Peak shape delaying forward suppressor and high-performance liquid chromatographic analysis device and method using the same

A high-performance liquid chromatography and suppressor technology, which is applied in the field of high-performance liquid chromatography analysis devices and peak-front suppressors, can solve the problems of reduced resolution, waste of resources, and poor separation efficiency, so as to avoid column pressure rise High, prolong service life, improve the effect of separation

CN104535699AActive Publication Date: 2015-04-22SHANGHAI PUNING ANALYSIS TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2015-04-22

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Abstract

The invention discloses a peak shape delaying forward suppressor for a high-performance liquid chromatographic analysis device and method. The peak shape delaying forward suppressor comprises a cutting sleeve and a suppressor core arranged in the interior of the cutting sleeve, the suppressor core is of a hollow structure and the interior of the suppressor core is provided with cavities, the end portions of the interior of the suppressor core are provided with screen plates, and the screen plates are communicated with the cavities. The invention further discloses the high-performance liquid chromatographic analysis device and method which use the peak shape delaying forward suppressor, and when sample solvents with samples flow through the cavities, the sample solvents can be diluted by the mobile phase. The peak shape delaying forward suppressor and the high-performance liquid chromatographic analysis device and method using the peak shape delaying forward suppressor has the advantages that the peak shape delaying forward phenomenon caused by the mismatching of the sample solvents and the mobile phase can be effectively suppressed, the interferences brought by the sample solvents are solved, the peak shape is improved, the column efficiency is increased, the separation degree is improved, the interferences brought by the sample solvents when the analysis, the preparation and the method development are carried out are greatly reduced, and man power and material resources are significantly saved.
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Description

technical field

[0001] The invention relates to the technical field of chromatographic analysis, in particular to high-performance liquid chromatography analysis and preparation, and in particular to a peak-forward suppressor, a high-performance liquid chromatography analysis device and a method using the same. Background technique

[0002] High performance liquid chromatography is currently the most important means and method in the process of production supervision and quality control in biological, pharmaceutical, medical, food, chemical and other industries. The world includes biopharmaceuticals, medical diagnosis, food safety and chemical quality inspection and other fields. More than 80% of the tens of thousands of compounds in the country are analyzed by high performance liquid chromatography, which is widely involved in various fields of national economy and people's livelihood. With the development of the times and the improvement of people's living standards, peopl...

Examples

Embodiment Construction

[0039] The present invention will be further described below in conjunction with the examples, but the protection scope of the present invention is not limited only to the examples.

[0040] combine figure 1 As shown, a high-performance liquid chromatography analysis device with a peak-shaped front extension suppressor is used for high-performance liquid chromatography analysis. In the application process, the connection sequence of the entire high-performance liquid chromatography device is, the high-performance liquid chromatography 3 Pump outlet—injector 2—peak front suppressor 1—chromatographic column 4—detector of high performance liquid chromatography 3. The peak front suppressor 1 is located between the injector 2 and the chromatographic column 4 , the inlet of the peak front suppressor 1 is connected with the sample injector 2 , and the outlet is connected with the chromatographic column 4 . The mobile phase flows through the injector 2 under the pressure provided by ...