Composition that helps to be absorbed through the skin to the bottom layer and decompose melanin
By using a compound composition of nicotinamide, arbutin and a variety of extracts, the problem that existing whitening skin care products are difficult to completely remove melanin in the skin is solved, and a rapid and significant whitening effect is achieved.
Patent Information
- Application Number
- CN202411101365.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-12
- Publication Date
- 2025-03-04
- Estimated Expiration
- 2044-08-12
AI Technical Summary
Existing whitening skin care products are difficult to completely remove melanin from the skin, and the whitening effect is relatively average and it is difficult to meet consumer needs.
The compound composition of nicotinamide, arbutin and pearl extract, Polygonatum extract, agave extract, horse chestnut extract, and coriander extract is used to form a composite extract by heating and stirring, and the ultrasonic vibration makes it easier to transdermal, reach the bottom of the skin, and inhibit the synthesis and decomposition of melanin.
The melanin decomposition effect of the skin from the inside to the outside is achieved, so that the melanin in the skin is quickly decomposed and metabolized, and the whitening effect is faster and the effect is better.
Smart Images
Figure BDA0004989462130000071
Abstract
Description
Technical Field
[0001] The invention relates to the field of skin care products, in particular to a composition which is helpful for transdermal absorption into the bottom layer of the skin and decomposing melanin. Background Art
[0002] Skin care products are products for skin care. With the development of science and technology, skin care products have entered the homes of ordinary people. Among them, based on the aesthetic needs of consumers, whitening effect is one of the most popular effects of skin care products. Usually, skin care products with whitening effect are mainly made by adding raw materials that can decompose melanin so that after the skin care products are applied to the skin, they can promote the decomposition of melanin on the skin surface and excrete it through metabolism, thereby reducing the melanin content in the skin's stratum corneum, thereby achieving a certain degree of whitening effect.
[0003] However, melanin is produced from the melanocytes in the bottom layer of the skin. When the skin is exposed to light, especially ultraviolet rays, it stimulates the melanocytes to synthesize melanin, and the melanin migrates to the surface of the skin to protect the skin. Therefore, simply decomposing the melanin on the surface of the skin cannot completely remove the melanin in the skin. Melanocytes will continue to synthesize melanin, and the melanin in the bottom layer of the skin will continue to migrate to the surface of the skin, resulting in a relatively general whitening effect that is difficult to meet the needs of consumers. Therefore, there is still room for improvement. Summary of the invention
[0004] In order to improve the whitening effect, the present application provides a composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin.
[0005] The present application provides a composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin using the following technical solution:
[0006] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, comprising the following components in parts by weight:
[0007] 2-4 parts of niacinamide;
[0008] Arbutin 2-4 parts;
[0009] 0.5-1 part of compound extract;
[0010] Solvent 91-95.5 parts;
[0011] The composite extract is a combination of pearl extract, polygonatum odoratum extract, agave extract, horse chestnut extract and coriander extract.
[0012] By adopting the above technical scheme, through the compounding of pearl extract, polygonatum extract, agave extract, horse chestnut extract and coriander extract, the composition has a good transdermal effect, can quickly open the skin channel, so that the composition can directly reach the bottom layer of the skin, and through the combination of niacinamide, arbutin and the composite extract, the activity of tyrosinase can be effectively inhibited, thereby inhibiting the synthesis of melanin. Since it can directly reach the bottom layer of the skin, it can well inhibit the synthesis of melanin by melanocytes, fundamentally reduce the production of melanin, and at the same time can play a good effect of decomposing melanin. Since it can directly reach the bottom layer of the skin, it can achieve the effect of decomposing melanin from the inside to the outside of the skin, so that the melanin in the skin can be quickly decomposed and quickly metabolized and excreted, so that the whitening effect is faster and the whitening effect is better.
[0013] Preferably, in the composite extract, the mass ratio of pearl extract, polygonatum odoratum extract, agave extract, horse chestnut extract and coriander extract is 0.1-0.2: 0.1-0.2: 0.1-0.2: 0.1-0.2: 0.1-0.2.
[0014] By adopting the above technical scheme and specifically selecting the mass ratio of pearl extract, polygonatum extract, agave extract, horse chestnut extract and coriander extract, the transdermal effect is better and the effect of rapid whitening can be better achieved.
[0015] Preferably, the solvent is water.
[0016] By adopting the above technical solution, water is specifically selected as the solvent, which makes it easier for the skin to absorb, has better solubility for each component, is more friendly to the skin and has no irritation, and has better quality.
[0017] Preferably, the method for preparing the composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin comprises the following steps:
[0018] Step 1), mixing the composite extract and the solvent, heating to 60-70° C., and stirring for 30-60 minutes to obtain a composite extract;
[0019] Step 2), cooling the composite extract to room temperature, adding niacinamide and arbutin, and stirring evenly to obtain a composition that helps to be absorbed through the skin to the bottom layer and decompose melanin.
[0020] By adopting the above technical scheme, the composite extract and the solvent are mixed and then heated to 60-70°C, so that the pearl extract, polygonatum extract, agave extract, horse chestnut extract and coriander extract can better cooperate with each other at 60-70°C, thereby making the transdermal effect of the composition better and the whitening effect better.
[0021] Preferably, in step 1), the rotation speed during stirring is 120-150 r / min.
[0022] By adopting the above technical solution, the pearl extract, polygonatum odoratum extract, agave extract, horse chestnut extract and coriander extract can be better dispersed and evenly matched with each other, and the quality of the composition is better.
[0023] Preferably, in step 2), during stirring, the rotation speed is 120-150 r / min and the stirring time is 3-5 min.
[0024] By adopting the above technical solution, the components are dispersed more evenly and the product performance is more stable.
[0025] Preferably, in the step 2), after stirring evenly, ultrasonic vibration is performed for 10-20 minutes.
[0026] By adopting the above technical solution, ultrasonic vibration can better cut large molecules, thereby forming more small molecular components, which are easier for the skin to absorb. Combined with the effect of opening skin channels, the transdermal effect is better, the composition can reach the deep layer of the skin more quickly, and the whitening effect is better.
[0027] Preferably, in step 2), the ultrasonic power is 1500-2000W.
[0028] By adopting the above technical solution and specifically selecting the ultrasonic power, the effect of cutting macromolecules is better and the quality of the composite is higher.
[0029] In summary, this application has the following beneficial effects:
[0030] 1. Since the present application uses a compound of pearl extract, polygonatum extract, agave extract, horse chestnut extract, and coriander extract, the composition has a good transdermal effect, can quickly open the skin channel, and allow the composition to reach the bottom layer of the skin. The combination of niacinamide, arbutin and the composite extract can effectively inhibit the activity of tyrosinase, thereby inhibiting the synthesis of melanin. Since it can reach the bottom layer of the skin directly, it can well inhibit the synthesis of melanin by melanocytes, fundamentally reducing the production of melanin, and at the same time can play a good effect of decomposing melanin. Since it can reach the bottom layer of the skin directly, it can achieve the effect of decomposing melanin from the inside to the outside of the skin, so that the melanin in the skin can be quickly decomposed and quickly metabolized and excreted, so that the whitening effect is faster and the whitening effect is better.
[0031] 2. In the present application, it is preferred to specifically select the mass ratio of pearl extract, polygonatum extract, agave extract, horse chestnut extract, and coriander extract to make the transdermal effect better and better achieve the effect of rapid whitening.
[0032] 3. In the present application, it is preferred that ultrasonic vibration can better cut macromolecules, thereby forming more small molecule components, which are easier for the skin to absorb. Combined with the effect of opening skin channels, the transdermal effect is better, the composition can reach the deep layer of the skin more quickly, and the whitening effect is better. DETAILED DESCRIPTION
[0033] The present application is further described in detail below in conjunction with embodiments.
[0034] Example 1
[0035] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, comprising the following components in parts by weight:
[0036] Niacinamide, arbutin, complex extract, solvent.
[0037] Nicotinamide is commercially available, CAS number: 98-92-0.
[0038] Arbutin is commercially available, CAS number: 497-76-7.
[0039] The solvent is water.
[0040] The compound extract is a combination of pearl extract, polygonatum extract, agave extract, horse chestnut extract and coriander extract.
[0041] Pearl extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0042] Polygonatum odoratum extract was purchased from Hebei Liqia Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0043] Agave extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0044] The horse chestnut extract was purchased from Shaanxi Snot Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0045] Coriander extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0046] The preparation method of the composition that helps to be transdermally absorbed into the bottom layer of the skin and decompose melanin comprises the following steps:
[0047] Step 1), 0.1 kg pearl extract, 0.1 kg polygonatum extract, 0.1 kg agave extract, 0.1 kg horse chestnut extract, 0.1 kg coriander extract, and 95.5 kg water are put into a stirring kettle, heated to 60° C., rotated at 120 r / min, and stirred for 30 minutes to obtain a composite extract.
[0048] Step 2), the composite extract is cooled to room temperature, 2 kg niacinamide and 2 kg arbutin are added, the rotation speed is 120 r / min, the stirring time is 3 min, ultrasonic vibration is performed for 10 min, the ultrasonic power is 1500 W, and the material is discharged to obtain a composition that helps to be transdermally absorbed into the bottom layer of the skin and decompose melanin.
[0049] Example 2
[0050] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, comprising the following components in parts by weight:
[0051] Niacinamide, arbutin, complex extract, solvent.
[0052] Nicotinamide is commercially available, CAS number: 98-92-0.
[0053] Arbutin is commercially available, CAS number: 497-76-7.
[0054] The solvent is water.
[0055] The compound extract is a combination of pearl extract, polygonatum extract, agave extract, horse chestnut extract and coriander extract.
[0056] Pearl extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0057] Polygonatum odoratum extract was purchased from Hebei Liqia Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0058] Agave extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0059] The horse chestnut extract was purchased from Shaanxi Snot Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0060] Coriander extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0061] The preparation method of the composition that helps to be transdermally absorbed into the bottom layer of the skin and decompose melanin comprises the following steps:
[0062] Step 1), 0.15 kg pearl extract, 0.15 kg polygonatum extract, 0.15 kg agave extract, 0.15 kg horse chestnut extract, 0.15 kg coriander extract, 93.25 kg water are put into a stirring kettle, heated to 65 ° C, rotated at 135 r / min, stirred for 45 minutes, and a composite extract is obtained.
[0063] Step 2), the composite extract is cooled to room temperature, 3 kg niacinamide and 3 kg arbutin are added, the rotation speed is 135 r / min, the stirring time is 4 min, ultrasonic vibration is performed for 15 min, the ultrasonic power is 1750 W, and the material is discharged to obtain a composition that helps to be transdermally absorbed into the bottom layer of the skin and decompose melanin.
[0064] Example 3
[0065] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, comprising the following components in parts by weight:
[0066] Niacinamide, arbutin, complex extract, solvent.
[0067] Nicotinamide is commercially available, CAS number: 98-92-0.
[0068] Arbutin is commercially available, CAS number: 497-76-7.
[0069] The solvent is water.
[0070] The compound extract is a combination of pearl extract, polygonatum extract, agave extract, horse chestnut extract and coriander extract.
[0071] Pearl extract was purchased from Ningxia Vanilla Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0072] Polygonatum odoratum extract was purchased from Hebei Liqia Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0073] Agave extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0074] The horse chestnut extract was purchased from Shaanxi Snot Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0075] Coriander extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0076] The preparation method of the composition that helps to be transdermally absorbed into the bottom layer of the skin and decompose melanin comprises the following steps:
[0077] Step 1), 0.2 kg pearl extract, 0.2 kg polygonatum extract, 0.2 kg agave extract, 0.2 kg horse chestnut extract, 0.2 kg coriander extract, and 91 kg water are put into a stirring kettle, heated to 70° C., rotated at 150 r / min, and stirred for 60 min to obtain a composite extract.
[0078] Step 2), the composite extract is cooled to room temperature, 4 kg niacinamide and 4 kg arbutin are added, the rotation speed is 150 r / min, the stirring time is 5 min, ultrasonic vibration is performed for 20 min, the ultrasonic power is 2000 W, and the material is discharged to obtain a composition that helps to be transdermally absorbed into the bottom layer of the skin and decompose melanin.
[0079] Comparative Example 1
[0080] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, compared with Example 2, the only difference is that:
[0081] In the composite extract, an equal amount of Glycyrrhiza glabra extract is used to replace the pearl extract.
[0082] The Glycyrrhiza glabra extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.
[0083] Comparative Example 2
[0084] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, compared with Example 2, the only difference is that:
[0085] In the composite extract, an equal amount of Polygonatum cuspidatum root extract was used to replace Polygonatum odoratum extract.
[0086] The root extract of Polygonum cuspidatum was purchased from Xi'an Jincuifang Plant Technology Development Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.
[0087] Comparative Example 3
[0088] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, compared with Example 2, the only difference is that:
[0089] In the composite extract, chrysanthemum extract is used to replace agave extract in equal amounts.
[0090] Chrysanthemum extract was purchased from Shaanxi Tianshengyuan Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0091] Comparative Example 4
[0092] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, compared with Example 2, the only difference is that:
[0093] In the composite extract, an equal amount of wolfberry extract was used to replace horse chestnut extract.
[0094] Lycium barbarum extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0095] Comparative Example 5
[0096] A composition that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, compared with Example 2, the only difference is that:
[0097] In the composite extract, the coriander extract was replaced with an equal amount of the magnolia bark extract.
[0098] Magnolia officinalis bark extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0099] Comparative Example 6
[0100] A composition that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin. Compared with Example 2, the only difference is that in the composite extract, an equal amount of Glycyrrhiza glabra extract is used to replace the pearl extract, an equal amount of Polygonatum cuspidatum root extract is used to replace the Polygonatum odoratum extract, an equal amount of Chrysanthemum flower extract is used to replace the Agave extract, an equal amount of Lycium barbarum extract is used to replace the Aesculus hippocastanum extract, and an equal amount of Magnolia officinalis bark extract is used to replace the Coriander extract.
[0101] The Glycyrrhiza glabra extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.
[0102] The root extract of Polygonum cuspidatum was purchased from Xi'an Jincuifang Plant Technology Development Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.
[0103] Chrysanthemum extract was purchased from Shaanxi Tianshengyuan Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0104] Lycium barbarum extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0105] Magnolia officinalis bark extract was purchased from Shaanxi Bolin Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.
[0106] Experiment 1
[0107] A number of volunteers, aged 20-30 years old, female, are recruited. When volunteers sign up, the melanin content is tested and recorded using the MX18 melanin tester from the German CK company. The testing point is the left cheek, which is recorded as the initial melanin content. The initial melanin content of the volunteer's facial skin must be between 300-400.
[0108] Ten volunteers form a group and are divided into different groups using the test samples.
[0109] The volunteers used the test sample once every night before going to bed. Before use, they cleaned their face with a disposable face towel and clean water, then wiped their face dry with a clean towel, and then applied 3 ml of the test sample to the face and spread it evenly.
[0110] After 14 days of use, the melanin content was tested on the morning of the 15th day, and recorded as the melanin content of whitening for 14 days; after 28 days of use, the melanin content was tested on the morning of the 29th day, and recorded as the melanin content of whitening for 28 days.
[0111] During the experiment, the volunteers were exposed to light outdoors for 2 hours every day, and apart from the test samples, they did not use any other skin care products.
[0112] Sample to be tested: the composition of each embodiment and comparative example that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin.
[0113] The mean value of each group of experimental data was taken.
[0114] The specific test data of Experiment 1 are shown in Table 1.
[0115] Table 1
[0116]
[0117] According to the data comparison of each embodiment and the comparative example in Table 1, after 14 days and 28 days of use, each embodiment has a significantly higher effect of reducing the melanin content of the skin than each comparative example. It can be seen that the whitening effect of each embodiment is significantly better than that of each comparative example, proving that when the pearl extract, polygonatum extract, dark green agave extract, horse chestnut extract, and coriander extract are compounded, the skin channels can be effectively opened, so that the composition can enter the bottom layer of the skin, thereby making the melanin in the skin decompose more thoroughly, and can effectively inhibit the synthesis of melanin by melanocytes from the source, so as to achieve rapid removal of melanin in the skin, so that the whitening effect is faster and the effect is better. In each comparative example, the extracts with whitening effect are used to replace the pearl extract, polygonatum extract, dark green agave extract, horse chestnut extract, and coriander extract alone or in whole. Orchid extract, horse chestnut extract, and coriander extract, which destroy the effect of the cooperation between pearl extract, polygonatum extract, dark green agave extract, horse chestnut extract, and coriander extract, resulting in a general effect of opening the skin channels, and it is difficult to inhibit and decompose melanin from the bottom layer of the skin, and can only decompose melanin on the surface of the skin. Therefore, after 14 days of use in each comparative example, the rate of decrease of melanin content is relatively general, and in the process from the 14th to the 28th day, the rate of decrease of melanin content slows down significantly, resulting in an insufficient whitening effect. However, since each embodiment inhibits the production of melanin from the source, it achieves the effect of quickly metabolizing melanin to the body and inhibiting the production of new melanin, so that the melanin in the skin continues to decrease, achieving a fast and better whitening effect.
[0118] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.
Claims
1. A composition that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin, characterized in that: The composition includes the following components in parts by weight: 2-4 parts of niacinamide; Arbutin 2-4 parts; 0.5-1 part of compound extract; Solvent 91-95.5 parts; The composite extract is a combination of pearl extract, polygonatum odoratum extract, agave extract, horse chestnut extract, and coriander extract; The pearl extract, polygonatum odoratum extract, agave extract, horse chestnut extract and coriander extract are all water-soluble extracts, and the extraction ratio is 10:
1.
2. A composition according to claim 1 that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin, characterized in that: In the composite extract, the mass ratio of pearl extract, polygonatum odoratum extract, agave extract, horse chestnut extract and coriander extract is 0.1-0.2: 0.1-0.2: 0.1-0.2: 0.1-0.2: 0.1-0.
2.
3. A composition according to claim 2 that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin, characterized in that: The solvent is water.
4. A composition according to any one of claims 1 to 3 that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, characterized in that: The preparation method of the composition that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin comprises the following steps: Step 1), the composite extract and the solvent are mixed, heated to 60-70°C, and stirred for 30-60 minutes to obtain a composite extract; Step 2), cooling the composite extract to room temperature, adding niacinamide and arbutin, and stirring evenly to obtain a composition that helps to be absorbed through the skin to the bottom layer and decompose melanin.
5. A composition according to claim 4 that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin, characterized in that: In the step 1), the rotation speed during stirring is 120-150 r / min.
6. The composition according to claim 4 that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin, characterized in that: In the step 2), during stirring, the rotation speed is 120-150 r / min, and the stirring time is 3-5 min.
7. A composition according to claim 6 that helps to be absorbed through the skin to the bottom layer of the skin and decompose melanin, characterized in that: In the step 2), after stirring evenly, ultrasonic vibration is performed for 10-20 minutes.
8. The composition according to claim 7 that helps to be absorbed through the skin into the bottom layer of the skin and decompose melanin, characterized in that: In the step 2), the ultrasonic power is 1500-2000W.
Citation Information
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