Psoralea corylifolia tablet rich in inula nervosa and preparation method of psoralea corylifolia tablet

Abstract

The invention relates to the field of nutritional health-care products, and discloses a fructus psoraleae tablet rich in inula nervosa. The bone tonifying tablet comprises the following components in percentage by weight: 20%-30% of yak bone collagen peptide, 15%-25% of enzymolysis bone meal, 5%-10% of inula nervosa, 5%-10% of galangal, 3%-7% of gynura procumbens powder, 8%-12% of cinnamon powder, 8%-12% of turmeric, 5%-10% of zaocys dhumnade, 1%-5% of organic selenium oyster mushroom powder and 0.5%-2% of magnesium stearate. The yak bone collagen peptide and the enzymolysis bone meal are adopted, the small molecule peptide is prepared through high-temperature boiling and enzymolysis technologies, and the enzymolysis conditions are 4-6 hours and 45-55 DEG C. The enzymolysis bone meal is prepared by enzymolysis and spray drying after being pretreated, and is rich in calcium and collagen. According to the technology, the bioavailability of calcium and collagen is improved, and the bone density and strength are enhanced. Compared with the prior art, the problem of low absorptivity is solved, and excellent performance of a bone care product is realized.

Description

Technical Field

[0001] The invention relates to the technical field of nutritional health products, in particular to a bone-buying tablet rich in Inula japonica var. Background Art

[0002] With the aging of the population and the change of lifestyle, the incidence of bone health problems such as osteoporosis and osteoarthritis continues to rise and has become a global public health issue. In response to these problems, a large number of bone health products have appeared on the market, mainly including calcium tablets, vitamin D supplements and animal bone powder products. However, existing bone health products still have significant deficiencies in absorption effect, drug stability, overall functionality and preparation process, which are specifically manifested in the following aspects:

[0003] Problems with low bone meal absorption rate:

[0004] Most existing bone health products use animal bone meal or ordinary collagen as the main ingredients, but these ingredients have large molecular weights and complex structures. In the human digestive system, the calcium and collagen in ordinary bone meal are difficult to effectively decompose and absorb, resulting in low bioavailability. In particular, ordinary bone meal preparations, whose large molecular collagen and calcium are difficult to pass through the absorption barrier of the human gastrointestinal tract, greatly limit their actual effect as bone repair and bone strengthening products. Although traditional high-calcium formulas can provide a certain amount of calcium supplementation, they cannot effectively help improve bone health problems due to their low absorption rate.

[0005] Problems with unstable efficacy of plant extracts:

[0006] Some traditional Chinese herbal ingredients, such as Inula japonica and Curcuma longa, are often added to existing bone-strengthening products to exert anti-inflammatory and blood-activating effects. However, many plant extracts lack strict control measures during the processing process, such as extraction temperature, time, drying process, etc., which makes it difficult to stably preserve the active ingredients. In addition, untreated plant powders or crude extracts contain impurities, and the active ingredients are easily degraded, making the product's efficacy unstable and the therapeutic effect limited. This problem is especially significant when it comes to long-term health care products, which affects consumers' experience and the durability of product effects.

[0007] Problems with single efficacy and incomplete effects:

[0008] Existing bone health products are relatively simple in formula design, usually only targeting calcium supplementation or simple bone repair problems, and fail to effectively consider the complexity and multi-level needs of bone health. Common products mostly rely on the supplementation of a single ingredient, such as calcium, vitamin D or a small amount of Chinese herbal extracts. Although they can alleviate osteoporosis or bone calcium loss to a certain extent, they cannot fully solve comprehensive bone health problems such as osteoarthritis and bone hyperplasia. In addition, due to the lack of synergistic effects of multiple Chinese herbal ingredients, the efficacy of existing products is relatively limited and cannot fully meet users' bone health needs.

[0009] Problems with unstable formulation process:

[0010] In the production process of existing bone health products, many manufacturers fail to finely control the preparation processes such as mixing, tableting and drying, resulting in problems with the hardness, uniformity and stability of the finished tablets, especially uneven, fragile or insufficiently hard tablets, which affects the quality of the product and the experience of taking it. The use of lubricants in the existing process also lacks precise control, which often causes tablets to stick together or have poor fluidity during the tableting process, ultimately affecting the tablet's formability and consistency.

[0011] Therefore, the present invention provides a bone-buying tablet rich in Inula japonicae and a preparation method thereof to solve the deficiencies of the prior art. Summary of the invention

[0012] In view of the shortcomings of the prior art, the present invention provides a bone-buying tablet rich in Inula japonica var. erythraea and a preparation method thereof, which can effectively improve the bioavailability, drug stability and comprehensive therapeutic effect of bone health products, and improve the consistency and stability of the product in the preparation process.

[0013] To achieve the above object, the present invention is implemented by the following technical scheme: a bone-bucking tablet rich in Inula venosa, the bone-bucking tablet comprising the following components in percentage by weight:

[0014] Yak collagen peptide: 20%-30%,

[0015] Enzymatic bone meal: 15%-25%,

[0016] Inula japonica: 5%-10%,

[0017] Galangal: 5%-10%,

[0018] Chrysanthemum procumbentum powder: 3%-7%,

[0019] Cinnamon powder: 8%-12%,

[0020] Turmeric: 8%-12%,

[0021] Black-necked snake: 5%-10%,

[0022] Organic selenium oyster mushroom powder: 1%-5%,

[0023] Magnesium stearate: 0.5%-2%.

[0024] Preferably, the yak bone collagen peptide is gelatin obtained by high-temperature boiling of yak bones, which is then enzymatically hydrolyzed using alkaline protease, the enzymatic hydrolysis time is controlled at 4-6 hours, and the enzymatic hydrolysis temperature is 45-55°C, and finally a small molecule peptide with a molecular weight of 1000-3000 Daltons is obtained. The obtained yak bone collagen peptide is a white powder with good water solubility.

[0025] Preferably, the enzymatic bone powder is prepared by removing surface fat, blood and impurities from yak bones and then crushing the bones to a particle size of 40-80 mesh. The bones are then enzymatically hydrolyzed using trypsin or chymosin at a temperature of 50-60°C for 3-5 hours. The enzymatic bone powder is then obtained by a spray drying process. The obtained enzymatic bone powder is a white or light yellow powder with a high calcium content and collagen content.

[0026] Preferably, the Inula japonica flower is subjected to extraction and drying treatment, the extraction step comprising soaking the Inula japonica flower in clean water for 3-5 hours at a soaking temperature of 25-30°C, then distilling it using a distillation apparatus for 6-8 hours at an extraction temperature of 100-120°C, and drying the obtained extract by vacuum drying at 40-50°C for 6-10 hours. The obtained Inula japonica flower extract is a light brown powder.

[0027] Preferably, the galangal is cleaned, sliced, dried and crushed, the drying conditions are 50-60°C, the drying time is 8-12 hours, the particle size of the obtained galangal powder is controlled between 80-120 meshes, the galangal powder is light yellow, has a uniform particle size and stable composition.

[0028] Preferably, a method for preparing a bone-bucking tablet rich in Inula japonica var.

[0029] (1) Preliminarily mix yak bone collagen peptide, enzymatic bone powder, Inula japonica, Alpinia officinalis, Glehnia littoralis powder, cinnamon powder, turmeric, snakehead, and organic selenium Pleurotus ostreatus powder according to a certain proportion;

[0030] (2) stirring the mixture in step (1) uniformly at a temperature of 20-30° C. and a humidity of 10%-15% for 45-60 minutes;

[0031] (3) adding magnesium stearate as a lubricant to the mixture in step (2), and continuing to stir evenly for 15-20 minutes;

[0032] (4) feeding the mixture in step (3) into a tablet press at a tabletting pressure of 8-12 MPa to form tablets;

[0033] (5) Drying the obtained tablets at a temperature of 60-80° C. for 4-8 hours to obtain the final bone-replenishing tablets.

[0034] Preferably, the Inula japonica flower in step (1) is preliminarily treated by distillation extraction at an extraction temperature of 100-120° C. for 3-4 hours, and then the extract is mixed with the remaining ingredients.

[0035] Preferably, the drying process of the bone-filling slices is carried out at 60-80° C., and the air humidity is kept less than 10%.

[0036] The present invention provides a bone-buying tablet rich in Inula japonicae and a preparation method thereof, which has the following beneficial effects:

[0037] 1. The present invention uses yak bone collagen peptide and enzymatic bone powder as the main components of bone supplement tablets, wherein yak bone collagen peptide is obtained by high-temperature boiling of yak bones to obtain bone glue, and then enzymatic hydrolysis is performed using alkaline protease, the enzymatic hydrolysis time is controlled at 4-6 hours, and the enzymatic hydrolysis temperature is 45-55°C to obtain a small molecule peptide with a molecular weight of 1000-3000 Daltons; enzymatic bone powder is prepared by enzymatic hydrolysis and spray drying process after removing fat, blood and impurities from yak bones, and has a high calcium content and collagen content. This technical solution significantly improves the bioavailability of calcium and collagen, and effectively enhances the density and strength of bones. Unlike ordinary bone powder and ordinary collagen used in the prior art, the bone powder in the prior art has a large molecular weight and a low absorption rate, which limits the absorption and utilization of calcium and collagen by the human body. The present invention solves the problem that ordinary bone powder is difficult to be absorbed by the human body by adopting enzymatic hydrolysis technology, and realizes the excellent performance of bone care products in enhancing bone density and promoting bone cell regeneration.

[0038] 2. The present invention introduces Inula oblongata as an active ingredient, and performs soaking, distillation extraction and vacuum drying on it. The process involves soaking at 25-30°C for 3-5 hours to extract the active ingredients in Inula oblongata, followed by distillation extraction at 100-120°C for 6-8 hours, and finally preparing the extract into a light brown powder by vacuum drying at 40-50°C. Through this precisely controlled extraction process, the present invention retains the key active ingredients in Inula oblongata and enhances its anti-inflammatory, analgesic and immunomodulatory effects. Compared with the prior art that directly uses untreated plant powder or simple extracts, the present invention solves the problems of high impurity content and easy degradation of active ingredients in existing extracts by introducing distillation extraction and vacuum drying technology, thereby effectively improving the stability and efficacy of Inula oblongata in bone-boosting tablets.

[0039] 3. The bone-replenishing tablets of the present invention adopt a scientific ratio of multiple traditional Chinese medicine ingredients, including galangal, chrysanthemum and notoginseng powder, turmeric, cinnamon powder, etc. These ingredients are washed, sliced, dried and crushed, and the drying temperature, time and powder particle size are strictly controlled to give full play to their effective ingredients. Galangal has the effects of warming the middle and relieving pain, promoting blood circulation and removing blood stasis, chrysanthemum and notoginseng powder has the effect of promoting blood circulation and relieving pain, and turmeric and cinnamon powder have the functions of anti-inflammatory and enhancing blood circulation. Through reasonable formula design, the present invention achieves the comprehensive effect of gently promoting bone health, preventing osteoporosis and improving joint inflammation. Compared with the bone-replenishing products with single or small amounts of ingredients in the prior art, the multiple Chinese medicine ingredients of the present invention complement each other, solve the shortcomings of the existing products with single efficacy and inability to fully act on bone health problems, and significantly improve the overall efficacy of the product.

[0040] 4. The present invention adopts strictly controlled key process parameters such as temperature, humidity and tableting pressure during the preparation process to ensure the uniformity and stability of the bone-filling tablets. During the initial mixing, the present invention is carried out in an environment of 20-30°C, the humidity is controlled at 10%-15%, and the stirring time is 45-60 minutes, thereby ensuring the full mixing of the components. Subsequently, magnesium stearate is added as a lubricant to ensure that the tablets have good fluidity and anti-adhesion during the tableting process, the tableting pressure is controlled at 8-12 MPa, and the tablets are dried for 4-8 hours at 60-80°C to have ideal hardness and stability. Compared with the problem in the prior art that the process conditions are not strictly controlled, resulting in the tablets being prone to unevenness, insufficient hardness or fragmentation, the present invention solves the consistency problem in the production process through precise process control, ensures the appearance, formability and stability of the bone-filling tablets, and greatly improves the quality and production efficiency of the product. BRIEF DESCRIPTION OF THE DRAWINGS

[0041] Figure 1The present invention is a flow chart of the preparation method of bone-bucking tablets rich in Inula japonica var. DETAILED DESCRIPTION

[0042] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0043] Please see attached Figure 1 :

[0044] Embodiment 1:

[0045] Formula (by weight percentage):

[0046] Yak collagen peptide: 25%

[0047] Enzymatic bone meal: 20%

[0048] Inula japonica: 8%

[0049] Galangal: 8%

[0050] Chrysanthemum procumbentum powder: 5%

[0051] Cinnamon powder: 10%

[0052] Turmeric: 10%

[0053] Black snake: 8%

[0054] Organic selenium oyster mushroom powder: 4%

[0055] Magnesium stearate: 1%

[0056] Preparation process:

[0057] Raw material mixing: Yak bone collagen peptide, enzymatic bone powder, Inula japonica, Alpinia officinalis, Panax notoginseng powder, cinnamon powder, turmeric, snakehead, organic selenium oyster mushroom powder are preliminarily mixed in proportion. The mixing conditions are: temperature 20-25℃, humidity 10%-12%, stirring time 50 minutes to ensure uniform distribution of ingredients.

[0058] Lubricant addition: Add 1% magnesium stearate to the mixture and stir evenly for 20 minutes to ensure that the lubricant is evenly distributed to avoid sticking during tablet compression.

[0059] Tableting: The mixture is fed into a tablet press, the tableting pressure is controlled at 10 MPa, and tablets are obtained after tableting.

[0060] Drying: The obtained tablets were dried at 70°C for 6 hours with the air humidity controlled at 8%.

[0061] Summary of the embodiment: Under this formula and process conditions, the obtained bone-replenishing tablets have good formability and hardness, the tablets are uniform, and the absorption rate of the ingredients is high. By precisely controlling the ratio of yak bone collagen peptides and enzymatic bone powder, combined with Inula japonica and other Chinese medicinal ingredients, the calcium absorption rate and anti-inflammatory and analgesic effects of the product are significantly improved. The drying and tableting process parameters also ensure the stability of the product.

[0062] Embodiment 2:

[0063] Formula (by weight percentage):

[0064] Yak collagen peptide: 18%

[0065] Enzymatic bone meal: 14%

[0066] Inula japonica: 4%

[0067] Galangal: 4%

[0068] Chrysanthemum procumbentum powder: 2%

[0069] Cinnamon powder: 6%

[0070] Turmeric: 6%

[0071] Black snake: 4%

[0072] Organic selenium oyster mushroom powder: 1%

[0073] Magnesium stearate: 0.5%

[0074] Preparation process:

[0075] Raw material mixing: Yak bone collagen peptide, enzymatic bone powder, Inula obtusifolia, Alpinia officinalis, Panax notoginseng powder, cinnamon powder, turmeric, snakehead, and organic selenium oyster mushroom powder were preliminarily mixed in proportion. The mixing conditions were: temperature 18°C, humidity 8%, and stirring time 40 minutes. Short stirring time reduced the uniformity of the ingredients.

[0076] Lubricant addition: Add 0.5% magnesium stearate and stir evenly for 15 minutes.

[0077] Tabletting: The mixture is fed into the tablet press and the tableting pressure is controlled at 6 MPa, which is on the low side.

[0078] Drying: The obtained tablets were dried at 60°C for 4 hours with the air humidity controlled at 12%.

[0079] Summary of the examples: When the content of ingredients and process parameters are low, the hardness and formability of the obtained bone-filling tablets are poor, the tablets are easily broken, and due to the low content of yak bone collagen peptides and enzymatic bone powder, the calcium absorption rate is significantly reduced, and the efficacy is not as good as Example 1. At the same time, due to the low content of Inula japonica, the anti-inflammatory and analgesic effects of the tablets are weakened. Insufficient control of process conditions leads to poor tablet stability.

[0080] Example 3: Examples of innovative components higher than the range values ​​and examples of parameters in the preparation process higher than the range values

[0081] Formula (by weight percentage):

[0082] Yak collagen peptide: 32%

[0083] Enzymatic bone meal: 27%

[0084] Inula japonica: 12%

[0085] Galangal: 12%

[0086] Chrysanthemum procumbentum powder: 8%

[0087] Cinnamon powder: 13%

[0088] Turmeric: 13%

[0089] Black snake: 12%

[0090] Organic selenium oyster mushroom powder: 6%

[0091] Magnesium stearate: 2%

[0092] Preparation process:

[0093] Raw material mixing: Yak collagen peptide, enzymatic bone powder, Inula japonica, Alpinia officinalis, Panax notoginseng powder, cinnamon powder, turmeric, snakehead, and organic selenium oyster mushroom powder are preliminarily mixed in proportion. The mixing conditions are: temperature 28°C, humidity 14%, stirring time 60 minutes, stirring time too long will easily lead to degradation of some ingredients.

[0094] Lubricant addition: Add 2% magnesium stearate and stir evenly for 25 minutes. Excessive lubricant may affect tableting.

[0095] Tableting: The mixture is fed into the tablet press and the tableting pressure is controlled at 14 MPa. The higher the pressure, the greater the density of the tablet.

[0096] Drying: The obtained tablets were dried at 80°C for 8 hours with the air humidity controlled at 5%.

[0097] Summary of Examples: Although the ingredients and process parameters in this example are higher than the range, the high content of yak collagen peptides and enzymatic bone powder makes the tablets too compact, which affects the bioavailability. In addition, the high temperature drying time is too long, which may cause some active ingredients to degrade and reduce the efficacy. Although the hardness of the tablets is good, the absorption rate and stability fail to achieve the best effect. Comparative Example 1:

[0098] Comparative example formula (by weight percentage):

[0099] Enzymatic bone meal: 30%

[0100] Inula: 10%

[0101] Galangal: 10%

[0102] Chrysanthemum procumbentum powder: 7%

[0103] Cinnamon powder: 12%

[0104] Turmeric: 12%

[0105] Black snake: 10%

[0106] Organic selenium oyster mushroom powder: 5%

[0107] Magnesium stearate: 2%

[0108] Preparation process:

[0109] Raw material mixing: Enzymatic bone powder, Inula obliquus, Alpinia officinalis, Glehnia littoralis powder, Cinnamon bark powder, Turmeric, Snakehead snake, and Organic selenium Pleurotus ostreatus powder are mixed in proportion. The mixing conditions are: temperature 25°C, humidity controlled at 15%, and stirring time 40 minutes.

[0110] Lubricant Addition: Add magnesium stearate to the mixture and continue mixing for 10 minutes to ensure even distribution.

[0111] Tablet compression: The tablet press pressure was set to 7 MPa and the tablet weight was controlled at 500 mg for tablet compression.

[0112] Drying: The tablets were dried at 60°C for 4 hours with the air humidity maintained at 15%.

[0113] Comparison results: Although the formula lacking yak bone collagen peptides contains enzymatic bone powder, its calcium absorption rate is significantly reduced due to the lack of small molecule collagen. The absorption of collagen and calcium depends on peptides with smaller molecular weights. The lack of yak bone collagen peptides makes the tablet less effective in enhancing bone density.

[0114] Experimental data:

[0115] project Comparative Example 1 Example 1 Calcium absorption rate (%) 52 85 Collagen absorption rate (%) 40 78 <![CDATA[Tablet hardness (kg / cm 2 )]]> 3.5 6.0 Bone density improvement (%) 10 35 Bioavailability (%) 50 85

[0116] Comparative Example 2:

[0117] Comparative example formula (by weight percentage):

[0118] Yak collagen peptide: 25%

[0119] Enzymatic bone meal: 20%

[0120] Galangal: 10%

[0121] Chrysanthemum procumbentum powder: 5%

[0122] Cinnamon powder: 10%

[0123] Turmeric: 10%

[0124] Black snake: 8%

[0125] Organic selenium oyster mushroom powder: 5%

[0126] Magnesium stearate: 2%

[0127] Preparation process:

[0128] Raw material mixing: Yak bone collagen peptide, enzymatic bone powder, galangal, chrysanthemum notoginseng powder, cinnamon powder, turmeric, black snake, organic selenium oyster mushroom powder are mixed in proportion. The mixing conditions are: temperature is 20℃, humidity is controlled at 10%, and stirring time is 45 minutes.

[0129] Lubricant Addition: Add magnesium stearate to the mixture and continue mixing for 10 minutes to ensure even distribution of the lubricant.

[0130] Tabletting: The tableting pressure was set to 8 MPa and the tablet weight was controlled at 500 mg for tableting.

[0131] Drying: The tablets were dried at 70°C for 6 hours with the air humidity controlled at 10%.

[0132] Comparison results: Due to the lack of Inula oblongata, the tablets of this comparative example are significantly inferior to the examples of the present invention in terms of anti-inflammatory, analgesic and immunomodulatory effects. Inula oblongata extract contains a variety of active ingredients that can effectively reduce inflammatory reactions and improve immunity. The lack of this ingredient reduces the overall efficacy of the tablets.

[0133] Experimental data:

[0134] project Comparative Example 2 Example 1 Anti-inflammatory effect (% reduction in inflammatory markers) 35 70 Analgesic effect (pain reduction %) 25 65 Immunomodulatory ability (%) 20 60 Drug stability (%) 50 92 Bioavailability (%) 55 85

[0135] Comparative Example 3:

[0136] Comparative Example Formula (by weight percentage, the same as Example 1):

[0137] Yak collagen peptide: 25%

[0138] Enzymatic bone meal: 20%

[0139] Inula japonica: 8%

[0140] Galangal: 8%

[0141] Chrysanthemum procumbentum powder: 5%

[0142] Cinnamon powder: 10%

[0143] Turmeric: 10%

[0144] Black snake: 8%

[0145] Organic selenium oyster mushroom powder: 4%

[0146] Magnesium stearate: 1%

[0147] Preparation process:

[0148] Raw material mixing: Yak bone collagen peptide, enzymatic bone powder, Inula japonica, Alpinia officinalis, Panax notoginseng powder, cinnamon powder, turmeric, snakehead, and organic selenium oyster mushroom powder were mixed in proportion. The mixing conditions were: temperature of 15°C, humidity controlled at 20%, and stirring time of 30 minutes. The time was too short and the ingredients were not fully mixed.

[0149] Lubricant addition: Magnesium stearate was added to the mixture with a stirring time of 10 minutes. The lubricant was not evenly distributed.

[0150] Tablet pressing: The tablet press pressure was set at 5 MPa, resulting in poor tablet formability and insufficient hardness.

[0151] Drying: The tablets were dried at 40°C for 3 hours with the air humidity maintained at 20%.

[0152] Comparison results: The tablets of this comparative example are not hard enough and are easy to break due to improper process control, uneven mixing, insufficient tableting pressure, and poor drying conditions. At the same time, the distribution of ingredients in the tablets is uneven, and the drug efficacy stability is poor.

[0153] Experimental data:

[0154] project Comparative Example 3 Example 1 <![CDATA[Tablet hardness (kg / cm 2 )]]> 3.0 6.0 Tablet uniformity (%) 60 95 Stability (% activity retention during shelf life) 40 85 Production qualification rate (%) 50 98

[0155] Summarize:

[0156] The following conclusions can be drawn from the experimental data of three comparative examples:

[0157] Comparative Example 1: Due to the lack of yak bone collagen peptide, the calcium absorption rate is significantly reduced and the bone density improvement effect is poor, indicating that yak bone collagen peptide is crucial in improving bioavailability and bone strength.

[0158] Comparative Example 2: The lack of Inula japonica resulted in a significant decrease in anti-inflammatory, analgesic and immunomodulatory effects, indicating that the active ingredients of Inula japonica are indispensable in terms of efficacy stability and anti-inflammatory effects.

[0159] Comparative Example 3: Improper control of parameters in the preparation process (mixing, tableting and drying conditions) resulted in poor tablet hardness, uniformity and stability, proving that precise process control is critical to tablet consistency and quality.

[0160] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A bone-buying tablet rich in Inula japonica, characterized in that: The bone-replenishing tablet contains the following components in percentage by weight: Yak collagen peptide: 20%-30%, Enzymatic bone meal: 15%-25%, Inula japonica: 5%-10%, Galangal: 5%-10%, Chrysanthemum procumbentum powder: 3%-7%, Cinnamon powder: 8%-12%, Turmeric: 8%-12%, Black-necked snake: 5%-10%, Organic selenium oyster mushroom powder: 1%-5%, Magnesium stearate: 0.5%-2%.

2. The bone-buying tablet rich in Inula japonicae according to claim 1, characterized in that: The yak bone collagen peptide is obtained by high-temperature boiling of yak bones, and then enzymatically hydrolyzing the yak bones with alkaline protease. The enzymatic hydrolysis time is controlled at 4-6 hours and the enzymatic hydrolysis temperature is 45-55°C, and finally a small molecule peptide with a molecular weight of 1000-3000 Daltons is obtained. The obtained yak bone collagen peptide is in the form of white powder.

3. The bone-buying tablet rich in Inula japonicae according to claim 1, characterized in that: The enzymatic bone powder is prepared by removing fat, blood and impurities from the surface of yak bones, and then crushing the yak bones to a particle size of 40-80 meshes. The bones are then enzymatically hydrolyzed using trypsin or chymosin at a temperature of 50-60°C for 3-5 hours. The enzymatic bone powder is then obtained by a spray drying process. The enzymatic bone powder is white or light yellow powder.

4. The bone-buxing tablet rich in Inula japonicae according to claim 1, characterized in that: The Inula oblongata flower is subjected to extraction and drying treatments, wherein the extraction step comprises soaking the Inula oblongata flower in clean water for 3-5 hours at a soaking temperature of 25-30°C, then distilling the Inula oblongata flower using a distillation device for 6-8 hours at an extraction temperature of 100-120°C, and drying the obtained extract by vacuum drying at 40-50°C for 6-10 hours. The obtained Inula oblongata flower extract is a light brown powder.

5. The bone-buying tablet rich in Inula japonicae according to claim 1, characterized in that: The galangal is cleaned, sliced, dried and crushed, the drying condition is 50-60° C., the drying time is 8-12 hours, the particle size of the obtained galangal powder is controlled between 80-120 meshes, and the galangal powder is light yellow.

6. The method for preparing the bone-bucking tablets rich in Inula japonicae according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) Preliminarily mix yak bone collagen peptide, enzymatic bone powder, Inula japonica, Alpinia officinalis, Glehnia littoralis powder, cinnamon powder, turmeric, snakehead, and organic selenium Pleurotus ostreatus powder according to a certain proportion; (2) stirring the mixture in step (1) uniformly at a temperature of 20-30° C. and a humidity of 10%-15% for 45-60 minutes; (3) adding magnesium stearate as a lubricant to the mixture in step (2), and continuing to stir evenly for 15-20 minutes; (4) feeding the mixture in step (3) into a tablet press at a tabletting pressure of 8-12 MPa to form tablets; (5) Drying the obtained tablets at a temperature of 60-80° C. for 4-8 hours to obtain the final bone-replenishing tablets.

7. The method for preparing a bone-bucking tablet rich in Inula japonicae according to claim 6, characterized in that: The Inula japonica flower in step (1) is preliminarily treated by distillation extraction at a temperature of 100-120° C. for 3-4 hours, after which the extract is mixed with the remaining ingredients.

8. The method for preparing a bone-bucking tablet rich in Inula japonicae according to claim 6, characterized in that: The drying process of the bone-buying slices is carried out at 60-80° C., and the air humidity is kept less than 10%.

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