Process for loading benzalkonium chloride on dressing pad

Abstract

The invention relates to the technical field of dressing preparation, and discloses a process for loading benzalkonium chloride on a dressing pad, which comprises the following specific steps: step 1, proportioning dextran according to a ratio of 1: 3, then stirring for 2 hours at 60 DEG C by using a shear type emulsifying machine so that the dextran and the benzalkonium chloride are uniformly mixed to form 100g / L water, then distilling and concentrating under reduced pressure at 45-65 DEG C to form a concentrating agent, then the concentrated solution is poured into a mold with a Teflon anti-sticking coating to be coated into a film, the thickness of the Teflon anti-sticking coating is 45 + / -5 microns, the coated mold is put into a vacuum oven to be baked for 3 hours at the temperature of 60 DEG C, and a glucan film is obtained for standby application after demolding; according to the preparation method, the loading capacity of the BZK in the dressing pad can be remarkably improved, the loading capacity is ensured to reach an expected target value, the stability of the BZK is greatly improved, the retention time of the BZK in the dressing pad is prolonged, the antibacterial property is lasting and effective, the biocompatibility reaches an excellent level, and no irritant and toxic reaction is ensured when the dressing pad is in contact with a human body.

Description

Technical Field

[0001] The invention relates to the technical field of dressing preparation, in particular to a process for loading benzalkonium chloride on a dressing pad. Background Art

[0002] Abroad, the process research of dressing pads loaded with benzalkonium chloride (BZK) has made significant progress. Many well-known medical companies and scientific research institutions have invested a lot of resources in in-depth research and have accumulated rich experience in BZK loading technology, stability control, and antibacterial effect evaluation. They use advanced materials and processes to accurately control the loading amount and distribution uniformity of BZK in the dressing pad, thereby ensuring that the dressing pad has stable and efficient antibacterial properties. In addition, foreign countries also focus on the development of dressing pads with special functions, such as smart responsive dressing pads, which can automatically adjust the release rate of BZK according to environmental changes in the wound to improve the treatment effect. At the same time, they have also carried out rigorous testing and evaluation on the safety and biocompatibility of dressing pads to ensure that the product is harmless to the human body. In China, with the continuous improvement of medical standards and increasingly stringent requirements for wound care, the process research of dressing pads loaded with BZK has gradually received attention.

[0003] However, the existing dressing pads loaded with BZK still have certain defects in preparation, such as the low loading efficiency and stability of BZK, and the poor overall antibacterial effect of the dressing pads. Summary of the invention

[0004] The purpose of the present invention is to provide a process for loading benzalkonium chloride on a dressing pad, which solves the problems raised in the background technology.

[0005] The present application embodiment provides a process for loading benzalkonium chloride on a dressing pad, and the specific steps are as follows:

[0006] Step 1, mix dextran in a ratio of 1:3, and then stir it with a shear emulsifier at 60°C for 2 hours to make it mixed with 100g / L water, and then distill and concentrate under reduced pressure to form a concentrate at 45-65°C, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to form a film, the Teflon anti-stick coating has a coating thickness of 45±5μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, a dextran film is obtained for standby use;

[0007] Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use;

[0008] Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use;

[0009] Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use;

[0010] Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution;

[0011] Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride;

[0012] Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

[0013] Optionally, the relative molecular mass of the dextran aqueous solution in step 1 is 5000-7500.

[0014] Optionally, the mass ratio of the raw materials in step three is: 5-10 parts of cetylpyridinium chloride: 30-40 parts of phenoxyethanol: 30-35 parts of glycerol: 10-18 parts of benzalkonium chloride: 6-11 parts of chamomile extract: 10-16 parts of olive oil: 0.5-0.8 parts of citric acid: 100-150 parts of deionized water.

[0015] Optionally, the BZK solid powder and the benzalkonium chloride powder are both precisely weighed by a precision electronic balance.

[0016] Optionally, the antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution are mixed and stirred by a liquid mixer.

[0017] Optionally, the specific steps of the three-step soak drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soak drying, first immersing the Tiancan silk as the matrix in the antibacterial and antiviral liquid, and drying it once after taking it out; the second soak drying, then immersing the Tiancan silk after the first drying in the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soak drying, then immersing the Tiancan silk after the second drying in the BZK solution, and drying it three times after taking it out.

[0018] Optionally, the first drying, the second drying and the third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

[0019] Optionally, the performance testing machine in step six is ​​a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester, and a professional water absorption tester.

[0020] Compared with the prior art, the technical solution of this application has the following beneficial effects:

[0021] First, the present invention can significantly increase the loading amount of BZK in the dressing pad, ensure that the loading amount reaches the expected target value, and greatly improve its stability, so that the retention time of BZK in the dressing pad is prolonged, and the antibacterial performance is long-lasting and effective. Then, the various properties of the dressing pad can be optimized to make its air permeability reach a specific standard, ensure that the wound can breathe, and avoid the risk of infection caused by the hot and humid environment; the water absorption is improved to a certain level, and it can quickly absorb wound exudate and keep the wound clean and dry; the biocompatibility reaches an excellent level, ensuring that there is no irritation or toxic reaction when in contact with the human body, and providing a safe and comfortable healing environment for the wound. Secondly, the process of the present invention has repeatability and stability, can meet the requirements of large-scale production, and ensure the consistency of product quality, thereby effectively meeting the market's large demand for high-performance antibacterial dressing pads. Thereby, the production cost can be greatly reduced, the production efficiency can be improved, and the production loss can be reduced, so that the product has a stronger cost-effectiveness in the market and enhances the market competitiveness of the product. DETAILED DESCRIPTION

[0022] Example 1

[0023] The present invention provides a technical solution: a process for loading benzalkonium chloride on a dressing pad, and the specific steps are as follows:

[0024] Step 1, mix dextran in a ratio of 1:3, and then stir it at 60°C for 2 hours with a shear emulsifier to make it evenly mixed with 100g / L water, and then distill and concentrate under reduced pressure to form a concentrate at 45°C, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to form a film, the Teflon anti-stick coating has a coating thickness of 45μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, a dextran film is obtained for standby use;

[0025] Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use;

[0026] Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use;

[0027] Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use;

[0028] Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution;

[0029] Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride;

[0030] Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

[0031] Furthermore, the relative molecular mass of the dextran aqueous solution in step 1 is 5000.

[0032] Furthermore, the mass ratio of the raw materials in step three is: 5 parts of cetylpyridinium chloride: 30 parts of phenoxyethanol: 30 parts of glycerol: 10 parts of benzalkonium chloride: 6 parts of chamomile extract: 10 parts of olive oil: 0.5 parts of citric acid: 100 parts of deionized water.

[0033] Furthermore, the BZK solid powder and the benzalkonium chloride powder are both accurately weighed by a precision electronic balance.

[0034] Furthermore, the antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution are mixed and stirred by a liquid mixer.

[0035] Furthermore, the specific steps of the three-step soak drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soak drying, first immersing the Tiancan silk as the matrix in the antibacterial and antiviral liquid, and drying it once after taking it out; the second soak drying, then immersing the Tiancan silk after the first drying in the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soak drying, then immersing the Tiancan silk after the second drying in the BZK solution, and drying it three times after taking it out.

[0036] Furthermore, the first drying, the second drying and the third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

[0037] Furthermore, the performance testing machine in step six is ​​a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester and a professional water absorption tester.

[0038] Example 2

[0039] The present invention provides a technical solution: a process for loading benzalkonium chloride on a dressing pad, and the specific steps are as follows:

[0040] Step 1, mix dextran in a ratio of 1:3, and then stir it at 60°C for 2 hours with a shear emulsifier to make it evenly mixed with 100g / L water, and then distill and concentrate under reduced pressure to form a concentrate at 50°C, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to form a film, the Teflon anti-stick coating has a coating thickness of 46μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, a dextran film is obtained for standby use;

[0041] Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use;

[0042] Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use;

[0043] Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use;

[0044] Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution;

[0045] Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride;

[0046] Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

[0047] Furthermore, the relative molecular mass of the dextran aqueous solution in step 1 is 5500.

[0048] Furthermore, the mass ratio of the raw materials in step three is: 6 parts of cetylpyridinium chloride: 32 parts of phenoxyethanol: 31 parts of glycerol: 12 parts of benzalkonium chloride: 7 parts of chamomile extract: 11 parts of olive oil: 0.55 parts of citric acid: 110 parts of deionized water.

[0049] Furthermore, the BZK solid powder and the benzalkonium chloride powder are both accurately weighed by a precision electronic balance.

[0050] Furthermore, the antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution are mixed and stirred by a liquid mixer.

[0051] Furthermore, the specific steps of the three-step soak drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soak drying, first immersing the Tiancan silk as the matrix in the antibacterial and antiviral liquid, and drying it once after taking it out; the second soak drying, then immersing the Tiancan silk after the first drying in the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soak drying, then immersing the Tiancan silk after the second drying in the BZK solution, and drying it three times after taking it out.

[0052] Furthermore, the first drying, the second drying and the third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

[0053] Furthermore, the performance testing machine in step six is ​​a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester and a professional water absorption tester.

[0054] Example 3

[0055] The present invention provides a technical solution: a process for loading benzalkonium chloride on a dressing pad, and the specific steps are as follows:

[0056] Step 1, mix dextran in a ratio of 1:3, and then stir it at 60°C for 2 hours with a shear emulsifier to make it evenly mixed with 100g / L water, and then distill and concentrate under reduced pressure to form a concentrate at 55°C, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to form a film, the Teflon anti-stick coating has a coating thickness of 47μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, a dextran film is obtained for standby use;

[0057] Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use;

[0058] Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use;

[0059] Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use;

[0060] Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution;

[0061] Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride;

[0062] Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

[0063] Furthermore, the relative molecular mass of the dextran aqueous solution in step 1 is 6000.

[0064] Furthermore, the mass ratio of the raw materials in step three is: 7 parts of cetylpyridinium chloride: 34 parts of phenoxyethanol: 32 parts of glycerol: 14 parts of benzalkonium chloride: 8 parts of chamomile extract: 12 parts of olive oil: 0.6 parts of citric acid: 120 parts of deionized water.

[0065] Furthermore, the BZK solid powder and the benzalkonium chloride powder are both accurately weighed by a precision electronic balance.

[0066] Furthermore, the antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution are mixed and stirred by a liquid mixer.

[0067] Furthermore, the specific steps of the three-step soak drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soak drying, first immersing the Tiancan silk as the matrix in the antibacterial and antiviral liquid, and drying it once after taking it out; the second soak drying, then immersing the Tiancan silk after the first drying in the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soak drying, then immersing the Tiancan silk after the second drying in the BZK solution, and drying it three times after taking it out.

[0068] Furthermore, the first drying, the second drying and the third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

[0069] Furthermore, the performance testing machine in step six is ​​a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester and a professional water absorption tester.

[0070] Example 4

[0071] The present invention provides a technical solution: a process for loading benzalkonium chloride on a dressing pad, and the specific steps are as follows:

[0072] Step 1, mix dextran in a ratio of 1:3, and then stir it with a shear emulsifier at 60°C for 2 hours to mix it into 100g / L water, and then distill and concentrate it under reduced pressure, use 55°C to form a concentrate, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to coat it into a film, the Teflon anti-stick coating has a coating thickness of 48μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, obtain a dextran film for standby use;

[0073] Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use;

[0074] Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use;

[0075] Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use;

[0076] Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution;

[0077] Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride;

[0078] Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

[0079] Furthermore, the relative molecular mass of the dextran aqueous solution in step 1 is 6500.

[0080] Furthermore, the mass ratio of the raw materials in step three is: 58 parts of cetylpyridinium chloride: 36 parts of phenoxyethanol: 33 parts of glycerol: 16 parts of benzalkonium chloride: 9 parts of chamomile extract: 15 parts of olive oil: 0.7 parts of citric acid: 140 parts of deionized water.

[0081] Furthermore, the BZK solid powder and the benzalkonium chloride powder are both accurately weighed by a precision electronic balance.

[0082] Furthermore, the antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution are mixed and stirred by a liquid mixer.

[0083] Furthermore, the specific steps of the three-step soak drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soak drying, first immersing the Tiancan silk as the matrix in the antibacterial and antiviral liquid, and drying it once after taking it out; the second soak drying, then immersing the Tiancan silk after the first drying in the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soak drying, then immersing the Tiancan silk after the second drying in the BZK solution, and drying it three times after taking it out.

[0084] Furthermore, the first drying, the second drying and the third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

[0085] Furthermore, the performance testing machine in step six is ​​a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester and a professional water absorption tester.

[0086] Example 5

[0087] The present invention provides a technical solution: a process for loading benzalkonium chloride on a dressing pad, and the specific steps are as follows:

[0088] Step 1, mix dextran in a ratio of 1:3, and then stir it with a shear emulsifier at 60°C for 2 hours to mix it into 100g / L water, and then distill and concentrate it under reduced pressure, use 55°C to form a concentrate, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to coat it into a film, the Teflon anti-stick coating has a coating thickness of 49μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, obtain a dextran film for standby use;

[0089] Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use;

[0090] Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use;

[0091] Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use;

[0092] Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution;

[0093] Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride;

[0094] Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

[0095] Furthermore, the relative molecular mass of the dextran aqueous solution in step 1 is 7500.

[0096] Furthermore, the mass ratio of the raw materials in step three is: 58 parts of cetylpyridinium chloride: 36 parts of phenoxyethanol: 33 parts of glycerol: 16 parts of benzalkonium chloride: 11 parts of chamomile extract: 15 parts of olive oil: 0.8 parts of citric acid: 150 parts of deionized water.

[0097] Furthermore, the BZK solid powder and the benzalkonium chloride powder are both accurately weighed by a precision electronic balance.

[0098] Furthermore, the antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution are mixed and stirred by a liquid mixer.

[0099] Furthermore, the specific steps of the three-step soak drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soak drying, first immersing the Tiancan silk as the matrix in the antibacterial and antiviral liquid, and drying it once after taking it out; the second soak drying, then immersing the Tiancan silk after the first drying in the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soak drying, then immersing the Tiancan silk after the second drying in the BZK solution, and drying it three times after taking it out.

[0100] Furthermore, the first drying, the second drying and the third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

[0101] Furthermore, the performance testing machine in step six is ​​a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester and a professional water absorption tester.

[0102] The above examples were tested using a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester, and a professional water absorption tester. The results are shown in Table 1:

[0103]

[0104] It can be seen that the present invention can significantly increase the loading amount of BZK in the dressing pad, ensure that the loading amount reaches the expected target value, and greatly improve its stability, so that the retention time of BZK in the dressing pad is prolonged, and the antibacterial performance is long-lasting and effective. Then, the various properties of the dressing pad can be optimized, so that its air permeability reaches a specific standard, ensuring that the wound can breathe and avoiding the risk of infection caused by the hot and humid environment; the water absorption is increased to a certain level, which can quickly absorb wound exudate and keep the wound clean and dry; the biocompatibility reaches an excellent level, ensuring that there is no irritation or toxic reaction when in contact with the human body, and providing a safe and comfortable healing environment for the wound.

Claims

1. A process for loading benzalkonium chloride on a dressing pad, characterized in that: The specific steps are as follows: Step 1, mix dextran in a ratio of 1:3, and then stir it with a shear emulsifier at 60°C for 2 hours to make it mixed with 100g / L water, and then distill and concentrate under reduced pressure to form a concentrate at 45-65°C, and then pour the concentrated solution into a mold with a Teflon anti-stick coating to form a film, the Teflon anti-stick coating has a coating thickness of 45±5μm, and put the coated mold into a vacuum oven at 60°C for 3 hours, and after demoulding, a dextran film is obtained for standby use; Step 2, cetylpyridinium chloride, phenoxyethanol, glycerol, benzalkonium chloride, chamomile extract, olive oil, citric acid, and deionized water are uniformly mixed to prepare an antibacterial and antiviral solution for standby use; Step 3, pour the weighed BZK into an appropriate amount of deionized water to dissolve it to obtain a BZK solution for later use; Step 4, adding benzalkonium chloride powder to deionized water and mixing to obtain benzalkonium chloride antibacterial solution for standby use; Step 5, using silkworm silk as the matrix layer of the dressing pad, and then using a step-by-step laminating machine to cover one side of the dextran film with silkworm silk, and then on the other side through three-step dipping, drying, impregnation and absorption of antibacterial and disinfectant liquid, benzalkonium chloride antibacterial liquid and BZK solution; Step six, performing a performance test on the dressing pad loaded with benzalkonium chloride; Step seven, cutting and packaging the benzalkonium chloride loaded dressing pads that pass the performance test.

2. The process for loading benzalkonium chloride onto a dressing pad according to claim 1, characterized in that: The relative molecular mass of the dextran aqueous solution in the step 1 is 5000-7500.

3. The process for loading benzalkonium chloride onto a dressing pad according to claim 1, characterized in that: The mass ratio of the raw materials in step 3 is: 5-10 parts of cetylpyridinium chloride: 30-40 parts of phenoxyethanol: 30-35 parts of glycerol: 10-18 parts of benzalkonium chloride: 6-11 parts of chamomile extract: 10-16 parts of olive oil: 0.5-0.8 parts of citric acid: 100-150 parts of deionized water.

4. The process for loading benzalkonium chloride onto a dressing pad according to claim 1, characterized in that: The BZK solid powder and the benzalkonium chloride powder are both accurately weighed by a precision electronic balance.

5. The process for loading benzalkonium chloride onto a dressing pad according to claim 1, characterized in that: The antibacterial and disinfectant liquid, the benzalkonium chloride antibacterial liquid and the BZK solution are mixed and stirred by a liquid mixer.

6. The process for loading benzalkonium chloride on a dressing pad according to claim 1, characterized in that: The specific steps of the three-step soaking drying, immersion and adsorption of antibacterial and antiviral liquid, benzalkonium chloride antibacterial liquid and BZK solution in step five are as follows: the first soaking drying, first immersing the silk as the matrix into the antibacterial and antiviral liquid, and drying it once after taking it out; the second soaking drying, then immersing the silk after the first drying into the benzalkonium chloride antibacterial liquid, and drying it twice after taking it out; the third soaking drying, then immersing the silk after the second drying into the BZK solution, and drying it three times after taking it out.

7. A process for loading benzalkonium chloride onto a dressing pad according to claim 6, characterized in that: The first drying, second drying and third drying are all carried out in a constant temperature and humidity drying oven, and the drying temperature is 37°C.

8. The process for loading benzalkonium chloride on a dressing pad according to claim 1, characterized in that: The performance testing machines in step six are a UV-visible spectrophotometer, an intelligent inhibition zone measuring instrument, a scanning electron microscope, a high-performance air permeability tester, and a professional water absorption tester.

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