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Pro-endothelin-1 for the prediction of impaired peak oxygen consumption

A technique for endothelin, peak, in the field of proendothelin 1 for prediction of impaired peak oxygen consumption

Inactive Publication Date: 2017-11-28
BRAHMS GMBH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Similar studies in less selected patient groups and studies using other biomarkers are not yet available

Method used

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  • Pro-endothelin-1 for the prediction of impaired peak oxygen consumption
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  • Pro-endothelin-1 for the prediction of impaired peak oxygen consumption

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Embodiment

[0052] overview

[0053] The present study of representative samples of unselected patients recommended for CPET revealed two important findings: first, the correlation between CT-proET-1 measured at rest and peak VO 2 correlated, and are severely impaired at peak VO 2 outperforms BNP due to its high accuracy in the prediction of . Second, additional measurements of CT-proET-1 and BNP resulted in WL max Used to predict severely impaired peak VO 2 accuracy increased significantly.

[0054] method

[0055] research group

[0056] From May 2004 to June 2005, 185 consecutive patients recommended for CPET to assess unexplained exercise intolerance were eligible for enrollment. We excluded patients without informed consent (n = 12) and patients without CT-pro-ET-1 and / or BNP measurements (n = 11). This leaves a total of 162 patients for this analysis. This study was approved by the local ethics committee. Written informed consent was obtained from all participating patien...

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Abstract

Subject of the present invention is an in vitro method for the alternative assessment of peak oxygen consumption (VO2) for a subject not having a heart failure by measuring Pro-Endothelin-1 (ProET-1) or fragments thereof.

Description

[0001] This application has an international application date of April 8, 2009, international application number PCT / EP2009 / 054251 entered the Chinese national phase on November 26, 2010, application number 200980119411.X, and the title of the invention "For predicting damaged peak oxygen consumption Amount of proendothelin 1" divisional application. technical field [0002] The subject of the present invention is a method for predicting impaired peak oxygen consumption (VO2) in subjects without heart failure. 2 ) in vitro method: [0003] Determining the level of proendothelin 1 (ProET-1) or a fragment thereof of at least 12 amino acids in a sample obtained from said subject; [0004] Use stated levels of proendothelin 1 (ProET-1) or fragments thereof of at least 12 amino acids as peak VO 2 surrogate markers. [0005] Another subject of the invention is the use of this method for risk assessment prior to non-cardiac surgery. Background technique [0006] Maximal Cardiop...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6857G01N33/6893G01N2333/5754G01N2800/32
Inventor 约阿希姆·斯特鲁克尼尔斯·莫根塔勒安德烈亚斯·贝格曼克里斯蒂安·穆勒
Owner BRAHMS GMBH
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