Brain tissue removal tool and use method therefor

Abstract

Disclosed in the present invention are a brain tissue removal tool and a use method therefor. The brain tissue removal tool comprises a guide rod and a tissue removal rod; the guide rod has a cylindrical structure; one end of the tissue removal rod is a resecting end, wherein the length of the resecting end does not exceed the length of the guide rod, and the resecting end can extend into the guide rod and is movable in the guide rod; and the other end of the tissue removal rod is an operating end, and a limiting block is provided on the tissue removal rod, wherein the limiting block is provided between the resecting end and the operating end, and is in stop fit with the top surface of the guide rod. The present invention has the advantages of a simple structure, convenient operations, and low costs, and can guarantee smooth implantation of an endoscope without pressing and damaging a target brain area, thereby preventing the field of view of a lens from being blocked, avoiding resource waste, and saving material costs, time costs and labor costs.

Description

Tools for removing brain tissue and how to use them Technical Field

[0001] The present invention relates to the technical field of brain tissue research, in particular to a tool for removing brain tissue and a method for using the tool. Background Art

[0002] In the field of brain tissue research, it is usually necessary to inject drugs, stimulate or remove brain tissue in order to observe the activity of the brain area, neurons or neural structures that need to be studied. Endoscopes are tools commonly used for observation and operation. In order for the endoscope to accurately reach the target brain area to be observed or studied, it is generally positioned through a brain stereotaxic device. The brain stereotaxic device mainly includes a positioning device and a three-dimensional operating arm. The positioning device is used to clamp and position the experimental animal to be studied. The three-dimensional operating arm is used to connect various tools (endoscopes, drills, clamps, pins, etc.). The three-dimensional operating arm uses a Cartesian coordinate system to enable the connected tools to be accurately positioned in the up and down, left and right, front and back, and rotation directions.

[0003] Currently, most endoscopic implants are performed directly into the brain tissue, reaching the target brain region. However, the front end of the endoscope lens is a circular surface. During implantation, the front end of the brain tissue is squeezed forward, causing irreversible damage to the brain tissue, thereby affecting neurons in the target brain region. Furthermore, the squeezed dead brain tissue blocks the lens's field of view, hindering the research process. Cleaning the lens also takes more time, adversely affecting research results. This, in turn, requires more experimental animals, increasing research costs and wasting resources. Therefore, there is an urgent need to address these issues. Technical issues

[0004] The purpose of the present invention is to provide a tool for removing brain tissue and a method for using the tool in order to solve the above problems. Technical Solutions

[0005] The present invention achieves the above-mentioned object through the following technical solutions: A tool for removing brain tissue, comprising:

[0006] A guide rod, wherein the guide rod is a cylindrical structure;

[0007] A tissue removal rod, one end of which is a cutting end, the length of which does not exceed the length of the guide rod, and the cutting end can be inserted into and move within the guide rod; the other end of the tissue removal rod is an operating end, and a limit block is provided on the tissue removal rod, which is arranged between the cutting end and the operating end, and the limit block cooperates with the top surface stop of the guide rod.

[0008] Furthermore, along the direction from the top end to the bottom end of the guide rod, the wall thickness of the bottom end of the guide rod gradually decreases and forms a blade shape; a relatively flat resection surface can be formed without squeezing and damaging the target brain area.

[0009] Furthermore, the radial cross section of the guide rod is annular.

[0010] Furthermore, the tissue removal rod is a cylindrical structure, and a fan-shaped guide block is provided inside the bottom end of the tissue removal rod. The inner end face of the fan-shaped guide block is an inclined surface, and a cutting blade is formed on one edge of the fan-shaped guide block; the brain tissue in the guide rod can be better removed without squeezing and damaging the target brain area.

[0011] Furthermore, the inner wall of the guide rod is threadedly connected to the outer wall of the tissue removal rod, which enables the tissue removal rod to rotate while feeding along the axial direction, thereby quickly removing the brain tissue in the guide rod and ensuring work efficiency.

[0012] Furthermore, it also includes a clamping assembly, which is used to connect the guide rod to the three-dimensional operating arm of the brain stereotaxic instrument.

[0013] Furthermore, the clamping assembly includes a connecting sleeve and a fixing piece, the connecting sleeve is sleeved and fitted on the outer wall of the guide rod, and the connecting sleeve is provided with a protrusion connected to the three-dimensional operating arm; one end of the fixing piece is threadedly connected and fitted with the connecting sleeve, and the other end of the fixing piece extends into the connecting sleeve and abuts and fits with the guide rod; this facilitates the clamping of the guide rod, and facilitates positioning and subsequent brain tissue removal operations.

[0014] Furthermore, the operating end is connected to a drive assembly for driving the tissue removal rod to rotate around its axis. The drive assembly can replace manual operation of the tissue removal rod, thereby reducing labor intensity and improving work efficiency.

[0015] A method for using a tool for removing brain tissue, using the tool for removing brain tissue, comprises the following steps:

[0016] Connecting the guide rod to the three-dimensional manipulator arm;

[0017] Operate the 3D manipulator arm so that the bottom end of the guide rod is opposite to the target brain area;

[0018] The 3D manipulator is operated again to move the guide rod axially to insert into the brain tissue until the bottom end of the guide rod reaches the target brain area, and the 3D manipulator is locked.

[0019] Inserting the cutting end of the tissue removal rod into the guide rod and moving it within the guide rod until the stop block abuts against the top surface of the guide rod, thereby removing the brain tissue within the guide rod;

[0020] The movement of the tissue removal rod is stopped, and the three-dimensional manipulator arm is unlocked and operated to move the guide rod along the axial direction to remove the brain tissue. Beneficial effects

[0021] The beneficial effects of the present invention are: first, it is mainly composed of a guide rod and a tissue removal rod, and has a relatively simple structure, which can effectively reduce the cost of the equipment;

[0022] Secondly, in actual use, it is only necessary to first position the guide rod to the target brain area and insert it into the brain tissue to an appropriate depth. That is, the brain tissue to be removed is circled within the guide rod, and then the tissue removal rod can be used to accurately remove the brain tissue. The operation is relatively simple and convenient.

[0023] Third, after the tool of the present invention removes brain tissue, it is equivalent to opening a hole in the brain tissue that directly reaches the target brain area. The endoscope can be implanted along this hole without squeezing or damaging the target brain area, and there is no brain tissue blocking the lens. This ensures the observation field of view, allows the research process to proceed smoothly, avoids waste of resources, and saves material costs, time costs, and labor costs.

[0024] In general, the present invention has the advantages of simple structure, easy operation and low cost, and can ensure the smooth implantation of the endoscope without squeezing and damaging the target brain area, avoiding the lens from blocking the field of view, and avoiding waste of resources, saving material costs, time costs and labor costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] FIG1 is a schematic diagram of the overall structure of the present invention;

[0026] FIG2 is a schematic cross-sectional view of the present invention;

[0027] FIG3 is a schematic structural diagram of a tissue removal rod according to the present invention;

[0028] FIG4 is a partially cutaway enlarged schematic diagram of the tissue removal rod of the present invention.

[0029] The reference numerals are as follows: 1-guide rod; 2-tissue removal rod; 21-cutting end; 22-operating end; 23-fan-shaped guide block; 231-inclined surface; 232-cutting blade; 3-limiting block; 4-connecting sleeve; 41-bump; 5-fixing member. Best Mode for Carrying Out the Invention

[0030] For ease of understanding of the present invention, the present invention will be described in more detail below in conjunction with the accompanying drawings and specific embodiments. It should be noted that when an element is described as being "fixed to" another element, it can be directly on the other element, or there can be one or more centered elements therebetween. When an element is described as being "connected to" another element, it can be directly connected to the other element, or there can be one or more centered elements therebetween. The terms "upper", "lower", "left", "right", "inside", "outside" and similar expressions used in this specification are for illustrative purposes only.

[0031] Unless otherwise defined, all technical and scientific terms used in this specification have the same meanings as those commonly understood by those skilled in the art to which this invention belongs. The terms used in this specification and in the description of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" as used in this specification includes any and all combinations of one or more of the relevant listed items.

[0032] As shown in FIG1 to FIG4 , this embodiment provides a tool for removing brain tissue, comprising:

[0033] The guide rod 1 is a cylindrical structure;

[0034] The tissue removal rod 2 has one end which is a cutting end 21, the length of which does not exceed the length of the guide rod 1, and the cutting end 21 can be inserted into the guide rod 1 and move within the guide rod 1; the other end of the tissue removal rod 2 is an operating end 22, and a limit block 3 is provided on the tissue removal rod 2, which is arranged between the cutting end 21 and the operating end 22, and the limit block 3 cooperates with the top surface stop of the guide rod 1.

[0035] Specifically, the stopper 3 is fixedly connected to the tissue removal rod 2. The length of the resection end 21 is preferably equal to the length of the guide rod 1, ensuring that the resection end 21 completely removes the brain tissue within the guide rod 1. Of course, the stopper 3 can be a nut threaded onto the tissue removal rod 2. By rotating the stopper 3, the axial position of the stopper 3 on the tissue removal rod 2 can be changed, thereby adjusting the actual length of the resection end 21, and better adjusting the actual depth of brain tissue resection, further avoiding damage to the target brain area.

[0036] 2 , the wall thickness of the bottom end of the guide rod 1 gradually decreases from the top end to the bottom end of the guide rod 1 , and forms a cutting edge.

[0037] The radial cross-section of the guide rod 1 is annular, and the tissue removal rod 2 is a cylindrical structure. A fan-shaped guide block 23 is provided inside the bottom end of the tissue removal rod 2. The inner end face of the fan-shaped guide block 23 is an inclined surface 231, and a cutting blade 232 is formed on one side edge of the fan-shaped guide block 23 (see Figure 4). The inner wall of the guide rod 1 is threadedly connected to the outer wall of the tissue removal rod 2. It should be noted that the end faces of the fan-shaped guide block 23 refer to the two ends along the axial direction of the tissue removal rod 2, while the other plane is the side face; the outer end face of the fan-shaped guide block 23 is arranged to coincide with the bottom face of the tissue removal rod 2. Along the axis of the tissue removal rod 2, a number of fan-shaped guide blocks 23 are circumferentially spaced apart. When the tissue removal rod 2 rotates, the bottom face of the tissue removal rod 2 presses against the brain tissue, and the cutting blade 232 cuts it layer by layer under the action of rotation, and the excised brain tissue enters the tissue removal rod 2 through the gaps between adjacent fan-shaped guide blocks 23. It is worth mentioning that a spiral guide plate can be provided inside the tissue removal rod 2 and / or a spiral guide groove can be provided on the outer wall of the tissue removal rod 2, so that during the process of removing brain tissue, the brain tissue will be discharged along the outer side of the spiral guide plate and / or the spiral guide groove and will not be squeezed inside, thereby further avoiding damage to the target brain area.

[0038] The tool of the present invention also includes a clamping assembly, which is used to connect the guide rod 1 to the three-dimensional manipulator arm of the stereotaxic apparatus. The clamping assembly includes a connecting sleeve 4 and a fixing member 5. The connecting sleeve 4 is fitted onto the outer wall of the guide rod 1 and is provided with a bump 41 for connecting to the three-dimensional manipulator arm. One end of the fixing member 5 is threadedly connected to the connecting sleeve 4, while the other end of the fixing member 5 extends into the connecting sleeve 4 and abuts against the guide rod 1. The fixing member 5 is preferably a screw, which is relatively common and easily available.

[0039] Specifically, when clamping the guide rod 1, it is first fixedly connected to the three-dimensional operating arm through the protrusion 41 and then the guide rod 1 is placed in the connecting sleeve 4. The relative extension length of the bottom end of the guide rod 1 is adjusted to better match the experimental animal and facilitate operation and experiments. Then, the fixing part 5 is tightened so that the guide rod 1 is fixedly connected relative to the connecting sleeve 4 to complete the clamping.

[0040] The operating end 22 is connected to a drive assembly for driving the tissue removal rod 2 to rotate around its axis. Preferably, the drive assembly adopts a handheld portable electric drill, which is easy to drive and improves work efficiency. Of course, other manual drive assemblies can also be used, and the selection is made according to the actual situation on site.

[0041] The present invention also provides a method for using a tool for removing brain tissue, which uses the tool for removing brain tissue, comprising the following steps:

[0042] Connect the guide rod 1 to the three-dimensional operating arm through the clamping assembly. For details, please refer to the above clamping process, which will not be repeated here.

[0043] Operate the three-dimensional manipulator arm so that the bottom end of the guide rod 1 is opposite to the target brain area;

[0044] The 3D manipulator is operated again to move the guide rod 1 axially to insert into the brain tissue until the bottom end of the guide rod 1 reaches the target brain area, and the 3D manipulator is locked.

[0045] Insert the cutting end 21 of the tissue removal rod 2 into the guide rod 1 and move it inside the guide rod 1 until the stop block 3 abuts against the top surface of the guide rod 1, thereby removing the brain tissue inside the guide rod 1;

[0046] The movement of the tissue removal rod 2 is stopped, the three-dimensional operating arm is unlocked and operated, and the guide rod 1 is moved along the axial direction to remove the brain tissue.

[0047] The above shows and describes the basic principles, main features, and advantages of the invention. Those skilled in the art should understand that the invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the invention. Various changes and improvements are possible without departing from the spirit and scope of the invention. Such changes and improvements are intended to fall within the scope of the invention. The scope of the invention is defined by the appended claims and their equivalents.

Claims

1. A tool for removing brain tissue, characterized in that, Comprising: A guiding rod (1), the guiding rod (1) being of a tubular structure; A tissue removal rod (2), one end of the tissue removal rod (2) being a cutting end (21), the length of the cutting end (21) not exceeding the length of the guiding rod (1), the cutting end (21) being able to extend into the guiding rod (1) and move within the guiding rod (1); the other end of the tissue removal rod (2) being an operating end (22), a limiting block (3) being provided on the tissue removal rod (2), the limiting block (3) being arranged between the cutting end (21) and the operating end (22), the limiting block (3) being in stop cooperation with the top surface of the guiding rod (1).

2. The tool for removing brain tissue according to claim 1, characterized in that: In the direction from the top end to the bottom end of the guiding rod (1), the wall thickness of the bottom end of the guiding rod (1) gradually decreases and forms a blade shape.

3. The tool for removing brain tissue according to claim 1, characterized in that: The radial cross-section of the guiding rod (1) is in a circular ring shape.

4. The tool for removing brain tissue according to claim 3, characterized in that: The tissue removal rod (2) is of a cylindrical structure, a sector-shaped guiding block (23) being provided inside the bottom end of the tissue removal rod (2), the inner end surface of the sector-shaped guiding block (23) being an inclined surface (231), and a cutting edge (232) being formed at one side edge of the sector-shaped guiding block (23).

5. The tool for removing brain tissue according to claim 4, characterized in that: The inner wall of the guiding rod (1) is in threaded connection and cooperation with the outer wall of the tissue removal rod (2).

6. The tool for removing brain tissue according to claim 1, characterized in that: It further includes a clamping assembly for connecting the guiding rod (1) to the three-dimensional operating arm of a brain stereotactic apparatus.

7. The tool for removing brain tissue according to claim 6, characterized in that: The clamping assembly includes a connecting sleeve (4) and a fixing member (5), the connecting sleeve (4) being sleeved on the outer wall of the guiding rod (1), a convex block (41) for connecting the three-dimensional operating arm being provided on the connecting sleeve (4); one end of the fixing member (5) is in threaded connection and cooperation with the connecting sleeve (4), and the other end of the fixing member (5) extends into the connecting sleeve (4) and abuts against the guiding rod (1).

8. The tool for removing brain tissue according to claim 1, characterized in that: The operating end (22) is in driving connection with a driving assembly for driving the tissue removal rod (2) to rotate around its axis.

9. A method for using a tool for removing brain tissue, characterized in that, Using the tool for removing brain tissue according to any one of claims 1 to 8, comprising the following steps: Connect the guiding rod (1) to the three-dimensional operating arm; Operate the three-dimensional operating arm to make the bottom end of the guiding rod (1) face the target brain area; Operate the three-dimensional operating arm again to make the guiding rod (1) move axially to insert into the brain tissue until the bottom end of the guiding rod (1) reaches the target brain area, and lock the three-dimensional operating arm; Insert the cutting end (21) of the tissue removal rod (2) into the guiding rod (1) and move within the guiding rod (1) until the limiting block (3) abuts against the top surface of the guiding rod (1) to remove the brain tissue within the guiding rod (1); Stop the movement of the tissue removal rod (2), release the lock on the three-dimensional operating arm and operate to make the guiding rod (1) move axially to remove the brain tissue.

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