A stainless steel reaction tank for heparin production

Abstract

The invention discloses a stainless steel reaction tank for producing heparin-like substances, which relates to the field of chemistry and comprises: a reaction tank and a switch door arranged on the front of the reaction tank, wherein the outer surface of the switch door is rotatably connected to the inner wall of the reaction tank, the bottom plate of the reaction tank is evenly provided with supporting feet, the top of the supporting feet is fixedly connected to the bottom of the reaction tank, the top of the reaction tank is fixedly connected with a partition plate, and the top of the partition plate is provided with a picking block; a crushing mechanism, which is used to crush animal cartilage and perform enzymolysis; a transmission mechanism, which is used to transmit liquid after enzymolysis; an extraction mechanism, which is used to synthesize heparin-like substances; the bottom end of the inner wall of the reaction tank is fixedly connected to the bottom of the extraction mechanism, the bottom of the crushing mechanism is fixedly connected to the top of the partition plate, and the outer surface of the transmission mechanism is fixedly connected to the inner wall of the crushing mechanism.

Description

Technical Field

[0001] The invention relates to the field of chemical technology, in particular to a stainless steel reaction tank for producing heparin-like substances. Background Art

[0002] Heparinoids are substances similar to heparin. All acidic mucopolysaccharide substances that are similar to heparin in chemical structure to a certain extent and have anticoagulant activity are heparinoids, such as heparan sulfate, chondroitin sulfate A and C, and keratan sulfate. Heparinoids in a narrow sense refer to heparan sulfate.

[0003] Heparinoids are acidic mucopolysaccharides with anticoagulant activity. They have the functions of anti-thrombosis, anti-inflammatory, analgesia, improving blood circulation in the affected area, absorbing exudates, curing edema and swelling, and promoting tissue repair. They are clinically applicable to vascular thrombosis, varicose veins, superficial phlebitis, lymphadenitis, mastitis and softening scars.

[0004] When preparing heparinoids, the animal's soft tubes need to be crushed, and then undergo a series of chemical and physical reactions to form heparinoids. When crushing the animal cartilage, the animal cartilage can easily get stuck on the equipment. If it is not cleaned up, the working efficiency of the device will be reduced, or at least the device will be damaged. Summary of the invention

[0005] In view of the shortcomings of the prior art, the technical solution adopted by the present invention to solve the technical problems is: a stainless steel reaction tank for heparin production according to the present invention comprises:

[0006] A reaction tank, and a switch door arranged on the front of the reaction tank, wherein the outer surface of the switch door is rotatably connected to the inner wall of the reaction tank, the bottom plate of the reaction tank is evenly provided with support feet, the top of the support feet is fixedly connected to the bottom of the reaction tank, the top of the reaction tank is fixedly connected with a partition plate, and the top of the partition plate is provided with a pick-up block;

[0007] A grinding mechanism, which is used to grind animal cartilage and perform enzymatic hydrolysis;

[0008] A transmission mechanism, which is used to transmit the liquid after enzymatic hydrolysis;

[0009] An extraction mechanism for synthesizing heparinoids;

[0010] The bottom end of the inner wall of the reaction tank is fixedly connected to the bottom of the extraction mechanism, the bottom of the crushing mechanism is fixedly connected to the top of the partition plate, and the outer surface of the transmission mechanism is fixedly connected to the inner wall of the crushing mechanism;

[0011] The crushing mechanism comprises a crushing cylinder, a support rod 1 is evenly arranged on the top of the crushing cylinder, the bottom of the support rod 1 is fixedly connected to the top of the crushing cylinder, the top of the support rod 1 is fixedly connected to a support plate 1, the inner wall of the support plate 1 is fixedly connected to a servo motor 1, and the output end of the servo motor 1 is rotatably connected to a rotating mechanism;

[0012] The rotating mechanism includes a main rotating shaft, a telescopic rod 1 is evenly arranged on the top of the main rotating shaft, the top of the telescopic rod 1 is fixedly connected to the top of the main rotating shaft, the bottom of the telescopic rod 1 is fixedly connected to a drooping rod, the bottom of the drooping rod is fixedly connected to a disc, the bottom of the disc is evenly arranged with a rolling block, the top of the rolling block is fixedly connected to the bottom of the disc, the bottom of the main rotating shaft is fixedly connected with a sweeping plate, and the outer surface of the sweeping plate is evenly arranged with a cleaning mechanism.

[0013] Preferably, the bottom of the rolling drum is fixedly connected to the top of the partition plate, and the top of the main shaft is fixedly connected to the top of the servo motor.

[0014] Preferably, the cleaning mechanism includes a semicircular plate, the top of the semicircular plate is slidably connected to a sliding disk, an end of the sliding disk close to the main rotating shaft is fixedly connected to a telescopic spring, brushes are evenly arranged on the top of the sliding disk, the bottom of the brush is fixedly connected to the top of the sliding disk, and an impact block is fixedly connected to the inner wall of the sliding disk.

[0015] Preferably, one end of the telescopic spring away from the sliding disk is fixedly connected to the outer surface of the main rotating shaft, and one end of the semicircular plate away from the sliding disk is fixedly connected to the outer surface of the main rotating shaft.

[0016] Preferably, the transmission mechanism includes a liquid outlet, the outer surface of the liquid outlet is fixedly connected to a transmission tube, the end of the liquid outlet away from the transmission tube is fixedly connected to an anti-blocking mechanism, and the outer surface of the transmission tube is fixedly connected to the anti-blocking mechanism.

[0017] Preferably, the anti-clogging mechanism includes a filter plate, an end of the filter plate away from the liquid outlet is rotatably connected to the rotating shaft 2, the end of the rotating shaft 2 away from the filter plate is evenly provided with a spiral fan, the outer surface of the spiral fan is fixedly connected to the end of the rotating shaft 2 away from the filter plate, the end of the rotating shaft 2 close to the filter plate is fixedly connected to a scraper, the side of the filter plate away from the rotating shaft 2 is fixedly connected to a sliding rod, the end of the sliding rod away from the filter plate is fixedly connected to a baffle, the outer surface of the sliding rod is slidably connected to a sliding block, the side of the sliding block close to the baffle is fixedly connected to a magnetic block, the side of the sliding block away from the magnetic block is evenly provided with extrusion columns, the outer surface of the extrusion column is fixedly connected to the side of the sliding block away from the magnetic block.

[0018] Preferably, the outer surface of the liquid outlet is fixedly connected to the inner wall of the roller, and the outer surface of the filter plate is fixedly connected to an end of the liquid outlet away from the transmission pipe.

[0019] Preferably, the extraction mechanism includes a drooping column, the top of the drooping column is fixedly connected to the bottom of the partition plate, the bottom of the drooping column is fixedly connected to a support plate 2, the bottom of the support plate 2 is fixedly connected to a telescopic rod 2, the bottom of the telescopic rod 2 is fixedly connected to a shoveling mechanism, the extraction mechanism also includes an extraction cylinder, the inner wall of the extraction cylinder is slidably connected to the outer surface of the shoveling mechanism, the top of the extraction cylinder is fixedly connected to an inclined plate, and the bottom of the inclined plate is fixedly connected to a drying mechanism.

[0020] Preferably, the shoveling mechanism includes a support plate three, the top of the support plate three is fixedly connected to the bottom of the telescopic rod two, the outer surface of the support plate three is fixedly connected to the servo motor two, the output end of the servo motor two is the rotating shaft three, the outer surface of the rotating shaft three is fixedly connected to a connecting rod, the bottom of the connecting rod is hingedly connected to an eccentric wheel, the bottom of the eccentric wheel is fixedly connected to an extraction plate, the support plate three is fixedly connected to a hanging rod on one side close to the rotating shaft three, the bottom of the hanging rod is rotatably connected to the outer surface of the extraction plate, the top of the extraction plate is slidably connected to a scratch plate, the surface of the scratch plate is provided with a notch, the bottom of the scratch plate is fixedly connected to a connecting rope, and the bottom of the connecting rope is fixedly connected to the inner wall of the extraction cylinder.

[0021] Preferably, the drying mechanism comprises a drying box, the bottom of which is fixedly connected to the inner wall of the reaction tank, the inner wall of the drying box is fixedly connected with a drying device, and the bottom of the drying box is slidably connected with a collecting pull plate.

[0022] The beneficial effects of the present invention are as follows:

[0023] (1) The present invention is provided with a crushing mechanism. After the animal bones or softened cartilage are placed in the crushing cylinder, the rotating mechanism will crush the cartilage, and sodium hydroxide is added to the crushing cylinder for pretreatment and then enzymes are added for enzymatic hydrolysis, so that the substances in the animal bones are decomposed. At the same time, the telescopic rod can adjust the crushing direction and crushing force of the disc and the crushing block on the animal bones, and the sweeping plate at the bottom will also sweep the animal bones to the bottom of the crushing block, so that the bones can be fully crushed.

[0024] (2) The present invention provides a cleaning mechanism. When the main shaft rotates, the centrifugal force generated by the rotation will stretch the telescopic spring, causing the sliding disk to move outward along the semicircular plate. When the circular plate is located above the sliding disk, the wire ring will rub against the rolling block, causing the bone stuck on the rolling block to fall off.

[0025] (3) The present invention provides an anti-clogging mechanism. When the clear liquid after enzymatic hydrolysis enters the liquid outlet, the filter plate will block the crushed animal hose. The clear liquid that flows in will drive the spiral fan to rotate, and then drive the second rotating shaft to rotate, so that the scraper can scrape out the cartilage fragments on the filter plate to avoid the filter plate from being blocked. After the transmission is completed, a magnetic object that repel each other with the magnetic block is placed next to the liquid outlet, and the sliding block and the extrusion column are driven to extrude the cartilage stuck on the filter plate.

[0026] (4) The present invention provides a shoveling mechanism. As the telescopic rod moves upward, the extraction plate will lift the sediment. At the same time, the servo motor 2 will drive the rotating shaft 3 to rotate. The connecting rod and the eccentric wheel work together to tilt the extraction plate. As the height of the extraction plate increases, the connecting rope will pull the scraping plate downward, making it convenient to scrape the sediment on the extraction plate into the drying mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a schematic diagram of the structure of the present invention;

[0028] Figure 2 It is a cross-sectional view of the structure of the present invention;

[0029] Figure 3 It is a structural schematic diagram of the crushing mechanism of the present invention;

[0030] Figure 4 It is a structural schematic diagram of the rotating mechanism of the present invention;

[0031] Figure 5 It is a structural schematic diagram of the cleaning mechanism of the present invention;

[0032] Figure 6 It is a structural schematic diagram of the transmission mechanism of the present invention;

[0033] Figure 7 It is a structural schematic diagram of the anti-blocking mechanism of the present invention;

[0034] Figure 8 It is a partial structural schematic diagram of the anti-blocking mechanism of the present invention;

[0035] Fig. 9 It is a structural schematic diagram of the extraction mechanism of the present invention;

[0036] Fig.10 It is a structural schematic diagram of the shoveling mechanism of the present invention;

[0037] Fig.11 It is a structural schematic diagram of the drying mechanism of the present invention;

[0038] In the figure: 1, reaction tank; 2, switch door; 3, support foot; 4, partition plate; 5, crushing mechanism; 6, transmission mechanism; 7, extraction mechanism; 51, crushing cylinder; 52, support rod one; 53, support plate one; 54, servo motor one; 55, rotating mechanism; 41, picking block; 551, main shaft; 552, telescopic rod one; 553, drooping rod; 554, disc; 555, crushing block; 556, sweeping plate; 557, cleaning mechanism; 5571, semicircular plate; 5572, telescopic spring; 5573, sliding disc; 5574, brush; 5575, impact block; 61, liquid outlet; 62, transmission pipe; 63, valve; 64, anti-blocking mechanism; 6 41. Filter plate; 642. Rotating shaft two; 643. Spiral fan; 644. Scraper; 645. Sliding rod; 646. Baffle; 647. Sliding block; 648. Magnetic block; 649. Extrusion column; 71. Drooping column; 72. Support plate two; 73. Telescopic rod two; 74. Shoveling mechanism; 75. Extraction cylinder; 76. Inclined plate; 77. Drying mechanism; 741. Support plate three; 742. Servo motor two; 743. Rotating shaft three; 744. Connecting rod; 745. Extraction plate; 746. Hanging rod; 747. Scratching plate; 748. Notch; 749. Connecting rope; 7410. Eccentric wheel; 771. Drying box; 772. Drying device; 773. Collecting pull plate. DETAILED DESCRIPTION

[0039] The present invention is further described in detail below in conjunction with the accompanying drawings and specific embodiments. The embodiments of the present invention are provided for the purpose of illustration and description, and are not intended to be exhaustive or to limit the present invention to the disclosed forms. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are selected and described in order to better illustrate the principles and practical applications of the present invention, and to enable those of ordinary skill in the art to understand the present invention and thereby design various embodiments with various modifications suitable for specific uses.

[0040] Example 1, using Figure 1-Figure 11 A stainless steel reaction tank 1 for producing heparinoids according to one embodiment of the present invention is described below.

[0041] like Figure 1-Figure 11 As shown, a stainless steel reaction tank 1 for producing heparinoids of the present invention comprises:

[0042] A reaction tank 1, and a switch door 2 arranged on the front of the reaction tank 1, the outer surface of the switch door 2 is rotatably connected to the inner wall of the reaction tank 1, the bottom plate of the reaction tank 1 is evenly provided with support feet 3, the top of the support feet 3 is fixedly connected to the bottom of the reaction tank 1, the top of the reaction tank 1 is fixedly connected with a partition plate 4, and the top of the partition plate 4 is provided with a pick-up block 41;

[0043] A grinding mechanism 5, the grinding mechanism 5 is used to grind animal cartilage and perform enzymatic hydrolysis;

[0044] A transmission mechanism 6, the transmission mechanism 6 is used to transmit the liquid after enzymatic hydrolysis;

[0045] An extraction mechanism 7, the extraction mechanism 7 is used to synthesize heparinoids;

[0046] The bottom end of the inner wall of the reaction tank 1 is fixedly connected to the bottom of the extraction mechanism 7, the bottom of the crushing mechanism 5 is fixedly connected to the top of the partition plate 4, and the outer surface of the transmission mechanism 6 is fixedly connected to the inner wall of the crushing mechanism 5;

[0047] When a stainless steel reaction tank 1 for the production of heparinoids is in operation, animal cartilage is first placed in a crushing mechanism 5 for crushing, and sodium hydroxide is added for pretreatment, and then enzymes are added for enzymolysis. The clear liquid produced by the enzymolysis will enter the extraction mechanism 7 through the transmission mechanism 6, and after a series of physical and chemical reactions, the heparinoids will be extracted from the clear liquid.

[0048] The crushing mechanism 5 includes a crushing cylinder 51, a support rod 52 is evenly arranged on the top of the crushing cylinder 51, the bottom of the support rod 52 is fixedly connected to the top of the crushing cylinder 51, the top of the support rod 52 is fixedly connected to a support plate 53, the inner wall of the support plate 53 is fixedly connected to a servo motor 54, and the output end of the servo motor 54 is rotatably connected to a rotating mechanism 55;

[0049] After the animal bones or cartilage are placed in the crushing cylinder 51 , the servo motor 54 drives the rotating mechanism 55 to rotate, and the animal cartilage poured into the crushing cylinder 51 is located below the disc 554 .

[0050] The rotating mechanism 55 includes a main rotating shaft 551, a telescopic rod 552 is evenly arranged on the top of the main rotating shaft 551, the top of the telescopic rod 552 is fixedly connected to the top of the main rotating shaft 551, the bottom of the telescopic rod 552 is fixedly connected to a drooping rod 553, the bottom of the drooping rod 553 is fixedly connected to a disc 554, a rolling block 555 is evenly arranged on the bottom of the disc 554, the top of the rolling block 555 is fixedly connected to the bottom of the disc 554, a sweeping plate 556 is fixedly connected to the bottom of the main rotating shaft 551, and a cleaning mechanism 557 is evenly arranged on the outer surface of the sweeping plate 556.

[0051] As the rotating mechanism 55 rotates, the telescopic rod 552 moves the circular plate and the crushing block 555 downward, and the crushing block 555 will crush the animal bones. At the same time, the telescopic rod 552 can adjust the crushing direction and crushing strength of the circular plate 554 and the crushing block 555 on the animal bones. The sweeping plate 556 at the bottom will also sweep the animal bones to the bottom of the crushing block 555, so that the bones can be fully crushed. After the bones are crushed, sodium hydroxide and enzymatic hydrolysis solution are poured in for pretreatment.

[0052] The bottom of the rolling drum 51 is fixedly connected to the top of the partition plate 4, and the top of the main shaft 551 is fixedly connected to the top of the servo motor 54.

[0053] The cleaning mechanism 557 includes a semicircular plate 5571, the top of the semicircular plate 5571 is slidably connected to a sliding disk 5573, one end of the sliding disk 5573 close to the main shaft 551 is fixedly connected to a telescopic spring 5572, brushes 5574 are evenly arranged on the top of the sliding disk 5573, the bottom of the brush 5574 is fixedly connected to the top of the sliding disk 5573, and the inner wall of the sliding disk 5573 is fixedly connected to a collision block 5575.

[0054] When the main shaft 551 rotates, the centrifugal force generated by the rotation will stretch the telescopic spring 5572, so that the sliding plate 5573 moves outward along the semicircular plate 5571. When the circular plate is located above the sliding plate 5573, the brush 5574 will rub against the rolling block 555, so that the bone stuck on the rolling block 555 will fall off. When the circular plate is located below the sliding plate 5573, the impact block 5575 will collide with the drooping rod 553, so that the bones attached to the drooping rod 553 and the telescopic rod will fall off, thereby preventing the cartilage from getting stuck on the telescopic rod 552.

[0055] One end of the telescopic spring 5572 away from the sliding disk 5573 is fixedly connected to the outer surface of the main rotating shaft 551 , and one end of the semicircular plate 5571 away from the sliding disk 5573 is fixedly connected to the outer surface of the main rotating shaft 551 .

[0056] The transmission mechanism 6 includes a liquid outlet 61 , an outer surface of which is fixedly connected to a transmission tube 62 , an end of the liquid outlet 61 away from the transmission tube 62 is fixedly connected to an anti-blocking mechanism 64 , and the bottom of the transmission tube 62 is located above the side of the extraction cylinder 75 .

[0057] By opening the valve 63, the clear liquid will enter the mechanism below through the liquid outlet 61 and the transmission pipe 62;

[0058] The anti-clogging mechanism 64 includes a filter plate 641, and the end of the filter plate 641 away from the liquid outlet 61 is rotatably connected to the rotating shaft 2 642, and the end of the rotating shaft 2 642 away from the filter plate 641 is evenly provided with a spiral fan 643, the outer surface of the spiral fan 643 is fixedly connected to the end of the rotating shaft 2 642 away from the filter plate 641, and the end of the rotating shaft 2 642 close to the filter plate 641 is fixedly connected to a scraper 644, a side of the filter plate 641 away from the rotating shaft 2 642 is fixedly connected to a sliding rod 645, and the end of the sliding rod 645 away from the filter plate 641 is fixedly connected to a baffle 646, and the outer surface of the sliding rod 645 is slidably connected to a sliding block 647, and the side of the sliding block 647 close to the baffle 646 is fixedly connected to a magnetic block 648, and the side of the sliding block 647 away from the magnetic block 648 is evenly provided with an extrusion column 649, and the outer surface of the extrusion column 649 is fixedly connected to the side of the sliding block 647 away from the magnetic block 648.

[0059] When the clear liquid after enzymatic hydrolysis enters the liquid outlet 61, the filter plate 641 will block the crushed animal hose, and the clear liquid flowing in will drive the spiral fan 643 to rotate, and then drive the second shaft 642 to rotate, so that the scraper 644 can scrape out the cartilage fragments on the filter plate 641 to avoid the filter plate 641 from being blocked. After the transmission is completed, a magnetic object that repeles each other with the magnetic block 648 is placed next to the liquid outlet 61, and the sliding block 647 and the extrusion column 649 are driven to squeeze out the cartilage stuck on the filter plate 641.

[0060] The outer surface of the liquid outlet 61 is fixedly connected to the inner wall of the roller, and the outer surface of the filter plate 641 is fixedly connected to one end of the liquid outlet 61 away from the transmission pipe 62 .

[0061] The specific workflow is as follows:

[0062] During operation, after the animal bones or softened bones are placed in the crushing cylinder 51, the servo motor 54 drives the rotating mechanism 55 to rotate. As the rotating mechanism 55 rotates, the telescopic rod 552 moves the disc and the crushing block 555 downward, and the crushing block 555 crushes the animal bones. At the same time, the telescopic rod can adjust the crushing direction and crushing strength of the disc 554 and the crushing block 555 on the animal bones. The sweeping plate 556 at the bottom will also sweep the animal bones to the bottom of the crushing block 555, so that the bones are fully crushed. By opening the valve 63, The clear liquid will enter the mechanism below through the liquid outlet 61 and the transmission tube 62. The filter plate 641 will block the crushed animal hose. The clear liquid that flows in will drive the spiral fan 643 to rotate, and then drive the second shaft 642 to rotate, so that the scraper 644 will scrape out the cartilage fragments on the filter plate 641 to avoid the filter plate 641 from being blocked. After the transmission is completed, a magnetic object that repeles each other with the magnetic block 648 is placed next to the liquid outlet 61, and the sliding block 647 and the extrusion column 649 are driven to squeeze out the cartilage stuck on the filter plate 641.

[0063] Embodiment 2, use Figure 1-Figure 11 A stainless steel reaction tank 1 for producing heparinoids according to one embodiment of the present invention is described below.

[0064] like Figure 1-Figure 11 As shown, a stainless steel reaction tank 1 for heparin production of the present invention is based on the first embodiment, and the extraction mechanism 7 includes a drooping column 71, the top of the drooping column 71 is fixedly connected to the bottom of the partition plate 4, the bottom of the drooping column 71 is fixedly connected to a support plate 2 72, the bottom of the support plate 2 72 is fixedly connected to a telescopic rod 2 73, the bottom of the telescopic rod 2 73 is fixedly connected to a shoveling mechanism 74, the extraction mechanism 7 also includes an extraction cylinder 75, the inner wall of the extraction cylinder 75 is slidably connected to the outer surface of the shoveling mechanism 74, the top of the extraction cylinder 75 is fixedly connected to an inclined plate 76, and the bottom of the inclined plate 76 is fixedly connected to a drying mechanism 77.

[0065] After the clear liquid enters the extraction cylinder 75 through the transmission tube 62 , ethanol is added for precipitation. The precipitate is a heparin-like intermediate. The telescopic rod 73 drives the extraction plate 745 to move upward from the bottom of the extraction cylinder 75 .

[0066] The shoveling mechanism 74 includes a support plate three 741, the top of the support plate three 741 is fixedly connected to the bottom of the telescopic rod two 73, the outer surface of the support plate three 741 is fixedly connected to the servo motor two 742, the output end of the servo motor two 742 is the rotating shaft three 743, the outer surface of the rotating shaft three 743 is fixedly connected to the connecting rod 744, the bottom of the connecting rod 744 is hingedly connected to the eccentric wheel 7410, the bottom of the eccentric wheel 7410 is fixedly connected to the extraction plate 745, the support plate three 741 is fixedly connected to the side of the rotating shaft three 743, the bottom of the hanging rod 746 is rotatably connected to the outer surface of the extraction plate 745, the top of the extraction plate 745 is slidably connected to the scratching plate 747, the surface of the scratching plate 747 is provided with a notch 748, the bottom of the scratching plate 747 is fixedly connected to the connecting rope 749, and the bottom of the connecting rope 749 is fixedly connected to the inner wall of the extraction cylinder 75.

[0067] Servo motor 2 742 will drive shaft 3 743 to rotate, which will in turn drive connecting rod 744 to rotate. Combined with eccentric wheel 7410, it will drive extraction plate 745 to tilt, thereby facilitating the sediment to enter the next mechanism. As the height of the extraction plate increases, connecting rope 749 will pull the scraping plate 747 downward, making it easier to scrape the sediment on the extraction plate 745 into the drying mechanism 77.

[0068] The drying mechanism 77 comprises a drying box 771 , the bottom of which is fixedly connected to the inner wall of the reaction tank 1 , a drying device 772 is fixedly connected to the inner wall of the drying box 771 , and a collecting pull plate 773 is slidably connected to the bottom of the drying box 771 .

[0069] The heparin-like intermediate entering the drying oven 771 will be dehydrated, and then the intermediate will be subjected to polysulfation, ethanol precipitation, decolorization, graded alcohol precipitation, and drying to obtain fine heparin-like.

[0070] The specific workflow is as follows:

[0071] During operation, after the clear liquid enters the extraction cylinder 75 through the transmission tube 62, ethanol is added for precipitation. The precipitate is a heparin-like intermediate. The telescopic rod 2 73 will drive the extraction plate 745 to move upward from the bottom of the extraction cylinder 75. At the same time, the servo motor 2 742 will drive the rotating shaft 3 to rotate, so that the outer wall of the extraction plate 745 and the inner wall of the extraction cylinder 75 will be scratched, and then the precipitate attached to the inner wall of the extraction cylinder 75 will be hung and dropped. As the height of the extraction plate increases, the connecting rope 749 will pull the scratching plate 747 downward to facilitate the scraping of the precipitate on the extraction plate 745 into the drying mechanism 77. This series of operations is performed multiple times, and the formed precipitate will be taken out by the extraction plate 745. The heparin-like intermediate entering the drying box 771 will be dehydrated, and then the intermediate will be subjected to polysulfation, ethanol precipitation, decolorization, graded alcohol precipitation, and drying to obtain a fine heparin-like intermediate.

[0072] Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field and related fields without creative work should fall within the scope of protection of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention are implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A stainless steel reaction tank for heparin production, characterized in that: include: A reaction tank (1), and a switch door (2) arranged on the front of the reaction tank (1), the outer surface of the switch door (2) being rotatably connected to the inner wall of the reaction tank (1), and the bottom plate of the reaction tank (1) being evenly provided with support feet (3); A grinding mechanism (5), the grinding mechanism (5) is used to grind animal cartilage and perform enzymatic hydrolysis; A transmission mechanism (6), the transmission mechanism (6) is used to transmit the liquid after enzymatic hydrolysis; An extraction mechanism (7), the extraction mechanism (7) being used to synthesize heparinoids; An extraction mechanism (7) is arranged in the inner cavity of the reaction tank (1), a partition plate (4) is arranged between the crushing mechanism (5) and the reaction tank (1), a taking block (41) is arranged on the top of the partition plate (4), and the transmission mechanism (6) is arranged on the crushing mechanism (5); The crushing mechanism (5) comprises a crushing cylinder (51), the top of the crushing cylinder (51) is evenly provided with support rods (52), the top of the support rods (52) is fixedly connected to a support plate (53), the inner wall of the support plate (53) is fixedly connected to a servo motor (54), and the output end of the servo motor (54) is rotatably connected to a rotating mechanism (55); The rotating mechanism (55) comprises a main rotating shaft (551), a telescopic rod (552) is evenly arranged on the top of the main rotating shaft (551), a drooping rod (553) is fixedly connected to the bottom of the telescopic rod (552), a disc (554) is fixedly connected to the bottom of the drooping rod (553), a rolling block (555) is evenly arranged on the bottom of the disc (554), a sweeping plate (556) is fixedly connected to the bottom of the main rotating shaft (551), and a cleaning mechanism (557) is evenly arranged on the outer surface of the sweeping plate (556); The cleaning mechanism (557) comprises a semicircular plate (5571), the top of the semicircular plate (5571) being slidably connected to a sliding disk (5573), one end of the sliding disk (5573) close to the main rotating shaft (551) being fixedly connected to a telescopic spring (5572), brushes (5574) being evenly arranged on the top of the sliding disk (5573), and an impact block (5575) being fixedly connected to the inner wall of the sliding disk (5573).

2. The stainless steel reaction tank for heparin production according to claim 1, characterized in that: The bottom of the rolling cylinder (51) is fixedly connected to the top of the partition plate (4), and the main rotating shaft (551) is controlled to rotate by a servo motor 1 (54).

3. The stainless steel reaction tank for heparin production according to claim 1, characterized in that: One end of the telescopic spring (5572) away from the sliding disk (5573) is fixedly connected to the outer surface of the main rotating shaft (551), and one end of the semicircular plate (5571) away from the sliding disk (5573) is fixedly connected to the outer surface of the main rotating shaft (551).

4. The stainless steel reaction tank for heparin production according to claim 1, characterized in that: The transmission mechanism (6) comprises a liquid outlet (61), the outer surface of the liquid outlet (61) being fixedly connected to a transmission tube (62), an end of the liquid outlet (61) away from the transmission tube (62) being fixedly connected to an anti-blocking mechanism (64), and the outer surface of the transmission tube (62) being fixedly connected to the anti-blocking mechanism (64).

5. The stainless steel reaction tank for heparin production according to claim 4, characterized in that: The anti-clogging mechanism (64) comprises a filter plate (641), one end of the filter plate (641) away from the liquid outlet (61) is rotatably connected to a second rotating shaft (642), one end of the second rotating shaft (642) away from the filter plate (641) is evenly provided with a spiral fan (643), one end of the second rotating shaft (642) close to the filter plate (641) is fixedly connected to a scraper (644), one side of the filter plate (641) away from the second rotating shaft (642) is fixedly connected to a sliding rod (645), one end of the sliding rod (645) away from the filter plate (641) is fixedly connected to a baffle (646), an outer surface of the sliding rod (645) is slidably connected to a sliding block (647), a side of the sliding block (647) close to the baffle (646) is fixedly connected to a magnetic block (648), and a side of the sliding block (647) away from the magnetic block (648) is evenly provided with extrusion columns (649).

6. The stainless steel reaction tank for heparin production according to claim 5, characterized in that: The outer surface of the liquid outlet (61) is fixedly connected to the inner wall of the rolling cylinder (51), and the outer surface of the filter plate (641) is fixedly connected to an end of the liquid outlet (61) away from the transmission pipe (62).

7. The stainless steel reaction tank for heparin production according to claim 1, characterized in that: The extraction mechanism (7) comprises a drooping column (71), the top of the drooping column (71) being fixedly connected to the bottom of the partition plate (4), the bottom of the drooping column (71) being fixedly connected to a second support plate (72), the bottom of the second support plate (72) being fixedly connected to a second telescopic rod (73), the bottom of the second telescopic rod (73) being fixedly connected to a shoveling mechanism (74), and the extraction mechanism (7) further comprises an extraction cylinder (75), the inner wall of the extraction cylinder (75) being slidably connected to the outer surface of the shoveling mechanism (74), the top of the extraction cylinder (75) being fixedly connected to an inclined plate (76), and the bottom of the inclined plate (76) being fixedly connected to a drying mechanism (77).

8. The stainless steel reaction tank for heparin production according to claim 7, characterized in that: The shoveling mechanism (74) comprises a support plate three (741), the top of the support plate three (741) is fixedly connected to the bottom of the telescopic rod two (73), the outer surface of the support plate three (741) is fixedly connected to a servo motor two (742), the output end of the servo motor two (742) is a rotating shaft three (743), the outer surface of the rotating shaft three (743) is fixedly connected to a connecting rod (744), the bottom of the connecting rod (744) is hinged with an eccentric wheel (7410), and the bottom of the eccentric wheel (7410) is fixedly connected to a lifting device. The extraction plate (745) is fixedly connected to a hanging rod (746) on one side of the support plate three (741) close to the rotating shaft three (743); the bottom of the hanging rod (746) is rotatably connected to the outer surface of the extraction plate (745); the top of the extraction plate (745) is slidably connected to a scratch plate (747); a notch (748) is provided on the surface of the extraction plate (745); the bottom of the scratch plate (747) is fixedly connected to a connecting rope (749); and the bottom of the connecting rope (749) is fixedly connected to the inner wall of the extraction cylinder (75).

9. The stainless steel reaction tank for heparin production according to claim 7, characterized in that: The drying mechanism (77) comprises a drying box (771), the bottom of the drying box (771) being fixedly connected to the inner wall of the reaction tank (1), the inner wall of the drying box (771) being fixedly connected to a drying device (772), and the bottom of the drying box (771) being slidably connected to a collecting pull plate (773).

Images