Formula of antibacterial liquid for rheumatic bone pain

Abstract

The invention relates to the field of traditional Chinese medicine preparations, and discloses a formula of an antibacterial liquid for rheumatic bone pain. Comprising the following medicinal materials: ligusticum wallichii, stiff silkworm, asarum, ground beetle, processed rhizoma arisaematis, prepared kusnezoff monkshood root, garden balsam stem, safflower, pseudo-ginseng, eucommia ulmoides, astragalus membranaceus, frankincense, myrrh, scorpio, centipede, camphor, borneol, menthol, thymol, philippine flemingia root, prepared kusnezoff monkshood root, ground beetle, divaricate saposhnikovia root, sargentgloryvine stem, dried ginger, galangal, rheum officinale, lycopodium clavatum, angelica dahurica, mint, radix angelicae pubescentis, notopterygium root, cortex fraxini, angelica sinensis, radix paeoniae alba, rhizoma corydalis, radix clematidis, dragon's blood and rhizoma atractylodis. , radix dipsaci, radix cyathulae, rhizoma typhonii, cinnamon and cassia twig. Most of the medicinal materials in the formula are traditional Chinese medicinal materials, are applied to treatment of rheumatism, ostalgia, arthritis and other diseases for a long time and are small in side effect and high in safety, dependence on chemical medicines is reduced by selecting natural herbal medicines, and side effects and toxic and side effects possibly caused by long-term use of the chemical medicines can be reduced.

Description

Technical Field

[0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a formula of antibacterial liquid for rheumatic bone pain. Background Art

[0002] With the rapid development of modern society, rheumatic bone pain, arthritis, muscle aches and other diseases related to joints and bones have become one of the major diseases that affect human health. According to statistics, the number of patients with rheumatic diseases worldwide has increased year by year. In particular, as people age, the incidence of rheumatic diseases in the elderly population has gradually increased, causing great physical pain and a decline in the quality of life for patients. In addition, rheumatic bone pain is often accompanied by symptoms such as local swelling, inflammation, and limited mobility, which can even affect normal work and life in severe cases.

[0003] Traditional treatment methods are mainly drugs, physical therapy, surgery, etc. Drug therapy, especially the widespread use of non-steroidal anti-inflammatory drugs (NSAIDs) and steroids, can effectively relieve pain, but long-term use will bring some side effects, such as gastrointestinal discomfort, liver and kidney damage, osteoporosis and other problems. In addition, some chemical drugs have drug dependence and drug resistance, resulting in a gradual decline in treatment effects. Therefore, how to find a safe and effective treatment method with few side effects has become an urgent need in medical research and clinical treatment. Summary of the invention

[0004] In view of the deficiencies of the prior art, the present invention provides a formula of an antibacterial liquid for rheumatic bone pain, which solves the problem that although traditional treatment methods can effectively relieve pain, long-term use may cause some side effects.

[0005] To achieve the above objectives, the present invention is implemented through the following technical scheme: a formula of antibacterial liquid for rheumatic bone pain, comprising the following medicinal materials: chuanxiong, bombyx batryticatus, asarum, earthworm, processed arisaema, processed aconite, radix schoenopraeviae, safflower, panax notoginseng, eucommia, astragalus, frankincense, myrrh, scorpion, centipede, camphor, borneol, menthol, thymol, kelp, processed aconite, earthworm, siler, chicken blood teng, dried ginger, galangal, rhubarb, spatholobus, angelica dahurica, mint, angelica pubescens, notopterygium wilfordii, qinjiu, angelica sinensis, white peony root, corydalis yanhusuo, clematis root, blood clotting, atractylodes, chuanduan, cyathula officinalis, white aconite, cinnamon bark and cassia twig.

[0006] Preferably, the chuanxiong is 8-12 parts, the bombyx batryticatus is 6-10 parts, the asarum is 4-6 parts, the earthworm is 5-7 parts, the processed arisaema is 3-5 parts, the processed aconite is 3-5 parts, the radix schoenopraegi is 5-9 parts, the safflower is 5-7 parts, the notoginseng is 4-6 parts, the eucommia is 5-9 parts, the astragalus is 8-12 parts, the frankincense is 5-7 parts, the myrrh is 5-7 parts, the scorpion is 2-4 parts, the centipede is 2-4 parts, the camphor is 3-5 parts, the borneol is 2-4 parts, the menthol is 4-6 parts, the thymol is 3-5 parts, the quinquefolius is 4-6 parts, the earthworm is 5-7 parts, the windproof is 4-6 parts, chicken blood teng 3-5 parts, dried ginger 5-7 parts, galangal 4-6 parts, rhubarb 4-6 parts, schizonepeta tenuifolia 5-7 parts, angelica dahurica 4-6 parts, mint 4-6 parts, angelica pubescens 5-7 parts, notopterygium wilfordii 4-6 parts, Qinjiu 3-5 parts, safflower 5-7 parts, angelica sinensis 5-7 parts, white peony 5-7 parts, Corydalis yanhusuo 4-6 parts, clematis 4-6 parts, blood clotting 3-5 parts, atractylodes lancea 3-5 parts, Chuanduan 3-5 parts, Cyathula officinalis 4-6 parts, white aconite 3-5 parts, cinnamon bark, cassia twig 3-5 parts.

[0007] Preferably, the effective ingredients of the medicinal materials are extracted by decocting or soaking, and the obtained extract is used as an external antibacterial liquid for rheumatic bone pain.

[0008] Preferably, a method for preparing an antibacterial liquid for rheumatic bone pain comprises the following steps:

[0009] S1. Mixing of medicinal materials: Mix all medicinal materials evenly according to the proportion range;

[0010] S2. Select solvent: When using the decoction method, choose clean water or deionized water as the solvent; when using the immersion method, choose alcohol as the solvent;

[0011] S3. Extraction method

[0012] S301, decoction method: adding mixed medicinal materials and water into a decoction pot, heating the water to boiling, then lowering the heat to continue decocting. During this process, the active ingredients in the medicinal materials are gradually released into the water, and the extract is concentrated and then taken out;

[0013] S302, soaking method: put the mixed medicinal materials and alcohol into a sealed container, soak at room temperature, and shake it every week to promote the release of active ingredients;

[0014] S4, filtration and concentration: Regardless of whether the decoction method or the soaking method is used, the extract must be filtered through a filter screen or gauze to remove the drug residue and obtain a clear extract;

[0015] S5. Adding preservative: adding preservative to the extract;

[0016] S6, dilution and preparation: further dilute the extract according to the patient's needs and liquid concentration requirements;

[0017] S7. Packaging and storage: Package the processed extract in sealed glass or plastic bottles, avoid direct sunlight, and store in a cool and dry place.

[0018] Preferably, the alcohol concentration in step S2 is 70%.

[0019] Preferably, in step S301, the mixed medicinal materials and water are added to the decoction pot in a ratio of 1:5, and the decoction time is 1-2 hours over low heat.

[0020] Preferably, in step S302, the soaking ratio of medicinal materials to alcohol is 1:5, the soaking time at room temperature is 4-6 weeks, and the mixture is shaken 2-3 times a week.

[0021] Preferably, in the step S4, the extract is further concentrated to 1 / 2 to 1 / 3 of the original solution in the water decoction method.

[0022] Preferably, in step S5, the preservatives include sodium benzoate and potassium sorbate, and the amount of preservative added is 0.05%-0.1%.

[0023] Preferably, in step S6, the concentration of the stock solution is diluted from 20%-30% to 5%-10%.

[0024] The present invention provides a formula of antibacterial liquid for rheumatic bone pain, which has the following beneficial effects:

[0025] 1. Most of the medicinal materials in the formula of the present invention are traditional Chinese medicinal materials, which have been used in the treatment of rheumatic bone pain, arthritis and other diseases for a long time. They have little side effects and high safety. By selecting natural herbs, the dependence on chemical drugs is reduced, which helps to reduce the side effects and toxic side effects that may be caused by long-term use of chemical drugs.

[0026] 2. The antibacterial liquid formula of the present invention combines the advantages of various Chinese herbal medicines and has a compound therapeutic effect for the treatment of rheumatic bone pain: Pain relief: By selecting medicinal materials with blood circulation and blood stasis removal and analgesic effects (such as Chuanxiong, Panax notoginseng, safflower, angelica, etc.), joint swelling and pain caused by rheumatoid arthritis or bone pain can be quickly relieved. Anti-inflammatory and detumescence: Medicinal materials such as Astragalus, Eucommia, and Clematis in the formula have significant anti-inflammatory effects. Antibacterial effect: Herbs such as frankincense, myrrh, scorpion, and centipede have strong antibacterial, antiviral, and antifungal effects, which can prevent bacterial infections or skin discomfort caused by long-term use of drugs. Promote blood circulation and tendon and bone repair: Medicinal materials such as Stretch Marks, Sanguisorba officinalis, and Drynaria can promote blood circulation, improve blood flow in joints, and help promote tissue repair and regeneration.

[0027] 3. The extraction method adopted by the present invention combines the decoction method with the soaking method, which can extract the effective ingredients in the herbal medicine to the maximum extent, and prolong the stability of the liquid medicine by adding preservatives. The antibacterial liquid can maintain its therapeutic effect for a long time, and has good storage conditions. It is not easy to deteriorate during the storage period, and can effectively avoid the loss of drug efficacy.

[0028] 4. Through the preparation and preparation method of the present invention, the concentration of the drug solution can be adjusted according to the specific conditions of different patients (such as the severity of symptoms, the location of pain, etc.). The concentration of the drug solution can be adjusted between 5% and 10% to meet the needs of different patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The present invention is a flow chart of a method for preparing an antibacterial liquid for rheumatic bone pain. DETAILED DESCRIPTION

[0030] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] Please see attached Figure 1 , the embodiment of the present invention provides a formula of antibacterial liquid for rheumatism and bone pain, including the following medicinal materials: chuanxiong, bombyx batryticatus, asarum, earthworm, processed arisaema, processed aconite, radix striata, safflower, panax notoginseng, eucommia, astragalus, frankincense, myrrh, scorpion, centipede, camphor, borneol, menthol, thymol, kelp, processed aconite, earthworm, siler, chicken blood teng, dried ginger, galangal, rhubarb, lycopodiella, angelica dahurica, mint, angelica pubescens, notopterygium, qinjiu, angelica sinensis, white peony root, corydalis, clematis, blood clotting, atractylodes, chuanduan, cyathula officinalis, white aconite, cinnamon bark and cassia twig;

[0032] Specifically, Chuanxiong has the effects of promoting blood circulation, removing blood stasis, promoting qi and relieving pain, and is often used to treat rheumatic bone pain, headache and other diseases.

[0033] Bombyx batryticatus: It has the effects of dispersing wind and dampness, unblocking meridians and relieving pain. It is often used to treat rheumatoid arthritis and spasmodic pain.

[0034] Asarum: It can warm the meridians and dispel cold, has the effects of detoxification, reducing swelling and relieving pain, and is often used for rheumatic pain and neuralgia.

[0035] Earthworm: It has the effects of promoting blood circulation, dredge meridians, dissipating blood stasis and relieving pain. It is often used to treat rheumatism, traumatic injuries, etc.

[0036] Processed Arisaema: It has the effects of resolving phlegm and relieving cough, removing rheumatism, reducing swelling and relieving pain. It is suitable for rheumatoid arthritis and muscle and bone pain.

[0037] Processed Aconitum: It has the effects of warming the meridians and relieving pain, dispelling wind and dampness. It is mainly used to treat rheumatoid arthritis and limb numbness.

[0038] Radix Polygoni Multiflori: It has the effects of clearing away heat, detoxifying, promoting blood circulation and dredging collaterals. It is often used for symptoms such as rheumatism, joint swelling and pain.

[0039] Safflower: It has the effects of promoting blood circulation, removing blood stasis and relieving pain. It is suitable for bruises, swollen and painful joints, rheumatic pain, etc.

[0040] Panax notoginseng: It has the effects of promoting blood circulation, removing blood stasis and relieving pain. It is often used for pain, trauma, arthritis, etc. caused by blood stasis.

[0041] Eucommia ulmoides: It has the effects of nourishing the liver and kidneys, strengthening the tendons and bones, and relieving pain. It is suitable for the treatment of rheumatic bone pain, arthritis and other diseases.

[0042] Astragalus: It has the effects of invigorating Qi and strengthening the exterior, improving immunity, and anti-inflammatory and swelling. It is often used for rheumatism, low immunity and other diseases.

[0043] Frankincense: It has the effects of promoting blood circulation, relieving pain, reducing swelling and dispersing nodules. It is often used to treat rheumatoid arthritis, muscle and bone pain, etc.

[0044] Myrrh: It has the effects of promoting blood circulation, removing blood stasis, relieving pain and anti-inflammatory, and is used for symptoms such as rheumatism, bruises and injuries.

[0045] Scorpion: used for removing rheumatism, relieving pain, antibacterial and anti-inflammatory, often used to treat arthritis, neuralgia, rheumatism, etc.

[0046] Centipede: It has the effect of removing rheumatism, unblocking meridians and relieving pain. It is suitable for rheumatic bone pain, neuralgia, etc.

[0047] Camphor: It has the effects of dispelling cold and relieving pain, unblocking meridians and relieving itching. It is often used for rheumatic pain, muscle soreness, etc.

[0048] Borneol: It has the effects of clearing away heat, detoxifying, reducing swelling and relieving pain. It is often used to relieve joint swelling and pain and neuralgia.

[0049] Menthol: It has the effects of clearing away heat and detoxifying, relaxing muscles and tendons, and relieving pain. It is used to relieve rheumatic pain, arthritis, etc.

[0050] Thymol: It has antibacterial and anti-inflammatory effects, and can relax muscles and activate blood circulation. It can effectively relieve inflammation caused by arthritis and rheumatism.

[0051] Qianjinba: It has the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. It is often used for rheumatic bone pain, bruises, etc.

[0052] Earth element: It has the effect of removing rheumatism and relieving pain, and is often used to treat rheumatism, joint pain, etc.

[0053] Fangfeng: It has the effect of dispelling wind and cold, relaxing muscles and activating blood circulation. It is often used for symptoms such as rheumatoid arthritis and muscle pain.

[0054] Chicken Blood Teng: It has the effect of relaxing muscles and tendons and relieving pain. It is often used to treat rheumatic bone pain, swollen and painful joints and other symptoms.

[0055] Dried ginger: It has the effects of warming the meridians and dispelling cold, promoting blood circulation and relieving pain. It is suitable for joint pain caused by cold and dampness.

[0056] Alpinia officinalis: It has the effects of warming the middle and dispersing cold, promoting qi and relieving pain. It is suitable for rheumatic pain caused by cold and dampness.

[0057] Rhubarb: It has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis. It is often used for rheumatic bone pain, phlegm and dampness blocking the meridians, etc.

[0058] Stretching grass: It has the effect of relaxing muscles and tendons and relieving pain. It is suitable for treating rheumatism, arthritis, etc.

[0059] Angelica dahurica: It has the effects of dispelling wind and dampness, opening the orifices and relieving pain. It is often used to relieve rheumatic pain, headaches, etc.

[0060] Mint: It has the effects of clearing heat and detoxifying, anti-inflammatory and analgesic, and is suitable for relieving muscle soreness caused by rheumatism.

[0061] Angelica dahurica: It has the effects of removing rheumatism, relieving pain, relaxing muscles and activating blood circulation, and is often used to treat rheumatoid arthritis.

[0062] Qianghuo: It has the effect of removing rheumatism, relaxing muscles and activating blood circulation, and is suitable for treating rheumatic bone pain and swollen and painful joints.

[0063] Qinjiu: It has the effects of promoting blood circulation, removing blood stasis, relaxing muscles and relieving pain. It is often used to treat joint diseases and rheumatic pain.

[0064] Angelica: It has the effect of promoting blood circulation, replenishing blood, and harmonizing qi and blood. It is often used to relieve pain caused by blood deficiency.

[0065] White Peony Root: It has the effects of nourishing blood, softening the liver and relieving pain. It is often used to treat rheumatic pain caused by blood deficiency.

[0066] Yuanhu: It has the effects of promoting qi and relieving pain, promoting blood circulation and removing blood stasis, and is often used to treat pain caused by qi stagnation and blood stasis.

[0067] Clematis: It has the effects of promoting blood circulation, removing blood stasis, unblocking meridians and relieving pain. It is often used for rheumatic bone pain, swollen and painful joints, etc.

[0068] Xuejie: ​​It has the effects of stopping bleeding, reducing swelling and relieving pain, and is often used in the treatment of fractures and rheumatic pain.

[0069] Atractylodes: It has the effects of drying dampness, strengthening the spleen, dispelling wind and cold. It is suitable for the treatment of rheumatoid arthritis and rheumatism with heavy dampness.

[0070] Chuanduan: It has the effects of promoting blood circulation, dredge meridians and relieving pain, and is often used to relieve arthritis, rheumatic pain, etc.

[0071] Sichuan Achyranthes bidentata: It has the effects of promoting blood circulation, dredging meridians, strengthening tendons and bones, and is often used to treat rheumatic bone pain and joint diseases.

[0072] White aconite: It has the effects of dispelling wind and dampness, resolving phlegm and relieving pain. It is often used to treat rheumatism, traumatic injuries, etc.

[0073] Cinnamon: It has the effects of warming the meridians and dispelling cold, promoting blood circulation and relieving pain. It is suitable for treating rheumatic bone pain of cold and dampness type.

[0074] Cinnamon twig: It has the effects of dispelling cold, relaxing muscles and activating blood circulation, and is often used to relieve the symptoms of rheumatoid arthritis.

[0075] The above-mentioned medicinal materials have their own unique functions in traditional Chinese medicine. They can work synergistically with each other to relieve rheumatic bone pain, reduce inflammation and fight bacteria, promote blood circulation and remove blood stasis, and relax muscles and tendons.

[0076] 8-12 parts of Chuanxiong, 6-10 parts of Bombyx Batryticatus, 4-6 parts of Asarum, 5-7 parts of Eupolyphaga Seu Steleophaga, 3-5 parts of processed Arisaema, 3-5 parts of processed Aconitum, 5-9 parts of Radix Angelicae Pubescentis, 5-7 parts of Carthamus tinctorius, 4-6 parts of Notoginseng, 5-9 parts of Eucommia, 8-12 parts of Astragalus, 5-7 parts of Frankincense, 5-7 parts of Myrrh, 2-4 parts of Scorpio, 2-4 parts of Scolopendra, 3-5 parts of Camphor, 2-4 parts of Borneolum, 4-6 parts of Menthol, 3-5 parts of Thymol, 4-6 parts of Tripterygium wilfordii, 5-7 parts of Earthworm, 4-6 parts of Saposhnikovia divaricata, 3-5 parts of Chicken Blood Teng, 5-7 parts of Dried Ginger, 4-6 parts of galangal, 4-6 parts of rhubarb, 5-7 parts of smilax glabra, 4-6 parts of angelica dahurica, 4-6 parts of mint, 5-7 parts of angelica pubescens, 4-6 parts of notopterygium wilfordii, 3-5 parts of chinensis, 5-7 parts of safflower, 5-7 parts of angelica sinensis, 5-7 parts of white peony root, 4-6 parts of corydalis, 4-6 parts of clematis, 3-5 parts of blood clotting, 4-6 parts of atractylodes, 3-5 parts of chuanduan, 4-6 parts of cyathula, 3-5 parts of white aconite, 4-6 parts of cinnamon bark, and 3-5 parts of cassia twig; the effective ingredients of the medicinal materials are extracted by decoction or soaking, and the obtained extract is used as an external antibacterial liquid for rheumatic bone pain;

[0077] Specifically, using water decoction or soaking methods to extract the active ingredients in the medicinal materials helps ensure that the active ingredients in the medicinal materials can be fully dissolved, released and quickly take effect, thereby achieving the effect of treating rheumatic bone pain.

[0078] A method for preparing an antibacterial liquid for rheumatic bone pain comprises the following steps:

[0079] S1. Mixing of medicinal materials: Mix all medicinal materials evenly according to the proportion range;

[0080] S2. Select solvent: When using the decoction method, choose clean water or deionized water as the solvent; when using the immersion method, choose alcohol as the solvent;

[0081] S3. Extraction method

[0082] S301, decoction method: adding mixed medicinal materials and water into a decoction pot, heating the water to boiling, then lowering the heat to continue decocting. During this process, the active ingredients in the medicinal materials are gradually released into the water, and the extract is concentrated and then taken out;

[0083] S302, soaking method: put the mixed medicinal materials and alcohol into a sealed container, soak at room temperature, and shake it every week to promote the release of active ingredients;

[0084] S4, filtration and concentration: Regardless of whether the decoction method or the soaking method is used, the extract must be filtered through a filter screen or gauze to remove the drug residue and obtain a clear extract;

[0085] S5. Adding preservative: adding preservative to the extract;

[0086] S6, dilution and preparation: further dilute the extract according to the patient's needs and liquid concentration requirements;

[0087] S7. Packaging and storage: Package the processed extract in sealed glass or plastic bottles, avoid direct sunlight, and store in a cool and dry place.

[0088] The alcohol concentration in step S2 is 70%;

[0089] In step S301, the mixed medicinal materials and water are added into the decoction pot in a ratio of 1:5, and the decoction time is 1-2 hours over low heat;

[0090] In step S302, the soaking ratio of the medicinal material to the alcohol is 1:5, the soaking time at room temperature is 4-6 weeks, and the mixture is shaken 2-3 times a week;

[0091] In step S4, the extract is further concentrated to 1 / 2 to 1 / 3 of the original solution in a water decoction method;

[0092] In step S5, the preservatives include sodium benzoate and potassium sorbate, and the amount of the preservatives added is 0.05%-0.1%;

[0093] In step S6, the concentration of the stock solution is diluted from 20%-30% to 5%-10%.

[0094] Specifically, the final antibacterial liquid product is a transparent liquid with the unique smell and curative effect of medicinal materials, suitable for external application or wiping. Its main function is to relieve rheumatic arthritis, bone pain, muscle pain, and has certain antibacterial and anti-inflammatory effects. It is suitable for symptoms such as joint pain and swelling caused by rheumatic bone pain.

[0095] The preparation method of the present invention ensures that the effective ingredients in the medicinal solution can be fully extracted and kept active by reasonably selecting medicinal materials, solvents and extraction processes. At the same time, accurate filtering, concentration, preservation, dilution and packaging steps ensure the stability, efficacy and safety of the product. The final external antibacterial liquid not only effectively relieves rheumatic bone pain, but also has a strong antibacterial and anti-inflammatory effect, is suitable for clinical treatment of diseases such as rheumatic bone pain, and has a wide range of application prospects.

[0096] The following is an introduction in conjunction with specific embodiments:

[0097] Example: Preparation of antibacterial solution for rheumatic bone pain

[0098] According to the formula of the present invention, the following medicinal materials are selected and weighed according to the mass ratio:

[0099] Chuanxiong: 15g

[0100] Bombyx batryticatus: 10g

[0101] Asarum: 5g

[0102] Earthworm: 10g

[0103] Processed Arisaema: 12g

[0104] Processed Aconitum: 8g

[0105] Herba scutellariae: 20g

[0106] Safflower: 15g

[0107] Panax notoginseng: 10g

[0108] Eucommia ulmoides: 15g

[0109] Astragalus: 12g

[0110] Frankincense: 5g

[0111] Myrrh: 5g

[0112] Scorpio: 8g

[0113] Centipede: 5g

[0114] Camphor: 2g

[0115] Borneol: 3g

[0116] Menthol: 2g

[0117] Thymol: 0.5g

[0118] Qianjinba: 10g

[0119] Processed Aconitum: 8g

[0120] Earth element: 6g

[0121] Windproof: 8g

[0122] Millettia reticulata: 10g

[0123] Dried ginger: 5g

[0124] Galangal: 6g

[0125] Rhubarb: 5g

[0126] Stretching grass: 8g

[0127] Angelica dahurica: 10g

[0128] Mint: 4g

[0129] Angelica dahurica: 6g

[0130] Notopterygium root: 6g

[0131] Qin Jiu: 6g

[0132] Safflower: 10g

[0133] Angelica: 12g

[0134] White peony root: 8g

[0135] Yuanhu: 10g

[0136] Clematis: 6g

[0137] Dragon's blood: 3g

[0138] Atractylodes: 5g

[0139] Chuandan: 6g

[0140] Sichuan Cyathula: 8g

[0141] White aconite root: 3g

[0142] Cinnamon: 4g

[0143] Cinnamon twig: 5g

[0144] Solvent selection and solvent quantity

[0145] Deionized water and 70% ethanol were used as solvents:

[0146] Deionized water: Use appropriate amount for decoction extraction, ensuring that the ratio of each medicinal material to water is 1:5. When using the decoction method, take about 800ml of water.

[0147] 70% ethanol: appropriate amount is used for immersion extraction, the ratio of medicinal materials to ethanol is 1:5, take about 1500ml of ethanol.

[0148] Extraction process

[0149] Decoction extraction:

[0150] Weigh water-soluble medicinal materials such as Chuanxiong, Bombyx Batryticatus, and Asarum according to the formula ratio, put them into a decoction pot, and add 800 ml of deionized water.

[0151] Heat the herbs and water until boiling, then reduce to medium-low heat and simmer for 1.5 hours to ensure that the active ingredients in the herbs are dissolved in the water.

[0152] During the decoction process, if too much water evaporates, add appropriate amount of hot water to maintain one third of the original liquid volume.

[0153] After decoction is completed, the extract is filtered to remove the residue to obtain a clear liquid medicine (about 250 ml).

[0154] Soaking extraction:

[0155] Mix fat-soluble medicinal materials such as processed Arisaema, processed Aconitum, and Herba Polygoni Multiflori with 70% ethanol in a ratio of 1:5, using about 1500 ml of ethanol.

[0156] Place the mixed herbs and ethanol solution in a sealed container and soak them at room temperature for 4 weeks. Gently shake the container every week to ensure the release of active ingredients.

[0157] After soaking is completed, filter through a fine mesh sieve or gauze to remove the residue and obtain a transparent liquid medicine (about 400 ml).

[0158] Filtration and concentration

[0159] The decoction and soaking extractions are filtered separately, and the residues are removed before mixing. If the concentration of the liquid is low, the liquid can be concentrated to 1 / 2 to 1 / 3 of the original volume (about 450 ml) by reduced pressure concentration or normal pressure evaporation.

[0160] Addition of preservatives

[0161] Add an appropriate amount of preservative to the extract to extend the shelf life. Choose sodium benzoate and add 0.05%, that is, add 2.25g. Make sure the preservative is evenly mixed with the drug solution.

[0162] Dilution and preparation

[0163] The concentrated extract is diluted appropriately according to the requirements. If diluted to 10% concentration, add an appropriate amount of deionized water and mix well to obtain the final drug solution (about 500 ml).

[0164] Packaging and storage

[0165] Put the prepared antibacterial liquid for rheumatism and bone pain into a light-proof glass bottle, seal the bottle mouth and ensure it is sealed. Then store the liquid medicine in a cool and dry place, avoid direct sunlight, and keep it in the temperature range of 5℃-25℃.

[0166] The antibacterial liquid for rheumatic bone pain is a transparent, colorless to light yellow liquid with the aroma of herbal medicine, and is suitable for external application for rheumatic bone pain, arthritis and other symptoms. It has good antibacterial effect, and has a significant effect on relieving rheumatic bone pain, and can relieve local inflammation and pain in a short time.

[0167] Embodiment effect:

[0168] External effect: The antibacterial liquid for rheumatic bone pain prepared in this embodiment has strong analgesic, anti-inflammatory and antibacterial effects after clinical experiments. Patients can feel obvious relief in joints within 30 minutes after use, and inflammation and swelling are significantly reduced.

[0169] Safety: No obvious adverse reactions or allergic reactions occurred during use, the skin absorbs well, and it is suitable for long-term use.

[0170] Stability: By adding preservatives, the stability of the product is guaranteed and it can maintain a shelf life of at least 6 months.

[0171] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A formula of antibacterial liquid for rheumatic bone pain, characterized in that: Including the following medicinal materials: Chuanxiong, Bombyx Batryticatus, Asarum, Eucommia ulmoides, processed Arisaema, processed Aconitum, Radix Penicillii, Carthamus tinctorius, Panax notoginseng, Eucommia ulmoides, Astragalus, frankincense, myrrh, scorpion, centipede, camphor, borneol, menthol, thymol, Tripterygium wilfordii, processed Aconitum, earthworm, Saposhnikovia divaricata, Millettia reticulata, dried ginger, Alpinia officinalis, rhubarb, Lycopodiella cuneata, Angelica dahurica, mint, Duhuo, Notopterygium wilfordii, Qinjiu, Angelica sinensis, white peony root, Corydalis yanhusuo, Clematis chinensis, Sanguisorba officinalis, Atractylodes macrocephala, Chuanduan, Cyathula capitata, White aconite, cinnamon bark and cassia twig.

2. The antibacterial liquid formula for rheumatic bone pain according to claim 1, characterized in that: The rhizome of Chuanxiong is 8-12 parts, the bombyx batryticatus is 6-10 parts, the asarum is 4-6 parts, the earthworm is 5-7 parts, the processed arisaema is 3-5 parts, the processed aconite is 3-5 parts, the herb radix spatholobi is 5-9 parts, the safflower is 5-7 parts, the notoginseng is 4-6 parts, the eucommia is 5-9 parts, the astragalus is 8-12 parts, the frankincense is 5-7 parts, the myrrh is 5-7 parts, the scorpion is 2-4 parts, the centipede is 2-4 parts, the camphor is 3-5 parts, the borneol is 2-4 parts, the menthol is 4-6 parts, the thymol is 3-5 parts, the schizonepeta tenuifolia is 4 parts, the earthworm is 5-7 parts, the siler is 4 -6 parts, 3-5 parts of chicken blood, 5-7 parts of dried ginger, 4-6 parts of galangal, 4-6 parts of rhubarb, 5-7 parts of striata grass, 4-6 parts of angelica, 4-6 parts of mint, 5-7 parts of angelica dahurica, 4-6 parts of notopterygium wilfordii, 3-5 parts of Qinjiu, 5-7 parts of safflower, 5-7 parts of angelica sinensis, 5-7 parts of white peony root, 4-6 parts of Corydalis yanhusuo, 4-6 parts of Clematis, 3-5 parts of blood clotting, 4-6 parts of atractylodes, 3-5 parts of Chuanduan, 4-6 parts of Cyathula officinalis, 3-5 parts of white aconite, 4-6 parts of cinnamon bark, and 3-5 parts of cassia twig.

3. The antibacterial liquid formula for rheumatic bone pain according to claim 1, characterized in that: The effective components of the medicinal materials are extracted by water decoction or soaking, and the obtained extract is used as an external antibacterial liquid for rheumatic bone pain.

4. A method for preparing an antibacterial liquid for rheumatic bone pain, characterized in that: The antibacterial liquid formula for rheumatic bone pain according to any one of claims 1 to 3 comprises the following steps: S1. Mixing of medicinal materials: Mix all medicinal materials evenly according to the proportion range; S2. Select solvent: When using the decoction method, choose clean water or deionized water as the solvent; when using the immersion method, choose alcohol as the solvent; S3. Extraction method S301, decoction method: adding mixed medicinal materials and water into a decoction pot, heating the water to boiling, then lowering the heat to continue decocting. During this process, the active ingredients in the medicinal materials are gradually released into the water, and the extract is concentrated and then taken out; S302, soaking method: put the mixed medicinal materials and alcohol into a sealed container, soak at room temperature, and shake it every week to promote the release of active ingredients; S4, filtration and concentration: Regardless of whether the decoction method or the soaking method is used, the extract must be filtered through a filter screen or gauze to remove the drug residue and obtain a clear extract; S5. Adding preservative: adding preservative to the extract; S6, dilution and preparation: further dilute the extract according to the patient's needs and liquid concentration requirements; S7. Packaging and storage: Package the processed extract in sealed glass or plastic bottles, avoid direct sunlight, and store in a cool and dry place.

5. The method for preparing the antibacterial liquid for rheumatic bone pain according to claim 4, characterized in that: The alcohol concentration in step S2 is 70%.

6. The method for preparing the antibacterial liquid for rheumatic bone pain according to claim 4, characterized in that: In the step S301, the mixed medicinal materials and water are added into the decoction pot in a ratio of 1:5, and the decoction time is 1-2 hours on a low fire.

7. The method for preparing the antibacterial liquid for rheumatic bone pain according to claim 4, characterized in that: In the step S302, the soaking ratio of the medicinal material to the alcohol is 1:5, the soaking time at room temperature is 4-6 weeks, and the mixture is shaken 2-3 times a week.

8. The method for preparing the antibacterial liquid for rheumatic bone pain according to claim 4, characterized in that: In the step S4, the extract is further concentrated to 1 / 2 to 1 / 3 of the original solution in the water decoction method.

9. The method for preparing the antibacterial liquid for rheumatic bone pain according to claim 4, characterized in that: In the step S5, the preservatives include sodium benzoate and potassium sorbate, and the amount of preservative added is 0.05%-0.1%.

10. The method for preparing the antibacterial liquid for rheumatic bone pain according to claim 4, characterized in that: In the step S6, the concentration of the stock solution is diluted from 20%-30% to 5%-10%.

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