Anti-allergy soothing composition aiming at sensitive skin and preparation method of anti-allergy soothing composition

Abstract

The invention discloses an anti-allergy soothing composition for sensitive skin and a preparation method of the anti-allergy soothing composition. The anti-allergy soothing composition is prepared from the following components: a PIPER METHYSTICUM leaf / root / stem extract and a FORSYTHIA SUSPENSA fruit extract, wherein the PIPER METHYSTICUM leaf / root / stem extract and the FORSYTHIA SUSPENSA fruit extract are used as raw materials. Raw materials such as kava pepper and fructus forsythiae are preferably selected, lactobacillus is adopted for fermentation, and then purification and refinement are performed. The compound can be used as an active ingredient in a cosmetic formula. Tests prove that the anti-allergy soothing composition has a good sensitive skin care and repair effect.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to an anti-allergic and soothing composition for sensitive skin and a preparation method thereof. Background Art

[0002] Sensitive skin is common in dermatology, and researchers have conducted relevant epidemiological studies in the past few decades. A community-based survey conducted in Beijing and other cities showed that the overall incidence of the survey sample was 13%, with an average incidence of 8.62% for men and 15.93% for women. In another survey involving 408 Chinese women, 2% of the subjects considered their skin "very sensitive", 5% "moderately sensitive", and 16% "mildly sensitive".

[0003] The causes of sensitive skin are very complex. The current mainstream view is that the mechanism is: the patient's skin barrier function is damaged, causing an increase in sensory nerve afferent signals, resulting in increased skin reactivity to external stimuli, triggering skin immune inflammation, and leading to the occurrence of sensitive skin. Changes in the skin barrier include thinning of the stratum corneum and reduced hydration, reduced ceramides, increased neutral lipids, reduced sphingolipids, and increased sweat glands.

[0004] The stability of the skin barrier plays an important role in the onset of sensitive skin, and facial nerve dysfunction is also an important factor in its onset. However, there is still no specific medical treatment for sensitive skin, which is easy to diagnose but difficult to treat, and has a high recurrence rate. Skin care products not only consider maintaining the normal physiological functions of the skin, but also add anti-allergic and soothing ingredients to achieve the dual effects of treatment and beauty, and have a certain auxiliary treatment effect on skin diseases. Therefore, scientific daily skin care has been recognized as an important way to treat sensitive skin. Summary of the invention

[0005] In view of this, the object of the present invention is to provide an anti-allergic soothing composition for sensitive skin that is different from the prior art.

[0006] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0007] An anti-allergic soothing composition, characterized in that it comprises the following components: PipermethystICUM leaf / root / stem extract and Forsythia suspensa fruit extract.

[0008] In some embodiments, the anti-allergic soothing composition further comprises the following component: Gentiana scabra root extract.

[0009] The present invention discloses a preparation process of the anti-allergic soothing composition, and the specific steps are as follows:

[0010] (1) drying the following raw materials in parts by weight: 1-10 parts of Kava roots, 1-10 parts of Kava leaves, 1-10 parts of Kava stems, and 1-10 parts of Forsythia suspensa fruits in shade; crushing, then adding 20-200 parts by weight of water and 1-10 parts by weight of glucose, mixing evenly, adjusting the pH to 4-5, and sterilizing at high temperature to obtain a sterilized material;

[0011] (2) inoculating lactobacillus into a liquid culture medium for expansion culture to obtain lactobacillus seed liquid; inoculating the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 1-5% of the weight of the sterilized material; mixing evenly; evacuating; and fermenting at 30-35° C. for 1-3 days to obtain a fermentation liquid;

[0012] (3) Centrifuging the fermented liquid and taking the supernatant to obtain the anti-allergic soothing composition.

[0013] In some embodiments, the weight parts of the raw materials described in step (1) are: 5 parts of Piper mesona root, 2 parts of Piper mesona leaf, 3 parts of Piper mesona stem, and 8 parts of Forsythia suspensa fruit.

[0014] In some embodiments, the amount of glucose added in step (1) is 8 parts.

[0015] In some embodiments, the high temperature sterilization in step (1) is maintained at 121° C. for 30 minutes.

[0016] In one embodiment, 2 parts by weight of gentian root can also be added in step (1).

[0017] In some embodiments, the liquid culture medium in step (2) is MRS broth culture medium; the content of lactobacillus in the seed liquid is 1×10 6 -1×10 8 CFU / mL.

[0018] In some embodiments, the vacuuming step in step (2) is: first vacuuming, then filling with nitrogen to 0.05 MPa, and repeatedly filling and exhausting three times.

[0019] The anti-allergic soothing composition prepared in the embodiment of the present invention can be used as an active ingredient in cosmetic formulas. The cosmetics can be skin care and hair care products such as creams, lotions, facial masks, essences, lotions, facial cleansers, conditioners, shampoos, etc.

[0020] The embodiment of the present invention also discloses a water-in-oil quick repair cream, which contains the following components in percentage by weight: 3% of polyglycerol-6 pentaoleate, 0.5% of polyglycerol-3 diisostearate, 9% of mineral oil, 4% of isononyl isononanoate, 5% of polydimethylsiloxane, 0.2% of bisabolol, 2% of polymethyl methacrylate, 1% of magnesium stearate, 5% of zinc oxide, 1% of calamine, 20% of 1,3-propylene glycol, 2% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 1% of dipotassium glycyrrhizinate, 0.25% of arginine, 5% of the above-mentioned anti-allergic soothing composition, and the balance of water.

[0021] The technical solution provided by the embodiment of the present invention has the following beneficial effects:

[0022] (1) The present invention provides an anti-allergic soothing composition, which is preferably made of raw materials such as Kava Piper nigrum and Forsythia suspensa, fermented with lactobacillus, and then purified and refined. In particular, the skin care effects of various parts of Kava Piper nigrum were explored, and it was found that a better effect can be achieved after combining them in a certain proportion. The anti-allergic soothing composition can be used as an active ingredient in a cosmetic formula. Tests have shown that the anti-allergic soothing composition achieves good effects.

[0023] (2) The water-in-oil quick repair cream provided by the present invention is prepared by compounding polyglycerol-6 pentaoleate and polyglycerol-3 diisostearate, and only a small amount of polyglycerol-3 diisostearate needs to be added to prepare a water-in-oil cream containing a polyglycerol emulsifier including polyglycerol-3 diisostearate. The cream has good stability and can solve the limitations of the application of a single emulsifier, especially reduce the greasy feeling of the water-in-oil cream and the rapid spreading on the skin. The amount of polyglycerol-3 diisostearate added is reduced, which can effectively reduce the formulation cost. The polyglycerol emulsifier is natural, green, and non-irritating to the skin. The compounding of bisabolol, zinc oxide, calamine, dipotassium glycyrrhizinate, and anti-allergic soothing composition has a rapid repair, calming, and redness-removing effect on sensitive skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for describing the embodiments or the prior art are briefly introduced below.

[0025] Figure 1 The ear swelling rate of mice in each test group is shown. DETAILED DESCRIPTION

[0026] The present invention discloses an anti-allergic soothing composition. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to achieve it. It is particularly important to point out that all similar substitutions and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications described herein without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0027] The raw materials and reagents used in the anti-allergic and soothing composition provided by the present invention can be purchased from the market.

[0028] The present invention relates to the whole plant of Pipermethysticum Forst, a perennial upright shrub medicinal plant of the Piperaceae family, including leaves / roots / stems. The main active ingredients of Pipermethysticum Forst are kavalactone, anaesthetic piperine, capsaicin, etc., which can bidirectionally regulate neurotransmitters, have multiple effects such as anti-anxiety and depression, sedation and hypnosis, local anesthesia, anticonvulsant, and no drug dependence is observed.

[0029] The forsythia suspensa of the present invention is the mature fruit of the shrub Forsythia suspensa (Thunb.) Vahl of the Oleaceae family. According to the Compendium of Materia Medica, Forsythia suspensa has the effects of clearing away heat and detoxifying, reducing swelling and dispersing knots. It is one of the traditional Chinese medicines commonly used in clinical practice in China and is often used to treat acute wind-heat cold, lymph node tuberculosis and the like.

[0030] The gentian involved in the present invention is the root of a perennial herbaceous plant of the genus Gentianaceae. Gentiana is bitter in taste and cold in nature; it enters the liver and gallbladder meridians; it has the effects of clearing away heat and dampness, and purging liver and gallbladder fire. Gentiana also has antifungal, antibacterial, antimalarial, anti-inflammatory, liver-protecting, sedative and other effects.

[0031] The present invention will be further described below in conjunction with embodiments:

[0032] Example 1

[0033] An anti-allergic soothing composition is obtained by the following preparation process:

[0034] (1) Dry the following raw materials in parts by weight in the shade: 1 part of Kava root, 10 parts of Kava leaf, 1 part of Kava stem, and 10 parts of Forsythia suspensa fruit; crush them, then add 20 parts by weight of water and 10 parts by weight of glucose, mix them evenly, adjust the pH to 4, keep them at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0035] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×108 CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 1% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.05MPa; ferment at 30°C for 3 days to obtain a fermentation liquid;

[0036] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0037] Example 2

[0038] An anti-allergic soothing composition is obtained by the following preparation process:

[0039] (1) Dry the following raw materials in parts by weight: 10 parts of Kava root, 1 part of Kava leaf, 10 parts of Kava stem, and 1 part of Forsythia suspensa fruit in the shade; crush them, then add 200 parts by weight of water and 1 part by weight of glucose, mix them evenly, adjust the pH to 5, keep them at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0040] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 6 CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 5% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.01MPa; ferment at 35°C for 1 day to obtain a fermentation liquid;

[0041] (3) Centrifuging the fermented liquid at 3000 rpm for 30 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0042] Example 3

[0043] An anti-allergic soothing composition is obtained by the following preparation process:

[0044] (1) Dry the following raw materials in parts by weight in the shade: 5 parts of Kava root, 2 parts of Kava leaf, 3 parts of Kava stem, and 8 parts of Forsythia suspensa fruit; crush them, then add 100 parts by weight of water and 8 parts by weight of glucose, mix them evenly, adjust the pH to 4.5, keep at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0045] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 7CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 3% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.03MPa; ferment at 32°C for 2 days to obtain a fermentation liquid;

[0046] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0047] Example 4

[0048] An anti-allergic soothing composition is obtained by the following preparation process:

[0049] (1) Dry the following raw materials in parts by weight in the shade: 5 parts of Kava root, 2 parts of Kava leaf, 3 parts of Kava stem, 8 parts of Forsythia fruit, and 2 parts of Gentiana root; crush them, then add 100 parts by weight of water and 8 parts by weight of glucose, mix them evenly, adjust the pH to 4.5, keep them at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0050] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 7 CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 3% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.03MPa; ferment at 32°C for 2 days to obtain a fermentation liquid;

[0051] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0052] Comparative Example 1

[0053] An anti-allergic soothing composition is obtained by the following preparation process:

[0054] (1) Dry the following raw materials in parts by weight in the shade: 8 parts of Kava root; crush, then add 100 parts by weight of water and 8 parts by weight of glucose, mix well, adjust the pH to 4.5, maintain at 121° C. for 30 minutes, and sterilize at high temperature to obtain a sterilized material;

[0055] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 7CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 3% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.03MPa; ferment at 32°C for 2 days to obtain a fermentation liquid;

[0056] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0057] Comparative Example 2

[0058] An anti-allergic soothing composition is obtained by the following preparation process:

[0059] (1) Dry the following raw materials in parts by weight in the shade: 8 parts of Piper methysticum leaves; crush them, then add 100 parts by weight of water and 8 parts by weight of glucose, mix them evenly, adjust the pH to 4.5, keep them at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0060] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 7 CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 3% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.03MPa; ferment at 32°C for 2 days to obtain a fermentation liquid;

[0061] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0062] Comparative Example 3

[0063] An anti-allergic soothing composition is obtained by the following preparation process:

[0064] (1) Dry the following raw materials in parts by weight in the shade: 8 parts of Kava stems; crush them, then add 100 parts by weight of water and 8 parts by weight of glucose, mix them evenly, adjust the pH to 4.5, keep them at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0065] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 7 CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 3% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.03MPa; ferment at 32°C for 2 days to obtain a fermentation liquid;

[0066] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0067] Comparative Example 4

[0068] An anti-allergic soothing composition is obtained by the following preparation process:

[0069] (1) Dry the following raw materials in parts by weight in the shade: 8 parts of Forsythia suspensa fruit; crush them, then add 100 parts by weight of water and 8 parts by weight of glucose, mix them evenly, adjust the pH to 4.5, keep them at 121° C. for 30 minutes, and sterilize them at high temperature to obtain a sterilized material;

[0070] (2) inoculating lactobacillus into a liquid culture medium for expansion culture, wherein the liquid culture medium is an MRS broth culture medium; obtaining a lactobacillus seed solution, wherein the content of lactobacillus in the seed solution is 1×10 7 CFU / mL; inoculate the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 3% of the weight of the sterilized material; mix evenly; evacuate and fill with nitrogen to maintain the vacuum degree at -0.03MPa; ferment at 32°C for 2 days to obtain a fermentation liquid;

[0071] (3) Centrifuging the fermented liquid at 3000 rpm for 10 min, taking the supernatant to obtain the anti-allergic soothing composition.

[0072] Experiment 1 Mouse ear swelling anti-inflammatory test

[0073] With reference to the mouse ear swelling anti-inflammatory test method described in "T / CNMIA 0013-2020 Safety / Efficacy Evaluation Standards for Soothing Functional Skin Care Products", the anti-allergic soothing efficacy of the anti-allergic soothing compositions prepared in Examples 1-4 and Comparative Examples 1-4 was evaluated.

[0074] Through the mouse ear swelling anti-inflammatory test, the degree to which soothing functional skin care products and their active ingredients can reduce mouse ear swelling caused by inflammatory agents is detected, and this is used as one of the preclinical test bases for evaluating anti-inflammatory efficacy.

[0075] Test steps: male mice were selected, with a body weight of about 22 g, and 10 animals in each group; a) the inflammatory agent was xylene or croton oil mixed inflammatory solution, the concentration of xylene for mice was 100%, and the croton oil mixed inflammatory solution contained: 1% croton oil, 10% ethanol, 20% pyridine, and 69% ether; b) the experimental drug was dissolved in the inflammatory agent, and the drug concentration for mice was 0.05 mg / ml; c) the animals were anesthetized with ether, and the drug was applied to the front and back of the left and right ears. 20 minutes after the administration, the inflammatory agent was applied to the front and back of the right ear. The volume of the inflammatory agent was: 0.01 mg / mouse for xylene inflammatory agent and 0.01 ml / mouse for croton oil inflammatory agent. The left ear was treated with the corresponding solvent as a control. The animals were killed 30 minutes after the administration of the inflammatory agent, and both ears were immediately cut off and weighed; d) 4 hours later, the animals were anesthetized and killed, both ears were cut off, and round ear pieces were punched in the same position with an 8mm (mouse) diameter puncher and weighed; e) The weight of the right ear piece of each mouse minus the weight of the left ear piece is the swelling degree, swelling rate / % = (right ear mass - left ear mass) / left ear mass*100%.

[0076] By the attached Figure 1 It can be seen from the ear swelling rates of mice in each test group that the anti-allergic soothing composition prepared in Examples 1-4 is significantly better than that in Comparative Examples 1-4 in reducing the degree of ear swelling of mice caused by inflammatory agents.

[0077] Example 5

[0078] A water-in-oil quick repair cream contains the following components in percentage by weight: 3% of polyglycerol-6 pentaoleate, 0.5% of polyglycerol-3 diisostearate, 9% of mineral oil, 4% of isononyl isononanoate, 5% of polydimethylsiloxane, 0.2% of bisabolol, 2% of polymethyl methacrylate, 1% of magnesium stearate, 5% of zinc oxide, 1% of calamine, 20% of 1,3-propylene glycol, 2% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 1% of dipotassium glycyrrhizate, 0.25% of arginine, 5% of the anti-allergic soothing composition prepared in Example 4, and the balance of water.

[0079] Comparative Example 5

[0080] A water-in-oil quick repair cream contains the following components in percentage by weight: 3.5% of polyglycerol-6 pentaoleate, 9% of mineral oil, 4% of isononyl isononanoate, 5% of polydimethylsiloxane, 0.2% of bisabolol, 2% of polymethyl methacrylate, 1% of magnesium stearate, 5% of zinc oxide, 1% of calamine, 20% of 1,3-propylene glycol, 2% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 1% of dipotassium glycyrrhizate, 0.25% of arginine, 5% of the anti-allergic soothing composition prepared in Example 4, and the balance of water.

[0081] Comparative Example 6

[0082] A water-in-oil quick repair cream contains the following components in percentage by weight: 3.5% of polyglyceryl-3 diisostearate, 9% of mineral oil, 4% of isononyl isononanoate, 5% of polydimethylsiloxane, 0.2% of bisabolol, 2% of polymethyl methacrylate, 1% of magnesium stearate, 5% of zinc oxide, 1% of calamine, 20% of 1,3-propylene glycol, 2% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 1% of dipotassium glycyrrhizate, 0.25% of arginine, 5% of the anti-allergic soothing composition prepared in Example 4, and the balance of water.

[0083] Test 2: Formula stability and skin feel test

[0084] 1. Formula stability test

[0085] The stability test of the water-in-oil quick repair cream prepared in Example 5 and Comparative Examples 5-6 was carried out based on the method described in "QB / T 1857 Moisturizing Cream".

[0086] The specific evaluation indicators are as follows: Heat resistance: the sample is kept at (40±1)℃ for 1 month, and there is no oil-water separation in the paste after returning to room temperature; cold resistance: the sample is kept at -5℃~-10℃ for 1 month, and there is no obvious difference in properties after returning to room temperature.

[0087] Table 1. Stability test results

[0088] Heat resistant Cold resistant Example 5 pass pass Comparative Example 5 pass Demulsification, failed Comparative Example 6 pass Demulsification, failed

[0089] As can be seen from Table 1, Example 5 in which polyglycerol-6 pentaoleate and polyglycerol-3 diisostearate are compounded exhibits good heat and cold resistance, while Comparative Examples 5-6 have poor cold resistance.

[0090] 2. Sensory test

[0091] 90 people were randomly selected and divided into 3 groups. The water-in-oil quick repair cream of Example 5 and Comparative Examples 5-6 was tested for a single trial. The volunteers filled out a questionnaire on site after trying the product. The evaluation dimensions were divided into refreshing and moisturizing, smooth spreading and fast absorption speed. The volunteers gave a subjective score of 1-5 for each dimension, where 1 was the worst, 3 was acceptable, and 5 was satisfactory.

[0092] Table 2 Skin feel performance test results

[0093] Refreshing and hydrating Spreads smoothly and fits snugly Fast absorption Example 5 4.5 4.6 4.6 Comparative Example 5 4.2 3.8 4.1 Comparative Example 6 4.4 3.7 3.8

[0094] As can be seen from Table 2, compared with Comparative Examples 5-6, the product of Example 5 is smoother and more adherent when spread on the skin and is absorbed faster.

[0095] Experiment 3: Volunteer Trial Test

[0096] The water-in-oil quick repair cream prepared in Example 5 was distributed to 20 female volunteers with sensitive skin aged between 25 and 45 years old who had symptoms such as itching, erythema, papules, blisters, etc. for trial use, once in the morning and once in the evening. A return visit was conducted after 3 months, and the self-evaluation results of the volunteers were collected to calculate the improvement rate.

[0097] Self-assessment criteria for improvement of sensitive skin of volunteers: if the symptoms such as itching, erythema, papules, blisters, etc. were improved, it was recorded as effective; if the symptoms such as itching, erythema, papules, blisters, etc. were resolved, it was recorded as markedly effective; if the symptoms such as itching, erythema, papules, blisters, etc. were not improved, it was recorded as ineffective.

[0098] The statistical results showed that 5 volunteers showed marked effects, 12 volunteers showed effective effects, and the total effective rate reached 85%. Therefore, the water-in-oil quick repair cream prepared in the embodiment of the present invention achieved good anti-allergic and soothing effects.

[0099] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. An anti-allergic soothing composition, characterized in that: The invention comprises the following components: Piper METHYSTICUM leaf / root / stem extract and Forsythia suspensa fruit extract.

2. The anti-allergic soothing composition according to claim 1, characterized in that: Also included are the following ingredients: Gentiana scabra root extract.

3. The anti-allergic soothing composition according to claim 1, characterized in that: The preparation process includes the following steps: (1) drying the following raw materials in parts by weight: 1-10 parts of Kava roots, 1-10 parts of Kava leaves, 1-10 parts of Kava stems, and 1-10 parts of Forsythia suspensa fruits in shade; crushing, then adding 20-200 parts by weight of water and 1-10 parts by weight of glucose, mixing evenly, adjusting the pH to 4-5, and sterilizing at high temperature to obtain a sterilized material; (2) inoculating lactobacillus into a liquid culture medium for expansion culture to obtain lactobacillus seed liquid; inoculating the lactobacillus seed liquid into the sterilized material, wherein the amount of the seed liquid added is 1-5% of the weight of the sterilized material; mixing evenly; evacuating; and fermenting at 30-35° C. for 1-3 days to obtain a fermentation liquid; (3) Centrifuging the fermented liquid and taking the supernatant to obtain the anti-allergic soothing composition.

4. The anti-allergic soothing composition according to claim 3, characterized in that: The weight parts of the raw materials described in step (1) are: 5 parts of Piper mesona root, 2 parts of Piper mesona leaf, 3 parts of Piper mesona stem and 8 parts of Forsythia suspensa fruit.

5. The anti-allergic soothing composition according to claim 3, characterized in that: The amount of glucose added in step (1) is 8 parts; the high temperature sterilization is maintained at 121° C. for 30 minutes.

6. The anti-allergic soothing composition according to claim 3, characterized in that: In step (1), 2 parts by weight of gentian root are also added.

7. The anti-allergic soothing composition according to claim 3, characterized in that: The liquid culture medium in step (2) is MRS broth culture medium; the content of lactobacillus in the seed liquid is 1×10 6 -1×10 8 CFU / mL.

8. The anti-allergic soothing composition according to claim 3, characterized in that: The vacuuming step described in step (2) is: first vacuuming, then filling with nitrogen to 0.05 MPa, and repeatedly filling and exhausting three times.

9. Use of the anti-allergic soothing composition according to any one of claims 1 to 8 as an active additive in the preparation of cosmetics.

10. A water-in-oil quick repair cream, characterized in that: The invention comprises the following components in percentage by weight: 3% of polyglyceryl-6 pentaoleate, 0.5% of polyglyceryl-3 diisostearate, 9% of mineral oil, 4% of isononyl isononanoate, 5% of polydimethylsiloxane, 0.2% of bisabolol, 2% of polymethyl methacrylate, 1% of magnesium stearate, 5% of zinc oxide, 1% of calamine, 20% of 1,3-propylene glycol, 2% of p-hydroxyacetophenone, 0.05% of disodium EDTA, 1% of dipotassium glycyrrhizate, 0.25% of arginine, 5% of the anti-allergic soothing composition according to any one of claims 1 to 8, and the balance of water.

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