A skin cream for repairing hormone-induced facial dermatitis and its preparation method

Abstract

The present invention provides a skin care cream for repairing hormone face and a preparation method thereof, wherein the components of the skin care cream for repairing hormone face include an emulsifier, a moisturizer, an antioxidant, a thickener, an anti-allergic repair agent, and deionized water; the anti-allergic repair agent is a combination of Aotingmin, a mussel extract, a kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin, and bisabolol. The skin care cream of the present invention starts from the essence of causing hormone face, uses mild and non-irritating ingredients, forms a protective film on the skin surface, not only has the effect of antibacterial and anti-inflammatory, but also has the effects of improving capillary dilation, repairing stratum corneum, and moisturizing and hydrating, and can scientifically and effectively repair hormone face.

Description

Technical Field

[0001] The invention belongs to the field of cosmetics, and in particular relates to a skin care cream for repairing hormone face and a preparation method thereof. Background Art

[0002] Modern people live at a fast pace, and everything is pursued to be fast and efficient. Therefore, when encountering skin problems, cosmetics or ointments containing hormones with significant effects are our first choice. However, long-term abuse of such products will lead to serious consequences: hormone face. Hormone face is also called hormone-dependent dermatitis. Its essence is that long-term topical use of glucocorticoids can make the keratin thinner, the barrier function of the epidermis damaged, and the water loss of the skin increased. The destruction of the barrier integrity can lead to reduced skin resistance and increased sensitivity to external stimuli.

[0003] CN112263495A discloses a plant anti-allergic agent and its preparation method and application, wherein the plant anti-allergic agent comprises: Swertia japonica extract, Coptis chinensis extract and moisturizer. The plant anti-allergic agent of the present invention has antibacterial, anti-inflammatory and anti-allergic effects through the synergistic effect between the Swertia japonica extract, the Coptis chinensis extract and the moisturizer, and has a calming and soothing effect on the skin through a reasonable ratio between the components, and can repair hormone face and skin erosion caused by allergies. Under the condition of the same addition amount, the efficacy is 3 to 5 times that of similar products; the preparation process is simple and efficient, energy-saving and environmentally friendly; the cosmetics added with the plant anti-allergic agent are mild and non-irritating, and have a wide range of application value.

[0004] CN110292539A discloses a polypeptide composition with the function of quickly repairing hormone face and its application in cosmetics. The polypeptide composition contains antibacterial peptides, anti-inflammatory peptides and copper peptides. The polypeptide composition of the present invention has no toxic side effects and can effectively repair the skin atrophy, thinning, diffuse flushing, skin erythema, local swelling, acne, folliculitis pustules, etc. caused by hormone face; at the same time, the polypeptide composition of the present invention can also repair damaged skin and restore the skin to a healthy state.

[0005] However, although the above products can quickly reduce redness and inflammation, they ignore the cause of hormone face and do not solve the problem fundamentally, which often leads to repeated hormone face, seriously affecting people's physical and mental health. Therefore, providing a mild and non-irritating skin care product that starts from the essence of hormone face has important market value. Summary of the invention

[0006] In view of the deficiencies in the prior art, the object of the present invention is to provide a skin care cream for repairing hormone face and a preparation method thereof. The skin care cream starts from the essence of what causes hormone face, uses mild and non-irritating ingredients to form a protective film on the skin surface, and not only has antibacterial and anti-inflammatory effects, but also has the effects of improving capillary dilation, repairing the stratum corneum, and moisturizing and hydrating, and can scientifically and effectively repair hormone face.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a skin care cream for repairing hormone-induced acne, wherein the components of the skin care cream for repairing hormone-induced acne include an emulsifier, a moisturizer, an antioxidant, a thickener, an anti-allergic repair agent, and deionized water;

[0009] The anti-allergic repair agent is a combination of Otingmin, mussel extract, Kava pepper leaf / root / stem extract, Nanopro CERAII, β-1,3 glucan, fibronectin and bisabolol.

[0010] The skin care cream for repairing hormone face described in the present invention starts from the essence of causing hormone face, uses mild and non-irritating ingredients, and forms a protective film on the skin surface. It not only has antibacterial and anti-inflammatory effects, but also can scientifically and effectively repair hormone face. Among them, the mussel extract forms a protective film on the skin surface, which can reduce the stimulation of external stimuli to the skin, and improve capillary dilation, thereby relieving facial edema and redness; the bisabolol and kava pepper leaf / root / stem extract have antibacterial and anti-inflammatory effects, can reduce skin sensitivity and the content of inflammatory factors, and improve the tingling, redness and burning sensation caused by hormone face; the Otingmin, fibronectin, and Nanopro CERA II can restore the internal environment of facial skin, repair damaged stratum corneum, reduce transepidermal water loss, and replenish skin moisture; the β-1,3 glucan promotes tissue regeneration and repairs skin barrier; the Otingmin, mussel extract, kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol described in the present invention are used in combination, which has a synergistic effect in anti-allergic and anti-inflammatory, and maintaining skin ecological balance, so that the skin cream can repair hormone face more scientifically and effectively.

[0011] Preferably, the Otingmin is a mixture of water, lactobacillus / soymilk fermentation product filtrate, butylene glycol and 1,2-pentanediol.

[0012] Preferably, the Nanopro CERAII is a mixture of ceramide NS / ceramide NG, lecithin, tocopherol acetate, octyldodecanol, glycerin and water.

[0013] Preferably, the mass ratio of the autumin, mussel extract, kava leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol is (0.5-1):(0.1-0.5):(2-3):(1-1.5):(0.1-0.5):(0.1-0.8):(0.1-0.5).

[0014] Wherein “0.5-1” can be 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9 or 0.95, etc.;

[0015] The first "0.1-0.5" can be 0.15, 0.2, 0.25, 0.3, 0.35, 0.4 or 0.45, etc.;

[0016] "2-3" can be 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8 or 2.9, etc.;

[0017] The second "0.1-0.5" can be 0.15, 0.2, 0.25, 0.3, 0.35, 0.4 or 0.45, etc.;

[0018] “1-1.5” can be 1.1, 1.15, 1.2, 1.25, 1.3, 1.35, 1.4 or 1.45, etc.;

[0019] The third "0.1-0.5" can be 0.15, 0.2, 0.25, 0.3, 0.35, 0.4 or 0.45, etc.;

[0020] “0.1-0.8” can mean 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7 or 0.8, etc.

[0021] Preferably, the moisturizing agent includes any one of avocado butter, betaine, Tremella heteropolysaccharide, 1,2-hexanediol, 1,3-butanediol, or a combination of at least two thereof.

[0022] Preferably, the thickener is acrylic acid (ester) / C10-30 alkyl acrylate crosspolymer and / or Aristoflex AVC.

[0023] Preferably, the emulsifier comprises any one of Emulium Mellifera, MONTANOV 82, SIMULSOL165, Pellicer LB-10 or cetyl alcohol, or a combination of at least two thereof.

[0024] Preferably, the Emulium Mellifera consists of polyglyceryl-6 distearate, jojoba esters, polyglyceryl-3 beeswax acid ester and cetyl alcohol.

[0025] Preferably, the MONTANOV 82 is a mixture of cetearyl alcohol and coco-glucoside.

[0026] Preferably, the SIMULSOL 165 is a mixture of glyceryl stearate and PEG-100 stearate.

[0027] Preferably, the Pellicer LB-10 consists of sodium di(laurylamideglutamine)lysine, butylene glycol, and water.

[0028] Preferably, the antioxidant comprises any one of tocopherol acetate or p-hydroxyacetophenone or a combination of at least two thereof.

[0029] Preferably, the skin care cream for repairing hormone face also includes a softener.

[0030] Preferably, the emollient comprises argania spinosa kernel oil, isononyl isononanoate, polydimethylsiloxane or Any one or a combination of at least two from Ultimate.

[0031] Preferably, the Ultimate is composed of undecane and tridecane.

[0032] Preferably, the emollient is argania spinosa kernel oil, isononyl isononanoate, polydimethylsiloxane and The ultimate combination.

[0033] As a preferred technical solution of the present invention, the emollient is argania spinosa kernel oil, isononyl isononanoate, polydimethylsiloxane and The Ultimate combination of the four can make the skin care cream better at enhancing skin metabolism, repairing the stratum corneum, and moisturizing.

[0034] Preferably, the argania spinosa kernel oil, isononyl isononanoate, polydimethylsiloxane and The ultimate mass ratio is (0.5-1):(3-5):(1-2):(2-3).

[0035] Wherein “0.5-1” can be 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9 or 0.95, etc.;

[0036] "3-5" can be 3.2, 3.4, 3.6, 3.8, 4, 4.2, 4.4, 4.6 or 4.8, etc.;

[0037] "1-2" can be 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8 or 1.9, etc.;

[0038] “2-3” can be 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8 or 2.9, etc.

[0039] Preferably, the skin care cream for repairing hormone face also includes a pH regulator and / or a chelating agent.

[0040] Preferably, the pH adjuster comprises aminomethyl propanol.

[0041] Preferably, the chelating agent comprises Zeastat TM .

[0042] Preferably, the Zeasat TM It is a mixture of 1,3-propylene glycol and caprylhydroxamic acid.

[0043] Preferably, the components of the skin care cream for repairing hormone face include, by weight, 1-15 parts of emulsifier, 1-10 parts of moisturizer, 0.5-5 parts of antioxidant, 0.1-0.5 parts of thickener, 1-15 parts of anti-allergic repair agent, 1-10 parts of emollient, 0.1-0.3 parts of pH adjuster, 0.5-1 parts of chelating agent, and deionized water.

[0044] The amount of the emulsifier added to the skin cream of the present invention can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts or 14 parts, etc.;

[0045] The amount of the moisturizer added can be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, etc.;

[0046] The antioxidant may be added in an amount of 0.5 parts, 0.8 parts, 1 parts, 1.5 parts, 1.8 parts, 2 parts, 2.5 parts, 2.8 parts, 3 parts, 3.5 parts, 4 parts or 4.5 parts, etc.;

[0047] The thickener may be added in an amount of 0.1, 0.2, 0.3, 0.4 or 0.5 parts, etc.;

[0048] The amount of the anti-allergic repair agent added can be 1 part, 2.5 parts, 4 parts, 5.5 parts, 7 parts, 8.5 parts, 10 parts, 11.5 parts or 13 parts, etc.;

[0049] The amount of the emollient added can be 1 part, 2 parts, 3 parts, 4 parts, 4 parts, 6 parts, 7 parts, 8 parts or 9 parts, etc.;

[0050] The amount of the chelating agent added can be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts or 0.9 parts, etc.;

[0051] The added amount of the pH adjuster can be 0.12 parts, 0.15 parts, 0.18 parts, 0.2 parts, 0.22 parts, 0.25 parts or 0.28 parts, etc.

[0052] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0053] In a second aspect, the present invention provides a method for preparing a skin care cream for repairing hormone face as described in the first aspect, the preparation method comprising:

[0054] (1) mixing a thickener, a portion of an emulsifier, a portion of a humectant, and deionized water, stirring, and dissolving them uniformly to obtain a mixture A;

[0055] (2) mixing and stirring the remaining emulsifier, part of the antioxidant, and bisabolol until they are uniformly dissolved to obtain a mixture B;

[0056] (3) mixing mixture A and mixture B homogeneously;

[0057] (4) The mixture obtained in step (3) is mixed and homogenized with the remaining moisturizer, the remaining antioxidant, Otingmin, the mussel extract, Nanopro CERA II, β-1,3 glucan, fibronectin, and the Kava pepper leaf / root / stem extract, and the mixture is allowed to stand to obtain the skin cream.

[0058] The preparation method of the skin care cream involved in the invention has simple process and is easy to operate, and is very suitable for large-scale industrial production.

[0059] Preferably, the mixing and stirring temperature in step (1) is 75-85°C (for example, it can be 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C or 84°C, etc.), and the rotation speed is 300-500rpm (for example, it can be 320rpm, 340rpm, 360rpm, 380rpm, 400rpm, 420rpm, 440rpm, 460rpm or 480rpm, etc.).

[0060] Preferably, step (2) further includes adding a softener during mixing and stirring.

[0061] Preferably, the mixing and stirring temperature in step (2) is 75-85°C (for example, it can be 76°C, 77°C, 78°C, 79°C, 80°C, 81°C, 82°C, 83°C or 84°C, etc.), and the rotation speed is 400-600rpm (for example, it can be 420rpm, 440rpm, 460rpm, 480rpm, 500rpm, 520rpm, 540rpm, 560rpm or 580rpm).

[0062] Preferably, step (3) further comprises adding a pH neutralizer after mixing and homogenizing.

[0063] Preferably, the mixing and homogenizing temperature in step (3) is 65-70°C (for example, 66°C, 67°C, 68°C, 69°C or 70°C, etc.), and the rotation speed is 50-150rpm (for example, 60rpm, 70rpm, 80rpm, 90rpm, 100rpm, 110rpm, 120rpm, 130rpm or 140rpm).

[0064] Preferably, the mixing and stirring in step (4) also includes adding a chelating agent.

[0065] Preferably, the mixing and stirring temperature in step (4) is 30-50°C (for example, it can be 31°C, 33°C, 35°C, 37°C, 39°C, 41°C, 43°C, 45°C, 47°C or 49°C, etc.), and the rotation speed is 50-150rpm (for example, it can be 60rpm, 70rpm, 80rpm, 90rpm, 100rpm, 110rpm, 120rpm, 130rpm or 140rpm).

[0066] Other specific point values ​​within the above numerical ranges can be selected and will not be described in detail here.

[0067] Compared with the prior art, the present invention has the following beneficial effects:

[0068] The skin care cream of the present invention starts from the essence of what causes hormone face, uses mild and non-irritating ingredients to form a protective film on the skin surface, and not only has the effects of antibacterial and anti-inflammatory, but also has the effects of improving capillary dilation, repairing the stratum corneum, and moisturizing and hydrating, and can scientifically and effectively repair hormone face. The mussel extract in the anti-allergic and anti-inflammatory agent forms a protective film on the skin surface, which can reduce the stimulation of external stimuli to the skin, and improve capillary dilation, thereby relieving facial edema and redness; the bisabolol and kava pepper leaf / root / stem extract have antibacterial and anti-inflammatory effects, can reduce skin sensitivity and the content of inflammatory factors, and improve the tingling, redness and burning sensation caused by hormone face; the Otingmin, fibronectin, and NanoproCERA II can restore the internal environment of facial skin, repair damaged stratum corneum, reduce transepidermal water loss, and replenish skin moisture; the β-1,3 glucan promotes tissue regeneration and repairs skin barrier. The Otingmin, mussel extract, kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol described in the present invention are used in combination, which has a synergistic effect in anti-allergic and anti-inflammatory and maintaining skin ecological balance, so that the skin cream can repair hormone face more scientifically and effectively. DETAILED DESCRIPTION

[0069] The technical solution of the present invention is further described below by specific implementation methods. It should be understood by those skilled in the art that the embodiments are only to help understand the present invention and should not be regarded as specific limitations of the present invention.

[0070] The specifications of some raw materials involved in the following examples and comparative examples are as follows:

[0071]

[0072] Example 1

[0073] This embodiment provides a skin care cream for repairing hormone-induced facial skin, and its formula is as follows:

[0074]

[0075]

[0076] The preparation method of the skin care cream for repairing hormone face is as follows:

[0077] (1) Deionized water is placed in a water pot, and acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, Aristoflex AVC, betaine, Pellicer LB-10, and Tremella fuciformis polysaccharide are slowly added thereto, and the mixture is heated to 80° C. and stirred at 400 rpm for 30 min until the mixture is uniform and free of particles, thereby obtaining a mixture A;

[0078] (2) Add Emulium Mellifera, MONTANOV 82, SIMULSOL 165, isononyl isononanoate, argania spinosa kernel oil, cetyl alcohol, avocado butter, tocopherol acetate, bisabolol, Ultimate, polydimethylsiloxane, heated to 80°C, stirred at 400 rpm for 30 min until the mixture was completely dissolved, to obtain mixture B;

[0079] (3) Pump mixture A and mixture B into the main pot, stir at 90 rpm for 12 min, and start cooling after homogenization;

[0080] (4) When the temperature drops to 68°C, add aminomethyl propanol and stir at 90 rpm for 10 min;

[0081] (5) When the temperature drops to 50°C, add 1,3-butanediol, p-hydroxyacetophenone, and Zeastat TM , 1,2-hexanediol, stirring at 90 rpm for 8 min;

[0082] (6) The temperature was lowered to 35° C., Nanopro CERA II, Kava leaf / root / stem extract, Otinmin, mussel extract, β-1,3 glucan, and fibronectin were added, and the mixture was stirred at 90 rpm for 15 min to obtain the skin cream.

[0083] Example 2

[0084] This embodiment provides a skin care cream for repairing hormone-induced facial skin, and its formula is as follows:

[0085]

[0086] The preparation method of the skin care cream for repairing hormone face is as follows:

[0087] (1) Deionized water is placed in a water pot, and acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and betaine are slowly added, the temperature is raised to 75° C., and stirred at 300 rpm for 30 min until the mixture is uniform and free of particles, thereby obtaining a mixture A;

[0088] (2) Add Emulium Mellifera, MONTANOV 82, SIMULSOL 165, isononyl isononanoate, argania spinosa kernel oil, avocado butter, bisabolol, Ultimate, polydimethylsiloxane, and tocopherol acetate were heated to 85°C and stirred at 500 rpm for 30 min until the mixture was completely dissolved to obtain mixture B;

[0089] (3) Pump mixture A and mixture B into the main pot, stir at 120 rpm for 12 min, and start cooling after homogenization;

[0090] (4) When the temperature drops to 65°C, add aminomethyl propanol and stir at 110 rpm for 10 min;

[0091] (5) When the temperature drops to 48°C, add 1,3-butanediol and Zeasat TM , p-hydroxyacetophenone, stirring at 150 rpm for 8 min;

[0092] (6) The temperature was lowered to 38° C., Nanopro CERA II, Kava leaf / root / stem extract, Otinmin, mussel extract, β-1,3 glucan, and fibronectin were added, and the mixture was stirred at 100 rpm for 15 min to obtain the skin cream.

[0093] Example 3

[0094] This embodiment provides a skin care cream for repairing hormone-induced facial skin, and its formula is as follows:

[0095]

[0096]

[0097] The preparation method of the skin care cream for repairing hormone face is as follows:

[0098] (1) Deionized water was placed in a water pot, and Aristoflex AVC, Pellicer LB-10, and Tremella fuciformis polysaccharide were slowly added thereto. The temperature was raised to 85° C., and the mixture was stirred at 500 rpm for 30 min until the mixture was uniform and free of particles, thereby obtaining a mixture A.

[0099] (2) Add SIMULSOL 165, Argania spinosa kernel oil, isononyl isononanoate, cetyl alcohol, tocopheryl acetate, bisabolol, Ultimate, polydimethylsiloxane, heated to 75°C, stirred at 600 rpm for 30 min until the mixture was completely dissolved, to obtain mixture B;

[0100] (3) Pump mixture A and mixture B into the main pot, stir at 100 rpm for 12 min, and start cooling after homogenization;

[0101] (4) When the temperature drops to 45°C, add 1,3-butanediol, p-hydroxyacetophenone, and Zeastat TM , 1,2-hexanediol, stirring at 80 rpm for 8 min;

[0102] (5) The temperature was lowered to 40° C., Nanopro CERA II, Kava leaf / root / stem extract, Otinmin, mussel extract, β-1,3 glucan, and fibronectin were added, and the mixture was stirred at 80 rpm for 15 min to obtain the skin cream.

[0103] Example 4

[0104] This embodiment provides a skin care cream for repairing hormone face. The only difference between this embodiment and embodiment 1 is that the emollient is not included in the components, and its content is supplemented by water. The other components remain unchanged. The preparation method refers to embodiment 1.

[0105] Example 5

[0106] This embodiment provides a skin care cream for repairing hormone-induced facial skin. The difference between this embodiment and embodiment 1 is that the emollient does not include Ultimate, and The reduced amount of Ultimate is distributed to argania spinosa kernel oil, isononyl isononanoate and polydimethylsiloxane according to the proportion of parts, and the other components remain unchanged. The preparation method refers to Example 1.

[0107] Example 6

[0108] This embodiment provides a skin care cream for repairing hormone-induced facial skin. The difference between this embodiment and embodiment 1 is that the emollient does not include isononyl isononanoate, and the reduced amount of isononyl isononanoate is distributed to argania spinosa kernel oil, polydimethylsiloxane and In Ultimate, the other components remain unchanged, and the preparation method is referred to Example 1.

[0109] Example 7

[0110] This embodiment provides a skin care cream for repairing hormone-induced facial skin. The difference between this embodiment and embodiment 1 is that the emollient does not include polydimethylsiloxane, and the reduced amount of polydimethylsiloxane is distributed to argania spinosa kernel oil, isononyl isononanoate and In Ultimate, the other components remain unchanged, and the preparation method is referred to Example 1.

[0111] Example 8

[0112] This embodiment provides a skin care cream for repairing hormone-induced facial skin. The difference between this embodiment and embodiment 1 is that the emollient does not include argania spinosa kernel oil, and the reduced amount of argania spinosa kernel oil is distributed to isononyl isononanoate, polydimethylsiloxane and In Ultimate, the other components remain unchanged, and the preparation method is referred to Example 1.

[0113] Comparative Example 1

[0114] This embodiment provides a skin care cream for repairing hormone face. The only difference between this cream and Example 1 is that the anti-allergic repair agent is not included in the components, and the reduced amount is supplemented by water. The other components and the added amounts remain unchanged. The preparation method refers to Example 1.

[0115] Comparative Example 2

[0116] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include Otinmin, and the reduced amount of Otinmin is distributed to mussel extract, kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0117] Comparative Example 3

[0118] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include mussel extract, and the reduced amount of mussel extract is distributed to Otingmin, Kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0119] Comparative Example 4

[0120] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include Kava Piper methysticum leaf / root / stem extract, and the reduced amount of Kava Piper methysticum leaf / root / stem extract is distributed to Otingmin, mussel extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0121] Comparative Example 5

[0122] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include Nanopro CERA II, and the reduced amount of Nanopro CERA II is distributed to Otingmin, mussel extract, kava pepper leaf / root / stem extract, β-1,3 glucan, fibronectin and bisabolol according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0123] Comparative Example 6

[0124] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include β-1,3 glucan, and the reduced amount of β-1,3 glucan is distributed to Otingmin, mussel extract, Kava pepper leaf / root / stem extract, Nanopro CERA II, fibronectin and bisabolol according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0125] Comparative Example 7

[0126] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include fibronectin, and the reduced amount of fibronectin is distributed to Otingmin, mussel extract, Kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan and bisabolol according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0127] Comparative Example 8

[0128] This embodiment provides a skin care cream for repairing hormone face, which is different from Example 1 only in that the anti-allergic repair agent in the components does not include bisabolol, and the reduced amount of bisabolol is distributed to Otingmin, mussel extract, Kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan and fibronectin according to the proportion of parts, and the other components and addition amounts remain unchanged. The preparation method refers to Example 1.

[0129] Test Example 1: Detection of anti-inflammatory effects on inflammatory factors:

[0130] (1) Dilute the Raw264.7 cells in good culture state to a concentration of 1×10 5 cfu / mL;

[0131] (2) Prepare a 12-well cell plate and add a concentration of 1×10 5 cfu / mL of Raw264.7 cells were transferred to a 12-well plate using a pipette, 1 mL was added to each well, and cultured at 37°C for 24 h;

[0132] (3) The experiment included 21 groups, including a blank group (no sample), an LPS group (1 μg / mL LPS), a test group (2 mg / mL samples of Examples 1-12 and Comparative Examples 1-5 were added, containing 1 μg / mL LPS), and a positive control group (0.1 mg / mL dexamethasone was added). The supernatant of the Raw264.7 cell culture fluid was discarded, and the corresponding solution of each group was added, and cultured at 37°C for 24 h;

[0133] (4) The supernatant was centrifuged and the concentrations of inflammatory factors TNF-α and IL-6 were detected according to the test steps on the ELISA kit. Each group was measured 5 times in parallel and the average value was taken.

[0134] The results are shown in Table 1:

[0135] Table 1

[0136]

[0137]

[0138] It can be seen from the data in Table 1 that the skin care cream involved in the present invention has a very significant inhibitory effect on the inflammatory factors TNF-α and IL-6. The Otingmin, mussel extract, kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol have a synergistic effect. The simultaneous presence of the seven can make the skin care cream have a better inhibitory effect on inflammatory factors.

[0139] Test Example 2: Skin barrier strengthening experiment

[0140] 160 volunteers aged 20 to 45 were randomly selected as research subjects, including 80 men and 80 women. The tested parts had no skin problems in the past month and no history of systemic diseases. The volunteers were randomly divided into 16 groups, with 5 men and 5 women in each group. Each group tried the skin cream prepared by Examples 1-8 and Comparative Examples 1-8. Before the test, the volunteers were required to wipe their arms with clean water and sit quietly for 30 minutes in a constant temperature and humidity environment (temperature: 25±1°C, relative humidity: 40±5%) to keep relaxed. A 4cm×4cm test area was marked on the inner side of the volunteer's arm 5cm away from the base of the palm. Multiple areas can be marked on the same arm at the same time (1cm apart). The products to be tested were randomly applied to the marked areas. The products (skin creams prepared by Examples 1-8 and Comparative Examples 1-8) were applied to the marked areas of the volunteers for four consecutive weeks. The amount used was 2.0±0.1μL / cm 2 During the test period, no drugs or cosmetics unrelated to the experiment were allowed to be applied. The transepidermal water loss tester (Tewameter TM300) was used to test and record the transepidermal water loss (TEWL0, TEWL1, TEWL2) before application, in the first week of application, and in the second week of application. The test results are shown in Table 2 (the results are the average of the results of 10 subjects).

[0141] Table 2

[0142]

[0143]

[0144] It can be seen from Table 2 that the skin care cream involved in the present invention has excellent barrier repair ability and water locking ability, and improves the moisturizing effect. It can be seen from Example 1 and Example 4 and Comparative Example 1 that the emollient and anti-inflammatory repair agent have a significant effect on the moisturizing effect of the skin care cream; it can be seen from Examples 5-8 and Comparative Examples 2-8 that the type of the emollient and anti-allergic repair agent also has a certain influence on the moisturizing performance of the final product.

[0145] Test Example 3: Relief Test

[0146] The anti-allergic soothing creams prepared in Examples 1-3 and Comparative Examples 1-8 were subjected to a soothing test:

[0147] 110 volunteers with sensitive skin were selected as research subjects, including 55 males and 55 females. The volunteers were randomly divided into 11 groups, each with 10 people, 5 males and 5 females. Each group tried the skin cream prepared by Examples 1-3 and Comparative Examples 1-8 respectively. The subjects were not allowed to use makeup and skin care products in the morning of the test day. After cleaning the facial skin with clean water, they waited for 30 minutes in a constant temperature and humidity room, and then used VISIA-CR to take photos of the volunteers' faces. IPP software analyzed the a value of the red component picture. Then, 10% lactic acid was applied to the nasolabial groove on either side of the volunteers at room temperature. After applying for 5 minutes, the skin creams of Examples 1-3 and Comparative Examples 1-5 were used respectively. After 15 minutes of use, VISIA-CR was used to take photos of the volunteers' faces. IPP software analyzed the a value of the red component picture. The changes in a value before and after using the product were compared (the lower the a value, the lower the redness of the skin), and the volunteers were asked to evaluate the use experience. The specific test results are shown in Table 3.

[0148] Table 3

[0149]

[0150] It can be seen from Table 3 that the skin care creams prepared in Examples 1-3 can quickly regulate and relieve skin discomfort symptoms and have excellent soothing effects. The change in a value after use by volunteers is significantly better than that in Comparative Example 1, indicating that the addition of an anti-allergic repair agent to the skin care cream of the present invention can make the product have obvious soothing effects. From the products of Comparative Examples 2-8, it can be seen that the Otingmin, mussel extract, kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol described in the present invention cooperate with each other and have a synergistic effect in soothing the skin care cream. The lack of any one ingredient will reduce the soothing effect of the skin care cream.

[0151] Test Example 4 Safety Evaluation:

[0152] This test example conducts a safety test on the skin care cream prepared in Examples 1-8, and the test method is as follows:

[0153] The chorioallantoic membrane (CAM) is a respiratory membrane that surrounds the chicken embryo. Since the surface of the chicken embryo chorioallantoic membrane is rich in blood vessels and can be regarded as a complete organism, this test uses the characteristics of the complete, clear and transparent vascular system of the chorioallantoic membrane of the mid-stage incubated chicken embryo. A certain amount of the test substance is directly exposed to the chicken embryo chorioallantoic membrane. After the specified time, the changes in the toxic effect indicators of the chorioallantoic membrane (such as bleeding, coagulation and vascular melting) are observed, and scores are given. The mathematical mean value is calculated to evaluate the irritation of the test substance.

[0154] (1) Preparation of chicken embryos: Fertilized chicken embryos of varieties such as White Leghorn chicken, weighing 50g-60g, preferably SPF chicken embryos, are placed in an incubator for incubation, the temperature is controlled at 37.5°C ± 0.5°C, the relative humidity is 55%-70%, and the egg turning frequency is 3 times / h-6 times / h. On the 8th day of incubation, the eggs are checked with an egg candling device, unfertilized and inactive chicken embryos are discarded, and chicken embryos with well-developed blood vessels are selected, and the position of the air chamber is marked on the eggshell surface.

[0155] (2) Test process: There are at least 6 chicken embryos in each group, and negative and positive controls need to be set up for each test. The test started on the 9th day. Use dental curved forceps to carefully peel off the air chamber eggshell part, and drop a few drops of physiological saline on the surface of the eggshell membrane to fully moisten it. After pouring it out, use forceps to carefully remove the eggshell membrane to ensure that the exposed chorioallantoic membrane is intact and not damaged in any way. Take 0.3ml / 0.3g of the test substance and apply it directly to the CAM. Spread it as much as possible to ensure that the coverage area reaches at least 50%. After 3 minutes of action, gently rinse the surface of the CAM with double distilled water. The rinsing should be completed within 30s, pour out the liquid, and immediately observe the degree of change of each toxic effect under a stereomicroscope, and give a score (ES) according to the capillary bleeding, coagulation, and vascular melting.

[0156] (3) Observation results:

[0157] Bleeding: blood flows out of the blood vessels or capillaries of the CAM. No bleeding, mild bleeding, moderate bleeding, and severe bleeding are scored as 0, 1, 2, and 3 points, respectively.

[0158] Coagulation: refers to the denaturation of proteins inside and outside blood vessels, manifested as thrombus, swelling of the vessel wall, the appearance of coagulation points inside and outside blood vessels, milky turbidity outside blood vessels, etc. No coagulation, mild coagulation, moderate coagulation, and severe coagulation are scored as 0, 1, 2, and 3 points respectively.

[0159] Vascular ablation: refers to the ablation of blood vessels on the CAM membrane. No vascular ablation, mild vascular ablation, moderate vascular ablation, and severe vascular ablation were scored as 0, 1, 2, and 3 points, respectively.

[0160] (4) Result calculation and evaluation

[0161] Calculate the average ES score according to the following formula and determine the stimulus classification according to Table 4.

[0162]

[0163] Table 4 Results evaluation

[0164] End point score Irritation classification ES≤12 No / mild irritation 12<ES<16 Moderate irritation ES≥16 Severe irritation

[0165] The test results are shown in Table 5 below:

[0166] Table 5

[0167]

[0168]

[0169] From the data in Table 5, it can be seen that the skin creams obtained from the specific components of the present application have no hemolysis phenomenon and are safe and non-irritating. It is determined that the product of the present invention has no adverse reactions to the human body and is highly safe.

[0170] The applicant declares that the present invention illustrates the skin care cream for repairing hormone face and its preparation method through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned detailed method, that is, it does not mean that the present invention must rely on the above-mentioned detailed method to be implemented. The technicians in the relevant technical field should understand that any improvement of the present invention, the equivalent replacement of the raw materials of the product of the present invention, the addition of auxiliary ingredients, the selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

Claims

1. A skin care cream for repairing hormone face, It is characterized in that The components of the skin care cream for repairing hormone face include, by weight, 1-15 parts of emulsifier, 1-10 parts of moisturizer, 0.5-5 parts of antioxidant, 0.1-0.5 parts of thickener, 1-15 parts of anti-allergic repair agent, 1-10 parts of emollient, 0.1-0.3 parts of pH regulator, 0.5-1 parts of chelating agent, and deionized water; The anti-allergic repair agent is a combination of Otinmin, mussel extract, Kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol; The mass ratio of the Aotingmin, mussel extract, kava pepper leaf / root / stem extract, Nanopro CERA II, β-1,3 glucan, fibronectin and bisabolol is (0.5-1): (0.1-0.5): (2-3): (1-1.5): (0.1-0.5): (0.1-0.8): (0.1-0.5); The Otingmin is a mixture of water, lactobacillus / soy milk fermentation product filtrate, butylene glycol, and 1,2-pentanediol; the Nanopro CERA II is a mixture of ceramide NS / ceramide NG, lecithin, tocopherol acetate, octyldodecanol, glycerin, and water.

2. The skin care cream for repairing hormone face according to claim 1, It is characterized in that The moisturizing agent includes any one of avocado oil, betaine, Tremella heteropolysaccharide, 1,2-hexanediol, and 1,3-butanediol, or a combination of at least two of them.

3. The skin care cream for repairing hormone face according to claim 1, It is characterized in that The thickener is acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer and / or Aristoflex AVC.

4. The skin care cream for repairing hormone face according to claim 1, It is characterized in that The emulsifier includes any one of Emulium Mellifera, MONTANOV 82, SIMULSOL 165, Pellicer LB-10 or cetyl alcohol or a combination of at least two thereof.

5. The skin care cream for repairing hormone face according to claim 1, It is characterized in that The antioxidant includes tocopherol acetate and / or p-hydroxyacetophenone.

6. The skin care cream for repairing hormone face according to claim 1, It is characterized in that The emollient includes any one of argania spinosa kernel oil, isononyl isononanoate, dimethicone or Cetiol® Ultimate, or a combination of at least two thereof.

7. The skin care cream for repairing hormone face according to claim 6, It is characterized in that The emollient is a combination of argania spinosa kernel oil, isononyl isononanoate, dimethicone and Cetiol® Ultimate.

8. The skin care cream for repairing hormone face according to claim 7, It is characterized in that The mass ratio of the argania spinosa kernel oil, isononyl isononanoate, polydimethylsiloxane and Cetiol® Ultimate is (0.5-1):(3-5):(1-2):(2-3).

9. The skin care cream for repairing hormone face according to claim 1, It is characterized in that The pH adjuster includes aminomethyl propanol.

10. The skin care cream for repairing hormone face according to claim 1, It is characterized in that Such chelating agents include Zeasat™.

11. A method for preparing a skin care cream for repairing hormone-induced facial skin according to any one of claims 1 to 10, It is characterized in that The preparation method comprises: (1) Mixing a thickener, a portion of an emulsifier, a portion of a humectant, and deionized water, stirring, and dissolving them uniformly to obtain a mixture A; (2) Mix and stir the remaining emulsifier, part of the antioxidant, bisabolol, and the emollient until they are uniformly dissolved to obtain a mixture B; (3) Mixing mixture A and mixture B until homogeneous, and then adding a pH adjuster; (4) The mixture obtained in step (3) is mixed and homogenized with the remaining moisturizer, the remaining antioxidant, Otingmin, mussel extract, Nanopro CERA II, β-1,3 glucan, fibronectin, kava leaf / root / stem extract, and chelating agent, and the mixture is allowed to stand to obtain the skin cream.

12. The method for preparing the skin care cream for repairing hormone face according to claim 11, It is characterized in that The mixing and stirring in step (1) is carried out at a temperature of 75-85°C and a rotation speed of 300-500 rpm.

13. The method for preparing the skin care cream for repairing hormone face according to claim 11, It is characterized in that The mixing and stirring in step (2) is carried out at a temperature of 75-85° C. and a rotation speed of 400-600 rpm.

14. The method for preparing the skin care cream for repairing hormone face according to claim 11, It is characterized in that The mixing and homogenizing temperature in step (3) is 65-70° C. and the rotation speed is 50-150 rpm.

15. The method for preparing the skin care cream for repairing hormone face according to claim 11, It is characterized in that The mixing and homogenizing temperature in step (4) is 30-50°C and the rotation speed is 50-150 rpm.

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