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Compositions for reducing, ameliorating, treating, or preventing condition of dry eye and methods of making and using same

A composition and technology for dry eye, which can be used in pharmaceutical combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as preservative discomfort

Active Publication Date: 2013-03-20
BAUSCH & LOMB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for sensitive patients, especially those who already suffer from dry eye, these preservatives may cause some discomfort

Method used

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  • Compositions for reducing, ameliorating, treating, or preventing condition of dry eye and methods of making and using same
  • Compositions for reducing, ameliorating, treating, or preventing condition of dry eye and methods of making and using same
  • Compositions for reducing, ameliorating, treating, or preventing condition of dry eye and methods of making and using same

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Embodiment Construction

[0029] In general, the present invention provides compositions capable of alleviating, ameliorating, treating or preventing the discomfort caused by dry eye.

[0030] In one aspect, the composition has a low risk of introducing undesired exogenous side effects such as undesired irritation, burning or stinging sensations. Alternatively, the composition is mild to the ocular surface.

[0031] In another aspect, the composition of the present invention comprises: (a) alginate; (b) a combination of at least two organic acids or salts thereof; and (c) a pharmaceutically acceptable carrier; wherein the pH of the composition in the range of about 5 to about 7.5. In one embodiment, the pH of the composition is in the range of about 5.5 to about 7.5. In another embodiment, the pH of the composition is from about 6 to about 7.5 (or alternatively, from about 6 to about 7, or from about 5.5 to about 7, or from about 5.5 to about 6.5, or from about 5 to about 6.8, or about 5.5 to about ...

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Abstract

Compositions for relief, treatment, or prevention of a condition of dry eye comprise alginate, a polyol, and a combinations of at least two organic acids or salts thereof, wherein the compositions have pH in the range from about 5 to about 7.5, at least one of the organic acids or salts thereof has a pKa in the range from and 6 to about 10. In some embodiments, the second organic acid or a salt thereof has a pKa that is no more than 1.5 units less than the pH.

Description

technical field [0001] The present invention relates to a composition for relieving, improving, treating or preventing dry eye (condition of dry eye) and methods for preparing and using the composition. In particular, the present invention relates to compositions and methods for alleviating, ameliorating, treating or preventing the discomfort of dry eye. Background technique [0002] Dry eye, also known as keratoconjunctivitis sicca or dyslacrima, is a common ophthalmic disorder affecting millions of people. Patients with dry eye may experience burning, dryness and constant irritation. In severe cases, dry eye can severely impair a person's vision and thus impair the patient's activities such as driving. Certain diseases such as Xerosis (Sjogren's disease) show the symptom of dry eye. In addition, as a person ages, the lacrimal glands of the eye produce less moisture, resulting in dry, red, itchy, and gritty eyes. [0003] Although it appears that dry eye may be caused b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/734A61K9/00A61K47/36A61P27/04
CPCA61K31/734A61K31/715A61K9/0048A61P27/02A61P27/04
Inventor 夏尔宁A·K·多比T·J·克莱伯
Owner BAUSCH & LOMB INC