An adaptive diameter-reducing nerve cuff for use in a severed nerve injury and a method of making

By using an adaptive narrowing nerve cannula to achieve close contact and fixation of the nerve at body temperature through light stimulation, the problem of long operation time and nerve damage caused by suturing is solved, and a highly efficient nerve repair effect is achieved.

CN122581932APending Publication Date: 2026-08-18PEOPLES HOSPITAL PEKING UNIV
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Patent Information

Application Number
CN202610785076.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-02
Publication Date
2026-08-18

AI Technical Summary

Technical Problem

Existing nerve repair methods require suturing, which leads to long operation time, high anesthesia risk and nerve damage. In addition, the size of the nerve cannula is mismatched, making it difficult to insert the nerve.

Method used

An adaptive shrinking nerve cannula is designed. It uses light stimulation to adaptively shrink the cannula at body temperature. The inner diameter is larger than the nerve to be repaired. The cannula contains biodegradable materials and photothermal effect materials. It achieves close contact and fixation of the nerve through physical stimulation. The degradation period is matched with the nerve regeneration rate.

Benefits of technology

Shorten operation time, reduce anesthesia risks, avoid suturing, achieve tight nerve connection and no foreign body residue, and promote nerve regeneration.

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Abstract

The application discloses a self-adapting diameter-reducing nerve sleeve applied to a nerve injury of a disconnecting type and a preparation method of the nerve sleeve. The inner diameter of the nerve sleeve is larger than the outer diameter of a nerve to be repaired. The nerve sleeve is a tube with a consistent diameter. The nerve sleeve can be self-adaptively shrunk under the body temperature or a safe stimulation to the human body, so that the nerve sleeve is in close contact with the nerve in the nerve sleeve. The main body of the nerve sleeve is a phase-change shrinkable hydrogel. An adhesive coating is arranged on the inner layer of the nerve sleeve. In order to improve the shrinkage efficiency, the nerve sleeve contains a photo-thermal effect material, such as a carbon nanotube. In the preparation, a hydrogel precursor solution is prepared first, then is cast into a mold, is shaped through calcium ion cross-linking and / or ultraviolet cross-linking, and is demolded after shaping. The adhesive coating is arranged after demolding. The application of the nerve sleeve can reduce the difficulty of nerve butt joint. The 360-degree self-adapting shrinkage can greatly reduce the contact difficulty of the nerve sleeve and the nerve. In addition, the contact effectiveness is ensured, and the operation time is saved.
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