Digitalized design method and application of meridian prescription component food-medicine homologous substance substitution based on decoction meridian method medicine property combinatorial analysis

Abstract

The invention belongs to the technical field of food science and modern medicine, and particularly relates to a digitized design method and application of meridian prescription component food and medicine homologous substance substitution based on decoction meridian method medicine property combinatorial analysis. According to the invention, a decoction method is taken as a theoretical core, a food-medicine homology database is established, and new traditional Chinese medicine prescriptions are accurately matched with classical prescriptions. On one hand, the candidate components are screened out from the established food and medicine homology database, so that the comprehensiveness of the candidate components is ensured; on the other hand, on the basis of channel tropism, tonifying and reducing of five internal organs and drug properties of medicinal information, substitute raw materials needing to be replaced are screened, and prescription compatibility is carried out; and finally, the grades of the raw materials are investigated again for priority matching, and the efficacy of each medicine in the prescription is fully considered, so that the optimal matching of non-edible-medicine homologous components and edible-medicine homologous components of the traditional Chinese medicine meridian prescription to be identified is realized. Moreover, the method can be realized by intelligent terminal equipment, is simple, convenient and quick to operate, has good accuracy, and has a wide market application prospect.

Description

Technical Field

[0001] The present invention belongs to the field of food science and modern medical technology, and specifically relates to a digital design method and application of food and medicine homologous substance substitution for prescription components based on decoction and medicinal property combination analysis. Background Art

[0002] Traditional Chinese medicine prescriptions have been popular for thousands of years, and their effectiveness has been verified by countless doctors. They are a brilliant treasure house of traditional Chinese medicine. To date, the system of traditional Chinese medicine prescriptions in treating diseases has been relatively complete and the methods of use have become more diverse. However, the toxic side effects such as hepatotoxicity caused by the complex ingredients of traditional Chinese medicine still cause troubles for clinical medication and patients.

[0003] The theory of the homology of food and medicine was first seen in Huangdi Neijing Taisu: "Eating it on an empty stomach is food, and eating it with a sick person is medicine." Compared with traditional Chinese medicine, substances with the same origin of food and medicine have higher safety and are an important carrier of the concept of "preventing disease before it occurs" in traditional Chinese medicine. Today, the concept of the homology of food and medicine, which originated from traditional Chinese medicine culture, has attracted much attention in the application of disease prevention.

[0004] In a prescription, different drugs play different roles to achieve different effects, and the same drug plays different roles in different prescriptions. Replacing drugs in prescription components with food-drug homologous substances that have both drug efficacy and food safety will have greater application advantages. The current replacement method based on simple medicinal properties or consistent functions is too extensive. This method lacks systematic scientific theoretical support, and its subjectivity and limitations are relatively large, which will weaken or even greatly reduce the effect of the prescription.

[0005] In addition, in the current market, there is more research on the use of computer technology for TCM syndrome differentiation. The research and use of digital design screening + classical prescriptions is still difficult. It is difficult to achieve a systematic application of classical prescriptions, and it is impossible to accurately match new Chinese medicine prescriptions with classic prescriptions. Summary of the invention

[0006] Tangye Jingfa describes a complete and logically rigorous system of syndrome differentiation and treatment methodology based on the theory of syndrome differentiation of deficiency and excess of the five internal organs and the theory of five flavors for tonifying and purging treatment. It accurately explains the theoretical principles of Chinese medicine prescription compatibility and can be used for prescription identification, interpretation and prescription composition. The present invention takes Tangye Jingfa as the theoretical core and develops a digital design method for replacing food-drug homologous substances (substances that are traditionally both food and Chinese medicinal materials) for the components of the classic prescriptions. It can accurately match and replace the non-drug-food homologous components in the classic prescriptions, and provide guidance and inspiration for the subsequent development of high-quality functional foods and health foods.

[0007] In order to achieve the above technical objectives, the present invention adopts the following technical solutions:

[0008] A digital design method and application of food and medicine homologous substance substitution of prescription components based on decoction and medicinal property combination analysis, the steps are as follows:

[0009] (1) Medicinal information includes the five internal organs, tonifying and purging, medicinal properties and meridians; the medicinal information corresponding to a food or medicinal material can be obtained through public channels; the public channels include Chinese medicine dictionaries, online channels or common knowledge;

[0010] Preferably, the Chinese medicine dictionary in step (1) includes "Tangye Jingfa Wei Tu", "Zhongyao Da Cidian" and "Chinese Pharmacopoeia"; the network channel includes but is not limited to China Traditional Chinese Medicine Network and the Pharmacopoeia of the People's Republic of China Network;

[0011] Preferably, the five internal organs tonifying and purging in step (1) are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, consolidating the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys.

[0012] Preferably, the medicinal properties in step (1) are warm, hot, cold, cool, or neutral.

[0013] Preferably, the meridians in step (1) are liver, heart, spleen, lung, kidney, stomach, and large intestine.

[0014] (2) establishing a drug database, wherein the drugs include Chinese medicinal materials; the drug database includes n medicinal materials, where n is a positive integer and is sequentially recorded as drug 1, drug 2, drug 3, drug 4, ... drug n; forming a drug database based on the medicinal information corresponding to each drug;

[0015] The medicinal information is denoted as i, and the medicinal information i includes the five internal organs, the medicinal properties and the meridians; wherein the value of i is a positive integer, and each medicinal information corresponds to a value; if the drug n has the medicinal information i, then the corresponding x i,n =1; otherwise, x i,n＝ 0, n is a positive integer;

[0016] Preferably, in step (2), the value of i is 1-27; the five internal organs tonifying and purging are divided into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, consolidating the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15 respectively;

[0017] The medicinal properties are divided into warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20;

[0018] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding values ​​of i are 21, 22, ... 27;

[0019] Therefore, the relationship expression between the drug number and the corresponding medicinal information can be established in sequence.

[0020] Drug 1 is denoted as x 1,1 、x 2,1 ,……x 27,1 ;

[0021] Drug 2 is denoted as x 1,2 、x 2,2 ,……x 27,2 ;

[0022] …

[0023] Drug n is denoted as x 1,n 、x 2,n ,……x 27,n ;

[0024] And so on, until drug n, all drugs are numbered;

[0025] Drug database list:

[0026]

[0027]

[0028] (3) Search the Chinese medicine dictionary and the management catalogue of food and medicine homologous substances formulated and published by the state to summarize the raw materials and the corresponding medicinal information of each raw material to form a food and medicine homologous database;

[0029] The food and medicine homology database includes j flavor raw materials, j is a positive integer, and is sequentially recorded as raw material 1, raw material 2, raw material 3, ... raw material j; and corresponding to the medicinal information, the food homology database information matrix is ​​listed:

[0030] The raw materials in the food and drug homology database were prioritized and divided into primary raw materials, secondary raw materials and tertiary raw materials.

[0031] First-level raw materials: substances that are traditionally both food and Chinese medicinal materials announced by the state, new resource foods and new food raw materials, and edible fungi; substances that are traditionally both food and Chinese medicinal materials announced by the state include but are not limited to American ginseng, sword bean, wolfberry, raspberry, patchouli, and perilla; new resource foods and new food raw materials include but are not limited to Cordyceps militaris, Angelica dahurica, Eucommia ulmoides male flower, Ligusticum chuanxiong leaf, edible leaf grass, loquat leaf, and tea tree flower.

[0032] Secondary raw materials: raw materials that are released by the state as common food management and substances with local food safety standards; raw materials for common food management include corn silk, sea buckthorn leaves, and bitter melon; substances with local food safety standards include cornus officinalis, fairy leaves, and wax gourd.

[0033] Level 3 raw materials: Cereals, fruits and vegetables that have food and medicine properties among common foods; including but not limited to polished round-grained rice, adzuki beans, hawthorn, black plum, grapes, oranges, mushrooms and onions.

[0034] The medicinal information i of the raw material includes the five internal organs tonifying and purging properties, medicinal properties and meridians; the value of i is a positive integer, and each medicinal information corresponds to a value;

[0035] Preferably, in step (3), the five internal organs tonifying and purging are divided into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, consolidating the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15 respectively;

[0036] The medicinal properties are divided into warm, hot, cold, cool, and neutral, and the corresponding values ​​of i are 16, 17, ... 20;

[0037] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding values ​​of i are 21, 22, ... 27;

[0038] Therefore, the relationship expression between the raw material number and the corresponding medicinal information can be established in sequence:

[0039] The relational expressions corresponding to the medicinal information of raw material 1 are established in sequence, recorded as y 1,1 ,y 2,1 ,……y 27,1 ;

[0040] The relational expressions corresponding to the medicinal information of raw material 2 are established in sequence, recorded as y 1,2 ,y 2,2 ,……y 27,2 ;

[0041] …

[0042] Drug j is denoted as y 1,j ,y 2,j ,……y 27,j ;

[0043] And so on, until raw material j, all raw materials are numbered;

[0044] Among them, if raw material j is a third-level raw material and has medicinal information i, then y i,j =3; if it is a secondary raw material, when it has medicinal information i, then y i,j =2; if it is a primary raw material, when it has medicinal information i, then y i,j =1; if raw material j does not have medicinal information i, then y i,j =0.

[0045] Food and medicine homology database information table:

[0046]

[0047]

[0048] (4) Screening based on a given prescription: Select the non-food-drug homologous drugs to be replaced from the provided traditional Chinese medicine prescriptions, and query their corresponding medicinal information based on the drug database;

[0049] The drug to be replaced is denoted as w, and the selected replacement raw material is denoted as k; where w = 1, 2, 3 ... n, k = 1, 2, 3 ... J;

[0050] When i,k ≠0 and x i,w ≠0; if y i,k =x i,w +m, where m is an integer between 0 and 2;

[0051] Then further verify whether i=16, 17…, 20 satisfies y i,k =x i,w +m;

[0052] If it is satisfied, then verify whether i=21, 22…, 27 satisfies y i,k =x i,w +m;

[0053] If it is satisfied, raw material k can be used to replace drug w.

[0054] For all raw materials k that can replace drug w, screen them according to the priority of raw materials;

[0055] Preferably, the specific steps of the priority screening in step (4) are as follows: first-class raw materials are selected first, second-class raw materials are selected second, and third-class raw materials are selected last;

[0056] (1) Let m = 0, if y i,k =x i,w +m is established, then y i,k The corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27;

[0057] (2) If no corresponding raw material is found through (1), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27;

[0058] (3) If no corresponding raw material is found through (2), then set m = 2. If y i,k =x i,w +m is established, then y i,kThe corresponding raw material is a tertiary raw material, which is used to replace the drug w, where i=1, 2..., 27.

[0059] The method provided by the present invention is used for replacing non-food and medicine homologous components in traditional Chinese medicine prescriptions with food and medicine homologous components.

[0060] Finally, the present invention also provides a screening and identification system for traditional Chinese medicine prescriptions, comprising:

[0061] A storage module, including a drug database and a medicine-food homologous database, wherein the database is used to store medicinal information of each drug and medicine-food homologous raw material;

[0062] An input unit, used to input medicinal information of drugs that need to be replaced in traditional Chinese medicine prescriptions;

[0063] A drug attribute determination unit, used to determine the attributes of the drug to be replaced and the medicinal information of the raw material of medicinal and edible homology, the attributes including the five internal organs tonifying and purging, the medicinal properties and the meridians;

[0064] (a) Among them, the five internal organs are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15;

[0065] The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20;

[0066] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding i values ​​are 21, 22, ... 27;

[0067] The relationship between the drug number and the corresponding medicinal information is established in the following order:

[0068] Drug 1 is denoted as x 1,1 、x 2,1 ,……x 27,1 ;

[0069] Drug 2 is denoted as x 1,2 、x 2,2 ,……x 27,2 ;

[0070] …

[0071] Drug n is denoted as x 1,n 、x 2,n ,……x 27,n ;

[0072] And so on, until drug n, all drugs are numbered;

[0073] (b) Priority matching was performed on the raw materials in the food and drug homology database, which were divided into primary raw materials, secondary raw materials, and tertiary raw materials;

[0074] First-level raw materials: substances that are traditionally both food and Chinese medicinal materials announced by the state, new resource foods and new food raw materials, and edible fungi; substances that are traditionally both food and Chinese medicinal materials announced by the state include but are not limited to American ginseng, sword bean, wolfberry, raspberry, patchouli, and perilla; new resource foods and new food raw materials include but are not limited to Cordyceps militaris, Angelica dahurica, Eucommia ulmoides male flower, Ligusticum chuanxiong leaf, edible leaf grass, loquat leaf, and tea tree flower.

[0075] Secondary raw materials: raw materials that are released by the state as common food management and substances with local food safety standards; raw materials for common food management include corn silk, sea buckthorn leaves, and bitter melon; substances with local food safety standards include cornus officinalis, fairy leaves, and wax gourd.

[0076] Level 3 raw materials: Cereals, fruits and vegetables that have food and medicine properties among common foods; including but not limited to polished round-grained rice, adzuki beans, hawthorn, black plum, grapes, oranges, mushrooms and onions.

[0077] The medicinal information of the raw material of medicinal and edible origin includes the five internal organs tonifying and purging, medicinal properties and meridians;

[0078] Among them, the five internal organs are tonifying and purging: tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3…14, 15;

[0079] The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20;

[0080] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding i values ​​are 21, 22, ... 27;

[0081] Therefore, the relationship expression between the raw material number and the corresponding medicinal information can be established in sequence:

[0082] The relational expressions corresponding to the medicinal information of raw material 1 are established in sequence, recorded as y 1,1 ,y 2,1 ,……y 27,1 ;

[0083] The relational expressions corresponding to the medicinal information of raw material 2 are established in sequence, recorded as y 1,2 ,y 2,2 ,……y 27,2 ;

[0084] …

[0085] Drug j is denoted as y 1,j ,y2,j ,……y 27,j ;

[0086] And so on, until raw material j, all raw materials are numbered;

[0087] The digital processing unit 1 is used to digitally process the attributes of the drug information to be replaced. If drug n has medicinal information i, then the corresponding x i,n =1; otherwise, x i,n =0, i ranges from 1 to 27, and n is a positive integer.

[0088] The second numerical processing unit is used to perform numerical processing on the attributes of raw material drug information in the medicine-food homology database; if raw material j is a third-level raw material and has medicinal information i, then y i,j =3; if it is a secondary raw material, when it has medicinal information i, then y i,j =2; if it is a primary raw material, when it has medicinal information i, then y i,j =1; if raw material j does not have medicinal information i, then y i,j =0.

[0089] Discrimination screening module: for the drug w to be replaced, w = 1, 2, 3...n, y i,k ≠0 and x i,w ≠0 hours;

[0090] If y i,k =x i,w +m, m is a positive integer from 0 to 2, i is a positive integer from 1 to 15, and k is a positive integer from 1 to j;

[0091] Then further verify whether i=16, 17…, 20 satisfies y i,k =x i,w +m;

[0092] If it is satisfied, then verify whether i=21, 22…, 27 satisfies y i,k =x i,w +m;

[0093] If it is satisfied, raw material k can be used to replace drug w.

[0094] Finally, the raw materials that meet the conditions are screened out; for all raw materials k that can replace drug w, they are screened according to the priority of the raw materials; first-level raw materials are selected first, second-level raw materials are selected second, and third-level raw materials are selected last;

[0095] The priority determination is as follows:

[0096] (1) Let m = 0, if y i,k =x i,w +m is established, then y i,kThe corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27;

[0097] (2) If no corresponding raw material is found through (1), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27;

[0098] (3) If no corresponding raw material is found through (2), then set m = 2. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a tertiary raw material, which is used to replace the drug w, where i = 1, 2, ..., 27;

[0099] Output module: Output replacement raw materials according to the priority order of raw material grades to achieve the best match for the drugs to be replaced.

[0100] The technical solution of the present invention has the following advantages:

[0101] The present invention uses the digital design of substitution of food-drug homologous substances in prescription components based on the combined analysis of medicinal properties of Tangye Jingfa, takes Tangye Jingfa as the theoretical core, establishes a food-drug homologous database, and accurately matches new Chinese medicine prescriptions with classical prescriptions.

[0102] On the one hand, candidate prescription components are screened out from the established food-drug homology database to ensure the comprehensiveness of the candidate prescriptions; on the other hand, alternative raw materials that need to replace components are screened based on the meridians, five-organ tonification and purgation, and medicinal properties of the medicinal information to make the prescription compatible; finally, the levels of the replacement raw materials are re-examined for priority matching, and the efficacy of each drug in the prescription is fully considered, thereby achieving the best matching of the non-food-drug homology components and food-drug homology components of the traditional Chinese medicine prescription to be identified. The operation is simple and fast, and it has good accuracy, and has broad market application prospects.

[0103] The present invention provides a digital design method for replacing food-drug homologous substances (substances that are traditionally both food and Chinese medicinal materials) in prescription components. The method can be implemented by an intelligent terminal device, and a food homologous database and a drug database are pre-stored in a storage module of the intelligent terminal device; at the same time, the intelligent terminal device has a built-in input unit, a discrimination and screening module, and an output module; an operator inputs the drug to be replaced in the TCM prescription through the input unit, and based on the information recorded in the food homologous database and the drug database, the discrimination and screening module is used to discriminate and screen the drug to be replaced, and finally the replacement raw materials that meet the conditions are screened out, and finally the corresponding replacement raw materials are output through the output module; wherein the intelligent terminal device includes a dedicated or general-purpose computer device, a smart phone, and a tablet computer. DETAILED DESCRIPTION

[0104] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0105] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0106] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention without departing from the scope or spirit of the present invention. Other embodiments obtained from the present invention description will be apparent to those skilled in the art.

[0107] Embodiment 1:

[0108] (1) The medicinal information of the herbal medicine includes the five internal organs tonifying and purging effects, medicinal properties and meridians;

[0109] The Chinese medicine dictionaries include "Tangye Jingfa Wei Tu", "Zhongyao Da Cidian" and "Chinese Pharmacopoeia";

[0110] The five internal organs tonifying and purging are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys.

[0111] The medicinal properties are warm, hot, cold, cool and neutral.

[0112] The meridians are liver, heart, spleen, lung, kidney, stomach and large intestine.

[0113] (2) A drug database was established based on the drugs and medicinal information recorded in the Tangye Jingfaweitu, the Chinese Pharmacopoeia, and the Chinese Pharmacopoeia, including n medicinal materials, where n is a positive integer and is recorded as drug 1, drug 2, drug 3, drug 4, and so on;

[0114] The medicinal information i includes the five internal organs' tonifying and purging properties, medicinal properties and meridians;

[0115] Among them, the five internal organs are tonifying and purging, namely tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3…14, 15;

[0116] The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding values ​​of i are 16, 17, ... 20;

[0117] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding values ​​of i are 21, 22, ... 27;

[0118] Therefore, the relationship expression between the drug number and the corresponding medicinal information can be established in sequence.

[0119] Drug 1 is denoted as x 1,1 、x 2,1 ,……x 27,1 ;

[0120] Drug 2 is denoted as x 1,2 、x 2,2 ,……x 27,2 ;

[0121] …

[0122] Drug n is denoted as x 1,n 、x 2,n ,……x 27,n ;

[0123] And so on, until drug n, all drugs are numbered;

[0124] If drug n has medicinal information i, then the corresponding x i,n =1; otherwise, x i,n＝ 0; i ranges from 1 to 27, and n is a positive integer.

[0125] The drug database is listed as follows, Table 1:

[0126]

[0127]

[0128] This embodiment selects the traditional Chinese medicine prescription - Dabuyuan decoction;

[0129] Dabuyuan decoction includes 8 medicinal materials, namely ginseng, yam, rehmannia, eucommia bark, angelica, cornus officinalis, wolfberry and licorice; according to the drug database, the medicinal information of each medicinal material in the traditional Chinese medicine prescription is listed as follows.

[0130] The medicinal information of each component of Dabuyuan Decoction is as follows, Table 2:

[0131]

[0132]

[0133] (3) Search the Chinese medicine dictionary and relevant national standards to summarize the raw materials and corresponding medicinal information to form a food-drug homology database; (Note: The raw materials include: substances that are traditionally both food and Chinese medicinal materials announced by the state, new resource foods and new food raw materials, edible fungi, raw materials that are managed as ordinary foods announced by the state, substances with local food safety standards, and grains, fruits and vegetables that have food-drug homology properties).

[0134] The food and medicine homology database includes j flavor raw materials, where j is a positive integer, and is recorded as raw material 1, raw material 2, raw material 3, ... raw material j in sequence; and the corresponding medicinal information is listed in the food homology database information table:

[0135] The raw materials in the food and drug homology database were prioritized and divided into primary raw materials, secondary raw materials and tertiary raw materials;

[0136] First-level raw materials: substances that are traditionally both food and Chinese medicinal materials announced by the state, new resource foods and new food raw materials, and edible fungi; substances that are traditionally both food and Chinese medicinal materials announced by the state include but are not limited to American ginseng, sword bean, wolfberry, raspberry, patchouli, and perilla; new resource foods and new food raw materials include but are not limited to Cordyceps militaris, Angelica dahurica, Eucommia ulmoides male flower, Ligusticum chuanxiong leaf, edible leaf grass, loquat leaf, and tea tree flower.

[0137] Secondary raw materials: raw materials that are released by the state as common food management and substances with local food safety standards; raw materials for common food management include corn silk, sea buckthorn leaves, and bitter melon; substances with local food safety standards include cornus officinalis, fairy leaves, and wax gourd.

[0138] Level 3 raw materials: Cereals, fruits and vegetables that have food and medicine properties among common foods; including but not limited to polished round-grained rice, adzuki beans, hawthorn, black plum, grapes, oranges, mushrooms and onions.

[0139] The medicinal information of the raw material includes the five internal organs tonifying and purging properties, medicinal properties and meridians;

[0140] Among them, the five internal organs are tonifying and purging, namely tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3…14, 15;

[0141] The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding values ​​of i are 16, 17, ... 20;

[0142] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding values ​​of i are 21, 22, ... 27;

[0143] Therefore, the relationship expression between the raw material number and the corresponding medicinal information can be established in sequence:

[0144] The relational expressions corresponding to the medicinal information of raw material 1 are established in sequence, recorded as y 1,1 ,y 2,1 ,……y 27,1 ;

[0145] The relational expressions corresponding to the medicinal information of raw material 2 are established in sequence, recorded as y 1,2 ,y 2,2 ,……y 27,2 ;

[0146] …

[0147] Drug j is denoted as y 1,j ,y 2,j ,……y 27,j ;

[0148] And so on, until raw material j, all raw materials are numbered;

[0149] Among them, if raw material j is a third-level raw material and has medicinal information i, then y i,j =3; if it is a secondary raw material, when it has medicinal information i, then y i,j =2; if it is a primary raw material, when it has medicinal information i, then y i,j =1; if raw material j does not have medicinal information i, then y i,j =0.

[0150] Food homology database information matrix, Table 3:

[0151]

[0152]

[0153] Among them, Eucommia ulmoides is a non-food-medicine medicinal material. Taking Eucommia ulmoides as an example, it is used as a drug to be replaced; 5 raw materials in the food-medicine homology database are selected as examples to provide a step-by-step description of the discrimination and screening. The corresponding food homology database information table is as follows, Table 4;

[0154]

[0155]

[0156] (4) Screening based on a given prescription: For the drug to be replaced, Eucommia ulmoides, comparison and verification are performed in the food homology database; the value of m is 0, 1 or 2

[0157] S1, select sword bean for verification;

[0158] The first level of “five internal organs tonifying and purging” screening and judgment: the corresponding medicinal information number i = 1, 2, 3…, 14, 15, for y i,1 , both satisfy y i,1 =x i，4 +m;

[0159] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i,1 =x i，4 +m;

[0160] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; where y 21，1 <x 21，4 , does not satisfy y 21，1 =x 21，4 +m;

[0161] Therefore, sword bean cannot be used as a substitute medicine and no further identification is required.

[0162] S2, select wolfberry for verification;

[0163] The first level of screening and judgment of "five internal organs tonifying and purging": the corresponding medicinal information number i = 1, 2, 3..., 14, 15; for y i,2 , both satisfy y i,2 =x i,4 +m;

[0164] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; where y 16，4 <x 16，2 , that is, it does not satisfy y 16,4 =x 16,2 +m, so sword bean cannot be used as a substitute medicine and no further identification is required.

[0165] S3, select raspberry for verification;

[0166] The first level of screening and judgment of "five internal organs tonifying and purging": the corresponding medicinal information number i = 1, 2, 3..., 14, 15; for y i3 , both satisfy y i,3 =x i,4 +m;

[0167] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i,3 =x i,4 +m;

[0168] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; all meet y i,3 =x i,4 +m;

[0169] So raspberries can be used as an alternative medicine.

[0170] S4, select pine nuts for verification;

[0171] The first level of screening and judgment of "five internal organs tonifying and purging": the corresponding medicinal information number i = 1, 2, 3..., 14, 15; for y i,4 , both satisfy y i,4 =x i,4 +m;

[0172] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i,4 =x i,4 +m;

[0173] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; where y 25，4 <x 25，4 , that is, it does not satisfy y 25,4 =x 25,4 +m, so pine nuts cannot be used as a substitute medicine and no further identification is required.

[0174] S5. Select walnut kernels for verification;

[0175] In the first level, “Five internal organs tonification and purgation”: the corresponding medicinal information number i = 1, 2, 3…, 14, 15; all satisfy y i5 =x i2 +m;

[0176] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i5=x i2 +m;

[0177] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; all meet y i5 =x i2 +m;

[0178] Therefore, walnut kernels can be used as an alternative medicine.

[0179] S6. Grade determination:

[0180] (I) Let m = 0, if y i,k =x i,w +m is established, then y i,k The corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27;

[0181] (II) If no corresponding raw material is found through (I), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27;

[0182] (III) If no corresponding raw material is found through (II), let m = 2. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a tertiary raw material, which is used to replace the drug w, where i=1, 2..., 27.

[0183] Among them, for raspberries, the equation is valid when m=0, and raspberries are first-class raw materials; for walnut kernels, the equation is valid when m=2, and walnut kernels are third-class raw materials;

[0184] The screening results show that raspberry is the preferred food and medicine raw material to replace Eucommia ulmoides.

[0185] Embodiment 2:

[0186] (1) Medicinal information of medicinal materials includes meridians, five internal organs tonifying and purging, and medicinal properties;

[0187] The Chinese medicine dictionaries include Tangye Jingfaweitu and Chinese Pharmacopoeia;

[0188] The five internal organs tonifying and purging are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys.

[0189] The medicinal properties are warm, hot, cold, cool and neutral.

[0190] The meridians are liver, heart, spleen, lung, kidney, stomach and large intestine.

[0191] (2) Obtaining the TCM prescription to be identified and establishing a database of drugs to be replaced as in Example 1;

[0192] This embodiment selects the traditional Chinese medicine prescription - Ganjiang Renshen Banxia Wan;

[0193] Ganjiang Renshen Banxia Wan includes three medicinal materials, namely, Ganjiang, Ginseng, and Banxia. The medicinal information of each medicinal material in the traditional Chinese medicine prescription is listed as follows;

[0194] The medicinal information of each component of Ganjiang Renshen Banxia Wan is as follows, Table 5:

[0195]

[0196]

[0197] (3) extracting medicinal information of each food-drug homology raw material in the Chinese medicine dictionary to form a food-drug homology database, listing the food-drug homology database information matrix, and operating as step (2) of Example 1:

[0198] Pinellia tuber is used as a drug to be substituted; at the same time, four raw materials that are both medicinal and edible are listed, and the steps of identification and screening are explained;

[0199] The medicinal information is as follows, Table 6:

[0200]

[0201]

[0202] (4) Screening based on a given prescription: Select Pinellia ternata for replacement, and compare and verify the Pinellia ternata to be replaced in the food homology database; the value of m is 0, 1 or 2

[0203] S1, select Piper longum for verification;

[0204] The first level of “five internal organs tonifying and purging” screening and judgment: the corresponding medicinal information number i = 1, 2, 3…, 14, 15, for y i,1 , satisfying y i,1 =x i,3 +m;

[0205] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; does not meet y i,1 =x i,3 +m, because y 16，1 <x 16，3 ;

[0206] Therefore, Piper longum cannot be used as a substitute medicine and no further identification is required.

[0207] S2, select Perilla for verification;

[0208] The first level of screening and judgment of "five internal organs tonifying and purging": the corresponding medicinal information number i = 1, 2, 3..., 14, 15; for y i,2 , both satisfy y i,2 =x i,3 +m;

[0209] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i,2 =x i,3 +m;

[0210] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; does not meet y i,2 =x i,3 +m, because y 26，1 <x 26，3 ;

[0211] Therefore, perilla cannot be used as a raw material for alternative medicines.

[0212] S3, select Patchouli for verification;

[0213] The first level of screening and judgment of “five internal organs tonifying and purging”: the corresponding medicinal information number i = 1, 2, 3…, 14, 15; for y i,3 , both satisfy y i,3 =x i,3 +m;

[0214] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i,3 =x i,3 +m;

[0215] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; all meet y i,3 =x i,3 +m;

[0216] Therefore, Patchouli can be used as a raw material for alternative medicines.

[0217] S4, select garlic for verification;

[0218] The first level of screening and judgment of “five internal organs tonifying and purging”: the corresponding medicinal information number i = 1, 2, 3…, 14, 15; for y i,4 , both satisfy y i,4 =x i,3 +m;

[0219] Continue to verify the second level "drug properties", the corresponding medicinal information number i = 16, 17, 18, 19, 20; all meet y i,4 =x i,3 +m;

[0220] Continue to verify the third level "meridian", the corresponding medicinal information number i = 21, 22...27; all meet y i,4 =x i,3 +m;

[0221] Therefore, garlic can be used as a raw material for alternative medicine.

[0222] S6. Grade determination:

[0223] (I) Let m = 0, if y i,k =x i,w +m is established, then y i,k The corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27;

[0224] (II) If no corresponding raw material is found through (I), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27;

[0225] (III) If no corresponding raw material is found through (II), let m = 2. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a tertiary raw material, which is used to replace the drug w, where i=1, 2..., 27.

[0226] Among them, for Patchouli, the equation is valid when m=0, and Patchouli is a first-class raw material; for Garlic, the equation is valid when m=2, and Garlic is a third-class raw material;

[0227] Therefore, for the raw materials that can replace the medicinal Pinellia, Patchouli is preferred as the edible and medicinal raw material that can replace Pinellia.

[0228] Embodiment 3:

[0229] A screening and identification system for traditional Chinese medicine prescriptions, specifically: a screening and identification system for replacing non-food and drug homologous components in traditional Chinese medicine prescriptions with food and drug homologous components, the system comprising:

[0230] A storage module, including a drug database and a medicine-food homologous database, wherein the database is used to store medicinal information of each drug and medicine-food homologous raw material;

[0231] An input unit, used to input medicinal information of drugs that need to be replaced in traditional Chinese medicine prescriptions;

[0232] A drug attribute determination unit, used to determine the attributes of the drug to be replaced and the medicinal information of the raw material of medicinal and edible homology, the attributes including the five internal organs tonifying and purging, the medicinal properties and the meridians;

[0233] (a) Among them, the five internal organs are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15;

[0234] The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20;

[0235] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding i values ​​are 21, 22, ... 27;

[0236] The relationship between the drug number and the corresponding medicinal information is established in the following order:

[0237] Drug 1 is denoted as x 1,1 、x 2,1 ,……x 27,1 ;

[0238] Drug 2 is denoted as x 1,2 、x 2,2 ,……x 27,2 ;

[0239] …

[0240] Drug n is denoted as x 1,n 、x 2,n ,……x 27,n ;

[0241] And so on, until drug n, all drugs are numbered;

[0242] (b) Priority matching was performed on the raw materials in the food and drug homology database, which were divided into primary raw materials, secondary raw materials, and tertiary raw materials;

[0243] First-level raw materials: substances that are traditionally both food and Chinese medicinal materials announced by the state, new resource foods and new food raw materials, and edible fungi; substances that are traditionally both food and Chinese medicinal materials announced by the state include but are not limited to American ginseng, sword bean, wolfberry, raspberry, patchouli, and perilla; new resource foods and new food raw materials include but are not limited to Cordyceps militaris, Angelica dahurica, Eucommia ulmoides male flower, Ligusticum chuanxiong leaf, edible leaf grass, loquat leaf, and tea tree flower.

[0244] Secondary raw materials: raw materials that are released by the state as common food management and substances with local food safety standards; raw materials for common food management include corn silk, sea buckthorn leaves, and bitter melon; substances with local food safety standards include cornus officinalis, fairy leaves, and wax gourd.

[0245] Level 3 raw materials: Cereals, fruits and vegetables that have food and medicine properties among common foods; including but not limited to polished round-grained rice, adzuki beans, hawthorn, black plum, grapes, oranges, mushrooms and onions.

[0246] The medicinal information of the raw material of medicinal and edible origin includes the five internal organs tonifying and purging, medicinal properties and meridians;

[0247] Among them, the five internal organs are tonifying and purging: tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3…14, 15;

[0248] The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20;

[0249] The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding i values ​​are 21, 22, ... 27;

[0250] Therefore, the relationship expression between the raw material number and the corresponding medicinal information can be established in sequence:

[0251] The relational expressions corresponding to the medicinal information of raw material 1 are established in sequence, recorded as y 1,1 ,y 2,1 ,……y 27,1 ;

[0252] The relational expressions corresponding to the medicinal information of raw material 2 are established in sequence, recorded as y 1,2 ,y 2,2 ,……y 27,2 ;

[0253] …

[0254] Drug j is denoted as y 1,j ,y 2,j ,……y 27,j ;

[0255] And so on, until raw material j, all raw materials are numbered;

[0256] The digital processing unit 1 is used to digitally process the attributes of the drug information to be replaced. If drug n has medicinal information i, then the corresponding x i,n =1; otherwise, x i,n＝ 0, i ranges from 1 to 27, and n is a positive integer.

[0257] The second numerical processing unit is used to perform numerical processing on the attributes of raw material drug information in the medicine-food homology database; if raw material j is a third-level raw material and has medicinal information i, then y i,j =3; if it is a secondary raw material, when it has medicinal information i, then y i,j =2; if it is a primary raw material, when it has medicinal information i, then y i,j =1; if there is no medicinal information i, then y i,j =0.

[0258] Discrimination screening module: for the drug w to be replaced, w = 1, 2, 3...n, y i,k ≠0 and x i,w ≠0 hours;

[0259] If y i,k =x i,w +m, m is a positive integer from 0 to 2, i is a positive integer from 1 to 15, and k is a positive integer from 1 to j;

[0260] Then further verify whether i=16, 17…, 20 satisfies y i,k =x i,w +m;

[0261] If it is satisfied, then verify whether i=21, 22…, 27 satisfies y i,k =x i,w +m;

[0262] If it is satisfied, raw material k can be used to replace drug w.

[0263] Finally, the raw materials that meet the conditions are screened out; for all raw materials k that can replace drug w, they are screened according to the priority of the raw materials; first-level raw materials are selected first, second-level raw materials are selected second, and third-level raw materials are selected last;

[0264] The priority determination is as follows:

[0265] (1) Let m = 0, if y i,k =x i,w +m is established, then y i,k The corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27;

[0266] (2) If no corresponding raw material is found through (1), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27;

[0267] (3) If no corresponding raw material is found through (2), then set m = 2. If yi,k =x i,w +m is established, then y i,k The corresponding raw material is a tertiary raw material, which is used to replace the drug w, where i = 1, 2, ..., 27;

[0268] Output module: Output replacement raw materials according to the priority order of raw material grades to achieve the best match for the drugs to be replaced.

[0269] The present invention uses a digital design of food-drug homologous substance substitution based on the combined analysis of the medicinal properties of the decoction method, takes the decoction method as the theoretical core, and establishes a food-drug homologous database based on the five internal organs' tonification and purgation, medicinal properties and meridian information, so as to accurately match new Chinese medicine prescriptions with classical prescriptions. At the same time, based on the constructed screening and discrimination system, it can achieve rapid matching of drugs and has good market application prospects.

[0270] Note: The series of detailed descriptions listed above are only specific descriptions of the feasible embodiments of the present invention. They are not intended to limit the scope of protection of the present invention. All equivalent embodiments or changes that do not deviate from the technical spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. A digital design method for replacing food and medicine homologous substances in prescription components based on the combined analysis of decoction and medicinal properties, characterized in that: The following steps are involved: (1) Medicinal information includes the five internal organs, tonifying and purging, medicinal properties and meridians; the medicinal information corresponding to a food or medicinal material can be obtained through public channels; the public channels include Chinese medicine dictionaries, online channels or common knowledge; (2) establishing a drug database, wherein the drugs include Chinese medicinal materials; the drug database includes n medicinal materials, where n is a positive integer and is sequentially recorded as drug 1, drug 2, drug 3, drug 4, ... drug n; forming a drug database based on the medicinal information corresponding to each drug; The medicinal information is denoted as i, and the medicinal information i includes the five internal organs, the medicinal properties and the meridians; wherein the value of i is a positive integer, and each medicinal information corresponds to a value; if the drug n has the medicinal information i, then the corresponding x i,n =1; otherwise, x i,n＝ 0, n is a positive integer; (3) Search the Chinese medicine dictionary and the management catalogue of food and medicine homologous substances formulated and published by the state to summarize the raw materials and the corresponding medicinal information of each raw material to form a food and medicine homologous database; The food and medicine homology database includes j flavor raw materials, j is a positive integer, and is sequentially recorded as raw material 1, raw material 2, raw material 3, ... raw material j; and corresponding to the medicinal information, the food homology database information matrix is ​​listed: The raw materials in the food and drug homology database were prioritized and divided into primary raw materials, secondary raw materials and tertiary raw materials. First-class raw materials: substances that are traditionally both food and Chinese medicinal materials, new resource foods and new food raw materials, and edible fungi announced by the state; substances that are traditionally both food and Chinese medicinal materials announced by the state include but are not limited to American ginseng, sword bean, wolfberry, raspberry, patchouli, and perilla; new resource foods and new food raw materials include but are not limited to Cordyceps militaris, Angelica keiskei, Eucommia ulmoides male flower, Ligusticum chuanxiong leaf, leaf-eating grass, loquat leaf, and tea tree flower; Secondary raw materials: raw materials that are released by the state as common food management and materials with local food safety standards; raw materials for common food management include corn silk, sea buckthorn leaves, and bitter melon, and materials with local food safety standards include dogwood, fairy leaves, and wax gourd; Level 3 raw materials: common foods that have the properties of food and medicine, such as grains, fruits and vegetables; including but not limited to polished rice, adzuki beans, hawthorn, black plum, grapes, oranges, mushrooms and onions; The medicinal information i of the raw material includes the five internal organs tonifying and purging, medicinal properties and meridians, and the value of i is a positive integer, and each medicinal information corresponds to a value; among them, if the raw material j is a third-level raw material, when it has medicinal information i, then y i,j =3; if it is a secondary raw material, when it has medicinal information i, then y i,j =2; if it is a primary raw material, when it has medicinal information i, then y i,j =1; if raw material j does not have medicinal information i, then y i,j =0; (4) Screening based on a given prescription: Select the non-food-drug homologous drugs to be replaced from the provided traditional Chinese medicine prescriptions, and query their corresponding medicinal information based on the drug database; The drug to be replaced is denoted as w, and the selected replacement raw material is denoted as k; where w = 1, 2, 3 ... n, k = 1, 2, 3 ... J; When i,k ≠0 and x i,w ≠0; if y i,k =x i,w +m, where m is an integer between 0 and 2; Then further verify whether i=16, 17…, 20 satisfies y i,k =x i,w +m; If it is satisfied, then verify whether i=21, 22…, 27 satisfies y i,k =x i,w +m; If it is satisfied, then raw material k can be used to replace drug w; For all raw materials k that can replace drug w, screen them according to the priority of the raw materials.

2. A digital design method for replacing food and medicine homologous substances of prescription components based on decoction and medicinal property combination analysis according to claim 1, characterized in that: The Chinese medicine dictionary in step (1) includes "Tangye Jingfa Wei Tu", "Zhongyao Da Cidian" and "Chinese Pharmacopoeia"; the network channel includes but is not limited to China Traditional Chinese Medicine Network and the Pharmacopoeia of the People's Republic of China Network.

3. A digital design method for replacing food and medicine homologous substances of prescription components based on decoction and medicinal property combination analysis according to claim 1, characterized in that: The five internal organs tonifying and purging in step (1) are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, consolidating the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys.

4. A digital design method for replacing food and medicine homologous substances of prescription components based on decoction and medicinal property combination analysis according to claim 1, characterized in that: The medicinal properties in step (1) are warm, hot, cold, cool, and neutral.

5. The digital design method for replacing the food and medicine homologous substances of the prescription components based on the combined analysis of the medicinal properties of decoctions according to claim 1 is characterized in that: The meridians mentioned in step (1) are liver, heart, spleen, lung, kidney, stomach and large intestine.

6. A digital design method for replacing food and medicine homologous substances of prescription components based on decoction and medicinal property combination analysis according to claim 1, characterized in that: In step (2), the value of i ranges from 1 to 27; the five internal organs tonifying and purging are divided into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15 respectively; The medicinal properties are divided into warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20; The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding values ​​of i are 21, 22, ... 27; Therefore, the relationship expression between the drug number and the corresponding medicinal information can be established in sequence. Drug 1 is denoted as x 1,1 、x 2,1 ,……x 27,1 ; Drug 2 is denoted as x 1,2 、x 2,2 ,……x 27,2 ; …… Drug n is denoted as x 1,n 、x 2,n ,……x 27,n ; And so on, until drug n, all drugs are numbered.

7. The digital design method for replacing the food and medicine homologous substances of the prescription components based on the combined analysis of the medicinal properties of decoctions according to claim 1 is characterized in that: In step (3), the value of i ranges from 1 to 27; the five internal organs tonifying and purging are divided into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15 respectively; The medicinal properties are divided into warm, hot, cold, cool, and neutral, and the corresponding values ​​of i are 16, 17, ... 20; The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding values ​​of i are 21, 22, ... 27; Therefore, the relationship expression between the raw material number and the corresponding medicinal information can be established in sequence: The relational expressions corresponding to the medicinal information of raw material 1 are established in sequence, recorded as y 1,1 ,y 2,1 ,……y 27,1 ; The relational expressions corresponding to the medicinal information of raw material 2 are established in sequence, recorded as y 1,2 ,y 2,2 ,……y 27,2 ; …… Drug j is denoted as y 1,j ,y 2,j ,……y 27,j ; And so on, until raw material j, all raw materials are numbered.

8. The digital design method for replacing the food and medicine homologous substances of the prescription components based on the combined analysis of the medicinal properties of decoctions according to claim 1 is characterized in that: In step (4), the priority screening step is as follows: first-class raw materials are selected first, second-class raw materials are selected second, and third-class raw materials are selected last; (1) Let m = 0, if y i,k =x i,w +m is established, then y i,k The corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27; (2) If no corresponding raw material is found through (1), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27; (3) If no corresponding raw material is found through (2), then set m = 2. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a tertiary raw material, which is used to replace the drug w, where i=1, 2..., 27.

9. Use of the method according to any one of claims 1 to 8 in replacing non-food and drug homologous components in traditional Chinese medicine prescriptions with food and drug homologous components.

10. A screening and identification system for traditional Chinese medicine prescriptions, characterized in that: The system comprises: A storage module, including a drug database and a medicine-food homologous database, wherein the database is used to store medicinal information of each drug and medicine-food homologous raw material; An input unit, used to input medicinal information of drugs that need to be replaced in traditional Chinese medicine prescriptions; A drug attribute determination unit, used to determine the attributes of the drug to be replaced and the medicinal information of the raw material of medicinal and edible homology, the attributes including the five internal organs tonifying and purging, the medicinal properties and the meridians; (a) Among them, the five internal organs are transformed into tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3...14, 15; The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20; The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding i values ​​are 21, 22, ... 27; The relationship between the drug number and the corresponding medicinal information is established in the following order: Drug 1 is denoted as x 1,1 、x 2,1 ,……x 27,1 ; Drug 2 is denoted as x 1,2 、x 2,2 ,……x 27,2 ; …… Drug n is denoted as x 1,n 、x 2,n ,……x 27,n ; And so on, until drug n, all drugs are numbered; (b) Priority matching was performed on the raw materials in the food and drug homology database, which were divided into primary raw materials, secondary raw materials, and tertiary raw materials; First-class raw materials: substances that are traditionally both food and Chinese medicinal materials, new resource foods and new food raw materials, and edible fungi announced by the state; substances that are traditionally both food and Chinese medicinal materials announced by the state include but are not limited to American ginseng, sword bean, wolfberry, raspberry, patchouli, and perilla; new resource foods and new food raw materials include but are not limited to Cordyceps militaris, Angelica keiskei, Eucommia ulmoides male flower, Ligusticum chuanxiong leaf, leaf-eating grass, loquat leaf, and tea tree flower; Secondary raw materials: raw materials that are released by the state as common food management and materials with local food safety standards; raw materials for common food management include corn silk, sea buckthorn leaves, and bitter melon, and materials with local food safety standards include dogwood, fairy leaves, and wax gourd; Level 3 raw materials: common foods that have the properties of food and medicine, such as grains, fruits and vegetables; including but not limited to polished rice, adzuki beans, hawthorn, black plum, grapes, oranges, mushrooms and onions; The medicinal information of the raw material of medicinal and edible origin includes the five internal organs tonifying and purging, medicinal properties and meridians; Among them, the five internal organs are tonifying and purging: tonifying the liver, purging the liver, soothing the liver, tonifying the heart, purging the heart, contracting the heart, tonifying the spleen, purging the spleen, drying the spleen, tonifying the lungs, purging the lungs, dispersing the lungs, tonifying the kidneys, purging the kidneys, and moistening the kidneys, and the corresponding values ​​of i are 1, 2, 3…14, 15; The medicinal properties are warm, hot, cold, cool, and neutral, and the corresponding i values ​​are 16, 17, ... 20; The meridians are liver, heart, spleen, lung, kidney, stomach, and large intestine, and the corresponding i values ​​are 21, 22, ... 27; Therefore, the relationship expression between the raw material number and the corresponding medicinal information can be established in sequence: The relational expressions corresponding to the medicinal information of raw material 1 are established in sequence, recorded as y 1,1 ,y 2,1 ,……y 27,1 ; The relational expressions corresponding to the medicinal information of raw material 2 are established in sequence, recorded as y 1,2 ,y 2,2 ,……y 27,2 ; …… Drug j is denoted as y 1,j ,y 2,j ,……y 27,j ; And so on, until raw material j, all raw materials are numbered; The digital processing unit 1 is used to digitally process the attributes of the drug information to be replaced. If drug n has medicinal information i, then the corresponding x i,n =1; otherwise, x i,n＝ 0, i ranges from 1 to 27, and n is a positive integer; The second numerical processing unit is used to perform numerical processing on the attributes of raw material drug information in the medicine-food homology database; if raw material j is a third-level raw material and has medicinal information i, then y i,j =3; if it is a secondary raw material, when it has medicinal information i, then y i,j =2; if it is a primary raw material, when it has medicinal information i, then y i,j =1; if raw material j does not have medicinal information i, then y i,j =0; Discrimination screening module: for the drug w to be replaced, w = 1, 2, 3...n, y i,k ≠0 and x i,w ≠0 hours; If y i,k =x i,w +m, m is a positive integer from 0 to 2, i is a positive integer from 1 to 15, and k is a positive integer from 1 to j; Then further verify whether i=16, 17…, 20 satisfies y i,k =x i,w +m; If it is satisfied, then verify whether i=21, 22…, 27 satisfies y i,k =x i,w +m; If it is satisfied, raw material k can be used to replace drug w; Finally, the raw materials that meet the conditions are screened out; for all raw materials k that can replace drug w, they are screened according to the priority of the raw materials; first-level raw materials are selected first, second-level raw materials are selected second, and third-level raw materials are selected last; The priority determination is as follows: (1) Let m = 0, if y i,k =x i,w +m is established, then y i,k The corresponding raw material is a primary raw material, and the raw material is used to replace the drug w, where i = 1, 2..., 27; (2) If no corresponding raw material is found through (1), then set m = 1. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a secondary raw material, which is used to replace drug w, where i = 1, 2, ..., 27; (3) If no corresponding raw material is found through (2), then set m = 2. If y i,k =x i,w +m is established, then y i,k The corresponding raw material is a tertiary raw material, which is used to replace drug w, where i = 1, 2, ..., 27; Output module: Output replacement raw materials according to the priority order of raw material grades to achieve the best match for the drugs to be replaced.

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