits detection result to server by wireless network again.Or, main control module 6 is by the data transfer of the fluorescent signal acquired in real time to electronic equipment, and electronic equipment transmits the data transfer of fluorescent signal to server by wireless network, and server processes data and obtains detection result.Detection result can be presented on electronic equipment by the form of report, and the format of report can be such as PDF format or other visual formats applicable to the disclosed embodiment.

[0071] Third, building on the second approach, the server can also connect to a hospital information system (HIS) or laboratory information system (LIS) to transmit test results to the HIS or LIS. Alternatively, the server can transmit data to the HIS or LIS, which then processes the data to generate test results.

[0072] Fourth, based on the second method, the server is further connected to the user's electronic device (such as a mobile phone, pad, or computer). The main control module 6 transmits the collected data to the server in real time. The server then transmits the data to the electronic device in real time. The electronic device processes the data, draws a quantitative curve in real time, and displays the test results. Alternatively, the server directly transmits the test results to the electronic device.

[0073] Fifth, based on the first method, the main control module 6 can also be connected to an electronic device to achieve direct interaction. The electronic device can be a mobile phone, pad, computer, etc. A matching application, applet or APP is preset in the electronic device to facilitate real-time reception of the fluorescence signal data transmitted by the main control module 6 and real-time quantitative curve drawing based on the data, and the test results are obtained after processing the data. The test results in the electronic device include but are not limited to: negative / positive of the detected target, the concentration of the target, whether the target exists, and the quantitative curve results. In addition, the electronic device can also directly receive the test results transmitted by the main control module 6. This interactive method is more flexible and convenient, allowing users to obtain relevant information anytime and anywhere. The electronic device can also be further connected to the cloud server to transmit the test results to the cloud server. The above five methods can be implemented in any one way, or these implementation methods can be used in combination at will.

[0074] In one embodiment, as shown in Figures 1-2, the handheld medical IoT terminal device of the disclosed embodiment further includes a button assembly 7, which includes an execution button 71 and a selection button 72. Both execution button 71 and selection button 72 are electrically connected to the main control module 6. The selection button 72 is used to switch between different built-in reaction programs within the main control module 6. Specifically, the selection button 72 transmits a selection signal to the main control module 6. The main control module 6 receives the selection signal, determines the current test item and the reaction program corresponding to the test item, and controls the corresponding backlight 52 to illuminate. For example, the backlights 52 can be named, from left to right, as the first backlight, the second backlight, and the nth backlight. When the selection button 72 is clicked for the first time, the first backlight illuminates, and the operator can confirm the current test item based on the order in which the backlights 52 illuminate. Clicking the selection button 72 again switches the test item, and the main control module 6 controls the second backlight to illuminate while the first backlight turns off. The illumination of these backlights can be displayed in the same color, or different colors can be used to indicate different test items. By analogy, by continuously clicking the select button 72 to switch test items, the corresponding background lights will light up in sequence or in combination, and the operator can confirm the current test item by comparing the diagram in the operation manual. The execute button 71 transmits an execution signal to the main control module 6. After receiving the execution signal, the main control module 6 starts to execute the test, specifically controlling the light emitting module, heating module, and fluorescence sensor to start working.

[0075] In one embodiment, as shown in Figure 3-11, the handheld medical Internet of Things terminal device of the embodiment of the present disclosure also includes a carrying module 11, a main body 1, a light hole 111, a first observation hole 112, a groove 113, a mounting plate 114, a mounting hole 115, a heating module 12, a light emitting module 13, a cover body 15, a pressure plate 151, a magnetic switch 152, a cover body mounting plate 153, an elastic member 154, a pressure plate groove 155, a shell 16, a power module 18, a reaction tube 2, and an object to be tested 21.

[0076] Among them, the main body 1 is provided with an installation cavity for installing a carrying module 11, the carrying module 11 is used to accommodate the reaction tube 2, and the reaction tube 2 is used to accommodate the object to be tested 21; the carrying module 11 is also connected to a heating module 12, and the heating module 12 is used to adjust the temperature of the carrying module 11 to adjust the temperature of the reaction tube 2.

[0077] The main body 1 is connected to a light-emitting module 13, which is mounted at the bottom of the carrier module 11. The carrier module 11 has a light hole 111 disposed toward the light-emitting module 13, as shown in FIG10 . This allows light emitted by the light-emitting module 13 to illuminate the reaction tube 2 through the light hole 111. A first observation hole 112 is disposed on a first side of the carrier module 11 for observing the reaction tube 2. The optical detection module 4 is mounted on a first side of the carrier module 11.

[0078] The carrier module 11 is provided with a plurality of grooves 113, which are used for embedding the reaction tube 2; the number of light holes 111 is consistent with the number of grooves 113, and the light holes 111 are arranged at the bottom of the grooves 113. The light-emitting module 13 is fastened to the bottom of the carrier module 11 so that the emitted light of the light-emitting module 13 is irradiated on the reaction tube 2 through the light holes 111; the carrier module 11 also includes a mounting plate 114, which is used to cooperate with the main body 1 to fix the carrier module 11 in the mounting cavity.

[0079] The heating module 12 is connected to a second side of the carrier module 11, which is different from the first side. The heating module 12 includes a heating element, a temperature sensor, and an overheating protection module. The temperature sensor is disposed between the heating element and the carrier module 11. The heating module 12 is used to adjust the temperature of the carrier module 11, and the temperature sensor is used to detect the temperature of the carrier module 11. The temperature sensor is connected to the overheating protection module, which is connected to the heating element. When the temperature detected by the temperature sensor is higher than a specified temperature, the overheating protection module is used to stop the heating element from heating. The temperature sensor includes at least one or more of a thermistor, a platinum resistor, and a thermocouple, and the heating element includes at least one or more of a ceramic heating plate, an electric heating film, a heating wire, a power resistor, and a semiconductor heating plate.

[0080] The main body 1 includes a cover 15 and a housing 16, which are rotatably connected to each other. The housing 16 is used to abut the carrier module 11. The cover 15 includes a C-shaped pressure plate 151, which is elastically connected to the cover 15 via an elastic member 154. The cover 15 may be provided with a cover mounting plate 153, which is formed with a pressure plate groove 155 for the pressure plate 151 to connect with. When the cover 15 is closed on the housing 16, the pressure plate 151 is used to press the reaction tube 2 into the carrier module 11. That is, the two ends of the C-shaped pressure plate 151 abut against the carrier module 11. This is because there is a height difference between the end face of the carrier module 11 and the end face of the reaction tube 2. Therefore, when the cover 15 is closed on the housing 16, the two ends of the pressure plate abut against the end face of the carrier module 11, and the middle part of the pressure plate presses against the end face of the reaction tube 2, thereby pressing the reaction tube 2 tightly. The cover 15 is provided with a magnetic switch 152, which is used to cooperate with the housing 16, that is, the housing 16 is also equipped with a magnetic switch 152 at a corresponding position and is located below the mounting plate 114, so as to open or close the cover 15 and generate a certain magnetic attraction force between the cover 15 and the housing 16 when the cover 15 is closed. The handheld medical Internet of Things final draft device of the embodiment of the present disclosure is also provided with a main control module 6. The main control module 6 does not interfere with the installation of other components during installation and is generally installed at the bottom of the installation cavity. The main control module 6 is connected to the heating module 12 for controlling the heating module 12 to adjust the temperature of the carrier module 11; the main control module 6 is also connected to the light emitting module 13 for controlling the light emitting module 13 to emit light to illuminate the reaction tube 2. It should also be noted that the above-mentioned specific technical features can be combined with the technical solutions disclosed in the Chinese patent application (publication number CN115404159A) if there is no contradiction. In order to avoid unnecessary repetition, the combination method will not be described separately in the embodiment of the present disclosure.

[0081] The following describes in detail the actual operation process of the handheld medical Internet of Things terminal device according to the embodiment of the present disclosure:

[0082] The first practical operation process, mobile interactive version:

[0083] a1: Plug in the power supply, turn on the power switch 18, the backlight 52 will light up sequentially, and the device will enter the standby mode and wait for the next instruction.

[0084] a2: The mobile phone is connected to the device via wireless, and the mobile phone uploads the set reaction program to the handheld medical Internet of Things terminal device. The uploaded reaction program includes the reaction stages and the reaction temperature and reaction time corresponding to each stage.

[0085] a3: When the handheld medical IoT terminal device receives data uploaded by the mobile phone, it will automatically execute according to the reaction stage, reaction time, and reaction temperature set in the program.

[0086] a4: During the reaction process, the background light 52 will light up in sequence according to the current reaction time, and convey the current reaction progress to the operator.

[0087] a5: During the reaction, the background light 52 will display a corresponding color according to the temperature threshold of the current heating module 12. The operator can observe the color of the background light 52 and understand the current reaction temperature by combining it with the color-temperature comparison chart.

[0088] a6: During the reaction process, the optical detection module 4 collects the reaction data in real time, uploads the data to the mobile phone and the server, and draws the reaction curve in real time on the mobile phone.

[0089] a7: After the reaction is completed, the built-in program of the handheld medical Internet of Things terminal device will interpret the result based on the detected data and transmit the result to the operator through the display module 5. When the result is positive, the background light 5 is red, and when the result is negative, the background light 52 is green; at the same time, the mobile phone will also receive feedback on the test results.

[0090] The second actual operation process, independent execution version:

[0091] b1: Plug in the power supply, turn on the power switch, the backlight will light up 52 times in sequence, and the device will enter standby mode, waiting for the next instruction.

[0092] b2: The experiment is completed through the button component 7 on the housing 16 of the handheld medical Internet of Things terminal device. Click the selection button 72 to switch between different built-in reaction programs. Common reaction temperatures and times are generally built-in, including recombinase polymerase amplification technology (RPA), loop-mediated isothermal amplification technology (LAMP) and other constant temperature reactions. Users can also set their own commonly used reaction temperatures and times in the instrument according to their needs. Different reaction presets correspond to different background lights 52 when selecting.

[0093] b3: After selecting the required reaction program through the selection button 72, click the execution button 71.

[0094] b4: After the reaction is completed, the built-in program of the handheld medical Internet of Things terminal device will interpret the result based on the detected data and transmit the result to the operator through the display module 5. When the result is positive, the background light 52 is red, and when the result is negative, the background light 52 is green.

[0095] Furthermore, based on the second actual operation process, when the expandable, independent version is executed, if the handheld medical Internet of Things terminal device of the embodiment of the present disclosure is linked to the server side, the data collected by the detection module 4 can be uploaded to the server side; however, in the absence of a wireless connection, the device can execute normally, but will not upload data.

[0096] The following is an example of a specific detection of a handheld medical IoT terminal device according to an embodiment of the present disclosure:

[0097] Example 1: Two-stage, mobile interactive version

[0098] HPV testing involves the following steps:

[0099] Scan the QR code to enter the information of the person to be tested.

[0100] Sampling: Use a sampling swab to take a cervical swab to complete the sampling.

[0101] Preparation of crude reaction extract: Immerse the sample swab in the nucleic acid release (lysis) reagent and let it stand for 1-2 minutes to obtain a crude nucleic acid extract.

[0102] Reaction preparation and loading: Drop the crude nucleic acid extract into the reaction tube containing the freeze-dried nucleic acid amplification reagent, shake / tap to completely dissolve and mix the freeze-dried reagent, and load the reaction tube loaded with the reagent into the heating module 12.

[0103] The handheld medical IoT terminal device is activated to perform a constant-temperature nucleic acid amplification reaction. Pressing the execute button 71 on the handheld medical IoT terminal device completes the constant-temperature nucleic acid amplification reaction at the preset temperature and time (65°C, 25 minutes; 95°C, 20 minutes). During this time, the device can be connected to a mobile phone to view the device's operating status and real-time detection signals through a mini-program or app.

[0104] Results test:

[0105] (A) The results are directly presented through the background light 52 of the status and result display module 5. The built-in program of the device will interpret the results based on the detected data and transmit the results to the operator through the background light 52 of the status and result display module 5. Positive results are different degrees of red (the redder, the stronger the positive), and negative results are green.

[0106] (B) The test results are wirelessly uploaded to the server, and the data or results are distributed to the test subject and the operator. The operator can view the test results at any time through the supporting application, mini-program, or app. The results are presented in text format, and will display words such as strong positive, weak positive, and negative.

[0107] Example 2: Single-stage, independent version.

[0108] SARS-CoV-2 is an enveloped, positive-strand RNA virus belonging to the genus Betacoronavirus, responsible for the 2019 coronavirus disease (COVID-19) pandemic. Efficient and rapid detection is crucial for early detection and prevention of viral spread. In Example 2, primers were designed for the conserved sequences of the SARS-CoV-2 ORF1ab and N genes, respectively, for rapid screening of SARS-CoV-2 and its mutants.

[0109] SARS-Cov-2 testing involves the following steps:

[0110] 1. Enter the information of the person to be tested.

[0111] 2. Sampling: Use a sampling swab to take a nasal / pharyngeal swab to complete the sampling.

[0112] 3. Preparation of crude reaction extract: Immerse the sample swab in the nucleic acid release (lysis) reagent and let it stand for 3-5 minutes to obtain the crude nucleic acid extract.

[0113] 4. Reaction setup and loading: Drop the crude nucleic acid extract into the reaction tube containing the freeze-dried nucleic acid amplification reagent, which includes primers, enzymes, and other reactants. Shake to completely dissolve and mix the freeze-dried reagent. Load the loaded reaction tube into the sample loading module.

[0114] 5. Reaction proceeds. Select the preset temperature of 63° C. and the preset time of 30 minutes by selecting button 72 , and click the execute button 71 to complete the isothermal nucleic acid amplification at the preset temperature and time.

[0115] 6. Result detection. Fluorescence data is collected in real time. After the reaction is completed, the handheld medical IoT terminal device's built-in data processing program processes the collected data and transmits the color display to the operator through the background light 52 of the status and result display module 5. Positive results are displayed in varying degrees of red, with the redder the stronger the positive result, and negative results are displayed in green.

[0116] Example 3

[0117] As shown in Figures 12-13, the structure of this embodiment 3 is substantially the same as that of embodiment 1, except that the background light 52 of embodiment 1 is replaced by a display screen 8. That is, the status and result display module 5 of this embodiment 2 includes a display screen 8 and a protective screen 51.

[0118] Specifically, a handheld medical Internet of Things terminal device includes a housing, a main control module, and a carrier module. The carrier module is used to accommodate reaction tubes and is provided with a first observation port. The carrier module also includes a status and result display module 5 and an optical detection module. The status and result display module 5 includes a display screen 8 connected to the main control module. The optical detection module includes a fluorescence sensor connected to the main control module and mounted on a side of the carrier module. The fluorescence sensor quantitatively detects the fluorescence signal from the reaction tube in real time through the first observation port and transmits the fluorescence signal to the main control module. The main control module processes the fluorescence signal and controls the display screen 8 to display the current detection result in real time. The detection result includes not only the real-time detection result during the reaction process but also the detection result after the detection is completed.

[0119] In this embodiment 3, after the main control module processes the fluorescence signal, the current detection result is displayed in real time through the display screen 8. The detection result includes but is not limited to the fluorescence value 82 in the reaction tube, the reaction tube number 81, the reaction progress bar, the reaction temperature 85 and the reaction time 86. Among them, the reaction progress bar includes a light reaction progress bar 83 and a digital reaction progress bar 84, as shown in Figures 12-13. When the handheld medical Internet of Things terminal device of the disclosed embodiment is performing a test, the light reaction progress bar 83 and the digital reaction progress bar 84 on the display screen 8 directly reflect the progress of the test. The fluorescence value in the reaction tube is displayed in real time through the display screen during the test process, and the fluorescence value after the test is completed is displayed through the display screen. The user can compare the test results corresponding to the fluorescence value according to the operation manual, such as whether the detected target is negative or positive.

[0120] Preferably, the light response progress bar 83 can also be set to different colors. After the test is completed, the main control module can also control the color of the light response progress bar 83 to reflect the final test result. For example, when the light response progress bar 83 is green, it indicates a negative result; when it is red, it indicates a strong positive result. This can be set to a variety of colors according to the specific situation, indicating negative, positive, strong positive, or weak positive. The light response progress bar 83 and the fluorescence value can be used to synchronously display the final test result. This two-pronged approach can effectively prevent misjudgment by non-professional testers.

[0121] In one embodiment, the display screen 8 may be an organic light emitting diode (OLED) display screen, a liquid crystal display (LCD) display screen, or a light emitting diode (LED) display screen.

[0122] In one embodiment, the main control module is further connected to a printer, and the main control module prints the detection results by controlling the printer; the main control module is also connected to a sound module, and the main control module plays the detection results by controlling the sound module.

[0123] In one embodiment, the handheld medical Internet of Things terminal device of the embodiment of the present disclosure also includes a button component, which includes a selection button 72 and an execution button 71 connected to the main control module. The selection button 72 transmits the selection signal to the main control module, and the main control module receives the selection signal to confirm the current detection item and controls the display screen to display the corresponding detection item name and project information; the execution button 71 transmits the execution signal to the main control module, and the main control module receives the execution signal and executes the detection.

[0124] It should be understood that the various forms of the processes shown above can be used to reorder, add, or delete steps. For example, the steps described in this disclosure can be performed in parallel, sequentially, or in a different order, as long as the desired results of the technical solutions disclosed in this disclosure can be achieved. This is not a limitation herein.

[0125] In addition, the terms "first" and "second" are used for descriptive purposes only and are not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present disclosure, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined. In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present disclosure. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, unless they are mutually inconsistent.

[0126] The above description is merely a specific embodiment of the present disclosure, but the scope of protection of the present disclosure is not limited thereto. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in this disclosure should be included in the scope of protection of the present disclosure. Therefore, the scope of protection of the present disclosure should be based on the scope of protection of the claims.

Claims

1. A handheld medical Internet of Things terminal device, comprising a shell, a main control module and a bearing module, wherein the bearing module is used to accommodate a reaction tube and is provided with a first observation hole, and further comprises a status and result display module and an optical detection module; the status and result display module comprises a background light connected to the main control module, and the background light is provided with at least one; the optical detection module comprises a fluorescence sensor connected to the main control module, and the fluorescence sensor is installed on one side of the bearing module; the fluorescence sensor detects the fluorescence signal of the reaction tube in real time and quantitatively through the first observation hole and transmits the fluorescence signal to the main control module, and the main control module processes the fluorescence signal after receiving the fluorescence signal to obtain the detection result, and controls and adjusts the color of the background light to display the current detection result.

2. The handheld medical Internet of Things terminal device according to claim 1, wherein: The optical detection module also includes a fluorescence sensor mounting substrate. The fluorescence sensors are provided in plurality and the number is equal to the first observation holes. The fluorescence sensors are arranged in sequence on the fluorescence sensor mounting substrate and the mounting positions of the fluorescence sensors are opposite to the positions of the first observation holes.

3. The handheld medical Internet of Things terminal device according to claim 2, wherein: The optical detection module also includes a filter and a filter mounting substrate. The filter is provided in plurality and the number is equal to the first observation hole. The filter is arranged on the filter mounting substrate. The filter mounting substrate is arranged between the fluorescence sensor mounting substrate and the carrier module and the position of the filter is opposite to the position of the first observation hole.

4. The handheld medical Internet of Things terminal device according to claim 1, wherein: The background light is a lamp bead with different colors. There are 4-8 background lights, which are arranged in sequence and installed on the shell. The main control module is used to control the background light to display the reaction progress in real time during the detection process, and to control and adjust the color of the background light to display the current reaction temperature during the detection process. The main control module is used to control and adjust the color of the background light according to the concentration of the detected target after the detection is completed.

5. The handheld medical Internet of Things terminal device according to claim 4, wherein: The state and result display module also includes a protection screen, which covers the backlight and is connected to the housing.

6. The handheld medical Internet of Things terminal device according to any one of claims 1 to 5, wherein: It also includes a server, which is connected to the main control module. The main control module is used to transmit data of the fluorescence signal acquired in real time to the server, and the server processes the data to obtain the detection result.

7. The handheld medical Internet of Things terminal device according to claim 6, wherein: The server is connected to a hospital information system HIS or a laboratory information system LIS, and the server transmits the acquired data of the fluorescence signal to the HIS or LIS, and the HIS or LIS processes the data to obtain the test result.

8. The handheld medical Internet of Things terminal device according to claim 6, wherein: The server is connected to the electronic device, and the server transmits the detection result to the electronic device; or the server transmits data to the electronic device in real time, and the electronic device analyzes and processes the data to obtain the detection result.

9. The handheld medical Internet of Things terminal device according to any one of claims 1 to 5, wherein: It also includes a button component, which includes a selection button and an execution button connected to the main control module. The selection button transmits a selection signal to the main control module, and the main control module receives the selection signal to confirm the current detection item and control the corresponding background light to light up; the execution button transmits an execution signal to the main control module, and the main control module receives the execution signal and executes the detection.

10. A handheld medical Internet of Things terminal device, comprising a shell, a main control module and a bearing module, wherein the bearing module is used to accommodate a reaction tube and is provided with a first observation hole, and further comprises a status and result display module and an optical detection module; the status and result display module comprises a display screen connected to the main control module, the optical detection module comprises a fluorescence sensor connected to the main control module, and the fluorescence sensor is installed on one side of the bearing module; the fluorescence sensor detects the fluorescence signal of the reaction tube in real time and quantitatively through the first observation hole and transmits the fluorescence signal to the main control module, and the main control module controls the display screen to display the current detection result in real time after processing the fluorescence signal.

11. The handheld medical Internet of Things terminal device according to claim 10, wherein: The display screen displays the current test result in real time, including being used to display the fluorescence value in the reaction tube in real time; The optical detection module also includes a fluorescence sensor mounting substrate. The fluorescence sensors are provided in plurality and the number is equal to the first observation holes. The fluorescence sensors are arranged in sequence on the fluorescence sensor mounting substrate and the mounting positions of the fluorescence sensors are opposite to the positions of the first observation holes.

12. The handheld medical Internet of Things terminal device according to claim 11, wherein: The display screen is also used to display at least one of the reaction tube number, reaction progress bar, reaction temperature and reaction time in real time; The optical detection module also includes a filter and a filter mounting substrate. The filter is provided in plurality and the number is equal to the first observation hole. The filter is arranged on the filter mounting substrate. The filter mounting substrate is arranged between the fluorescence sensor mounting substrate and the carrier module and the position of the filter is opposite to the position of the first observation hole.

13. The handheld medical Internet of Things terminal device according to claim 10, wherein: The display screen is an organic light emitting diode (OLED) display screen, a liquid crystal (LCD) display screen, or a light emitting diode (LED) display screen; The main control module is also connected to a printer, and the main control module prints the test results by controlling the printer; The main control module is also connected to the sound module, and the main control module plays the detection results by controlling the sound module; The state and result display module also includes a protection screen, which covers the top of the display screen and is connected to the shell.

14. The handheld medical Internet of Things terminal device according to any one of claims 10 to 13, wherein: It also includes a server, which is connected to the main control module. The main control module is used to transmit data of the fluorescence signal acquired in real time to the server, and the server processes the data to obtain the detection result.

15. The handheld medical Internet of Things terminal device according to claim 14, wherein: The server is connected to a hospital information system HIS or a laboratory information system LIS, and the server transmits the acquired data of the fluorescence signal to the HIS or LIS, and the HIS or LIS processes the data to obtain the test result.

16. The handheld medical Internet of Things terminal device according to claim 15, wherein: The server is connected to the electronic device, and the server transmits the detection result to the electronic device; or the server transmits data to the electronic device in real time, and the electronic device analyzes and processes the data to obtain the detection result.

17. The handheld medical Internet of Things terminal device according to any one of claims 10 to 13, wherein: It also includes a button component, which includes a selection button and an execution button connected to the main control module. The selection button transmits a selection signal to the main control module, and the main control module receives the selection signal to confirm the current detection item and controls the display screen to display the corresponding detection item name and item information; the execution button transmits an execution signal to the main control module, and the main control module receives the execution signal and executes the detection.

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