Exosome derived from rice and preparation method and application thereof

By using suspension culture and freeze-drying of rice callus tissue, the problems of high cost and poor stability in exosome extraction have been solved, achieving efficient and low-cost preparation and application of exosomes, which are suitable for cosmetics and medical aesthetics.

CN120988969BActive Publication Date: 2026-05-26GUANGDONG COOPERATE BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202510914694.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-07-03
Publication Date
2026-05-26
Estimated Expiration
2045-07-03

AI Technical Summary

Technical Problem

The high cost, strong equipment dependence, difficulty in standardizing raw material sources, and poor stability of existing plant exosome extraction methods severely restrict their industrialization process.

Method used

Using rice callus tissue as raw material, exosomes are prepared through steps such as suspension culture, bioreactor scale-up culture, centrifugation and ultrafiltration, and freeze-dried powder is obtained by freeze-drying. This simplifies the process, reduces equipment requirements, and enables large-scale production.

Benefits of technology

We have developed rice-derived exosomes with high biosafety, stability, and sustainable mass production, which improve cell absorption efficiency and the delivery of active ingredients, making them suitable for functional cosmetics and medical aesthetics.

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Abstract

This invention provides exosomes derived from rice, their preparation method, and applications. The exosomes have a bilayered membrane spherical structure with a particle size ranging from 20 to 1000 nm. These exosomes are obtained from rice callus tissue and possess high biocompatibility, stability, and sustainable mass production characteristics. Furthermore, experiments have demonstrated that these exosomes have anti-aging, cell regeneration and tissue repair promotion, and protective functions, and can also significantly improve cell absorption efficiency and the delivery efficiency of active ingredients such as peptides.
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