Storage and transfer container suitable for high-activity compound sample

Abstract

The storage and transfer container comprises a main body and a cover body, the cover body is arranged at an opening of the main body in a covering mode, the cover body is provided with a filter membrane, an inner cavity of the main body is separated from the external environment through the filter membrane, and the filter membrane is arranged in the inner cavity of the main body. The effective area of the filter membrane accounts for more than or equal to 70% of the area of the opening of the main body, the filter membrane is made of a hydrophobic material, and the pore diameter of the filter membrane is less than or equal to 0.5 mu m. According to the storage and transfer container suitable for the high-activity compound sample, the main body is used for containing the high-activity compound, the cover body is arranged on the main body in a covering mode, the cover body is provided with the filter membrane, and the cover body is matched with the main body so that the high-activity compound can be effectively prevented from overflowing. In addition, circulation and transmission smoothness of air and water molecules inside and outside the main body can be kept, the air-water separator can be directly stored or used in a constant-temperature and constant-humidity box or an isolator glove box, and the space utilization rate is increased.

Description

Technical Field

[0001] The utility model relates to the technical field of biomedical equipment, in particular to a storage and transfer container suitable for highly active compound samples. Background Art

[0002] With the development of pharmaceutical industry and organic synthesis technology, more and more highly active compounds have been developed, among which highly active compounds with OEB level 5 (occupational exposure limit <1μg / m3) have very strict protection requirements. When handling such highly active compounds, they must be operated in an isolator and a closed ventilation system, and strict leakage tests must be performed on the isolator and ventilation system.

[0003] The stability test of OEB5 samples must first ensure safety, and there must be no leakage of high-activity powder; secondly, the temperature and humidity conditions must be stably controlled to ensure the requirements for experimental condition review. In the prior art, patent documents such as CN201520270637.2, CN201721513754.2 and CN202321408420.4, as well as commercially available stability test chambers for storing OEB5 samples, all have the possibility of leakage; in actual research, there are also customized large isolators to isolate the drug stability test chamber, or use a desiccator to control the humidity and then place it in a constant temperature oven, but these two methods are costly and have low space utilization, which is not conducive to the research and development of multiple samples and multiple conditions in R&D laboratories, and the method of controlling humidity through salt solution in the desiccator cannot meet all experimental needs, and the humidity stability is poor. Utility Model Content

[0004] The technical problem to be solved by the utility model is to provide a storage and transfer container suitable for high-activity compound samples, which can effectively prevent the overflow of high-activity compounds, maintain the smooth circulation and transfer of air and water molecules between the inside and outside of the main body, and can be directly stored or used in a constant temperature and humidity chamber or an isolator glove box.

[0005] In order to solve the above technical problems, the utility model provides a storage and transfer container suitable for highly active compound samples, comprising:

[0006] A main body, which is used to contain a highly active compound sample;

[0007] The cover body is arranged at the opening of the main body, and the cover body is provided with a filter membrane, which separates the inner cavity of the main body from the external environment. The effective area of ​​the filter membrane accounts for greater than or equal to 70% of the area of ​​the opening of the main body. The filter membrane is made of a hydrophobic material, and the pore size of the filter membrane is less than or equal to 0.5μm.

[0008] Specifically, the main body is made of polypropylene, polytetrafluoroethylene or ethylene-polytetrafluoroethylene copolymer.

[0009] Specifically, the volume of the main body is 0.8-1.2L.

[0010] Specifically, the side wall of the cover body is connected to the main body through a threaded connection, and a sealing ring is provided between the cover body and the main body.

[0011] Specifically, a stepped hole is provided on the top wall of the cover body, the small diameter hole of the stepped hole is connected to the interior of the main body, the large diameter hole of the stepped hole is connected to the external environment, the large diameter hole of the stepped hole is provided with an annular plug matching its aperture, and the annular plug cooperates with the large diameter hole to fasten the filter membrane in the stepped hole.

[0012] Specifically, the inner diameter of the annular plug is larger than the diameter of the small-diameter hole of the stepped hole.

[0013] Specifically, the annular plug is interference-fitted with the large-diameter hole of the stepped hole.

[0014] Specifically, the annular plug is threadedly matched with the large-diameter hole of the stepped hole.

[0015] Specifically, the cover body is provided with a through hole, and the filter membrane is adhered to the cover body and covers the through hole.

[0016] Specifically, the size of the filter membrane is larger than the size of the through hole.

[0017] The utility model provides a storage and transfer container suitable for high-activity compound samples, wherein the main body is used to hold the high-activity compound, and the cover body is arranged on the main body. The cover body is provided with a filter membrane, and the cooperation between the cover body and the main body can effectively prevent the high-activity compound from overflowing, and can also maintain the smoothness of the circulation and transfer of air and water molecules inside and outside the main body. The container can be directly stored or used in a constant temperature and humidity chamber or an isolator glove box, thereby improving the space utilization rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solution of the utility model, the following briefly introduces the drawings required for use in the utility model. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 It is a schematic diagram of an embodiment of a container for storing and transferring highly active compound samples according to the utility model;

[0020] Figure 2 This is an exploded view of the cover of an embodiment of a container for storing and transferring highly active compound samples according to the utility model;

[0021] Figure 3 It is a schematic diagram of a cover body of an embodiment of a container for storing and transferring highly active compound samples according to the utility model;

[0022] In the figure, 1-main body; 2-cover body; 21-filter membrane; 22-step hole; 23-annular plug; 24-through hole; 3-sealing ring. DETAILED DESCRIPTION

[0023] The following will be combined with the accompanying drawings to clearly and completely describe the technical solutions in the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0024] refer to Figure 1 , showing a storage and transfer container suitable for highly active compound samples of the utility model, comprising:

[0025] A main body, which is used to contain a highly active compound sample;

[0026] The cover body is arranged at the opening of the main body, and the cover body is provided with a filter membrane, which separates the inner cavity of the main body from the external environment. The effective area of ​​the filter membrane accounts for greater than or equal to 70% of the area of ​​the opening of the main body. The filter membrane is made of a hydrophobic material, and the pore size of the filter membrane is less than or equal to 0.5μm.

[0027] In an embodiment of the utility model, the cover body can be covered on the main body by, for example, a threaded connection, and, for example, a sealing ring can be provided at the contact position of the openings of the cover body and the main body to increase the sealing and prevent leakage of highly active compound samples; the filter membrane provided on the cover body can effectively prevent leakage of highly active compounds because its pore size is less than or equal to 0.5 μm, and can also maintain the circulation and transfer of air and water molecules between the inside and outside of the main body, thereby ensuring that the humidity in the main body meets the experimental requirements and remains stable, thereby ensuring the smooth progress of the experiment; in addition, the filter membrane is preferably made of a hydrophobic material and a corrosion-resistant material, such as PTFE (polytetrafluoroethylene), and is preferably made of a hydrophobic material to prevent it from absorbing water and affecting the circulation of humidity inside and outside the main body. At the same time, in order to ensure the air and moisture circulation between the main body and the outside, the effective area of ​​the filter membrane cannot be less than 70%. If it is less than 70%, it will take longer for the air and humidity inside the main body to be consistent with the external environment, and thus it cannot meet the experimental requirements of the compound stability study, resulting in experimental failure; it should be noted that the effective area of ​​the filter membrane refers to the area where the air and humidity inside the main body and the external environment can circulate. The filter membrane that is set (for example, fastened) inside the cover body or blocked by the cover body does not provide a circulation channel, so it does not belong to the effective area; it should also be noted that the container provided by the utility model can be directly applied to a constant temperature and humidity chamber and an isolator glove box. The humidity of the constant temperature and humidity chamber can be effectively transferred to the inside of the main body through the filter membrane. The filter membrane can effectively prevent the leakage of highly active compounds, and at the same time, effectively improve the space utilization rate. The main body of the utility model generally adopts a columnar structure, such as a cylinder, a cuboid, etc., and its opening area must meet more than 50% of the cross section perpendicular to its height direction, which has ensured that the main body has sufficient contact area with the external environment.

[0028] In a specific embodiment, the main body is made of polypropylene, polytetrafluoroethylene or ethylene-polytetrafluoroethylene copolymer. Understandably, any material in the prior art that is stable in physical and chemical properties under high temperature conditions and colorless and odorless can be applied to the present invention.

[0029] In a specific embodiment, the volume of the main body is 0.8-1.2 L. It is understandable that the volume of the main body can be determined according to the amount of the sample and the capacity of the constant temperature and humidity chamber. Generally, the volume of the solvent is within the range of 0.8-1.2 L, which can meet the use requirements. However, it is not desired to be constrained by this, and the volume of the main body can also be larger or smaller.

[0030] In a specific embodiment, reference Figure 2The top wall of the cover body is provided with a stepped hole, the small diameter hole of the stepped hole is connected to the interior of the main body, the large diameter hole of the stepped hole is connected to the external environment, the large diameter hole of the stepped hole is provided with an annular plug matching its aperture, and the annular plug cooperates with the large diameter hole to fasten the filter membrane in the stepped hole. Preferably, the inner diameter of the annular plug is larger than the diameter of the small diameter hole of the stepped hole. Preferably, the annular plug is interference fit with the large diameter hole of the stepped hole. Preferably, the annular plug is threadedly fitted with the large diameter hole of the stepped hole.

[0031] In this specific embodiment, the filter membrane is fastened to the connection position of the large diameter hole and the small diameter hole of the stepped hole through the annular plug. Since the inner diameter of the annular plug is larger than the diameter of the small diameter hole of the stepped hole, the area of ​​the small diameter hole of the stepped hole is equal to the effective area of ​​the filter membrane. In order to better press or fix the filter membrane in the stepped hole, the annular plug is preferably interference fit or threaded fit with the large diameter hole of the stepped hole, which can increase the sealing of the filter membrane and the cover body and effectively prevent the highly active compound from spilling out.

[0032] In a specific embodiment, reference Figure 3 The cover body may also be provided with a through hole, and the filter membrane is adhered to the cover body and covers the through hole. Preferably, the size of the filter membrane is larger than the size of the through hole.

[0033] In this specific embodiment, the through hole area is equal to the effective area of ​​the filter membrane; the size of the filter membrane is larger than the size of the through hole, which means that the filter membrane can completely cover the through hole, and the part of the filter membrane that exceeds the through hole can be adhered to the cover body, and the filter membrane can be adhered to the inner side of the cover body (i.e., the side facing the inside of the main body), or it can be adhered to the outer side of the cover body. Without being bound by this, the filter membrane can also directly cover the opening of the main body, and when the cover body is set on the opening of the main body, the filter membrane is fastened (or pressed) between the cover body and the main body, which can also achieve the expected effect.

[0034] The above description is only a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A container suitable for storing and transferring samples of highly active compounds, characterized in that: include: A main body, which is used to contain a highly active compound sample; The cover body is arranged at the opening of the main body, and the cover body is provided with a filter membrane, which separates the inner cavity of the main body from the external environment. The effective area of ​​the filter membrane accounts for greater than or equal to 70% of the area of ​​the opening of the main body. The filter membrane is made of a hydrophobic material, and the pore size of the filter membrane is less than or equal to 0.5μm.

2. The storage and transfer container for highly active compound samples according to claim 1, characterized in that: The main body is made of polypropylene, polytetrafluoroethylene or ethylene-polytetrafluoroethylene copolymer.

3. The storage and transfer container for highly active compound samples according to claim 1, characterized in that: The volume of the main body is 0.8-1.2L.

4. The storage and transfer container for highly active compound samples according to claim 1, characterized in that: The side wall of the cover body is connected to the main body through a threaded connection, and a sealing ring is arranged between the cover body and the main body.

5. The storage and transfer container for highly active compound samples according to claim 1, characterized in that: A stepped hole is provided on the top wall of the cover body, the small diameter hole of the stepped hole is connected to the interior of the main body, the large diameter hole of the stepped hole is connected to the external environment, the large diameter hole of the stepped hole is provided with an annular plug matching its aperture, and the annular plug cooperates with the large diameter hole to fasten the filter membrane in the stepped hole.

6. The storage and transfer container for highly active compound samples according to claim 5, characterized in that: The inner diameter of the annular plug is larger than the diameter of the small-diameter hole of the stepped hole.

7. The storage and transfer container for highly active compound samples according to claim 5, characterized in that: The annular plug is interference fit with the large diameter hole of the stepped hole.

8. The storage and transfer container for highly active compound samples as claimed in claim 5, characterized in that: The annular plug is threadably matched with the large-diameter hole of the stepped hole.

9. The storage and transfer container for highly active compound samples according to claim 1, characterized in that: The cover body is provided with a through hole, and the filter membrane is adhered to the cover body and covers the through hole.

10. The storage and transfer container for highly active compound samples according to claim 9, characterized in that: The size of the filter membrane is larger than the size of the through hole.

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