Microneedle array interdigital electrode for skin electroporation

Abstract

A microneedle array interdigital electrode for skin electroporation comprises 2n microneedle pieces, 2n + 1 insulating pieces and microneedle piece fixing buckles, and n is a positive integer; the micro-needle array interdigital electrode provided by the invention can penetrate through the surface layer of the skin to directly contact with tissues at the lower layer of the skin, so that the impedance of the skin is greatly reduced. Therefore, the electroporation signal can be transmitted more effectively, and the electroporation efficiency and effect are improved. The microneedle array provided by the invention is fixed on the skin through slight puncture, so that the sliding of an electrode on the skin is reduced, and the accuracy and repeatability of an electroporation position are ensured. Compared with other electrodes, the microneedle array interdigital electrode provided by the invention has the advantages of higher penetration efficiency, more accurate treatment precision, lower pain and complication occurrence rate, wider application range, better patient comfort and treatment convenience and the like in the field of medical wound repair; and positive influence is brought to technical development and clinical treatment in the field of wound repair.

Description

Technical Field

[0001] The invention relates to the technical field of microneedle electrodes, and in particular to a microneedle array interdigital electrode for skin electroporation. Background Art

[0002] With the rapid development of bioelectronics and medical technology, skin electroporation as a non-invasive treatment method has attracted wide attention in the fields of pain management, neurorehabilitation and beauty. Traditional skin electroporation methods usually rely on surface electrodes, however, these electrodes have limitations in skin impedance and current distribution, resulting in a narrow range of electroporation or difficulty in reaching deep tissues.

[0003] In recent years, the emergence of microneedle electrode technology has provided a new way to solve this problem. Microneedle array electrodes can penetrate the stratum corneum of the skin through tiny needle tips, reduce skin impedance, and achieve more precise and deeper electroporation. However, most of the microneedle electrodes on the market are designed for specific application scenarios, lack versatility and flexibility, and still need to be optimized in terms of electrode materials, structural design, and manufacturing processes.

[0004] The unevenness of the local wound surface and the irregular shape of the wound increase the difficulty of promoting wound repair with pulsed electric field technology. There is still no good solution to the problem of local precise electroporation of the wound. Summary of the invention

[0005] The object of the present invention is to provide a microneedle array interdigital electrode for skin electroporation, comprising: 2n microneedle sheets, 2n+1 insulating sheets, and microneedle sheet fixing buckles, wherein n is a positive integer.

[0006] The microneedle sheet comprises a main body structure, a plurality of microneedles and a connecting part.

[0007] The main body structure is an I-shaped structure.

[0008] A guide connection portion is arranged on one side of the top of the main body structure, and a plurality of micro needles are arranged on the bottom.

[0009] The insulating sheet is an I-shaped structure consistent with the main body structure of the microneedle sheet.

[0010] The microneedle sheet fixing buckle is a C-shaped clamp.

[0011] The inner width of the microneedle sheet fixing buckle is adapted to the width of the web of the I-shaped structure of the insulating sheet.

[0012] The 2n microneedle sheets are alternately stacked with 2n+1 insulating sheets, wherein the conducting parts of n microneedle sheets face one side of the bottom of the insulating sheet for connecting to the positive circuit, and the conducting parts of the other n microneedle sheets face the other side of the bottom of the insulating sheet for connecting to the negative circuit.

[0013] The n microneedle sheets connected to the positive circuit are arranged crosswise with the n microneedle sheets connected to the negative circuit.

[0014] The microneedle sheet fixing buckle is fixed on the web of the I-shaped structure of 2n microneedle sheets and 2n+1 insulating sheets, and is used to fix the microneedle sheets and the insulating sheets.

[0015] When the microneedle array interdigital electrodes are used for skin electroporation, the positive and negative poles are connected to the conducting part, and the microneedles apply a pulse electric field to the wound surface area.

[0016] Furthermore, the material used for the microneedle sheet includes stainless steel.

[0017] Furthermore, the spacing between the microneedles of the microneedle sheet is determined according to actual needs.

[0018] Furthermore, the material used for the insulating sheet includes polytetrafluoroethylene.

[0019] Furthermore, a through hole is provided on the conducting part of the microneedle sheet.

[0020] The through hole is connected to the circuit signal by winding the wire.

[0021] Furthermore, the microneedle array interdigital electrodes are used for skin electroporation.

[0022] The technical effect of the present invention is unquestionable. The present invention proposes a new type of microneedle array electrode design, which aims to achieve a more efficient and safer skin electroporation effect by optimizing the electrode structure, materials and manufacturing process. At the same time, the electrode design has good versatility and can adapt to different application scenarios and individual needs, providing a new solution for skin electroporation treatment.

[0023] The microneedle array interdigitated electrode proposed in the present invention has the advantages of higher penetration efficiency, more precise treatment accuracy, lower pain and complication rate, wider scope of application, better patient comfort and treatment convenience in the field of medical wound repair compared with other electrodes, which will have a positive impact on the technological development and clinical treatment in the field of wound repair.

[0024] The microneedle array interdigitated electrodes can penetrate the surface of the skin and directly contact the tissue under the skin, thereby greatly reducing the impedance of the skin. This allows the electroporation signal to be transmitted more effectively, improving the efficiency and effect of electroporation.

[0025] The microneedle array is fixed on the skin by slight puncture, which reduces the slippage of the electrode on the skin and ensures the accuracy and repeatability of the electroporation location.

[0026] The design of the microneedle array ensures that each microneedle can evenly distribute the current, providing stable and consistent electroporation. Traditional electrodes are prone to unstable signals when the contact is poor or the skin surface state changes, but the microneedle array can effectively avoid this problem.

[0027] Compared with traditional electrodes, microneedle array interdigitated electrodes can be more accurately positioned on the wound surface due to their tiny tips and dense arrangement; and the uniformity of the electric field strength of the pulsed electric field under the skin layer is increased; the interdigitated arrangement increases the effective contact area of ​​the electrode, while reducing the current density of each electrode, reducing the risk of burns.

[0028] Compared with traditional chemotherapy or radiotherapy, electroporation technology is safer. Since electroporation only physically perforates the cell membrane, it does not involve the side effects of chemotherapy or radioactive damage, so it causes less damage to the wound surface and a shorter recovery period. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a schematic diagram of the stainless steel microneedle sheet structure;

[0030] Figure 2 It is a schematic diagram of the structure of the insulating sheet;

[0031] Figure 3 This is a schematic diagram of the stainless steel microneedle sheet fixing buckle structure;

[0032] Figure 4 Schematic diagram of electrode distribution of microneedle array interdigitated electrodes;

[0033] Figure 5 This is a schematic diagram of the stainless steel microneedle sheet fixing buckle assembly;

[0034] Figure 6 This is a schematic diagram of the stainless steel microneedle sheet fixing buckle;

[0035] In the figure, there are a microneedle sheet 1, a main body structure 101, microneedles 102, a connecting portion 103, a through hole 104, an insulating sheet 2, and a microneedle sheet fixing buckle 3. DETAILED DESCRIPTION

[0036] The present invention is further described below in conjunction with the embodiments, but it should not be understood that the above subject matter of the present invention is limited to the following embodiments. Without departing from the above technical ideas of the present invention, various substitutions and changes are made according to the common technical knowledge and customary means in the art, which should all be included in the protection scope of the present invention.

[0037] Embodiment 1:

[0038] See also Figures 1 to 6 A microneedle array interdigital electrode for skin electroporation comprises: 2n microneedle sheets 1, 2n+1 insulating sheets 2, and microneedle sheet fixing buckles 3, wherein n is a positive integer.

[0039] The microneedle sheet 1 includes a main body structure 101 , a plurality of microneedles 102 , and a connecting portion 103 .

[0040] The main body structure 101 is an I-shaped structure.

[0041] A conductive portion 103 is disposed on one side of the top of the main body structure 101 , and a plurality of microneedles 102 are disposed on the bottom.

[0042] The insulating sheet 2 is an I-shaped structure consistent with the main body structure 101 of the microneedle sheet 1 .

[0043] The microneedle sheet fixing buckle 3 is a C-shaped clamp.

[0044] The inner width of the microneedle sheet fixing buckle 3 is adapted to the web width of the I-shaped structure of the insulating sheet 2 .

[0045] The 2n microneedle sheets 1 and 2n+1 insulating sheets 2 are alternately stacked, wherein the conducting parts 103 of n microneedle sheets 1 face one side of the bottom of the insulating sheet 2 for connecting to the positive circuit, and the conducting parts 103 of the other n microneedle sheets 1 face the other side of the bottom of the insulating sheet 2 for connecting to the negative circuit.

[0046] The n microneedle sheets 1 connected to the positive circuit are arranged crosswise with the n microneedle sheets 1 connected to the negative circuit.

[0047] The microneedle sheet fixing buckle 3 is fixed on the web of the I-shaped structure of 2n microneedle sheets 1 and 2n+1 insulating sheets 2 to fix the microneedle sheets 1 and the insulating sheets 2 .

[0048] When the microneedle array interdigitated electrode is used for skin electroporation, the positive and negative circuits are connected through the conducting part 103, and the microneedles 102 apply a pulse electric field to the wound surface area.

[0049] Embodiment 2:

[0050] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in Example 1. Furthermore, the material used for the microneedle sheet 1 includes stainless steel.

[0051] Embodiment 3:

[0052] A microneedle array interdigitated electrode for skin electroporation, the main technical content of which is shown in any one of Examples 1 to 2. Furthermore, the spacing between the plurality of microneedles 102 of the microneedle sheet 1 is determined according to actual needs.

[0053] Embodiment 4:

[0054] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in any one of Examples 1 to 3, and further, the material used for the insulating sheet 2 includes polytetrafluoroethylene.

[0055] Embodiment 5:

[0056] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in any one of Examples 1 to 4. Furthermore, a through hole 104 is provided on the conducting portion 103 of the microneedle sheet 1.

[0057] The through hole 104 is connected to the circuit signal by winding the wire.

[0058] Embodiment 6:

[0059] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in any one of Examples 1 to 5. Furthermore, the microneedle array interdigital electrode is used for skin electroporation.

[0060] Embodiment 7:

[0061] See also Figures 1 to 6 A microneedle array interdigital electrode for skin electroporation includes: 10 microneedle sheets 1, 11 insulating sheets 2, and a microneedle sheet fixing buckle 3.

[0062] The microneedle sheet 1 includes a main body structure 101 , a plurality of microneedles 102 , and a connecting portion 103 .

[0063] The main body structure 101 is an I-shaped structure.

[0064] A conductive portion 103 is disposed on one side of the top of the main body structure 101 , and a plurality of microneedles 102 are disposed on the bottom.

[0065] The insulating sheet 2 is an I-shaped structure consistent with the main body structure 101 of the microneedle sheet 1 .

[0066] The microneedle sheet fixing buckle 3 is a C-shaped clamp.

[0067] The inner width of the microneedle sheet fixing buckle 3 is adapted to the web width of the I-shaped structure of the insulating sheet 2 .

[0068] The 2n microneedle sheets 1 and the 2n+1 insulating sheets 2 are alternately stacked, so that the microneedle array electrode is composed of 10x10 microneedles, wherein the conducting parts 103 of 5 microneedle sheets 1 face one side of the bottom of the insulating sheet 2 for connecting to the positive circuit, and the conducting parts 103 of the other 5 microneedle sheets 1 face the other side of the bottom of the insulating sheet 2 for connecting to the negative circuit.

[0069] The five microneedle sheets 1 connected to the positive circuit are arranged crosswise with the five microneedle sheets 1 connected to the negative circuit, so that the positive and negative electrodes are arranged alternately.

[0070] The microneedle sheet fixing buckle 3 is fixed on the web of the I-shaped structure of the 10 microneedle sheets 1 and the 11 insulating sheets 2 to fix the microneedle sheets 1 and the insulating sheets 2 .

[0071] When the microneedle array interdigital electrode is used for skin electroporation, the positive and negative circuits are connected through the conducting part 103, and the microneedles 102 apply a pulse electric field to the wound surface area.

[0072] Embodiment 8:

[0073] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in Example 7. Furthermore, the material used for the microneedle sheet 1 includes stainless steel.

[0074] Embodiment 9:

[0075] A microneedle array interdigitated electrode for skin electroporation, the main technical content of which is shown in any one of Examples 7 to 8. Furthermore, the spacing between the plurality of microneedles 102 of the microneedle sheet 1 is determined according to actual needs.

[0076] Embodiment 10:

[0077] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in any one of Examples 7 to 9, and further, the material used for the insulating sheet 2 includes polytetrafluoroethylene.

[0078] Embodiment 11:

[0079] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in any one of Examples 7 to 10. Furthermore, a through hole 104 is provided on the conducting portion 103 of the microneedle sheet 1.

[0080] The through hole 104 is connected to the circuit signal by winding the wire.

[0081] Embodiment 12:

[0082] A microneedle array interdigital electrode for skin electroporation, the main technical content of which is shown in any one of Examples 7 to 11. Furthermore, the microneedle array interdigital electrode is used for skin electroporation.

[0083] Embodiment 13:

[0084] See also Figures 1 to 6 , a microneedle array interdigital electrode for skin electroporation, the main technical contents are as follows:

[0085] Figure 1This is a schematic diagram of a 316L stainless steel microneedle sheet. The thickness of the microneedle sheet is 1 mm. The microneedle spacing of each microneedle sheet is 1 mm. Each microneedle sheet has 10 microneedles, and the microneedle tip is 5 mm long. Microneedle sheets with different tip lengths and different microneedle spacings can be prepared according to different needs.

[0086] Figure 2 It is an insulating sheet made of polytetrafluoroethylene material, which is used to isolate each microneedle sheet. The thickness of the insulating sheet is 1mm and its size is consistent with that of the microneedle sheet.

[0087] Figure 3 Fix the stainless steel microneedle sheet with a buckle to fix the microneedle sheet to the insulating sheet.

[0088] Figure 4 This is the electrode distribution diagram of the microneedle interdigitated array electrode. The electrode sheets with microneedles are arranged crosswise so that the positive and negative electrodes are arranged alternately.

[0089] Figure 5 and Figure 6 It is a schematic diagram and finished product picture of the assembly of microneedle interdigitated array electrode. The 316L stainless steel microneedle sheet and the polytetrafluoroethylene insulating sheet are cross-arranged, and the microneedle sheets are arranged and combined at intervals on the left and right. 10 stainless steel microneedle sheets and 11 insulating sheets are cross-arranged and combined, so that the microneedle array electrode is composed of 10x10 microneedles, and the distance between each needle tip is 1mm.

Claims

1. A microneedle array interdigital electrode for skin electroporation, characterized in that: include: 2n microneedle sheets (1), 2n+1 insulating sheets (2), and a microneedle sheet fixing buckle (3), wherein n is a positive integer; The microneedle sheet (1) comprises a main body structure (101), a plurality of microneedles (102), and a connecting portion (103); The main body structure (101) is an I-shaped structure. A guide portion (103) is provided on one side of the top of the main body structure (101), and a plurality of microneedles (102) are provided on the bottom; The insulating sheet (2) is an I-shaped structure consistent with the main body structure (101) of the microneedle sheet (1); The microneedle sheet fixing buckle (3) is a C-shaped clamp. The inner width of the microneedle sheet fixing buckle (3) is adapted to the width of the web of the I-shaped structure of the insulating sheet (2); The 2n microneedle sheets (1) and the 2n+1 insulating sheets (2) are alternately stacked, wherein the conducting parts (103) of the n microneedle sheets (1) face one side of the bottom of the insulating sheet (2) for connecting to a positive circuit, and the conducting parts (103) of the other n microneedle sheets (1) face the other side of the bottom of the insulating sheet (2) for connecting to a negative circuit; The n microneedle sheets (1) connected to the positive circuit and the n microneedle sheets (1) connected to the negative circuit are arranged crosswise; The microneedle sheet fixing buckle (3) is fixed on the web of the I-shaped structure of 2n microneedle sheets (1) and 2n+1 insulating sheets (2), and is used to fix the microneedle sheet (1) and the insulating sheet (2); When the microneedle array interdigital electrode is used for skin electroporation, the positive and negative poles are connected to the circuit through the conducting part (103), and the microneedles (102) apply a pulse electric field to the wound surface area.

2. A microneedle array interdigital electrode for skin electroporation according to claim 1, characterized in that: The material used for the microneedle sheet (1) includes stainless steel.

3. A microneedle array interdigital electrode for skin electroporation according to claim 1, characterized in that: The spacing between the plurality of microneedles (102) of the microneedle sheet (1) is determined according to actual needs.

4. A microneedle array interdigital electrode for skin electroporation according to claim 1, characterized in that: The material used for the insulating sheet (2) includes polytetrafluoroethylene.

5. The microneedle array interdigital electrode for skin electroporation according to claim 1, characterized in that: A through hole (104) is provided on the connecting portion (103) of the microneedle sheet (1); The through hole (104) is connected to the circuit signal by winding the wire.

6. A microneedle array interdigital electrode for skin electroporation according to any one of claims 1 to 5, characterized in that: The microneedle array interdigital electrode is used for skin electroporation.

Images