Preparation method of betaine hydrochloride

Abstract

Disclosed is a preparation method of betaine hydrochloride. According to the preparation method, chloroacetic acid, sodium carbonate and trimethylamine are used as main raw materials and undergo processes of reaction, condensation, drying, packaging, recondensation and the like, so as to produce high-purity betaine hydrochloride. By the adoption of the technology, original methanol dehydration and double-cone dryer drying equipment is saved, cost is saved, and productivity is raised.

Description

technical field

[0001] The invention relates to a production process for preparing betaine hydrochloride through chemical synthesis, in particular to a production process for preparing betaine hydrochloride with chloroacetic acid, sodium carbonate and trimethylamine as main raw materials. Background technique

[0002] Betaine is a natural vitamin-like substance with the molecular formula (CH 3 ) 3 NCH 2 COO, with a molecular weight of 117, is non-toxic, highly hygroscopic, sweet, and has a special smell. It exists widely in animals and plants and has important functions. Its value has been affirmed by countless scientific researches and practices. Betaine is very versatile. For example, in medicine, betaine can be used to produce drugs for the treatment and prevention of liver diseases, and raw materials for antibiotics. Betaine can be used as a food additive, which can play a good role in promoting the health care of the elderly and the growth and development of childre...

Examples

Embodiment 1

[0018] (1) Pour 2 tons of water into the reaction kettle, drop into 1450 kilograms of chloroacetic acid, stir until the chloroacetic acid is all dissolved, slowly drop into 800 kilograms of anhydrous sodium carbonate, pay attention to the reaction speed when feeding materials, as the criterion not to separate out a large amount of carbon dioxide, When the temperature exceeds 50°C, turn on a small amount of cooling water to keep the temperature of the material at 50°C, and stabilize for 30 minutes after feeding;

[0019] (2) Quantitatively feed 900 kg of trimethylamine, adjust the feeding speed of trimethylamine and the amount of cooling water, so that the reaction temperature is controlled at 55°C, and the maximum pressure of the reactor is not allowed to exceed 0.1Mpa. When feeding to the remaining trimethylamine When it is 150 kg, reduce the amount of cooling water supply, raise the reaction temperature to 60°C, observe the weighing instrument, after the feeding of trimethyla...

Embodiment 2

[0026] (1) Pour 2 tons of water into the reaction kettle, drop into 1550 kilograms of chloroacetic acid, stir until the chloroacetic acid is all dissolved, slowly drop into 900 kilograms of anhydrous sodium carbonate, pay attention to the reaction speed when feeding materials, as the criterion not to separate out a large amount of carbon dioxide, When the temperature exceeds 50°C, turn on a small amount of cooling water to keep the temperature of the material at 60°C, and stabilize for 30 minutes after feeding;

[0027] (2) Quantitatively feed 1000 kg of trimethylamine, adjust the feed rate of trimethylamine and the amount of cooling water, so that the reaction temperature is controlled at 60 °C, and the maximum pressure of the reactor is not allowed to exceed 0.1Mpa. When feeding to the remaining trimethylamine When it is 150 kg, reduce the amount of cooling water supply, raise the reaction temperature to 70°C, observe the weighing instrument, after the feeding of trimethylami...

technical field

[0001] The invention relates to a production process for preparing betaine hydrochloride through chemical synthesis, in particular to a production process for preparing betaine hydrochloride with chloroacetic acid, sodium carbonate and trimethylamine as main raw materials. Background technique

[0002] Betaine is a natural vitamin-like substance with the molecular formula (CH 3 ) 3 NCH 2 COO, with a molecular weight of 117, is non-toxic, highly hygroscopic, sweet, and has a special smell. It exists widely in animals and plants and has important functions. Its value has been affirmed by countless scientific researches and practices. Betaine is very versatile. For example, in medicine, betaine can be used to produce drugs for the treatment and prevention of liver diseases, and raw materials for antibiotics. Betaine can be used as a food additive, which can play a good role in promoting the health care of the elderly and the growth and development of childre...

Examples

Embodiment 1

[0018] (1) Pour 2 tons of water into the reaction kettle, drop into 1450 kilograms of chloroacetic acid, stir until the chloroacetic acid is all dissolved, slowly drop into 800 kilograms of anhydrous sodium carbonate, pay attention to the reaction speed when feeding materials, as the criterion not to separate out a large amount of carbon dioxide, When the temperature exceeds 50°C, turn on a small amount of cooling water to keep the temperature of the material at 50°C, and stabilize for 30 minutes after feeding;

[0019] (2) Quantitatively feed 900 kg of trimethylamine, adjust the feeding speed of trimethylamine and the amount of cooling water, so that the reaction temperature is controlled at 55°C, and the maximum pressure of the reactor is not allowed to exceed 0.1Mpa. When feeding to the remaining trimethylamine When it is 150 kg, reduce the amount of cooling water supply, raise the reaction temperature to 60°C, observe the weighing instrument, after the feeding of trimethyla...

Embodiment 2

[0026] (1) Pour 2 tons of water into the reaction kettle, drop into 1550 kilograms of chloroacetic acid, stir until the chloroacetic acid is all dissolved, slowly drop into 900 kilograms of anhydrous sodium carbonate, pay attention to the reaction speed when feeding materials, as the criterion not to separate out a large amount of carbon dioxide, When the temperature exceeds 50°C, turn on a small amount of cooling water to keep the temperature of the material at 60°C, and stabilize for 30 minutes after feeding;

[0027] (2) Quantitatively feed 1000 kg of trimethylamine, adjust the feed rate of trimethylamine and the amount of cooling water, so that the reaction temperature is controlled at 60 °C, and the maximum pressure of the reactor is not allowed to exceed 0.1Mpa. When feeding to the remaining trimethylamine When it is 150 kg, reduce the amount of cooling water supply, raise the reaction temperature to 70°C, observe the weighing instrument, after the feeding of trimethylami...