Plant-extracted anti-hair-loss hair-strengthening essence and preparation method thereof

Abstract

The invention relates to plant-extracted anti-hair-loss hair-strengthening essence and a preparation method thereof, and belongs to the technical field of scalp care. The plant-extracted anti-hair loss and hair-strengthening essence is prepared from an anti-hair loss agent A, an anti-hair loss agent B, a composite conditioner, pyrrolidinyl diaminopyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, ethanol, butanediol, a preservative and deionized water. Various plant extracts are added and cooperate with other components to jointly promote blood circulation, nourish scalp and stimulate hair follicle growth, meanwhile, the scalp environment is conditioned, nutrition is provided for scalp and hair roots, the hair roots are strengthened, and therefore the comprehensive effects of preventing hair loss and strengthening hair are achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of scalp care and relates to a plant-based anti-hair loss and health-promoting essence and a preparation method thereof. Background Art

[0002] With the accelerated pace of modern life and the influence of environmental factors, hair loss has become a common problem that troubles people. Factors such as life pressure, bad eating habits, environmental pollution, and frequent perming and dyeing can all cause hair to become fragile, break, and fall out. Consumers are increasingly demanding safe and effective anti-hair loss products.

[0003] Traditional chemical synthetic anti-hair loss products may have some potential side effects, such as causing scalp allergies and irritation. Plant extracts are increasingly favored by consumers due to their natural and mild properties. Based on this, research on plant extracts in the field of anti-hair loss and hair health has continued to deepen in recent years. Summary of the invention

[0004] The purpose of the present invention is to provide a plant-extracted herbal anti-hair loss and hair growth essence and a preparation method thereof. By adding a variety of plant extracts, blood circulation is synergistically promoted, the scalp is nourished, and the growth of hair follicles is stimulated. At the same time, the scalp environment is conditioned to provide nutrition for the scalp and hair roots, and the hair roots are strengthened, thereby achieving a comprehensive effect of preventing hair loss and strengthening hair.

[0005] The purpose of the present invention can be achieved by the following technical solutions:

[0006] The invention discloses a plant extract anti-hair loss and hair health essence. The raw materials of the plant extract anti-hair loss and hair health essence include, by percentage, 3.8-6.2% of an anti-hair loss agent A, 4.5-5.5% of an anti-hair loss agent B, 5.4-6.6% of a composite conditioner, 0.45-0.55% of pyrrolidino diaminopyrimidine oxide, 0.4-0.6% of pyridoxine hydrochloride, 0.11-0.13% of dipotassium glycyrrhizinate, 0.15-0.25% of allantoin, 24-26% of ethanol, 4.9-5.1% of butylene glycol, 0.28-0.32% of a preservative and the balance of deionized water.

[0007] Furthermore, the raw materials of the anti-hair loss agent A include, by percentage, 4-6% of a composite extract, 0.8-1.2% of butylene glycol, 0.4-0.5% of phenoxyethanol, 0.18-0.22% of p-hydroxyacetophenone, 0.03-0.07% of ethylhexylglycerin and the balance of deionized water.

[0008] Further, the composite extract is composed of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Angelica sinensis root extract, Capsicum fruit extract, Zanthoxylum fruit extract, Salvia miltiorrhiza root extract, Ginger root extract, Chuanxiong root extract, Ginseng root extract, Glycyrrhiza glabra root extract, Safflower extract in a weight ratio of

[0009] Composition: 4.4-4.44:8.83-8.89:8.84-8.86:6.6-6.68:6.63-6.65:4.41-4.43:2.62-2.68:2.2-2.24:2.2-2.22:2.18-2.24:0.86-0.9.

[0010] Furthermore, the raw materials of the anti-hair loss agent B include, by percentage, 16-20% of Platycladus orientalis leaf extract, 17-19% of 1,3-propylene glycol, 0.5-0.7% of PEG-40 hydrogenated castor oil, 0.05-0.15% of disodium EDTA and the balance of deionized water.

[0011] Furthermore, the composite conditioning agent is composed of Rehmannia root extract, Sophora flavescens root extract and Channa intestine extract in a mass ratio of 0.8-1:0.85-0.95:0.88-0.92.

[0012] Furthermore, the raw materials of the Rehmannia root extract include, by percentage, 2.2-2.8% Rehmannia root extract, 0.9-1.1% butylene glycol, 0.4-0.5% phenoxyethanol, 0.18-0.22% p-hydroxyacetophenone, 0.03-0.07% ethylhexylglycerin and the balance deionized water.

[0013] Furthermore, the raw materials of the sophora flavescens root extract include, by percentage, 2.4-2.6% of sophora flavescens root extract, 0.8-1.2% of butylene glycol, 0.43-0.47% of phenoxyethanol, 0.1-0.3% of p-hydroxyacetophenone, 0.02-0.08% of ethylhexylglycerin and the balance of deionized water.

[0014] Furthermore, the raw materials of the Channa intestine extract include, by percentage, 2.3-2.7% Channa intestine extract, 0.95-1.05% butylene glycol, 0.44-0.46% phenoxyethanol, 0.15-0.25% p-hydroxyacetophenone, 0.04-0.06% ethylhexylglycerin and the balance deionized water.

[0015] Furthermore, the preparation method of the plant extract anti-hair loss and hair health essence is:

[0016] After preparing the raw materials in proportion, mix 1 / 2 deionized water, ethanol and butanediol evenly, stir at a speed of 80-200 rpm for 10-30 min for use, add the composite conditioner and homogenize once for 1-3 min, then add the anti-hair loss agent A and homogenize twice for 5-7 min, then add the anti-hair loss agent B and homogenize three times for 2-4 min, finally add pyrrolidino diamino pyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, preservative and the remaining deionized water in sequence, homogenize four times for 1-5 min, keep warm for 1 h, sterilize at 120°C for 10 min, cool to room temperature, and obtain the plant extract anti-hair loss and hair care essence.

[0017] Furthermore, the homogenization pressure is 500-800 bar, the temperature of the first homogenization is 34-38°C, the temperature of the second homogenization is 39-41°C, the temperature of the third homogenization is 40-42°C, the temperature of the fourth homogenization is 43-47°C; the insulation temperature is 41-45°C.

[0018] Beneficial effects of the present invention:

[0019] (1) The present invention uses multiple plant extracts to work together to prevent hair loss and strengthen hair from different aspects. Platycladus orientalis leaf extract is present in both anti-hair loss agents A and B, and stimulates hair follicle growth through double protection. On the one hand, the active ingredients in Platycladus orientalis leaf extract can penetrate into the hair follicles, nourish the scalp, and stimulate the metabolism of scalp cells; on the other hand, it can also regulate the oil secretion of the scalp, promote blood circulation of the scalp, and create a good environment for hair growth.

[0020] (2) The anti-hair loss agent A of the present invention also contains a variety of other plant extracts, among which the root extract of Polygonum multiflorum, the root extract of Angelica sinensis, and the root extract of Ginseng ginseng work together to provide rich nutrition for the scalp and hair roots in all directions. The nutrients in the root extract of Polygonum multiflorum can nourish the hair roots, enhance the toughness of the hair roots, and reduce the breakage of hair; the root extract of Angelica sinensis improves the blood circulation of the scalp and delivers nutrients to the hair roots and hair follicles more efficiently; the ginsenosides and other ingredients in the root extract of Ginseng ginseng can stimulate the metabolism of scalp cells and promote hair growth; and the extracts of Capsicum annuum, Zanthoxylum bungeanum, and Prunus mume can promote blood circulation, protect the scalp from inflammation and free radical damage, and further enhance the absorption and effect of other ingredients. The synergistic effect of other anti-hair loss and health-promoting ingredients can better play a role and achieve the effect of anti-hair loss and health-promoting.

[0021] (3) The present invention also adds a composite conditioning agent, namely, Rehmannia root extract, Sophora flavescens root extract and Channa intestine extract. The Rehmannia root extract and Channa intestine extract used have multiple active ingredients, which can regulate the scalp environment, reduce oil secretion, and also have antioxidant effects. The ingredients such as matrine in the Sophora flavescens root extract have antibacterial and anti-inflammatory effects. The three cooperate with the anti-hair loss agent A and the anti-hair loss agent B to jointly regulate the scalp environment, balance the oil secretion of the scalp, prevent excessive oil from clogging the hair follicles, and thus reduce the occurrence of hair loss. At the same time, the antibacterial ingredients in these extracts can inhibit the growth of bacteria and fungi on the scalp, and prevent scalp infection and inflammation. Combined with the plant extracts in the anti-hair loss agent, they jointly create a healthy scalp environment for hair growth and synergistically exert the effects of anti-hair loss and hair health. DETAILED DESCRIPTION

[0022] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0023] The Platycladus orientalis leaf extracts in all the embodiments and comparative examples of the present invention are directly purchased from the market, and are all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; the Polygonum multiflorum root extracts are directly purchased from the market, and are all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; the Angelica sinensis root extracts are directly purchased from the market, and are all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; the pepper fruit extracts are directly purchased from the market, and are all purchased from Shaanxi Xiazhou Biotechnology Co., Ltd.; the Zanthoxylum fruit extracts are directly purchased from the market, and are all purchased from Shaanxi Bolin Biotechnology Co., Ltd.; the Salvia miltiorrhiza root extracts are directly purchased from the market, and are all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; the ginger root extracts are directly purchased from the market, and are all purchased from Gansu Yishengxiang Biotechnology Co., Ltd. Co., Ltd.; Chuanxiong root extracts were all purchased directly from the market, all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; ginseng root extracts were all purchased directly from the market, all purchased from Xi'an Wuling Biotechnology Co., Ltd.; Glycyrrhiza glabra root extracts were all purchased directly from the market, all purchased from Shaanxi Junhe Biotechnology Co., Ltd.; safflower extracts were all purchased directly from the market, all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; Rehmannia glutinosa root extracts were all purchased directly from the market, all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; Sophora flavescens root extracts were all purchased directly from the market, all purchased from Gansu Yishengxiang Biotechnology Co., Ltd.; Channa intestine extracts were all purchased directly from the market, all purchased from Fufeng Snot Biotechnology Co., Ltd.

[0024] Example 1

[0025] A plant extract anti-hair loss and hair health essence. The raw materials of the plant extract anti-hair loss and hair health essence of this embodiment include, by percentage, 3.8% anti-hair loss agent A, 4.5% anti-hair loss agent B, 5.4% composite conditioner, 0.45% pyrrolidino diamino pyrimidine oxide, 0.4% pyridoxine hydrochloride, 0.11% dipotassium glycyrrhizate, 0.15% allantoin, 24% ethanol, 4.9% butylene glycol, 0.28% preservative and the remainder deionized water.

[0026] The raw materials of the anti-hair loss agent A of this embodiment include, by percentage, 4% of the composite extract, 0.8% of butylene glycol, 0.4% of phenoxyethanol, 0.18% of p-hydroxyacetophenone, 0.03% of ethylhexylglycerin and the balance of deionized water.

[0027] The composite extract of this embodiment is composed of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Angelica sinensis root extract, Capsicum fruit extract, Zanthoxylum fruit extract, Salvia miltiorrhiza root extract, Ginger root extract, Ligusticum chuanxiong root extract, Panax ginseng root extract, Glycyrrhiza glabra root extract, and Carthamus tinctorius extract in a mass ratio of 4.4:8.83:8.84:6.6:6.63:4.41:2.62:2.2:2.2:2.18:0.86.

[0028] The raw materials of the anti-hair loss agent B of this embodiment include, by percentage, 16% of Platycladus orientalis leaf extract, 17% of 1,3-propylene glycol, 0.5% of PEG-40 hydrogenated castor oil, 0.05% of disodium EDTA and the balance of deionized water.

[0029] The composite conditioning agent of this embodiment is composed of Rehmannia root extract, Sophora flavescens root extract and Channa intestine extract in a mass ratio of 0.8:0.85:0.88.

[0030] The raw materials of the Rehmannia root extract of this embodiment include, by percentage, 2.2% of Rehmannia root extract, 0.9% of butylene glycol, 0.4% of phenoxyethanol, 0.18% of p-hydroxyacetophenone, 0.03% of ethylhexylglycerin and the balance of deionized water.

[0031] The raw materials of the Sophora flavescens root extract of this embodiment include, by percentage, 2.4% Sophora flavescens root extract, 0.8% butylene glycol, 0.43% phenoxyethanol, 0.1% p-hydroxyacetophenone, 0.02% ethylhexylglycerin and the balance deionized water.

[0032] The raw materials of the Channa intestine extract of this embodiment include, by percentage, 2.3% Channa intestine extract, 0.95% butylene glycol, 0.44% phenoxyethanol, 0.15% p-hydroxyacetophenone, 0.04% ethylhexylglycerin and the balance deionized water.

[0033] The preparation method of the plant extract anti-hair loss and hair-nourishing essence of this embodiment is as follows:

[0034] After preparing the raw materials in proportion, mix 1 / 2 deionized water, ethanol and butanediol evenly, stir at 80 rpm for 10 min for later use, add the composite conditioner and homogenize once for 1 min, then add the anti-hair loss agent A and homogenize twice for 5 min, then add the anti-hair loss agent B and homogenize three times for 2 min, finally add pyrrolidinopyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, preservative and the remaining deionized water in sequence, homogenize four times for 1 min, keep warm for 1 h, sterilize at 120°C for 10 min, cool to room temperature, and obtain the plant extract anti-hair loss and hair care essence.

[0035] The raw materials of the preservative in this embodiment include 80% phenoxyethanol, 15% benzoic acid and 5% benzyl alcohol by percentage.

[0036] The homogenization pressure of this embodiment is 500 bar, the temperature of the first homogenization is 34°C, the temperature of the second homogenization is 39°C, the temperature of the third homogenization is 40°C, and the temperature of the fourth homogenization is 43°C; the insulation temperature of this embodiment is 41°C.

[0037] Example 2

[0038] A plant extract anti-hair loss and hair health essence. The raw materials of the plant extract anti-hair loss and hair health essence of this embodiment include, by percentage, 6.2% anti-hair loss agent A, 5.5% anti-hair loss agent B, 6.6% composite conditioner, 0.55% pyrrolidino diamino pyrimidine oxide, 0.6% pyridoxine hydrochloride, 0.13% dipotassium glycyrrhizate, 0.25% allantoin, 26% ethanol, 5.1% butylene glycol, 0.32% preservative and the balance deionized water.

[0039] The raw materials of the anti-hair loss agent A of this embodiment include, by percentage, 6% of the composite extract, 1.2% of butylene glycol, 0.5% of phenoxyethanol, 0.22% of p-hydroxyacetophenone, 0.07% of ethylhexylglycerin and the balance of deionized water.

[0040] The composite extract of this embodiment is composed of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Angelica sinensis root extract, Capsicum fruit extract, Zanthoxylum fruit extract, Salvia miltiorrhiza root extract, Ginger root extract, Ligusticum chuanxiong root extract, Panax ginseng root extract, Glycyrrhiza glabra root extract, and Carthamus tinctorius extract in a mass ratio of 4.44:8.89:8.86:6.68:6.65:4.43:2.68:2.24:2.22:2.24:0.9.

[0041] The raw materials of the anti-hair loss agent B of this embodiment include, by percentage, 20% of Platycladus orientalis leaf extract, 19% of 1,3-propylene glycol, 0.7% of PEG-40 hydrogenated castor oil, 0.15% of disodium EDTA and the balance of deionized water.

[0042] The composite conditioning agent of this embodiment is composed of Rehmannia root extract, Sophora flavescens root extract and Channa intestine extract in a mass ratio of 1:0.95:0.92.

[0043] The raw materials of the Rehmannia root extract of this embodiment include, by percentage, 2.8% of Rehmannia root extract, 1.1% of butylene glycol, 0.5% of phenoxyethanol, 0.22% of p-hydroxyacetophenone, 0.07% of ethylhexylglycerin and the balance of deionized water.

[0044] The raw materials of the Sophora flavescens root extract of this embodiment include, by percentage, 2.6% Sophora flavescens root extract, 1.2% butylene glycol, 0.47% phenoxyethanol, 0.3% p-hydroxyacetophenone, 0.08% ethylhexylglycerin and the balance deionized water.

[0045] The raw materials of the Channa intestine extract of this embodiment include, by percentage, 2.7% Channa intestine extract, 1.05% butylene glycol, 0.46% phenoxyethanol, 0.25% p-hydroxyacetophenone, 0.06% ethylhexylglycerin and the balance deionized water.

[0046] The preparation method of the plant extract anti-hair loss and hair-nourishing essence of this embodiment is as follows:

[0047] After preparing the raw materials in proportion, mix 1 / 2 deionized water, ethanol and butanediol evenly, stir at 200 rpm for 30 minutes for use, add the composite conditioner and homogenize for 3 minutes, then add the anti-hair loss agent A and homogenize for 7 minutes, then add the anti-hair loss agent B and homogenize for 4 minutes, finally add pyrrolidinopyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, preservative and the remaining deionized water in sequence, homogenize for four times for 5 minutes, keep warm for 1 hour, sterilize at 120°C for 10 minutes, cool to room temperature, and obtain the plant extract anti-hair loss and hair care essence.

[0048] The raw materials of the preservative in this embodiment include 80% phenoxyethanol, 15% benzoic acid and 5% benzyl alcohol by percentage.

[0049] The homogenization pressure of this embodiment is 800 bar, the temperature of the first homogenization is 38°C, the temperature of the second homogenization is 41°C, the temperature of the third homogenization is 42°C, and the temperature of the fourth homogenization is 47°C; the insulation temperature of this embodiment is 45°C.

[0050] Example 3

[0051] A plant extract anti-hair loss and hair health essence. The raw materials of the plant extract anti-hair loss and hair health essence of this embodiment include, by percentage, 5% anti-hair loss agent A, 5% anti-hair loss agent B, 6% composite conditioner, 0.5% pyrrolidino diamino pyrimidine oxide, 0.5% pyridoxine hydrochloride, 0.12% dipotassium glycyrrhizinate, 0.2% allantoin, 25% ethanol, 5% butylene glycol, 0.3% preservative and the balance deionized water.

[0052] The raw materials of the anti-hair loss agent A of this embodiment include, by percentage, 5% of the composite extract, 1% of butylene glycol, 0.45% of phenoxyethanol, 0.2% of p-hydroxyacetophenone, 0.05% of ethylhexylglycerin and the balance of deionized water.

[0053] The composite extract of this embodiment is composed of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Angelica sinensis root extract, Capsicum fruit extract, Zanthoxylum fruit extract, Salvia miltiorrhiza root extract, Ginger root extract, Ligusticum chuanxiong root extract, Panax ginseng root extract, Glycyrrhiza glabra root extract, and Carthamus tinctorius extract in a mass ratio of 4.42:8.86:8.85:6.64:6.64:4.42:2.65:2.22:2.21:2.21:0.88.

[0054] The raw materials of the anti-hair loss agent B of this embodiment include, by percentage, 18% of Platycladus orientalis leaf extract, 18% of 1,3-propylene glycol, 0.6% of PEG-40 hydrogenated castor oil, 0.1% of disodium EDTA and the balance of deionized water.

[0055] The composite conditioning agent of this embodiment is composed of Rehmannia root extract, Sophora flavescens root extract and Channa intestine extract in a mass ratio of 0.9:0.9:0.9.

[0056] The raw materials of the Rehmannia root extract of this embodiment include, by percentage, 2.5% Rehmannia root extract, 1% butylene glycol, 0.45% phenoxyethanol, 0.2% p-hydroxyacetophenone, 0.05% ethylhexylglycerin and the balance deionized water.

[0057] The raw materials of the Sophora flavescens root extract of this embodiment include, by percentage, 2.5% Sophora flavescens root extract, 1% butylene glycol, 0.45% phenoxyethanol, 0.2% p-hydroxyacetophenone, 0.05% ethylhexylglycerin and the balance deionized water.

[0058] The raw materials of the Channa intestine extract of this embodiment include, by percentage, 2.5% Channa intestine extract, 1% butylene glycol, 0.45% phenoxyethanol, 0.2% p-hydroxyacetophenone, 0.05% ethylhexylglycerin and the balance deionized water.

[0059] The preparation method of the plant extract anti-hair loss and hair-nourishing essence of this embodiment is as follows:

[0060] After preparing the raw materials in proportion, mix 1 / 2 deionized water, ethanol and butanediol evenly, stir at 140 rpm for 20 min for later use, add the composite conditioner and homogenize for 2 min, then add the anti-hair loss agent A and homogenize for 6 min, then add the anti-hair loss agent B and homogenize for 3 min, finally add pyrrolidinopyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, preservative and the remaining deionized water in sequence, homogenize for four times for 3 min, keep warm for 1 h, sterilize at 120 ° C for 10 min, cool to room temperature, and obtain the plant extract anti-hair loss and hair care essence.

[0061] The raw materials of the preservative in this embodiment include 80% phenoxyethanol, 15% benzoic acid and 5% benzyl alcohol by percentage.

[0062] The homogenization pressure of this embodiment is 650 bar, the temperature of the first homogenization is 36°C, the temperature of the second homogenization is 40°C, the temperature of the third homogenization is 41°C, and the temperature of the fourth homogenization is 45°C; the insulation temperature of this embodiment is 43°C.

[0063] Comparative Example 1

[0064] On the basis of Example 3, the anti-hair loss agent A was removed and replaced with an equal weight of the anti-hair loss agent B, and the other conditions were the same as those in Example 3.

[0065] Comparative Example 2

[0066] On the basis of Example 3, the anti-hair loss agent B was removed and replaced with an equal weight of the composite conditioner, and the other conditions were the same as those in Example 3.

[0067] Comparative Example 3

[0068] On the basis of Example 3, the composite conditioner was removed and replaced with an equal weight of the anti-hair loss agent A, and other conditions were consistent with Example 3.

[0069] Comparative Example 4

[0070] On the basis of Example 3, the Rehmannia root extract in the composite conditioner was removed and replaced with an equal weight of Sophora flavescens extract, and other conditions were consistent with Example 3.

[0071] Comparative Example 5

[0072] On the basis of Example 3, the Sophora flavescens extract in the composite conditioner was removed and replaced with an equal weight of Channa intestine extract, and other conditions were consistent with Example 3.

[0073] Comparative Example 6

[0074] On the basis of Example 3, the Channa intestine extract in the composite extract was removed and replaced with an equal weight of Rehmannia root extract, and other conditions were the same as those in Example 3.

[0075] Comparative Example 7

[0076] On the basis of Example 3, keeping other conditions the same, the preparation method of the plant extract anti-hair loss and hair health serum is changed to:

[0077] After preparing the raw materials in proportion, mix 1 / 2 deionized water, ethanol and butanediol evenly, stir at 140 rpm for 20 min for use, add composite conditioner homogenizer, anti-hair loss agent A, anti-hair loss agent B, pyrrolidino diaminopyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, preservative and the remaining deionized water, homogenize for 14 min, keep warm for 1 h, sterilize at 120 ° C for 10 min, cool to room temperature, and obtain plant extract anti-hair loss and health essence.

[0078] The homogenization pressure of this comparative example is 650 bar, and the homogenization temperature is 45° C.; the insulation temperature of this comparative example is 43° C.

[0079] 1. Patch test

[0080] 45 volunteers with healthy skin were selected, half of them were male and half were female, aged between 20 and 60 years old. All volunteers had no history of skin disease, no known allergy to the test materials, and had not used any drugs or cosmetics that might affect skin reactions for at least 2 weeks before the test.

[0081] The plant extract anti-hair loss and hair health essence prepared in Example 1-3 was used as a sample, 0.02±0.005 of the sample was added dropwise and placed in a spot tester, and attached to the flexor side of the subject's forearm with a low-allergenic tape. The spot tester was removed after 24 hours, and the skin reactions were observed 0.5 hours, 24 hours, and 48 hours after removal. The results were recorded according to the skin reaction grading standard in the "Technical Specification for Safety of Cosmetics" (2015 edition), where the scoring is divided into 0-4 levels, 0 being a negative reaction, and the test results are shown in Table 1.

[0082] Table 1

[0083]

[0084] As can be seen from Table 1, the plant extract anti-hair loss and hair health essence prepared by the present invention has mild ingredients and is safe, and no adverse reactions will occur when used.

[0085] 2. Anti-hair loss efficacy test

[0086] 150 patients with hair loss were selected. The duration of the disease was more than 1 year. The male to female ratio was 7:3. The age ranged from 20 to 60 years old. The selected patients had not used cosmetics with anti-hair loss effects or other products with such effects or hair growth effects in the 3 months before the start of the trial, had not taken or topically used any drugs that affect hair growth in the past 6 months, had curly hair or had received hair transplants, did not suffer from severe androgenic alopecia, alopecia areata, inflammatory cicatricial alopecia or other scalp / hair diseases, and expressed their willingness to participate in the trial and signed a written informed consent before the trial.

[0087] Test product: The plant extract anti-hair loss and hair health essence prepared in Examples 1-3 and Comparative Examples 1-7 of the present invention was used as a test sample, and the patients were randomly divided into 10 groups, and each group of the test samples was coated separately.

[0088] The method of use is: select a 2cm×2cm hair loss area, wash it with clean water, take the sample and apply it directly to the hair loss area, the dosage is 2mL each time, apply it once in the morning and evening every day, take 4 weeks as a course of treatment, use it continuously for 4 courses without interruption in between, and evaluate each group of samples after 1 course of treatment

[0089] The evaluation criteria are: no hair loss and no obvious hair loss at the test site after 60 combings is considered as markedly effective, no obvious hair loss and hair loss (less than 10 hairs) at the test site after 60 combings is considered as effective, and hair loss and hair loss (more than 10 hairs) at the test site after 60 combings is considered as ineffective. The total effective rate (including markedly effective and effective) of each group is calculated, as shown in Table 2 below.

[0090] Table 2

[0091] Total effective rate / % Example 1 93.3 Example 2 93.3 Example 3 100 Comparative Example 1 73.3 Comparative Example 2 60.0 Comparative Example 3 86.7 Comparative Example 4 80.0 Comparative Example 5 86.7 Comparative Example 6 86.7 Comparative Example 7 66.7

[0092] As can be seen from Table 2, the plant extract anti-hair loss and hair health essence prepared in Examples 1-3 of the present invention has an effective rate of more than 90% for anti-hair loss treatment of patients, while Comparative Examples 1-3 adjust the compound combination of anti-hair loss agent A, anti-hair loss agent B and composite conditioner, Comparative Examples 4-6 adjust the compound combination of Rehmannia root extract, Sophora flavescens root extract and Channa intestine extract in the composite conditioner, and Comparative Example 7 changes the preparation steps of the final essence. The total effective rates obtained are not as good as those of Examples 1-3, indicating that the present invention uses a specific combination of multiple plant extracts to synergistically promote blood circulation, nourish the scalp, stimulate hair follicle growth, and regulate the scalp environment to provide nutrition to the scalp and hair roots, and strengthen the hair roots, thereby achieving a comprehensive effect of anti-hair loss and hair health. Any change or replacement of the composition and preparation method in the present invention cannot achieve the effect of the present invention.

[0093] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any indirect modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A plant extract anti-hair loss and hair health serum, characterized by: The raw materials of the plant extract anti-hair loss and hair health essence are calculated by percentage, including 3.8-6.2% of anti-hair loss agent A, 4.5-5.5% of anti-hair loss agent B, 5.4-6.6% of composite conditioner, 0.45-0.55% of pyrrolidino diamino pyrimidine oxide, 0.4-0.6% of pyridoxine hydrochloride, 0.11-0.13% of dipotassium glycyrrhizinate, 0.15-0.25% of allantoin, 24-26% of ethanol, 4.9-5.1% of butylene glycol, 0.28-0.32% of preservative and the balance of deionized water.

2. The plant extract anti-hair loss and hair health serum according to claim 1, characterized in that: The raw materials of the anti-hair loss agent A include, by percentage, 4-6% of a composite extract, 0.8-1.2% of butylene glycol, 0.4-0.5% of phenoxyethanol, 0.18-0.22% of p-hydroxyacetophenone, 0.03-0.07% of ethylhexylglycerin and the balance of deionized water.

3. The plant extract anti-hair loss and hair health serum according to claim 2, characterized in that: The composite extract is composed of Platycladus orientalis leaf extract, Polygonum multiflorum root extract, Angelica sinensis root extract, Capsicum fruit extract, Zanthoxylum fruit extract, Salvia miltiorrhiza root extract, Ginger root extract, Ligusticum chuanxiong root extract, Panax ginseng root extract, Glycyrrhiza glabra root extract and Safflower extract in a mass ratio of 4.4-4.44:8.83-8.89:8.84-8.86:6.6-6.68:6.63-6.65:4.41-4.43:2.62-2.68:2.2-2.24:2.2-2.22:2.18-2.24:0.86-0.

9.

4. The plant extract anti-hair loss and hair health serum according to claim 1, characterized in that: The raw materials of the anti-hair loss agent B include, by percentage, 16-20% of Platycladus orientalis leaf extract, 17-19% of 1,3-propylene glycol, 0.5-0.7% of PEG-40 hydrogenated castor oil, 0.05-0.15% of disodium EDTA and the balance of deionized water.

5. The plant extract anti-hair loss and hair health serum according to claim 1, characterized in that: The composite conditioning agent is composed of a root extract of Rehmannia glutinosa, a root extract of Sophora flavescens and an extract of Channa intestine in a mass ratio of 0.8-1:0.85-0.95:0.88-0.

92.

6. The plant extract anti-hair loss and hair health serum according to claim 5, characterized in that: The raw materials of the Rehmannia root extract include, by percentage, 2.2-2.8% of Rehmannia root extract, 0.9-1.1% of butylene glycol, 0.4-0.5% of phenoxyethanol, 0.18-0.22% of p-hydroxyacetophenone, 0.03-0.07% of ethylhexylglycerin and the balance of deionized water.

7. The plant extract anti-hair loss and hair health serum according to claim 5, characterized in that: The raw materials of the sophora flavescens root extract include, by percentage, 2.4-2.6% of sophora flavescens root extract, 0.8-1.2% of butylene glycol, 0.43-0.47% of phenoxyethanol, 0.1-0.3% of p-hydroxyacetophenone, 0.02-0.08% of ethylhexylglycerin and the balance of deionized water.

8. The plant extract anti-hair loss and hair health serum according to claim 5, characterized in that: The raw materials of the Channa intestine extract include, by percentage, 2.3-2.7% of Channa intestine extract, 0.95-1.05% of butylene glycol, 0.44-0.46% of phenoxyethanol, 0.15-0.25% of p-hydroxyacetophenone, 0.04-0.06% of ethylhexylglycerol and the balance of deionized water.

9. A method for preparing the plant extract anti-hair loss and hair health essence according to any one of claims 1 to 8, characterized in that: The preparation method of the plant extract anti-hair loss and hair-nourishing essence is as follows: After preparing the raw materials in proportion, mix 1 / 2 deionized water, ethanol and butanediol evenly, stir at a speed of 80-200 rpm for 10-30 min for use, add the composite conditioner and homogenize once for 1-3 min, then add the anti-hair loss agent A and homogenize twice for 5-7 min, then add the anti-hair loss agent B and homogenize three times for 2-4 min, finally add pyrrolidino diamino pyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, preservative and the remaining deionized water in sequence, homogenize four times for 1-5 min, keep warm for 1 h, sterilize at 120°C for 10 min, cool to room temperature, and obtain the plant extract anti-hair loss and hair care essence.

10. The plant extract anti-hair loss and hair health serum according to claim 9, characterized in that: The homogenization pressure is 500-800 bar, the temperature of the first homogenization is 34-38°C, the temperature of the second homogenization is 39-41°C, the temperature of the third homogenization is 40-42°C, the temperature of the fourth homogenization is 43-47°C; the insulation temperature is 41-45°C.

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