Fixing device suitable for blood sampling of mouse in waking state

Abstract

The invention relates to a fixing device suitable for blood sampling of a mouse in a waking state. The fixing device is used for solving the problem that an existing mouse blood sampling device easily enables the mouse to generate stress reaction, and the blood sampling quality is affected. The device is at least composed of a mouse fixing cavity, a mouse tail fixing module, a cutting and extruding module and a sample collecting module. Wherein the mouse fixing cavity is used for limiting the body action of the mouse. And the mouse tail fixing module is used for adaptively clamping the tails of the mice with different body types and reserving a tail extrusion blood sampling space. And the cutting and extruding module is used for tail tip cutting and blood sampling extruding. And the sample collection module is used for collecting tail tips and blood samples. The device can reduce the operation pressure of operators and the possibility of blood sample pollution as much as possible, and more importantly, the stress level of mice can be reduced as much as possible in the blood sampling process.

Description

Technical Field

[0001] The present disclosure relates to experimental equipment, and in particular to a mouse blood collection device. Background Art

[0002] At present, manual blood collection consumes manpower, collects a small amount of blood, is easily contaminated, and there is also the risk of being bitten and scratched by mice. Similarly, when mice are artificially fixed for blood collection, their stress state will have a great impact on the evaluation of their true stress level in the experiment. There are various fixation devices for mouse blood collection, but most of them focus on solving the problem of mouse fixation, reducing manpower and the risk of mouse bites, or increasing the amount of blood collected and reducing the time of blood collection by means such as water baths. It is not concerned that mice will be stressed during the fixation process, thereby affecting the content of stress-related substances such as corticosterone in mouse blood samples, and will also affect the changes in the secretion of other substances. Most of the existing fixation devices place the mouse torso in a small space (centrifuge tube) or fix the mouse limbs. This fixation method will cause mice to have a strong stress response. Summary of the invention

[0003] Based on this, the purpose of the present disclosure is to propose a fixing device suitable for blood collection in a mouse in an awake state, which can reduce the operating pressure of the operator and the possibility of blood sample contamination as much as possible, and more importantly, can reduce the stress level of the mouse as much as possible during the blood collection process. The specific technical solution is as follows.

[0004] A fixing device suitable for blood sampling in a mouse in a conscious state, the device comprising a mouse restraining cavity (1), a mouse tail fixing module, a cutting and squeezing module, and a sample collection module; the mouse restraining cavity is red and translucent, a temperature-controlled heating pad and a food / bite stick placement plate (3) are provided at the bottom of the cavity, and a tail plate (17) of the cavity places the mouse trunk in an independent space; the mouse tail fixing module comprises a tail root fixing component and a tail fixing component, the tail root fixing component is located on the tail plate (17) and is used to fix and clamp the mouse tail root passing through a hole in the tail plate (17), and the exposed part of the mouse tail is fixed using the tail fixing component, the tail fixing component comprises a placement slot (16) and an extension slot (14), the placement slot (16) has a temperature-controlled heating pad (13), and the extension slot (14) is used to position the mouse tail according to the different lengths of the mouse tail. Fine adjustment; the cutting and squeezing module comprises an electric cutting blade (25) and a mouse tail squeezing component, the mouse tail squeezing component comprises an electric squeezing chute (26), a squeezing arm (27), an electric squeezing slider (28), a telescopic arm (29), and an squeezing groove (30), a replaceable alcohol cotton is attached to the squeezing groove, and the squeezing groove is adjusted to be close to the mouse tail by the telescopic arm (29), the telescopic arm (29) is located in the middle of the squeezing arm (27), the squeezing arm (27) is straddled on the telescopic arm (29), and the lower ends of the two arms of the squeezing arm (27) are the electric squeezing sliders (28), after the electric cutting blade (25) cuts the mouse tail tip, the electric squeezing slider (28) reciprocates on the electric squeezing chute (26), so that the squeezing groove (30) is close to the mouse and reciprocates to achieve squeezing blood collection; the sample collection module is used to collect the tail tip and blood sample.

[0005] In one embodiment of the above technical solution, absorbent cotton or an odor trough is arranged in the mouse restraint cavity.

[0006] In one embodiment of the above technical solution, a temperature sensor is also provided at the bottom of the mouse restraint cavity.

[0007] In one embodiment of the above technical solution, the mouse restraint cavity has a breathable plate (2).

[0008] In one embodiment of the above technical solution, the tail base fixing component includes a slide groove (18), a tail base fixing slider (19) and a clamping groove (20), and by adjusting the position of the tail base fixing slider (19), the clamping groove (20) can be closely attached to the mouse tail base passing through the hole on the tail plate (17).

[0009] In one implementation of the above technical solution, the groove surface of the concave groove of the clamping groove (20) has anti-slip properties.

[0010] In one embodiment of the above technical solution, the tail fixing component also includes a card slot (22) and a card plate (21), the inner side of the card plate (21) is made of silicone material, and the card slot (22) and the card plate (21) are matched and used to restrain the tail of the mouse placed in the slot (16) and improve the comfort of the mouse.

[0011] In one embodiment of the above technical solution, the fixing device has an anti-slip base (6).

[0012] In one embodiment of the above technical solution, the sample collection module comprises a centrifuge tube rack (12), a rotating table (10), a telescopic table (9), an electric slider (8), and an electric slide trough (7); the centrifuge tube rack (12) has two holes, a blood sample collection hole (23) and a tail tip collection hole (24), and temperature control element semiconductor cooling plates (11) are arranged at the bottom under the two holes; the centrifuge tube rack (12) is located on the rotating table (10), and the blood sample collection hole (23) can be changed by rotating the rotating table (10). ) and the tail tip collection hole (24); the rotating platform (10) is located on the telescopic platform (9), and the heights of the blood sample collection hole (23) and the tail tip collection hole (24) are adjusted by the telescopic platform (9); under the telescopic platform (9) is an electric slider (8), and the positions of the blood sample collection hole (23) and the tail tip collection hole (24) can be adjusted horizontally by the cooperation of the electric slider (8) and the electric slide (7), so that the tail tip collection hole (24) or the blood sample collection hole (23) is just located below the tail tip.

[0013] In one embodiment of the above technical solution, the electric cutting blade (25) is anchored to the extension slot (14). Beneficial technical effects of the technical solution disclosed herein:

[0014] 1. By placing the mouse's torso in an independent space with a translucent red appearance, the risk of being bitten by animals during operation is eliminated; based on the fact that mice lack cones that can perceive red and are insensitive to red, the red appearance can reduce the impact on the mouse's daily rhythm to a certain extent and reduce its stress response, and the translucent appearance makes it easier to observe the animal's condition during operation.

[0015] 2. The mice are in an independent space, their trunks can move freely, and they are given food / bite sticks to reduce the anxiety and stress caused by the device fixation.

[0016] 3. Defatted cotton can be placed in the cavity to increase the comfort of mice in the cavity, or an odor trough can be placed and the bedding of the mice's original living cage can be placed to further reduce the mice's tension and anxiety. However, it needs to be replaced each time it is used to avoid the cotton / bedding that has been used for too long and may cause the mice to become nervous and anxious due to the adhesion of feces from other mice or the penetration of urine and odor.

[0017] 4. The replaceable alcohol cotton on the temperature control component and the mouse squeezing device can fill the blood vessels at the mouse's tail, increase the blood collection volume and reduce the blood collection time.

[0018] 5. According to the length of the mouse's tail, the position of the extension slot can be fine-tuned to an appropriate length (the tail tip is about 0.5m beyond the cutting piece), which is convenient for blood collection from different individuals and multiple blood collections from the same mouse;

[0019] 6. The centrifuge tube rack can be raised, lowered and rotated, and is equipped with a temperature control element. Sampling can be combined with the position of the extension slot to ensure the quality of blood samples and maintain different temperatures for different experimental requirements.

[0020] 7. The device can implement the chain operation of mouse tail tip cutting → mouse tail tip collection → rotating centrifuge tube rack to collect blood → tail squeezing, and can be easily operated automatically by setting a program, thereby reducing manpower and blood sample contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0022] Figure 1 , one A schematic diagram of the front structure of a device embodiment.

[0023] Figure 2 , one A schematic diagram of the structure of the tail root fixing component in an embodiment of the device.

[0024] Figure 3 , one A schematic diagram of a top view structure of a device implementation scheme.

[0025] Figure 4 , one A schematic diagram of the structure of the tail extrusion assembly in an embodiment of the device.

[0026] In the figure: 1 cavity, 2 air permeable plate, 3 placement plate, 4 temperature sensor, 5 display operation screen, 6 anti-slip base, 7 electric slide, 8 electric slider, 9 telescopic table, 10 rotating table, 11 semiconductor cold and hot plate, 12 centrifugal tube rack, 13 temperature control heating pad, 14 extension slot, 15 dust cover, 16 placement slot, 17 tail plate, 18 slide, 19 tail root fixed slider, 20 clamping slot, 21 card plate, 22 card slot, 23 blood sample collection hole, 24 tail tip collection hole, 25 electric cutting blade, 26 extrusion electric slide, 27 extrusion arm, 28 extrusion electric slider, 29 telescopic arm, 30 extrusion slot, DETAILED DESCRIPTION

[0027] Nowadays, in the research related to mouse brain science, it is usually necessary to conduct long-term behavioral training or fixed device adaptation training on mice, and the stress level of mice during training needs to be evaluated, because the experimental data (physiological state, behavioral records, brain activity, etc.) obtained when mice are in a state of stress cannot reflect the true state of mice. The content of stress-related substances such as corticosterone in the blood is an important evaluation indicator. Blood needs to be collected multiple times during the training process of mice to evaluate their stress level. The blood collection process will introduce a new stress state, which will affect the final evaluation of their true stress level.

[0028] Based on this, the present technical solution proposes a fixing device suitable for blood sampling in the awake state of mice, so as to reduce the operating pressure of the operator and reduce the possibility of blood sample contamination as much as possible, and more importantly, it can reduce the stress level of mice as much as possible during the blood sampling process. The device is composed of at least a mouse restraining cavity, a mouse tail fixing module, a cutting and squeezing module, and a sample collection module. The mouse restraining cavity is used to limit the body movements of the mouse, and through the color of the cavity, the design of the placement plate to provide food / bite sticks, a temperature heating pad, and even the arrangement of cotton, the addition of a breathable plate, etc., the mouse's nervous and anxious emotions are attenuated through a comfortable environment. The mouse tail fixing module is used to adapt to the clamping of the tails of mice of different sizes and leave space for tail squeezing and blood sampling. The cutting and squeezing module is used for tail tip cutting and blood sampling squeezing. The sample collection module is used to collect the tail tip and blood samples.

[0029] The following will be combined with the accompanying drawings to clearly and completely describe how to implement the technical solution of this case. Obviously, the described implementation method is only a part of the implementation method of this case, not all of the implementation methods. Based on the implementation method in this case, all other implementation methods obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0030] Figure 1The front structure diagram of the device is shown in FIG. The overall rectangular structure is composed of at least a mouse restraining cavity, a mouse tail fixing module, a cutting and squeezing module, and a sample collection module. There is an anti-slip base (6) under the device to stabilize the device.

[0031] The cavity (1) of the mouse restraint cavity is red in appearance. Since mice lack cone cells that can perceive red and are insensitive to red, the red appearance can reduce the impact on the daily rhythm of mice to a certain extent and reduce their stress response. The translucent appearance makes it easier to observe the animal's condition during operation. After the mouse enters the mouse restraint cavity (1), except for the tail, the rest of the body parts of the mouse are in the cavity (1), and the body trunk can move freely. A temperature-controlled heating pad is provided at the bottom of the cavity to maintain the body temperature of the mouse. A temperature sensor (4) is also provided to monitor the cavity temperature in real time. More importantly, a food / bite bar placement tray (3) is provided to reduce the anxiety and stress caused by the fixation of the device. The bite bar is particularly suitable for mice whose fasting blood sugar is tested.

[0032] A breathable plate (2) is provided on one side of the cavity (1), and a plurality of breathable holes are provided on the breathable plate (2) to prevent the mouse from suffocating in a relatively confined space. In one embodiment, the front plate is a breathable plate (2). The upper plate of the restraining cavity can be opened and closed to facilitate the placement of the mouse. Degreased cotton wool can be arranged in the cavity to increase the comfort of the mouse in the cavity, or an odor trough can be arranged to place the bedding of the mouse's original living cage, further reducing the nervousness and anxiety of the mouse. The bedding needs to be replaced each time it is used to avoid the cotton wool / bedding being used for too long and being adhered to the feces of other mice or permeated with the smell of urine, which may cause the mouse to feel nervous and anxious. The tail plate (17) of the cavity can be pulled up and down and taken out, and when it is put down, the mouse trunk can be placed in an independent space. The tail plate (18) has a hole, and the mouse tail can pass through the hole. That is, the tail plate (17) isolates the tail from the rest of the body to avoid the risk of being bitten by animals during operation.

[0033] The tail of the mouse entering the restraining cavity is clamped and fixed by a mouse tail fixing module, and the mouse tail fixing module at least includes a tail root fixing component and a tail fixing component.

[0034] The tail base fixing assembly is located on the tail board, see Figure 2, the tail root fixing component is at least composed of a slide groove (18), a tail root fixing slider (19) and a clamping groove (20). Specifically, there is a concave slide groove (18) on both sides of the hole through which the mouse tail can pass on the tail plate (17), and a tail root fixing slider (19) matching the slide groove (18) is provided on the slide groove (18), the tail root fixing slider (19) is anchored and slid on the slide groove (18), and the tail root fixing slider (19) is connected to the clamping groove (20). After putting down the tail plate (17), the mouse tail is passed through the hole of the tail plate (17), and the position of the tail root fixing slider (19) is adjusted so that the clamping grooves (20) on both sides are close to the mouse tail root for fixing. The groove surface of the groove of the clamping groove (20) has anti-slip properties. One embodiment is to use an anti-slip silicone material in the groove of the clamping groove (20), which can prevent the mouse from breaking free and will not cause damage to the mouse. The hole on the tail plate can be a semicircular notch, so that the tail of the mouse can be directly caught when the tail plate is lowered.

[0035] For the tail of the mouse, after clamping and fixing it with the tail base fixing component, the exposed part is further fixed with the tail fixing component. Figure 1 and Figure 3 As shown, the tail fixing assembly is composed of at least a mouse tail placement slot (16), a clamping slot (22), a clamping plate (21), and an extension slot (14). First, the exposed tail of the mouse after being clamped and fixed by the tail root fixing assembly is placed in the mouse tail placement slot (16), and the position of the extension slot (14) is adjusted according to the length of the mouse tail. Then, the clamping slot (22) and the clamping plate (21) are matched and used to restrain the mouse tail so that the tail tip is just on the extension slot (14). There are multiple clamping slots and clamping plates, and the selected clamping slot position can be selected according to actual operation, so that the front and rear sections of the mouse tail are fixed, and the middle section leaves space for squeezing blood collection. The inner side of the clamping plate is preferably made of silicone material to prevent the mouse from increasing comfort and preventing the animal from being injured during the restraint process. The placement slot (16) is a semi-concave slot, and the inside of the slot is also made of non-slip silicone material. A temperature-controlled heating pad (13) is also laid under the placement slot (16) to maintain the temperature of the mouse tail tip, activate blood vessels, and facilitate blood collection. The extension slot (14) can be adapted to mice of different sizes by adjusting the position. According to the different lengths of the mouse's tail, the position of the extension slot (14) can be fine-tuned to a suitable length.

[0036] The cutting and squeezing module is configured to cut the tip of the mouse tail and collect blood samples. The cutting and squeezing module includes an electric cutting blade (25) and a mouse tail squeezing assembly. The electric cutting blade (25) can realize rotary cutting from top to bottom, and after the cutting is completed, the cutting blade (25) returns to its original position. The electric cutting blade (25) can be disassembled and cleaned. A blade cover can be provided on the blade of the electric cutting blade (25) to prevent personnel from being accidentally injured during operation, and it should be removed before opening. The electric cutting blade (25) is arranged above the extension slot (14) and anchored to the extension slot (14). The position of the electric cutting blade (25) can be adjusted by adjusting the extension slot (14). When in use, first fine-tune the position of the extension slot (14) to an appropriate length according to the different lengths of the mouse tail, so that the tail tip exceeds the electric cutting blade (25) by about 0.5 mm, which is convenient for blood collection operations of different individuals and multiple blood collections from the same mouse. Blood collection is achieved through the mouse tail squeezing assembly.

[0037] See also Figure 3 and Figure 4 The mouse tail extrusion assembly is composed of at least an extrusion electric slide (26), an extrusion arm (27), an extrusion electric slider (28), a telescopic arm (29), and an extrusion groove (30). The telescopic arm (29) is located in the middle of the extrusion arm (27), and the extrusion arm (27) is across the telescopic arm (29). The lower ends of the two arms of the extrusion arm (27) are connected to the extrusion electric slider (28), and the extrusion arm (27) moves on the extrusion electric slide (26) through the extrusion electric slider (28), and the extrusion electric slide (26) is arranged outside the card slot (22). The extrusion arm (27) plays a supporting role, and the telescopic arm (29) can adjust the position of the extrusion groove (30) to make the extrusion groove (30) as close to the mouse tail as possible. The extrusion groove (30) is attached with a replaceable alcohol cotton, which can further play the role of filling blood vessels, reducing blood collection time, and can also disinfect the mouse tail to prevent blood sample contamination. Then, the electric slide block (28) is squeezed to make a reciprocating motion on the electric slide groove to squeeze and collect blood.

[0038] The sample collection module is used to collect tail tip and blood samples from mice. Figure 1 and Figure 3The sample collection module comprises at least a centrifuge tube rack (12), a rotating table (10), a telescopic table (9), an electric slider (8), and an electric slide groove (7). The centrifuge tube rack (12) is provided with two holes, a blood sample collection hole (23) and a tail tip collection hole (24). The centrifuge tube rack (12) is liftable and rotatable, and the position of the extension groove (14) is combined to perform sampling. Temperature control elements, semiconductor cooling and heating plates (11) are arranged at the bottom of the two holes, and their temperatures can be regulated and different temperatures can be maintained for different experimental requirements to ensure the quality of the blood sample. The position of the centrifuge tube rack is adjusted by the telescopic table, the electric slider, and the electric slide groove, and the rotating table can adjust the positions of the mouse tail tip collection hole (24) and the blood sample collection hole (23) to prevent blood contamination and waste. Specifically, the centrifuge tube rack (12) is located on the rotating table (10), and the positions of the blood sample collection hole (23) and the tail tip collection hole (24) can be changed by rotating the rotating table (10). The rotating platform (10) is located on the telescopic platform (9), and the heights of the blood sample collection hole (23) and the tail tip collection hole (24) are adjusted by the telescopic platform (9). Below the telescopic platform (9) is an electric slider (8), and the positions of the blood sample collection hole (23) and the tail tip collection hole (24) can be adjusted horizontally by the cooperation of the electric slider (8) and the electric slide (7), so that the tail tip collection hole (24) or the blood sample collection hole (23) is just located below the tail tip, so as to collect the tail tip or collect blood.

[0039] During the blood collection process, the device in this case adjusts the mouse tail, cutting and squeezing module, and sample collection module, and can automatically realize the continuous operation of mouse tail tip cutting → mouse tail tip collection → rotating centrifuge tube rack to collect blood → tail squeezing through the program, thereby reducing manpower and blood sample contamination. The program can be built into the device.

[0040] Specifically, after the mouse is restrained, the tail tip is fixed so that it protrudes about 0.5 mm from the cutting blade (27), and the cutting and extrusion module and the sample collection module are adjusted to the corresponding positions. If the electric cutting blade (25) of the cutting and extrusion module has a blade cover, remove it before opening. Close the dust cover (15) to further prevent external contamination during the sampling process. The dust cover (15) can be made of a translucent material to facilitate observation of the blood collection conditions. Start the built-in program on the display operation screen (5). After the program is started, the electric cutting blade (25) will automatically cut the mouse's tail, and the tail tip will fall into the tail tip collection hole (24). After receiving the fallen tail tip, the centrifuge tube rack rotates so that the blood sample collection hole (23) is located below the tail tip at the original position of the tail tip collection hole (24). Then the device automatically adjusts the telescopic arm (29) of the mouse tail squeezing assembly so that the squeezing arm (27) is at a suitable height, and the squeezing electric slider (28) moves back and forth along the squeezing groove (30) to squeeze blood. The blood sampling time can be flexibly set before the program starts, and it automatically stops when the program is completed to complete the blood sampling operation. Open the dust cover (15), put on the blade cover first to prevent accidental injury, and then remove the mouse.

[0041] In summary, the device proposed in the present invention adapts to mice of different sizes for blood collection operations through multiple adjustable components, and utilizes partial automation and other operations to minimize the operating pressure of operators and reduce the possibility of blood sample contamination. More importantly, the device reduces the stress level of mice during the blood collection process as much as possible by changing the appearance of the device and adding food / bite sticks.

[0042] It should be noted that the device disclosed in the present invention is not only suitable for blood sampling from the tail tip of mice, but also suitable for blood sampling and drug administration from the tail vein of mice, and the mouse tissue obtained through the collection hole at the tail tip can also be used for experiments. Blood can be collected from the same mouse multiple times.

[0043] Although the embodiments of the present disclosure are described above in conjunction with the accompanying drawings, the present disclosure is not limited to the above-mentioned specific embodiments and application fields, and the above-mentioned specific embodiments are merely illustrative and instructive, rather than restrictive. A person of ordinary skill in the art can also make many forms under the guidance of this specification and without departing from the scope of protection of the claims of the present disclosure, all of which belong to the scope of protection of the present disclosure.

Claims

1. A fixing device suitable for blood sampling in awake mice, characterized in that: The device comprises a mouse restraining cavity (1), a mouse tail fixing module, a cutting and squeezing module, and a sample collecting module; The mouse restraint cavity is red and translucent, and a temperature-controlled heating pad and a food / bite stick placement plate (3) are provided at the bottom of the cavity. The tail plate (17) of the cavity places the mouse trunk in an independent space; The mouse tail fixing module comprises a tail root fixing component and a tail fixing component. The tail root fixing component is located on the tail plate (17) and is used to fix and clamp the mouse tail root passing through the hole of the tail plate (17). The exposed part of the mouse tail is fixed using the tail fixing component. The tail fixing component comprises a placement groove (16) and an extension groove (14). A temperature-controlled heating pad (13) is provided in the placement groove (16). The extension groove (14) is used to fine-tune the position according to the different lengths of the mouse tail. The cutting and squeezing module comprises an electric cutting blade (25) and a mouse tail squeezing component. The mouse tail squeezing component comprises an electric squeezing chute (26), a squeezing arm (27), an electric squeezing slider (28), a telescopic arm (29), and an squeezing trough (30). A replaceable alcohol cotton is attached to the squeezing trough. The squeezing trough is adjusted to be close to the mouse tail by the telescopic arm (29). The telescopic arm (29) is located in the middle of the squeezing arm (27). The squeezing arm (27) spans the telescopic arm (29). The lower ends of the two arms of the squeezing arm (27) are electric squeezing sliders (28). After the electric cutting blade (25) cuts the tip of the mouse tail, the electric squeezing slider (28) reciprocates on the electric squeezing chute (26), so that the squeezing trough (30) is close to the mouse and reciprocates to realize squeezing blood collection. The sample collection module is used to collect tail tip and blood samples.

2. The device according to claim 1, characterized in that: The mouse restraining cavity is provided with absorbent cotton or a scent groove.

3. The device according to claim 1, characterized in that A temperature sensor is also provided at the bottom of the mouse restraining cavity.

4. The device according to claim 1, characterized in that: The mouse restraint cavity has a gas permeable plate (2).

5. The device according to claim 1, characterized in that: The tail base fixing component comprises a slide groove (18), a tail base fixing slider (19) and a clamping groove (20). By adjusting the position of the tail base fixing slider (19), the clamping groove (20) can be closely attached to the mouse tail base passing through the hole of the tail plate (17).

6. The device according to claim 5, characterized in that: The groove surface of the concave groove of the clamping groove (20) has anti-slip properties.

7. The device according to claim 1, characterized in that: The tail fixing assembly also includes a clamping slot (22) and a clamping plate (21); the inner side of the clamping plate (21) is made of silicone material; the clamping slot (22) and the clamping plate (21) are matched and used to restrain the tail of the mouse placed in the slot (16) and improve the comfort of the mouse.

8. The device according to claim 1, characterized in that: The fixing device has a non-slip base (6).

9. The device according to claim 1, characterized in that: The sample collection module comprises a centrifuge tube rack (12), a rotating table (10), a telescopic table (9), an electric slide block (8), and an electric slide trough (7); The centrifuge tube rack (12) has two holes, a blood sample collection hole (23) and a tail tip collection hole (24), and temperature control element semiconductor cooling and heating plates (11) are arranged at the bottom of the two holes; The centrifuge tube rack (12) is located on the rotating platform (10), and the positions of the blood sample collection hole (23) and the tail tip collection hole (24) can be changed by rotating the rotating platform (10); The rotating platform (10) is located on the telescopic platform (9), and the heights of the blood sample collection hole (23) and the tail tip collection hole (24) are adjusted by the telescopic platform (9); An electric slider (8) is disposed below the telescopic platform (9). The electric slider (8) cooperates with the electric slide groove (7) to horizontally adjust the positions of the blood sample collection hole (23) and the tail tip collection hole (24), so that the tail tip collection hole (24) or the blood sample collection hole (23) is located just below the tail tip.

10. The device according to claim 1, characterized in that: The electric cutting blade (25) is anchored to the extension slot (14).

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