Anti-inflammatory liquid dressing and preparation method thereof

Abstract

The invention relates to the technical field of medical dressings, in particular to an anti-inflammatory liquid dressing and a preparation method thereof.The anti-inflammatory liquid dressing is prepared from, by mass, natural anti-inflammatory ingredients including 1-3% of baicalin, 1-2% of honeysuckle extract and 0.5-2% of asiaticoside; a synthetic anti-inflammatory component: 0.1 to 0.5% of chlorhexidine digluconate; film forming materials: 5%-10% of carboxymethyl chitosan and 2%-5% of polyvinylpyrrolidone (PVP); a humectant: 1-3% of hyaluronic acid and 2-5% of glycerin; the pH regulator is 0.5-1% of lactic acid or citric acid and is used for regulating the pH of the system to 4.5-5.5; the traditional Chinese medicine composition has the effects of combining natural components with synthetic components (efficient bacteriostasis), reducing the risk of drug resistance and inhibiting bacterial proliferation.

Description

Technical Field

[0001] This invention relates to the field of medical dressing technology, specifically to an anti-inflammatory liquid dressing and its preparation method. Background Technology

[0002] Traditional dressings (such as gauze and cotton pads) have problems such as poor breathability, easy adhesion to the wound surface, and lack of active anti-inflammatory function. To avoid these problems, liquid dressings are now mostly used to replace traditional dressings.

[0003] Existing liquid dressings mostly focus on film-forming isolation, but their anti-inflammatory ingredients are singular (such as containing only silver ions or antibiotics), which can easily lead to drug resistance or irritation.

[0004] Based on this, the present invention designs an anti-inflammatory liquid dressing and its preparation method to solve the above problems. Summary of the Invention

[0005] To achieve the above objectives, the present invention provides the following technical solution: an anti-inflammatory liquid dressing comprising the following components by weight percentage: natural anti-inflammatory ingredients: baicalin 1-3%, honeysuckle extract 1-2%, total glycosides of Centella asiatica 0.5-2%; synthetic anti-inflammatory ingredients: chlorhexidine digluconate 0.1-0.5%; film-forming material: carboxymethyl chitosan 5-10%, polyvinylpyrrolidone (PVP) 2-5%; moisturizer: hyaluronic acid 1-3%, glycerin 2-5%; pH adjuster: lactic acid or citric acid 0.5-1%, used to adjust the pH of the system to 4.5-5.5; the balance being sterile deionized water or physiological saline.

[0006] Preferably, the total asiaticoside in the natural anti-inflammatory component can be replaced with an equal mass of dipotassium glycyrrhizate.

[0007] Preferably, the mass ratio of carboxymethyl chitosan to PVP in the film-forming material is (3:1) to (5:1).

[0008] Preferably, it contains 0.01-0.1% of a penetration enhancer, wherein the penetration enhancer is an azone or a menthol derivative.

[0009] Preferably, the mass ratio of glycerin to hyaluronic acid in the moisturizer is (1:1) to (3:1).

[0010] Preferably, the viscosity of the liquid dressing is 50-200 mPa·s (measured at 25°C), and the film-forming time after spraying is 5-15 seconds.

[0011] Preferably, a method for preparing the anti-inflammatory liquid dressing includes the following steps: a) dissolving chitosan and PVP in sterile deionized water at 50-60°C and stirring until completely dissolved to form a base solution; b) sequentially adding baicalin, honeysuckle extract, total asiaticoside, and chlorhexidine digluconate to the base solution and stirring for 20-40 minutes; c) adding hyaluronic acid and glycerin and homogenizing (2000-5000 rpm for 10-20 minutes); d) adjusting the pH of the mixture to 4.5-5.5 with lactic acid or citric acid and filtering through a 0.22 μm microporous membrane for sterilization; e) dispensing into sterile spray containers.

[0012] In summary, this application has the following beneficial technical effects: 1. The combination of natural and synthetic components (highly effective antibacterial) reduces the risk of drug resistance; Chitosan and PVP form an interpenetrating network structure, which controls the drug release rate and prolongs the duration of action. Hyaluronic acid moisturizes and glycerin nourishes, improving the microenvironment of the wound. It inhibits bacterial proliferation (such as Staphylococcus aureus) while promoting epithelial cell migration. Detailed Implementation

[0013] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0014] An anti-inflammatory liquid dressing in this embodiment 1 comprises the following components by weight percentage: Natural anti-inflammatory ingredients: baicalin 2%, honeysuckle extract 1.5%, and total glycosides of Centella asiatica 1%; Synthetic anti-inflammatory ingredient: chlorhexidine digluconate 0.3%; Film-forming materials: 8% carboxymethyl chitosan, 3% polyvinylpyrrolidone (PVP); Moisturizers: 2% hyaluronic acid, 3% glycerin; pH adjuster: 0.8% lactic acid or citric acid, used to adjust the system pH to 5.0; The remaining amount is sterile deionized water or physiological saline, which should be replenished to 100%.

[0015] Preferably, the mass ratio of carboxymethyl chitosan to PVP in the film-forming material is (3:1) to (5:1).

[0016] Preferably, it contains 0.01-0.1% of a penetration enhancer, wherein the penetration enhancer is an azone or a menthol derivative.

[0017] Preferably, the mass ratio of glycerin to hyaluronic acid in the moisturizer is (1:1) to (3:1).

[0018] Preferably, the viscosity of the liquid dressing is 50-200 mPa·s (measured at 25°C), and the film-forming time after spraying is 5-15 seconds.

[0019] Preferably, a method for preparing the anti-inflammatory liquid dressing includes the following steps: a) adding carboxymethyl chitosan and PVP K30 to sterile deionized water at 55±2℃ (water bath temperature control), and stirring with a magnetic stirrer for 40 minutes until the solution is clear and free of particles; b) Add baicalin, honeysuckle extract, and total glycosides of Centella asiatica in sequence. Stir for 10 minutes (300 rpm) after each addition to ensure complete dispersion. Add chlorhexidine digluconate and stir for 20 minutes in the dark (to avoid photodegradation). c) Add hyaluronic acid and glycerin, transfer to a high-pressure homogenizer, set the pressure to 100 bar and the speed to 3000 rpm, and cycle 3 times to make the solution homogenized; d) Add lactic acid dropwise to adjust the pH to 5.0 ± 0.1; e) Dispense into sterile aluminum spray bottles.

[0020] The antibacterial properties of the prepared liquid dressing were tested: the dressing was diluted to a concentration of 1% and incubated with the bacterial solution for 24 hours. The antibacterial rate was calculated, as shown in the table below.

[0021] Table 1 shows the antibacterial effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Based on Table 2, the beneficial effects achieved in this embodiment are: 1. The combination of natural and synthetic components (highly effective antibacterial agents) reduces the risk of drug resistance; 2. Chitosan and PVP form an interpenetrating network structure, which controls the drug release rate and prolongs the duration of action; 3. Hyaluronic acid moisturizes and glycerin nourishes, improving the wound microenvironment; 4. As can be seen from Table 1, the scheme in Example 1 has a good antibacterial effect, inhibiting bacterial proliferation (such as Staphylococcus aureus) and promoting epithelial cell migration.

[0022] In this second embodiment, the total glycosides of Centella asiatica can be replaced with dipotassium glycyrrhizate, while the other components are the same as in the first embodiment. The second embodiment is more suitable for the care of sensitive wounds and improves comfort.

[0023] In the description of this invention, it should be understood that the terms "coaxial", "bottom", "one end", "top", "middle", "other end", "upper", "side", "top", "inner", "front", "center", "both ends", etc., indicating orientation or positional relationships, are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0024] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "setting," "connection," "fixing," "screw connection," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0025] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An anti-inflammatory liquid dressing, characterized in that, The product comprises the following components by weight percentage: Natural anti-inflammatory ingredients: baicalin 1-3%, honeysuckle extract 1-2%, total glycosides of centella asiatica 0.5-2%; Synthetic anti-inflammatory ingredients: chlorhexidine digluconate 0.1-0.5%; Film-forming materials: carboxymethyl chitosan 5-10%, polyvinylpyrrolidone (PVP) 2-5%; Moisturizers: 1-3% hyaluronic acid, 2-5% glycerin; pH adjuster: 0.5-1% lactic acid or citric acid, used to adjust the pH of the system to 4.5-5.5; the remainder is sterile deionized water or physiological saline.

2. The anti-inflammatory liquid dressing according to claim 1, characterized in that: The total glycosides of Centella asiatica in the natural anti-inflammatory ingredients can be replaced with an equal mass of dipotassium glycyrrhizate.

3. The anti-inflammatory liquid dressing according to claim 2, characterized in that: The mass ratio of carboxymethyl chitosan to PVP in the film-forming material is (3:1) to (5:1).

4. The anti-inflammatory liquid dressing according to claim 1, characterized in that: It contains 0.01-0.1% of a penetration enhancer, wherein the penetration enhancer is an azone or a menthol derivative.

5. The anti-inflammatory liquid dressing according to claim 1, characterized in that: The mass ratio of glycerin to hyaluronic acid in the moisturizer is (1:1) to (3:1).

6. The anti-inflammatory liquid dressing according to claim 1, characterized in that: The viscosity of the liquid dressing is 50-200 mPa·s (measured at 25℃), and the film-forming time after spraying is 5-15 seconds.

7. A method for preparing the anti-inflammatory liquid dressing according to claim 1, characterized in that: Includes the following steps: a) Dissolve chitosan and PVP in sterile deionized water at 50-60℃ and stir until completely dissolved to form a base solution; b) Add baicalin, honeysuckle extract, total asiaticoside, and chlorhexidine digluconate to the base solution in sequence and stir for 20-40 minutes; c) Add hyaluronic acid and glycerin and homogenize (2000-5000 rpm for 10-20 minutes); d) Adjust the pH of the mixture to 4.5-5.5 with lactic acid or citric acid and filter through a 0.22 μm microporous membrane for sterilization; e) Dispense into sterile spray containers.