Long-acting food additive capable of rapidly relieving altitude stress and preparation method of long-acting food additive

Abstract

The invention discloses a long-acting food additive for rapidly relieving altitude stress and a preparation method thereof, and relates to the technical field of functional food. The additive comprises the following components in percentage by mass: 1-15% of arginine, 1-15% of cattle hide collagen polypeptide, 1-15% of cattle hide collagen, 60-80% of poloxamer 188 and 5-15% of fructose, totaling 100%. The food additive provided by the invention adopts a brand new formula and a unique preparation process, has the advantage of quick effect, and can continuously play a role in relieving altitude stress. Compared with a simple mixing mode, the additive shows a more excellent altitude stress relieving effect, and the action effect of the additive exceeds that of any other single component.

Description

Technical Field

[0001] The invention relates to the technical field of functional foods, and in particular to a long-acting food additive for rapidly relieving altitude sickness and a preparation method thereof. Background Art

[0002] With the rise of tourism, mountaineering and work in high-altitude areas around the world, altitude sickness has become a common health challenge people face in these environments. The main cause of altitude sickness is the stress of low-oxygen environments on the human body, which leads to a series of symptoms such as headaches, nausea and fatigue, and in severe cases may cause fatal complications such as high-altitude pulmonary edema or cerebral edema. Traditional coping methods include gradual adaptation and drug treatment, but with the increasing attention paid to nutritional intervention, the development of functional foods that can enhance the body's tolerance to low-oxygen environments and alleviate altitude sickness symptoms has become an important research direction. These foods provide natural, long-term and side-effect-free coping solutions by enhancing oxygen supply and anti-oxidation, and are increasingly attracting the attention of the scientific community and the public.

[0003] At present, research on relieving altitude sickness is mainly concentrated in the field of traditional Chinese medicine. However, in existing studies, most of the ingredients are relatively single, and their efficacy may not be very significant; or the ingredients are relatively complex, and long-term or excessive use may lead to abnormal liver and kidney metabolism or damage. In the existing disclosed technology, patent ZL202210724049.6 discloses a Chinese medicine composition for calming the nerves and helping sleep, including Platycladus orientalis, blue orchid, Artemisia bluntly, Rhodiola rosea, rose, Acorus calamus and Aquilaria sinensis, which can be used as an ointment or pillow core material. Patent CN201911012952.4 discloses a Chinese medicine composition for invigorating qi and activating blood circulation, protecting the heart and lungs, promoting sleep, and resisting altitude sickness, specifically including Astragalus, Angelica, Platycodon, Pueraria, Poria, Ziziphus jujuba, Eume, Licorice, Angelica dahurica, Polygonatum, Turmeric, Tangerine peel, Jujube, White Peony, Ginseng, Saffron, Panax notoginseng, Polygonum multiflorum and Gastrodia elata. Patent CN202410226242.6 discloses a functional solid beverage for resisting altitude sickness and its preparation method, including yak spleen small molecule polypeptide, yak milk small molecule polypeptide, taurine, phosphatidylserine, crystalline fructose and flaxseed, and its preparation method is a simple mixing of the components. At present, the composition of traditional Chinese medicine composition is complex, and the effect of protein and polypeptide in relieving altitude sickness is limited and insufficient in sustainability. Therefore, it is of great significance to find a functional food that is natural, non-toxic and has no side effects and can exert its efficacy sustainably. Summary of the invention

[0004] In view of the deficiencies in the above-mentioned background technology, the present invention provides a long-acting food additive for rapidly relieving altitude sickness and a preparation method thereof, so as to solve the problems that the current Chinese medicine composition has complex ingredients, and proteins and protein polypeptides are inefficient and cannot continuously exert their effects in relieving altitude sickness.

[0005] To achieve the above objectives, the first objective of the present invention is to provide a long-acting food additive that can quickly relieve altitude sickness. The additive comprises the following components in mass fractions: 1-15% arginine, 1-15% bovine collagen polypeptide, 1-15% bovine collagen, 60-80% poloxamer 188, and 5-15% fructose, totaling 100%.

[0006] Preferably, arginine, bovine collagen polypeptide and bovine collagen are functional factors, and poloxamer 188 and fructose are synergistic auxiliary ingredients.

[0007] Preferably, the bovine skin collagen is prepared by enzymatic hydrolysis and salting-out method.

[0008] Preferably, the bovine collagen polypeptide is prepared by enzymatic hydrolysis with pepsin.

[0009] The second object of the present invention is to provide a method for preparing a long-acting food additive that can quickly relieve altitude sickness, comprising the following steps: Sequentially adding bovine collagen, arginine, bovine collagen polypeptide and fructose to molten poloxamer 188, and mixing evenly to obtain a uniformly distributed molten mixture; The molten mixture is subjected to a rapid cooling process to form a solid, and the solid is ground into powder to obtain the food additive.

[0010] Preferably, when bovine collagen, arginine, bovine collagen polypeptide and fructose are added to the molten poloxamer 188 in sequence, each ingredient is stirred for 10 minutes after being added to ensure uniform mixing, and then the next ingredient is added to make the internal structure progressively wrapped.

[0011] Preferably, in the process of forming a solid, a mixture of molten bovine collagen, arginine, bovine collagen polypeptide, poloxamer 188 and fructose is poured into an aluminum or copper container and quickly immersed in a CaCl2 aqueous solution at a temperature of -20°C, and the molten mixture will quickly solidify into a solid.

[0012] The third object of the present invention is to provide a long-acting food additive that can quickly relieve altitude sickness and its use in preparing functional food or medicine for relieving altitude sickness.

[0013] Preferably, during application, it is prepared into powder, tablet, capsule or beverage.

[0014] Compared with the prior art, the present invention has the following beneficial effects: The present invention provides a long-acting food additive for quickly relieving altitude sickness and a preparation method thereof. The combined formula of the present invention includes arginine, cowhide collagen polypeptide, cowhide collagen, poloxamer 188 and fructose. These ingredients cooperate with each other through a special preparation process, and can quickly improve blood oxygen levels, improve blood circulation, and relieve symptoms of altitude sickness such as headaches, fatigue, and nausea. Arginine, cowhide collagen polypeptide, and cowhide collagen are used as functional factors, and poloxamer 188 and fructose are used as synergistic auxiliary ingredients, and a food additive is prepared by melt mixing, rapid cooling, and grinding special processes. After verification by examples and comparative examples, the additive has a significant and lasting effect of relieving altitude sickness and improving the body's blood oxygen saturation. The additive can be widely used in various foods and beverages, providing a convenient and effective means of protection for people who often enter plateau areas, and has broad application prospects.

[0015] Since the present invention adopts the innovative combination of "amino acid + polypeptide + protein", polypeptides can be quickly absorbed and play a role after entering the body, while amino acids are absorbed more slowly. Proteins are continuously degraded in the gastrointestinal tract to form new polypeptides and amino acids, which are continuously absorbed in the body, thereby prolonging the release time of the active ingredients.

[0016] The present invention adopts a combination of poloxamer 188 and fructose, which can help improve the solubility of functional factor components (amino acids + polypeptides + proteins) in a water-based environment and increase the bioavailability of the functional factor components. Therefore, it not only has a fast onset of effect, but also has a good lasting effect and high bioavailability.

[0017] The present invention uses a special melt-state quick-freezing process and adds functional factors in sequence, thereby successfully achieving layer-by-layer wrapping of the internal structure of the solid mixture, so that the components can work together more effectively and further improve the effect of alleviating altitude sickness.

[0018] In summary, the novel food additive disclosed in the present invention adopts a new formula and a unique preparation process, which not only has the advantage of rapid onset of action, but also can continuously exert the effect of relieving altitude sickness. Compared with a simple mixing method, the additive exhibits a better effect of relieving altitude sickness, and its effect exceeds that of any other single ingredient. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is the effect of this food additive on the blood oxygen saturation of volunteers in a high-altitude hypoxic environment. DETAILED DESCRIPTION

[0020] In order to enable those skilled in the art to better understand and implement the technical solution of the present invention, the present invention is further described below in conjunction with specific embodiments and drawings, but the embodiments are not intended to limit the present invention.

[0021] The present invention aims at the problems that the current Chinese medicine composition has complex ingredients, and proteins and protein polypeptides are inefficient and cannot sustainably exert their effects in relieving altitude sickness. The present invention provides a long-acting food additive that can quickly relieve altitude sickness, and aims to provide a functional additive that can effectively alleviate the discomfort symptoms caused by hypoxia in a plateau environment through a specific formula and preparation process. The combined formula involved in the present invention includes arginine, cowhide collagen polypeptide, cowhide collagen, poloxamer 188 and fructose. These ingredients cooperate with each other through a special preparation process, and can quickly increase blood oxygen levels, improve blood circulation, and relieve symptoms of altitude sickness such as headaches, fatigue, and nausea. Arginine, cowhide collagen polypeptide, and cowhide collagen are used as functional factors, and poloxamer 188 and fructose are used as synergistic auxiliary ingredients, and a food additive is prepared by melt mixing, rapid cooling, and grinding special processes. After verification by the examples and comparative examples, the additive has a significant and lasting effect of relieving altitude sickness and improving the blood oxygen saturation of the body. The additive can be widely used in various foods and beverages, providing a convenient and effective means of protection for people who often enter plateau areas, and has broad application prospects.

[0022] The first aspect of the present invention provides a long-acting food additive that can quickly relieve altitude sickness. The additive comprises the following components in mass fractions: 1-15% arginine, 1-15% bovine collagen polypeptide, 1-15% bovine collagen, 60-80% poloxamer 188, and 5-15% fructose, totaling 100%.

[0023] Among them, arginine, bovine collagen polypeptide and bovine collagen are functional factors, and poloxamer 188 and fructose are synergistic auxiliary ingredients.

[0024] The bovine collagen polypeptide is prepared by enzymatic hydrolysis with pepsin.

[0025] The specific preparation of cowhide collagen is as follows: After cleaning the defatted cowhide, crush it and add it to an appropriate amount of water. Use NaOH to adjust the pH to 9, and add alkaline protease for 48 hours of extraction. Subsequently, the extract is salted out with sodium chloride, and the salt in the precipitate is removed. Finally, the cowhide collagen is obtained by freeze-drying.

[0026] The bovine collagen polypeptide is prepared by enzymatic hydrolysis with pepsin.

[0027] The specific preparation of bovine collagen polypeptide is as follows: a certain amount of bovine collagen is dissolved in distilled water, and an appropriate amount of pepsin is added to adjust the pH of the solution to 2. Subsequently, the mixture is placed in a water bath and reacted at 37°C for 5 hours. After the reaction is completed, the enzyme activity is inactivated by heating in a boiling water bath for 10 minutes. Centrifuge at 8000 r / min for 10 minutes, take the supernatant for dialysis treatment, and finally obtain the bovine collagen polypeptide by freeze drying.

[0028] The invention uses arginine, bovine collagen polypeptide and bovine collagen as functional factors, poloxamer 188 and fructose as synergistic auxiliary components, and prepares the food additive through special processes of melt mixing, rapid cooling and grinding.

[0029] The second aspect of the present invention provides a method for preparing a long-acting food additive that can quickly relieve altitude sickness, comprising the following steps: Sequentially adding bovine collagen, arginine, bovine collagen polypeptide and fructose to molten poloxamer 188, and mixing evenly to obtain a uniformly distributed molten mixture; The molten mixture is subjected to a rapid cooling process to form a solid, and the solid is ground into powder to obtain the food additive.

[0030] Among them, when bovine collagen, arginine, bovine collagen polypeptide and fructose are added to the molten poloxamer 188 in sequence, each ingredient is stirred for 10 minutes after being added to ensure uniform mixing, and then the next ingredient is added to make its internal structure wrapped progressively.

[0031] In the process of forming a solid, pour the molten bovine collagen, arginine, bovine collagen polypeptide, poloxamer 188 and fructose mixture into an aluminum or copper container and quickly immerse it in a CaCl2 aqueous solution at a temperature of -20°C, and the molten mixture will quickly solidify into a solid.

[0032] In one embodiment, the preparation method of the food additive is as follows: Poloxamer 188 is heated to 60°C, and according to the above formula, Poloxamer 188 is heated to 60°C to be molten, and then cowhide collagen, arginine, cowhide collagen polypeptide and fructose are added to the molten poloxamer 188 in sequence, and each component is stirred for 10 minutes after addition to ensure uniform mixing, and then the next component is added to make its internal structure wrap progressively, and finally a uniformly distributed molten mixture is obtained. The molten mixture is poured into an aluminum or copper container and quickly immersed in a CaCl2 aqueous solution at a temperature of -20°C. The molten mixture will solidify rapidly to form a solid mixture. The solid mixture is ground and sieved through 80 mesh after grinding to obtain a powdery substance, which is the food additive of the present invention.

[0033] Statistical analysis: All experimental data were analyzed using GraphPad Prism 8.0 software (GraphPad-software Inc., CA, USA).

[0034] The third aspect of the present invention provides a long-acting food additive capable of rapidly alleviating altitude sickness, and its use in preparing functional food or medicine for alleviating altitude sickness.

[0035] In the application process, the composition is prepared into powder, tablet, capsule or beverage.

[0036] It should be noted that the experimental methods used in the present invention are all conventional methods unless otherwise specified; the reagents and materials used are all commercially available unless otherwise specified.

[0037] Example 1 A long-acting food additive that can quickly relieve altitude sickness is prepared according to the following formula: The mass fraction of arginine is 3%; the mass fraction of bovine collagen polypeptide is 4%; the mass fraction of bovine collagen is 3%; the mass fraction of poloxamer 188 is 80%; and the mass fraction of fructose is 10%.

[0038] Preparation method: Heat Poloxamer 188 to 60°C to melt; Then add bovine collagen, arginine, bovine collagen peptides and fructose to the molten poloxamer 188 in sequence. Stir for 10 minutes after adding each ingredient to ensure uniform mixing, and then add the next ingredient to make its internal structure progressively wrapped, and finally obtain a uniformly distributed molten mixture.

[0039] The molten mixture is poured into an aluminum or copper container and quickly immersed in a CaCl2 aqueous solution at a temperature of -20°C. The molten mixture will quickly solidify to form a solid mixture.

[0040] The solid mixture is ground and sieved through an 80-mesh screen to obtain a powdery substance, which is the food additive of the present invention.

[0041] Example 2 The difference from Example 1 is that the formula of this embodiment is: The mass fraction of arginine is 11%; the mass fraction of bovine collagen polypeptide is 11%; the mass fraction of bovine collagen is 11%; the mass fraction of poloxamer 188 is 60%; and the mass fraction of fructose is 7%.

[0042] Example 3 The difference from Example 1 is that the formula of this embodiment is: The mass fraction of arginine is 5%; the mass fraction of bovine collagen polypeptide is 5%; the mass fraction of bovine collagen is 5%; the mass fraction of poloxamer 188 is 80%; and the mass fraction of fructose is 5%.

[0043] Example 4 The difference from Example 1 is that the formula of this embodiment is: The mass fraction of arginine is 6%; the mass fraction of bovine collagen polypeptide is 6%; the mass fraction of bovine collagen is 6%; the mass fraction of poloxamer 188 is 67%; and the mass fraction of fructose is 15%.

[0044] Example 5 The difference from Example 1 is that the formula of this embodiment is: The mass fraction of arginine is 10%; the mass fraction of bovine collagen polypeptide is 10%; the mass fraction of bovine collagen is 10%; the mass fraction of poloxamer 188 is 65%; and the mass fraction of fructose is 5%.

[0045] Example 6 The difference from Example 1 is that the formula of this embodiment is: The mass fraction of arginine is 10%; the mass fraction of bovine collagen polypeptide is 10%; the mass fraction of bovine collagen is 10%; the mass fraction of poloxamer 188 is 60%; and the mass fraction of fructose is 10%.

[0046] Comparative Example 1 The difference from Example 6 is that the formula of this comparative example is: The mass fraction of arginine is 20%; the mass fraction of bovine collagen polypeptide is 20%; the mass fraction of bovine collagen is 20%; the mass fraction of poloxamer 188 is 30%; and the mass fraction of fructose is 10%.

[0047] Comparative Example 2 The difference from Example 6 is that the formula of this comparative example is: The mass fraction of arginine is 20%; the mass fraction of bovine collagen polypeptide is 20%; the mass fraction of bovine collagen is 20%; the mass fraction of poloxamer 188 is 20%; and the mass fraction of fructose is 20%.

[0048] Comparative Example 3 The difference from Example 6 is that the formula of this comparative example is: The mass fraction of arginine is 3%; the mass fraction of bovine collagen polypeptide is 3%; the mass fraction of bovine collagen is 3%; the mass fraction of poloxamer 188 is 90%; and the mass fraction of fructose is 1%.

[0049] Comparative Example 4 The difference from Example 6 is that the formula of this comparative example is: The mass fraction of arginine is 3%; the mass fraction of bovine collagen polypeptide is 3%; the mass fraction of bovine collagen is 4%; the mass fraction of poloxamer 188 is 50%; and the mass fraction of fructose is 40%.

[0050] Comparative Example 5 The difference from Example 6 is that the formula of this comparative example is: The mass fraction of arginine is 20%; the mass fraction of bovine collagen polypeptide is 10%; the mass fraction of bovine collagen is 20%; the mass fraction of poloxamer 188 is 30%; and the mass fraction of fructose is 20%.

[0051] Comparative Example 6 The difference from Example 6 is that the preparation process of this comparative example is: The mass fraction of arginine is 10%; the mass fraction of bovine collagen polypeptide is 10%; the mass fraction of bovine collagen is 10%; the mass fraction of poloxamer 188 is 60%; and the mass fraction of fructose is 10%.

[0052] The components are briefly mixed.

[0053] In order to illustrate the relevant properties of the additives provided by the present invention, the food additives obtained in Examples 1 to 6 and Comparative Examples 1 to 6 were tested for relevant properties.

[0054] Test 1: Normal pressure and low oxygen experiment The food additives obtained in Examples 1 to 6 and Comparative Examples 1 to 6 were gavaged into mice, with 6 mice in each group, and their hypoxia tolerance was determined based on the results of the normobaric hypoxia experiment.

[0055] Experimental animals: SPF-grade Kunming mice were purchased from the Experimental Mouse Center of the School of Medicine, Xi'an Jiaotong University (License No.: SCXK (Shaanxi) 2018-001).

[0056] Feeding method: The oral dose was 0.12 g / kg·BW, and the oral volume was 1% of the mouse body weight, once a day for five consecutive days.

[0057] Experimental method: 30 minutes after the last gavage, the mice were placed in transparent experimental bottles sealed with vacuum grease, 10 g of soda lime was put into the bottles, and after sealing, a stopwatch was used to time and record the time of death of the mice due to suffocation.

[0058] The results are shown in Table 1. The hypoxia tolerance effect of Example 6 is the most significant, and its survival time is 59.49±0.57 min. Under normal pressure and hypoxia environment, the survival time is significantly higher than that of the control group. The formula additive of Example 6 can improve the hypoxia tolerance of mice.

[0059] Table 1 Determination of normal pressure hypoxia experiment

[0060] Test 2: Rotarod test for anti-fatigue of mice under normobaric and normoxic environment The food additives obtained in Examples 1 to 6 and Comparative Examples 1 to 6 were gavaged into mice, with 6 mice in each group, and a mouse rotarod test was performed under a normobaric and normoxic environment to determine their anti-fatigue ability under normobaric and normoxic conditions.

[0061] Experimental animals: SPF-grade Kunming mice were purchased from the Experimental Mouse Center of the School of Medicine, Xi'an Jiaotong University (License No.: SCXK (Shaanxi) 2018-001).

[0062] Feeding method: The oral dose was 0.12 g / kg·BW, and the oral volume was 1% of the mouse body weight, once a day for five consecutive days.

[0063] Experimental method: The mice were trained to rotate the rod in advance to prevent errors in the experimental results due to the inability to rotate the rod. 30 minutes after the last oral administration, the mice were subjected to the rotating rod test under normal pressure and oxygen conditions. Each mouse was subjected to three rotations of the rod, and the average number was taken to record the mouse's rotation time.

[0064] Table 2 Anti-fatigue rotarod test of mice under normobaric and normoxic environment

[0065] The experimental results are shown in Table 2. The rotarod time of Example 6 is the longest, and its anti-fatigue effect is the most significant, which is significantly higher than that of the control group. The formula additive of Example 6 can improve the anti-fatigue ability of mice under normobaric and normoxic conditions.

[0066] Test 3: Rotarod test of mice in hypobaric hypoxia environment The food additives obtained in Examples 1 to 6 and Comparative Examples 1 to 6 were gavaged into mice, with 6 mice in each group, and a mouse rotarod test was performed under a low-pressure hypoxia environment to determine their anti-fatigue ability under the low-pressure hypoxia state.

[0067] Experimental animals: SPF-grade Kunming mice were purchased from the Experimental Mouse Center of the School of Medicine, Xi'an Jiaotong University (License No.: SCXK (Shaanxi) 2018-001).

[0068] Feeding method: The oral dose was 0.12 g / kg·BW, and the oral volume was 1% of the mouse body weight, once a day for five consecutive days.

[0069] Experimental method: The mice were trained to rotate the rod in advance to prevent errors in the experimental results due to the inability to rotate the rod. 30 minutes after the last oral administration, the mice were placed in a hypobaric oxygen chamber simulating an altitude of 4000 meters. In the hypobaric hypoxic environment, the mice were subjected to the rotating rod test. Each mouse was subjected to three rotations of the rod, and the average number was taken to record the mouse's rotation time.

[0070] Table 3 Anti-fatigue rotarod test of mice under low-pressure hypoxia environment

[0071] According to Table 3, Example 6 has the longest rotarod time in the hypobaric oxygen chamber, and its anti-fatigue effect in a hypoxic environment is the most significant, which is significantly higher than that of the control group. The formula additive of Example 6 can significantly improve the anti-fatigue ability of mice under low-pressure hypoxia.

[0072] Test 4: Effect of the additive on volunteers’ blood oxygen saturation In order to further verify the efficacy of Example 6, the following human trials were conducted: 14 volunteers aged 18-25 were recruited to study the effect of the food additive for relieving altitude sickness on the blood oxygen saturation of the body in a low oxygen environment. The 14 volunteers were randomly divided into two groups, a control group and an experimental group. The experimental group consumed 0.8 g of food each time, and the control group consumed the same dose of placebo (milk powder) for five consecutive days. The volunteers entered a hypobaric oxygen chamber before and after consumption. The hypobaric oxygen chamber was set to simulate a low oxygen environment at an altitude of 4,000 meters, and the blood oxygen saturation of the volunteers at an altitude of 4,000 meters was recorded. The results are shown in the attached Figure 1 As shown, this food additive significantly improved the blood oxygen saturation of the volunteers in the experimental group at an altitude of 4,000 meters. This additive can provide new ideas for alleviating altitude sickness.

[0073] When the additive provided by the present invention is ingested into the body, the cowhide collagen peptide is first digested and absorbed, and takes effect quickly. After the cowhide collagen enters the gastrointestinal tract, it forms new polypeptides and amino acids through the continuous degradation of the digestive system, which are continuously absorbed by the body, and the addition of arginine can also prolong the release of the effective ingredients. Poloxamer 188 and fructose are used as carriers to assist in solubilizing the cowhide collagen, help digestion, and increase the bioavailability of the composition. Therefore, it not only takes effect quickly, but also has good persistence of effect and high bioavailability. Compared with the simple mixing of the components (Comparative Example 6), the composition of the present invention can quickly increase the blood oxygen saturation level of the body and relieve altitude sickness after being prepared by the melting method.

[0074] Based on the above embodiments and comparative examples, it is found that the food additive can efficiently and rapidly improve the body's blood oxygen saturation level within a safe range. The additive can be widely used in various foods and beverages, providing a convenient and effective protective measure for people who frequently enter plateau areas, and has broad application prospects.

Claims

1. A long-acting food additive that can quickly relieve altitude sickness. It is characterized in that The additive comprises the following components in mass fractions: 1-15% of arginine, 1-15% of bovine collagen polypeptide, 1-15% of bovine collagen, 60-80% of poloxamer 188, and 5-15% of fructose, which totals 100%.

2. The long-acting food additive capable of rapidly alleviating altitude sickness according to claim 1, It is characterized in that Arginine, bovine collagen polypeptide and bovine collagen are functional factors, and poloxamer 188 and fructose are synergistic auxiliary ingredients.

3. The long-acting food additive capable of rapidly alleviating altitude sickness according to claim 1, It is characterized in that The cowhide collagen is prepared by enzymatic hydrolysis and salting-out method.

4. The long-acting food additive capable of rapidly alleviating altitude sickness according to claim 1, It is characterized in that The cowhide collagen polypeptide is prepared by enzymatic hydrolysis with pepsin.

5. A method for preparing the long-acting food additive capable of rapidly alleviating altitude sickness according to any one of claims 1 to 4, It is characterized in that The following steps are involved: Sequentially adding bovine collagen, arginine, bovine collagen polypeptide and fructose to molten poloxamer 188, and mixing evenly to obtain a uniformly distributed molten mixture; The molten mixture is subjected to a rapid cooling process to form a solid, and the solid is ground into powder to obtain the food additive.

6. The method for preparing the long-acting food additive capable of rapidly alleviating altitude sickness according to claim 5, It is characterized in that When bovine collagen, arginine, bovine collagen polypeptide and fructose are added to the molten poloxamer 188 in sequence, each ingredient is stirred for 10 minutes after being added to ensure uniform mixing, and then the next ingredient is added to allow the internal structure to be progressively wrapped.

7. The method for preparing the long-acting food additive capable of rapidly alleviating altitude sickness according to claim 5, It is characterized in that During the solidification process, the molten bovine collagen, arginine, bovine collagen peptide, poloxamer 188 and fructose mixture is poured into an aluminum or copper container and quickly immersed in a CaCl solution at a temperature of -20°C. 2 In aqueous solution, the molten mixture will quickly solidify into a solid.

8. Use of the long-acting food additive capable of rapidly relieving altitude sickness according to any one of claims 1 to 4 in the preparation of functional food or medicine for relieving altitude sickness.

9. The use according to claim 8, It is characterized in that During application, it is prepared into powder, tablet, capsule or drink.

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