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Epigenetic method to estimate extrinsic age of skin

A skin-extrinsic technology, applied in the field of detection and analysis of cytosine methylation patterns in genomic DNA, can solve the problems of inability to assess aging-extrinsic aging and intrinsic aging

Pending Publication Date: 2021-01-08
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is understandable that the model cannot assess different forms of aging - extrinsic and intrinsic

Method used

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  • Epigenetic method to estimate extrinsic age of skin
  • Epigenetic method to estimate extrinsic age of skin
  • Epigenetic method to estimate extrinsic age of skin

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Embodiment Construction

[0043] As discussed, the aging process in the skin is a highly multifactorial phenomenon that also varies physically. For example, protected skin is much less damaged than exposed skin, and thus obviously different areas of skin from the same individual will have different degrees of damage and thus have different "ages".

[0044] In the present invention, we consider two forms of skin age: intrinsic age; and extrinsic age.

[0045] In terms of intrinsic age, an individual's chronological age is dominant, but other intrinsic factors such as an individual's metabolism, diet, stress, and underlying health also have an impact on skin age. Thus, in the context of the present invention, intrinsic age means skin age caused by endogenous factors.

[0046] As far as extrinsic age is concerned, intrinsic age will still be a fundamental component, but in addition, exogenous factors such as UV radiation, pollution, dry conditions and extreme temperatures will also play a role. Thus, in...

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Abstract

The present invention provides a method for obtaining information useful for determining the extracutaneous age of an individual, the method comprising the steps: (a) obtaining genomic DNA from skin cells derived from the individual; (b) observing cytosine methylation of 30 CpG loci in the genomic DNA selected from the group consisting of obtaining information useful for determining the extracutaneous age of the subject.

Description

technical field [0001] The present invention relates to methods for detecting and analyzing cytosine methylation patterns in genomic DNA. More specifically, the present invention relates to the detection and analysis of cytosine methylation patterns at specific sites in genomic DNA to determine the apparent age and health of the skin. Background technique [0002] Aging is well known to be a multifactorial process primarily driven by an individual's age. Skin aging is a unique multifactorial phenomenon driven by both intrinsic and extrinsic factors. In terms of intrinsic factors, an individual's chronological age is the best known, but other intrinsic factors such as an individual's metabolism, diet, stress, and underlying health also have an impact on skin age. In addition to these intrinsic factors, the skin is exposed to external challenges such as UV radiation, pollution, dry conditions and extreme temperatures. These extrinsic factors thus also influence the skin age...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6837C12Q1/6876
CPCC12Q1/6837C12Q1/6876C12Q2600/154
Inventor D·A·冈恩T·卡瓦特拉
Owner UNILEVER IP HLDG BV