Urination disorder ameliorating agent

Abstract

Provided is a urination disorder ameliorating agent for treating or ameliorating (or alleviating) urination disorders irrespective of the degree or presence of prostatic hyperplasia. The urination disorder ameliorating agent contains, as an active ingredient, a 2-oxapregnane compound represented by formula (1). (In the formula, R1 to R3 represent an alkyl group such as a methyl group, R4 represents an alkylcarbonyl group such as an acetyl group, X represents a halogen atom such as a chlorine atom, and Y represents a hydroxyl or oxo group bonded to the 11-position, 15-position or 16-position of a steroid backbone.

Description

technical field [0001] The present invention relates to a useful urination disorder improving agent containing a pregnane compound or a pharmaceutically acceptable salt thereof as an active ingredient and for improving urination disorders such as residual urination. Background technique [0002] With the development of an aging society, it is desired to improve or alleviate (or lessen) the urination disorders of the elderly, wherein the urination disorders include diseases or symptoms such as dysuria, residual urination, frequent urination, and urinary incontinence. As an agent for improving such urination disorders, Japanese Patent Application Early Publication No. H5-155773 (JP H5-155773 A, Patent Document 1) discloses that rehmannia is effective in the treatment and prevention of urination disorders such as frequent urination or urinary incontinence Purine derivatives. Japanese Patent Application Early Publication No. H8-3045 (JP H8-3045 A, Patent Document 2) discloses a...

AI Technical Summary

Problems solved by technology

[0007] However, an enlarged prostate does not necessarily lead to voiding disorders

For example, World Journal of Urology, 13, 9-13 (1995) (Non-Patent Docume

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