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Formation of new tissues involves formation of new blood vessels. Some of the normal situations where angiogenesis is important and necessary include those for repair of wounds and the formation of the placenta during pregnancy. The normal body has controls over the process of angiogenesis.
A target for preparing a therapeutic for angiogenesis-related diseases and use thereof
This invention belongs to the field of biomedicine, specifically relating to a target for the treatment of angiogenesis-related diseases and its applications. This invention provides a method for intervening in the angiogenesis process by regulating the activity or expression level of Makorin ring finger protein 1 (MKRN1). Applications of this invention cover the development of drugs that promote or inhibit angiogenesis, the diagnosis and prognostic assessment of related diseases, and drug screening based on this target.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV