Preparation method of a foliage-affinity pesticide nano-loading system

Abstract

The invention discloses a preparation method of a nano drug-loading system of leaf surface affiliated pesticide. The method comprises the following steps: preparing a polylactic acid carrier, primaryemulsion and the nano drug-loading system, carrying out affiliated modification on the nano drug-loading system and the like. According to the nano drug-loading system of the leaf surface affiliated pesticide, disclosed by the invention, the average grain diameter range is 300nm to 800nm, the drug loading amount can reach 15 percent or more and the encapsulation rate reaches 75 percent or more; compared with an abamectin crude drug, traditional Chinese medicine components in the nano drug-loading system have remarkably improved the light stability, and the nano drug-loading system has a remarkable slow release effect. The preparation technology of the nano drug-loading system of the leaf surface affiliated pesticide is simple; the preparation cost and the equipment investment cost are low,pollutants are not generated and the quality of a product is stable and reliable; the leaf surface retention behavior of pesticide liquid drops can be remarkably improved. Therefore, the production method of the nano drug-loading system of the leaf surface affiliated pesticide has a very wide application prospect.

Description

Technical field

[0001] The invention relates to a pesticide nano-loading system with a directional affinity function, in particular to a leaf-surface-affinity pesticide nano-loading system and a preparation method thereof, belonging to the field of pesticides and insecticides.

Background technique

[0002] Due to the characteristics of high efficiency, rapidity, economy, and simplicity, pesticides have developed into an extremely important type of agricultural production means, and are the most important means of preventing and controlling crop diseases, insect pests and weeds, and are of great significance to ensuring agricultural production. my country has always been an area with a high incidence of agricultural diseases and insect pests. Based on this, since the 1990s, the amount of pesticides used in China has been increasing year by year. By 2012, the amount of pesticides used in my country has exceeded 1.8 million tons. Since the surface of most crop leaves has hy...

Examples

Embodiment 1

[0073] Example 1: Production of foliar-friendly efficient-cyhalothrin nano-loading system

[0074] The implementation steps of this embodiment are as follows:

[0075] A. Synthesis of polylactic acid carrier material

[0076] According to dichloromethane and HO-PLA-COOCH 2 CH 3 The weight ratio of 10:1, the HO-PLA-COOCH 2 CH 3 Dissolve in dichloromethane solvent to obtain solution 1; then according to the weight ratio of dichloromethane to triethylamine 1:0.003, dissolve triethylamine in dichloromethane to obtain solution 2, and mix solution 2 into the above solution 1; Under ice-bath conditions, slowly drop acetyl chloride:dichloromethane solution with a weight ratio of 0.001:106 to the above mixture; after stirring at room temperature for 4 hours, add 1.0% NaHCO 3 extracted, and washed twice with distilled water; the collected organic phase was washed with anhydrous Na 2 SO 4 Dry overnight; polylactic acid carrier material is obtained after rotary evaporation of the o...

Embodiment 2

[0085]Example 2: Production of Leaf-Affinity Chlorantraniliprole Nano-Drug Carrier System

[0086] The implementation steps of this embodiment are as follows:

[0087] A. Synthesis of polylactic acid carrier material

[0088] According to dichloromethane and HO-PLA-COOCH 2 CH 3 The weight ratio of 10:1, the HO-PLA-COOCH 2 CH 3 Dissolve in dichloromethane solvent to obtain solution 1; then according to the weight ratio of dichloromethane to triethylamine 1:0.003, dissolve triethylamine in dichloromethane to obtain solution 2, and mix solution 2 into the above solution 1; Under ice-bath conditions, slowly drop acetyl chloride:dichloromethane solution with a weight ratio of 0.001:106 to the above mixture; after stirring at room temperature for 4 hours, add 1.0% NaHCO 3 extracted, and washed twice with distilled water; the collected organic phase was washed with anhydrous Na 2 SO 4 Dry overnight; polylactic acid carrier material is obtained after rotary evaporation of the o...

Embodiment 3

[0097] Example 3: Production of Leaf-Affinity Lambda-Cyhalothrin Nano-Drug Carrier System

[0098] The implementation steps of this embodiment are as follows:

[0099] A. Synthesis of polylactic acid carrier material

[0100] According to dichloromethane and HO-PLA-COOCH 2 CH 3 The weight ratio of 10:1, the HO-PLA-COOCH 2 CH 3 Dissolve in dichloromethane solvent to obtain solution 1; then according to the weight ratio of dichloromethane to triethylamine 1:0.003, dissolve triethylamine in dichloromethane to obtain solution 2, and mix solution 2 into the above solution 1; Under ice-bath conditions, slowly drop acetyl chloride:dichloromethane solution with a weight ratio of 0.001:106 to the above mixture; after stirring at room temperature for 4 hours, add 1.0% NaHCO 3 extracted, and washed twice with distilled water; the collected organic phase was washed with anhydrous Na 2 SO 4 Dry overnight; polylactic acid carrier material is obtained after rotary evaporation of the o...

Technical field

[0001] The invention relates to a pesticide nano-loading system with a directional affinity function, in particular to a leaf-surface-affinity pesticide nano-loading system and a preparation method thereof, belonging to the field of pesticides and insecticides.

Background technique

[0002] Due to the characteristics of high efficiency, rapidity, economy, and simplicity, pesticides have developed into an extremely important type of agricultural production means, and are the most important means of preventing and controlling crop diseases, insect pests and weeds, and are of great significance to ensuring agricultural production. my country has always been an area with a high incidence of agricultural diseases and insect pests. Based on this, since the 1990s, the amount of pesticides used in China has been increasing year by year. By 2012, the amount of pesticides used in my country has exceeded 1.8 million tons. Since the surface of most crop leaves has hy...

Examples

Embodiment 1

[0073] Example 1: Production of foliar-friendly efficient-cyhalothrin nano-loading system

[0074] The implementation steps of this embodiment are as follows:

[0075] A. Synthesis of polylactic acid carrier material

[0076] According to dichloromethane and HO-PLA-COOCH 2 CH 3 The weight ratio of 10:1, the HO-PLA-COOCH 2 CH 3 Dissolve in dichloromethane solvent to obtain solution 1; then according to the weight ratio of dichloromethane to triethylamine 1:0.003, dissolve triethylamine in dichloromethane to obtain solution 2, and mix solution 2 into the above solution 1; Under ice-bath conditions, slowly drop acetyl chloride:dichloromethane solution with a weight ratio of 0.001:106 to the above mixture; after stirring at room temperature for 4 hours, add 1.0% NaHCO 3 extracted, and washed twice with distilled water; the collected organic phase was washed with anhydrous Na 2 SO 4 Dry overnight; polylactic acid carrier material is obtained after rotary evaporation of the o...

Embodiment 2

[0085]Example 2: Production of Leaf-Affinity Chlorantraniliprole Nano-Drug Carrier System

[0086] The implementation steps of this embodiment are as follows:

[0087] A. Synthesis of polylactic acid carrier material

[0088] According to dichloromethane and HO-PLA-COOCH 2 CH 3 The weight ratio of 10:1, the HO-PLA-COOCH 2 CH 3 Dissolve in dichloromethane solvent to obtain solution 1; then according to the weight ratio of dichloromethane to triethylamine 1:0.003, dissolve triethylamine in dichloromethane to obtain solution 2, and mix solution 2 into the above solution 1; Under ice-bath conditions, slowly drop acetyl chloride:dichloromethane solution with a weight ratio of 0.001:106 to the above mixture; after stirring at room temperature for 4 hours, add 1.0% NaHCO 3 extracted, and washed twice with distilled water; the collected organic phase was washed with anhydrous Na 2 SO 4 Dry overnight; polylactic acid carrier material is obtained after rotary evaporation of the o...

Embodiment 3

[0097] Example 3: Production of Leaf-Affinity Lambda-Cyhalothrin Nano-Drug Carrier System

[0098] The implementation steps of this embodiment are as follows:

[0099] A. Synthesis of polylactic acid carrier material

[0100] According to dichloromethane and HO-PLA-COOCH 2 CH 3 The weight ratio of 10:1, the HO-PLA-COOCH 2 CH 3 Dissolve in dichloromethane solvent to obtain solution 1; then according to the weight ratio of dichloromethane to triethylamine 1:0.003, dissolve triethylamine in dichloromethane to obtain solution 2, and mix solution 2 into the above solution 1; Under ice-bath conditions, slowly drop acetyl chloride:dichloromethane solution with a weight ratio of 0.001:106 to the above mixture; after stirring at room temperature for 4 hours, add 1.0% NaHCO 3 extracted, and washed twice with distilled water; the collected organic phase was washed with anhydrous Na 2 SO 4 Dry overnight; polylactic acid carrier material is obtained after rotary evaporation of the o...

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