Electrochemical detection method of dopamine

By loading SnS2 quantum dots on Zn-MOF and combining gold nanoparticles and dopamine aptamer single chains, Apt/AuNPs/SnS2QDs@Zn-MOF complex was constructed, and the high sensitivity and selective detection of dopamine was achieved using ECL technology, solving the problem of insufficient detection complexity and accuracy in the prior art.

CN119643665AActive Publication Date: 2025-03-18JIANGXI NORMAL UNIV
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Patent Information

Application Number
CN202510173725.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-02-18
Publication Date
2025-03-18
Estimated Expiration
2045-02-18

AI Technical Summary

Technical Problem

The existing dopamine detection methods have problems such as complexity, high cost, strict equipment requirements and unstable results, and the existing electrochemiluminescence technology still has room for improvement in accuracy and operational complexity.

Method used

By loading SnS2 quantum dots on Zn-MOF, SnS2QDs@Zn-MOF complex is formed, and gold nanoparticles and dopamine aptamer single chains are combined to construct Apt/AuNPs/SnS2QDs@Zn-MOF complex, and high sensitivity and selective detection of dopamine are achieved using electrochemical chemiluminescence (ECL) technology.

Benefits of technology

High sensitivity and selective detection of dopamine are achieved. The ECL intensity and the logarithm of dopamine concentration are linearly related within a certain range, and have the advantages of a wide linear range and a low detection line.

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Abstract

The invention discloses an electrochemical detection method of dopamine, and belongs to the technical field of analysis. According to the method, SnS2 quantum dots are loaded on Zn-MOF and modified on an electrode, then gold nanoparticles and a sulfydryl-containing dopamine aptamer single chain are sequentially fixed on the electrode, an Apt / AuNPs / SnS2QDs (at) Zn-MOF / GCE composite electrode (in an open state) is formed, an electrochemical signal of the composite electrode is greatly improved, and based on specific recognition between dopamine and an aptamer chain, the electrochemical performance of the composite electrode is improved. A large cavity of Zn-MOF is used for packaging SnS2 quantum dots with excellent electrochemical properties, electrochemical signal amplification is achieved, when a target object dopamine exists, dopamine can quench an ECL signal, an electric signal is obviously reduced (in a closed state), and therefore a linear relation between the change of the electrochemical signal and the concentration of dopamine is constructed, and the electrochemical property of the electrochemical signal is improved. Therefore, high-sensitivity and high-selectivity detection of dopamine is realized.
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