Drug delivery device for radiotherapy and chemotherapy

Abstract

The invention provides a radiotherapy and chemotherapy drug delivery device, which comprises a main tube body, which is internally provided with a radiotherapy liquid channel and a chemotherapy liquid channel which are not communicated with each other; the radiotherapy assembly comprises a first liquid inlet assembly and a first storage bag, the first liquid inlet assembly is arranged at the first end of the main catheter body and communicated with the radiotherapy liquid channel, and the first storage bag is arranged at the second end of the main catheter body and communicated with the radiotherapy liquid channel; and the chemotherapy assembly comprises a second liquid inlet assembly, the second liquid inlet assembly is arranged at the first end of the main pipe body and communicates with the chemotherapy liquid channel, a first liquid outlet hole communicating with the chemotherapy liquid channel is formed in the second end of the main pipe body, and the first liquid outlet hole is exposed out of the outer side surface of the main pipe body and is staggered from the first storage bag. After the device is placed, accurate and effective radiotherapy and chemotherapy can be carried out at the tumor position, repeated operations are not needed, the risk that brain tissue of a patient is injured and infected is reduced, and the service life of the patient is prolonged.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a radiotherapy and chemotherapy drug delivery device. Background Art

[0002] In the relevant technologies, surgery, radiotherapy and chemotherapy are commonly used to treat tumors in a coordinated manner. Radiotherapy generally places the radioactive source into the human body cavity or tumor tissue for close-range irradiation treatment. The replacement and removal of the radioactive source often require craniotomy. When chemotherapy is performed by intravenous injection of chemotherapy drugs, most drugs cannot penetrate the blood-brain barrier. When the chemotherapy solution actually reaches the tumor site, the concentration has been greatly reduced, and the efficacy is poor. Increasing the dosage of the drug will cause serious systemic toxic side effects, resulting in the need for multiple radiotherapy and chemotherapy treatments, which poses a risk of damage to the patient's brain tissue and infection. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a radiotherapy and chemotherapy drug delivery device, aiming to solve the problem in the related art that radiotherapy and chemotherapy may cause damage to the patient's brain tissue and the risk of infection due to repeated treatment.

[0004] In order to solve the above technical problems, the present invention provides a radiotherapy and chemotherapy drug delivery device, comprising:

[0005] A main body, in which a radiotherapy fluid channel and a chemotherapy fluid channel which are not connected to each other are provided, and the main body is provided with a first end and a second end which are oppositely distributed along the length direction thereof;

[0006] A radiotherapy assembly, comprising a first liquid inlet assembly and a first storage bag, wherein the first liquid inlet assembly is arranged at the first end of the main body and communicates with the radiotherapy liquid channel, and the first storage bag is arranged at the second end of the main body and communicates with the radiotherapy liquid channel; and

[0007] The chemotherapy component includes a second liquid inlet component, which is arranged at the first end of the main body and connected to the chemotherapy liquid channel. The second end of the main body is provided with a first liquid outlet hole connected to the chemotherapy liquid channel, and the first liquid outlet hole is exposed on the outer surface of the main body and is staggered with the first storage bag.

[0008] Optionally, the lengths of the radiotherapy fluid channel and the chemotherapy fluid channel both extend along the axial direction of the main tube, and the radiotherapy fluid channel and the chemotherapy fluid channel are parallel to each other.

[0009] Optionally, a second liquid outlet is provided at the second end of the main body, and the second liquid outlet is respectively connected to the radiotherapy fluid channel and the first storage bag.

[0010] Optionally, the second liquid outlet hole is exposed on the outer surface of the main body, and the first storage bag covers the second liquid outlet hole.

[0011] Optionally, the first liquid inlet component comprises:

[0012] A first branch tube body is connected to a first end of the main tube body, the first branch tube body is provided with a first liquid inlet channel communicating with the radiotherapy liquid channel, the first liquid inlet channel includes a first liquid inlet port formed in the first branch tube body; and

[0013] The first cap is connected to one end of the first branch pipe body away from the main pipe body, and the first cap covers the first liquid inlet.

[0014] Optionally, the second end of the main pipe extends to the outside of the first storage bag, and the first liquid outlet is provided at the portion of the main pipe extending to the outside of the first storage bag.

[0015] Optionally, the second liquid inlet component comprises:

[0016] a second branch tube body connected to the first end of the main tube body, the second branch tube body being provided with a second liquid inlet channel communicating with the radiotherapy liquid channel, the second liquid inlet channel comprising a second liquid inlet port formed in the second branch tube body; and

[0017] The second cap is connected to one end of the second branch pipe body away from the main pipe body, and the second cap covers the second liquid inlet.

[0018] Optionally, the second liquid inlet component further includes a second storage bag, which is respectively connected to the first end of the main pipe body and the second branch pipe body, and the second storage bag is respectively connected to the chemotherapy fluid channel and the second liquid inlet channel.

[0019] Optionally, the second liquid inlet component comprises:

[0020] A second storage bag is connected to the first end of the main tube, and the second storage bag is communicated with the chemotherapy liquid channel;

[0021] A second branch tube body is connected to the second storage bag, the second branch tube body is provided with a second liquid inlet channel communicating with the second storage bag, the second liquid inlet channel includes a second liquid inlet port formed in the second branch tube body; and

[0022] The second cap is connected to one end of the second branch pipe body away from the main pipe body, and the second cap covers the second liquid inlet.

[0023] Optionally, the radiotherapy and chemotherapy drug delivery device further comprises an introducer needle, which can be inserted into the second liquid inlet channel and the radiotherapy liquid channel, and the introducer needle can extend out of the second end of the main tube.

[0024] Compared with the related art, the radiotherapy and chemotherapy drug delivery device in the present invention has the following beneficial effects: by setting up unconnected radiotherapy liquid channels and chemotherapy liquid channels in the main body, radiotherapy or chemotherapy can be performed alone, or radiotherapy and chemotherapy can be performed in coordination, so that after the device is placed, accurate and effective radiotherapy and chemotherapy can be performed at the tumor location, without the need for repeated surgeries, reducing the risk of brain tissue damage and infection in patients, and prolonging the life of patients. Moreover, the main body and the first storage capsule are small in size, so that the damage to the patient's brain tissue is small, and the first liquid inlet component and the second liquid inlet component are set outside the body, which is easy to operate, and the injection operation is not limited by time and space. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or related technologies, the drawings required for use in the embodiments or related technical descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without paying any creative work.

[0026] Figure 1 is a cross-sectional view of a radiotherapy and chemotherapy drug delivery device provided by an embodiment of the present invention;

[0027] Figure 2 yes Figure 1 Sectional view of detail A;

[0028] Figure 3 yes Figure 1 Sectional view of detail B;

[0029] Figure 4 is a cross-sectional view of a radiotherapy and chemotherapy drug delivery device provided by another embodiment of the present invention;

[0030] Figure 5 Schematic diagram of the structure of the guide needle in the embodiment of the present invention.

[0031] In the accompanying drawings, each reference numeral represents:

[0032] 1. Main body; 11. Radiotherapy fluid channel; 12. Chemotherapy fluid channel; 13. First liquid outlet; 14. Second liquid outlet; 2. Radiotherapy component; 21. First storage capsule; 22. First branch tube; 221. First liquid inlet channel; 2211. First liquid inlet port; 2212. First liquid outlet; 23. First cover cap; 3. Chemotherapy component; 31. Second storage capsule; 32. Second branch tube; 321. Second liquid inlet channel; 3211. Second liquid inlet port; 3212. Second liquid outlet; 322. Third liquid outlet; 33. Second cover cap; 4. Guide needle; 41. Grip. DETAILED DESCRIPTION

[0033] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but are not to be construed as limiting the present invention. All other embodiments obtained by ordinary technicians in the field without creative work based on the embodiments of the present invention are within the scope of protection of the present invention.

[0034] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "circumferential", "radial" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0035] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0036] Example:

[0037] See also Figures 1 to 5The embodiment of the present invention provides a radiotherapy and chemotherapy drug delivery device, including a main body 1, a radiotherapy component 2 and a chemotherapy component 3. The main body 1 is provided with a radiotherapy fluid channel 11 and a chemotherapy fluid channel 12 which are not connected to each other. The main body 1 is provided with a first end and a second end which are relatively distributed along its length direction, wherein the first end is the proximal end of the main body 1, and the second end is the distal end of the main body 1, and after the device is placed, the first end is located outside the body, and the second end is located at the tumor resection position inside the body; the radiotherapy component 2 includes a first liquid inlet component and a first storage capsule 21, the first liquid inlet component is arranged at the first end of the main body 1 and is connected to the radiotherapy fluid channel 11, the first storage capsule 21 is arranged at the second end of the main body 1 and is connected to the radiotherapy fluid channel 11, and the radiotherapy fluid first passes through the first liquid inlet component The radiotherapy fluid is injected into the radiotherapy fluid channel 11 and then flows into the first storage capsule 21 to be stored. The radiotherapy fluid performs close-range irradiation treatment on the tumor tissue. The chemotherapy component 3 includes a second liquid inlet component, which is arranged at the first end of the main body 1 and is connected to the chemotherapy fluid channel 12. The second end of the main body 1 is provided with a first liquid outlet 13 connected to the chemotherapy fluid channel 12. The first liquid outlet 13 is exposed on the outer surface of the main body 1 and is staggered with the first storage capsule 21. The chemotherapy fluid is injected into the chemotherapy fluid channel 12 through the second liquid inlet component and then flows into the tumor tissue through the first liquid outlet 13 for chemical drug treatment.

[0038] By setting up the radiotherapy liquid channel 11 and the chemotherapy liquid channel 12 which are not connected to each other in the main body 1, radiotherapy or chemotherapy can be performed alone, or radiotherapy and chemotherapy can be performed in coordination, so that after the device is placed, accurate and effective radiotherapy and chemotherapy can be performed at the tumor location, without the need for repeated operations, reducing the risk of brain tissue damage and infection in patients, and prolonging the life of patients. Moreover, the main body 1 and the first storage capsule 21 are small in size, so as to cause little damage to the patient's brain tissue, and the first liquid inlet component and the second liquid inlet component are arranged outside the body, which is convenient to operate, and the injection operation is not limited by time and space.

[0039] It should be noted that, since the first liquid outlet 13 is exposed on the outer surface of the main body 1 and is staggered with the first storage capsule 21, the chemotherapy liquid can be prevented from flowing into the first storage capsule 21 through the first liquid outlet 13, thereby ensuring that the chemotherapy liquid can flow into the tumor tissue through the first liquid outlet 13.

[0040] See also Figure 1 , Figure 3 and Figure 4The lengths of the radiotherapy liquid channel 11 and the chemotherapy liquid channel 12 are both extended along the axial direction of the main body 1, and the radiotherapy liquid channel 11 and the chemotherapy liquid channel 12 are parallel to each other, which can ensure that the radiotherapy liquid channel 11 and the chemotherapy liquid channel 12 are not connected to each other. According to actual needs, the radiotherapy liquid channel 11 and the chemotherapy liquid channel 12 are arranged adjacent to each other, which is conducive to reducing the volume of the main body 1.

[0041] See also Figure 1 , Figure 3 and Figure 4 The second end of the main body 1 is provided with a second liquid outlet 14, which is connected to the radiotherapy liquid channel 11 and the first storage capsule 21 respectively. The radiotherapy liquid in the radiotherapy liquid channel 11 can flow into the first storage capsule 21 through the second liquid outlet 14, so as to perform close-range irradiation treatment on the tumor tissue in the first storage capsule 21. The second liquid outlet 14 is exposed on the outer surface of the main body 1, and the first storage capsule 21 covers the second liquid outlet 14. A plurality of second liquid outlets 14 can be provided, and the plurality of second liquid outlets 14 are evenly distributed on the outer surface of the main body 1.

[0042] See also Figure 1 , Figure 2 and Figure 4 The first liquid inlet assembly includes a first branch tube body 22 and a first cap 23. The first branch tube body 22 is connected to the first end of the main tube body 1, and the first branch tube body 22 is provided with a first liquid inlet channel 221 connected with the radiotherapy liquid channel 11, and the first liquid inlet channel 221 includes a first liquid inlet port 2211 formed in the first branch tube body 22, and the radiotherapy liquid is injected into the first liquid inlet channel 221 through the first liquid inlet port 2211; the first cap 23 is connected to the end of the first branch tube body 22 away from the main tube body 1, and the first cap 23 covers the first liquid inlet port 2211 to achieve sealing protection for the first liquid inlet channel 221. Among them, the first branch tube body 22 is arranged at the fork position of the main body 1, and the first cap 23 and the first branch tube body 22 are flexibly connected, so that the first cap 23 can cover the first liquid inlet 2211 or detach from the first liquid inlet 2211; the first liquid inlet channel 221 also includes a first liquid outlet 2212 formed with the first branch tube body 22, and the first liquid outlet 2212 and the first liquid inlet 2211 are respectively located at the two ends of the first branch tube body 22, and the first liquid outlet 2212 is connected to the radiotherapy fluid channel 11.

[0043] During radiotherapy, the first cap 23 is opened and radiotherapy liquid is injected into the first liquid inlet channel 221 through the first liquid inlet 2211. The radiotherapy liquid in the first liquid inlet channel 221 flows into the radiotherapy liquid channel 11 through the first liquid outlet 2212, and then flows into the first storage capsule 21 through the second liquid outlet 14. The radiotherapy liquid is stored in the first storage capsule 21 and performs close-range irradiation therapy on the tumor tissue. It should be understood that the first cap 23, the first liquid inlet 2211, the first liquid inlet channel 221, the first liquid outlet 2212, the radiotherapy liquid channel 11, the second liquid outlet 14 and the first storage capsule 21 form a completely closed channel, thereby avoiding adverse effects caused by leakage of radiotherapy liquid.

[0044] See also Figure 1 , Figure 3 and Figure 4 The second end of the main body 1 extends outward from the first storage capsule 21, and the first liquid outlet 13 is provided at the portion of the main body 1 extending outward from the first storage capsule 21, so as to prevent the chemotherapy liquid from flowing into the first storage capsule 21 through the first liquid outlet 13, and ensure that the chemotherapy liquid can flow into the tumor tissue through the first liquid outlet 13. According to actual needs, the length of the radiotherapy liquid channel 11 at the second end of the main body 1 is longer than the length of the chemotherapy liquid channel 12 at the second end of the main body 1.

[0045] See also Figure 1 and Figure 3 In some embodiments, the second liquid inlet assembly includes a second branch tube body 32 and a second cap 33. The second branch tube body 32 is connected to the first end of the main tube body 1, and the second branch tube body 32 is provided with a second liquid inlet channel 321 connected to the radiotherapy liquid channel 11. The second liquid inlet channel 321 includes a second liquid inlet port 3211 formed in the second branch tube body 32, and the chemotherapy liquid is injected into the second liquid inlet channel 321 through the second liquid inlet port 3211; the second cap 33 is connected to the end of the second branch tube body 32 away from the main tube body 1, and the second cap 33 covers the second liquid inlet port 3211 to achieve sealing protection for the second liquid inlet channel 321. Among them, the first branch tube body 22 can be integrally arranged with the main tube body 1 to simplify the structure of the device; the length of the radiotherapy fluid channel 11 at the first end of the main tube body 1 is shorter than the length of the chemotherapy fluid channel 12 at the first end of the main tube body 1, and the second cap 33 is flexibly connected to the second branch tube body 32, which facilitates the second cap 33 to cover the second liquid inlet 3211 or detach from the second liquid inlet 3211.

[0046] See also Figure 1 and Figure 2The second liquid inlet assembly also includes a second storage capsule 31, which is connected to the first end of the main body 1 and the second branch pipe body 32, and the second storage capsule 31 is connected to the chemotherapy liquid channel 12 and the second liquid inlet channel 321, respectively. The second storage capsule 31 can temporarily store the chemotherapy liquid, and the chemotherapy liquid can flow out slowly from the first liquid outlet hole 13. Among them, the outer side of the second branch pipe body 32 is provided with a third liquid outlet hole 322, and the third liquid outlet hole 322 can be provided with a plurality of third liquid outlet holes 322, which are connected to the second liquid inlet channel 321 and the second storage capsule 31, respectively, so that the chemotherapy liquid flows into the second storage capsule 31 through the third liquid outlet hole 322 in the second liquid inlet channel 321.

[0047] It should be understood that the second storage capsule 31 is connected to the first end of the main pipe body 1 and the second branch pipe body 32 respectively, and the first branch pipe body 22 and the main pipe body 1 are integrally arranged, which can improve the connection firmness of the second storage capsule 31 .

[0048] During the chemical treatment, the second cap 33 is opened and the chemotherapy liquid is injected into the second liquid inlet channel 321 through the second liquid inlet 3211. The radiotherapy liquid flows into the second storage capsule 31 through the third liquid outlet 322 in the second liquid inlet channel 321 and is temporarily stored in the second storage capsule 31. The chemotherapy liquid in the second storage capsule 31 will flow into the chemotherapy liquid channel 12, and then flow into the tumor tissue through the first liquid outlet 13, so as to perform chemical drug treatment on the tumor tissue. It should be understood that the second cap 33, the second liquid inlet 3211, the second liquid inlet channel 321, the third liquid outlet 322, the second storage capsule 31, the chemotherapy liquid channel 12 and the first liquid outlet 13 form a semi-enclosed channel to ensure that the chemotherapy liquid can flow into the tumor tissue.

[0049] See also Figure 4In other embodiments, the second liquid inlet assembly includes a second storage capsule 31, a second branch tube body 32, and a second cap 33. The second storage capsule 31 is connected to the first end of the main tube body 1, and the second storage capsule 31 is communicated with the chemotherapy liquid channel 12; the second branch tube body 32 is connected to the second storage capsule 31, and the second branch tube body 32 is provided with a second liquid inlet channel 321 communicated with the second storage capsule 31, and the second liquid inlet channel 321 includes a second liquid inlet port 3211 formed in the second branch tube body 32; wherein the second branch tube body 32 and the main tube body 1 are separated, and the second liquid inlet channel 321 also includes a second liquid inlet port 3211 formed with the second branch tube body 32; Two liquid outlets 3212, the second liquid outlet 3212 and the second liquid inlet 3211 are respectively located at the two ends of the second branch tube body 32, and the second liquid outlet 3212 is connected to the second storage bag 31, so there is no need to set a liquid outlet hole on the second branch tube body 32 to connect with the second storage bag 31, so that the chemotherapy liquid flows from the second liquid inlet channel 321 into the second storage bag 31; the second cap 33 is connected to the end of the second branch tube body 32 away from the main body 1, and the second cap 33 covers the second liquid inlet 3211.

[0050] See also Figure 5 The radiotherapy and chemotherapy drug delivery device further includes a guide needle 4, which can be inserted into the second liquid inlet channel 321 and the radiotherapy liquid channel 11, and can extend out of the second end of the main body 1. The main body 1 can be accurately placed at the tumor position through the guidance and support of the guide needle 4, and the guide needle 4 can be pulled out before treatment. Among them, one end of the guide needle 4 is provided with a gripping portion 41 for easy insertion and removal.

[0051] In some embodiments, the main body 1, the first branch tube 22, the second branch tube 32, the first storage bag 21 and the second storage bag 31 can be made of elastic materials such as silicone, and the first cap 23 and the second cap 33 can be made of elastic materials such as plastic and silicone.

[0052] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A radiotherapy and chemotherapy drug delivery device, characterized in that: include: A main body, in which a radiotherapy fluid channel and a chemotherapy fluid channel which are not connected to each other are provided, and the main body is provided with a first end and a second end which are oppositely distributed along the length direction thereof; A radiotherapy assembly, comprising a first liquid inlet assembly and a first storage bag, wherein the first liquid inlet assembly is arranged at the first end of the main body and communicates with the radiotherapy liquid channel, and the first storage bag is arranged at the second end of the main body and communicates with the radiotherapy liquid channel; and The chemotherapy component includes a second liquid inlet component, which is arranged at the first end of the main body and connected to the chemotherapy liquid channel. The second end of the main body is provided with a first liquid outlet hole connected to the chemotherapy liquid channel, and the first liquid outlet hole is exposed on the outer surface of the main body and is staggered with the first storage bag.

2. The radiotherapy and chemotherapy drug delivery device according to claim 1, characterized in that: The lengths of the radiotherapy fluid channel and the chemotherapy fluid channel both extend along the axial direction of the main tube, and the radiotherapy fluid channel and the chemotherapy fluid channel are parallel to each other.

3. The radiotherapy and chemotherapy drug delivery device according to claim 1, characterized in that: The second end of the main pipe is provided with a second liquid outlet, and the second liquid outlet is connected to the radiotherapy liquid channel and the first storage bag respectively.

4. The radiotherapy and chemotherapy drug delivery device according to claim 3, characterized in that: The second liquid outlet is exposed on the outer surface of the main body, and the first storage bag covers the second liquid outlet.

5. The radiotherapy and chemotherapy drug delivery device according to claim 1, characterized in that: The first liquid inlet component comprises: A first branch tube body is connected to a first end of the main tube body, the first branch tube body is provided with a first liquid inlet channel communicating with the radiotherapy liquid channel, the first liquid inlet channel includes a first liquid inlet port formed in the first branch tube body; and The first cap is connected to one end of the first branch pipe body away from the main pipe body, and the first cap covers the first liquid inlet.

6. The radiotherapy and chemotherapy drug delivery device according to claim 1, characterized in that: The second end of the main pipe extends out of the first storage bag, and the first liquid outlet is arranged at the portion of the main pipe extending out of the first storage bag.

7. The radiotherapy and chemotherapy drug delivery device according to claim 1, characterized in that: The second liquid inlet component comprises: a second branch tube body connected to the first end of the main tube body, the second branch tube body being provided with a second liquid inlet channel communicating with the radiotherapy liquid channel, the second liquid inlet channel comprising a second liquid inlet port formed in the second branch tube body; and The second cap is connected to one end of the second branch pipe body away from the main pipe body, and the second cap covers the second liquid inlet.

8. The radiotherapy and chemotherapy drug delivery device according to claim 7, characterized in that: The second liquid inlet component also includes a second storage bag, which is respectively connected to the first end of the main pipe body and the second branch pipe body, and the second storage bag is respectively connected to the chemotherapy fluid channel and the second liquid inlet channel.

9. The radiotherapy and chemotherapy drug delivery device according to claim 1, characterized in that: The second liquid inlet component comprises: A second storage bag is connected to the first end of the main tube, and the second storage bag is communicated with the chemotherapy liquid channel; A second branch tube body is connected to the second storage bag, the second branch tube body is provided with a second liquid inlet channel communicating with the second storage bag, the second liquid inlet channel includes a second liquid inlet port formed in the second branch tube body; and The second cap is connected to one end of the second branch pipe body away from the main pipe body, and the second cap covers the second liquid inlet.

10. The radiotherapy and chemotherapy drug delivery device according to claim 7 or 9, characterized in that: The radiotherapy and chemotherapy drug delivery device further comprises an introducer needle, which can be inserted into the second liquid inlet channel and the radiotherapy liquid channel, and can extend out of the second end of the main tube.

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