Preparation and Application of Polymer-Nanomolybdenum Disulfide Composite Hydrogel Based on Thermoreversible Diels-Alder Reaction

A technology of nano-molybdenum disulfide and molybdenum disulfide sheets, which is applied in the direction of analyzing materials, using stable tension/pressure to test the strength of materials, instruments, etc. Repair ability and other issues, to achieve good healing efficiency, stable self-healing performance, and low toxicity

CN108219480BActive Publication Date: 2020-06-05NANJING UNIV OF POSTS & TELECOMM
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2020-06-05

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Abstract

The invention belongs to the technical field of polymer biomedical materials and provides preparation and application of a thermally reversible Diels-Alder reaction based polymer-nanometer molybdenumdisulfide sheet composite hydrogel. The composite hydrogel is formed by performing thermally reversible Diels-Alder reaction in a nanometer thin-layer molybdenum disulfide sheet aqueous solution. Thethermally reversible Diels-Alder reaction is generated by maleimide groups in thiol-polyethylene glycol-maleimide and furan groups in furan hyaluronic acid under heat environment. The self-healing ability is that a material utilizes the photo-thermal transformation characteristic of a nanometer thin-layer molybdenum disulfide sheet under illumination of near infrared light to enable the temperature of hydrogel raise to a thermally reversible temperature of the Diels-Alder reaction, and thus the purpose of self healing is realized. According to the application, the nanometer two-dimensional material molybdenum disulfide sheet is applied to the field of self-healing materials and endows the material with good healing characteristic under the light stimulation condition.
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Description

technical field

[0001] The invention belongs to the technical field of macromolecular biomaterials, and in particular relates to a method for preparing a polymer-nanometer molybdenum disulfide sheet composite hydrogel based on a thermoreversible Diels-Alder reaction and an application thereof. Background technique

[0002] Self-healing hydrogels are an emerging biomimetic material inspired by the biological world. In recent years, biological tissues such as skin, bone, and muscle tissue that self-healing hydrogel can heal itself when the body is damaged have achieved rapid development (Phadke, C.Proc.Natl.Acad.Sci.109, 4383). However, most synthetic hydrogels do not possess this self-healing ability due to the lack of bond reformation mechanism after rupture (A.B. Ihsan, Macromolecules, 2016, 49, 4245). To this end, so far, considerable efforts have been made to design and fabricate self-healing hydrogels by incorporating dynamic covalent and non-covalent bonds into the hyd...

Examples

Embodiment 1

[0045] The invention provides a polymer composite self-healing hydrogel based on nano-thin molybdenum disulfide sheets, the polymer hydrogel is composed of nano-molybdenum disulfide sheets, mercapto-polyethylene glycol-maleimide , furanized hyaluronic acid synthesis, the mercapto-polyethylene glycol-maleimide and furanized hyaluronic acid react in molybdenum disulfide sheet aqueous solution, and mercapto-polyethylene glycol-maleimide Part of the maleimide group of the imide and the molecular chain of the furanized hyaluronic acid undergo a Diels-Alder reaction to link together. figure 1 It is a schematic diagram of the structure and synthesis of the polymer composite self-healing hydrogel of the present invention.

[0046] Before preparing the polymer composite self-healing hydrogel, it is necessary to prepare nano-thin molybdenum disulfide sheets and furanized hyaluronic acid. figure 2 It is the hydrogen nuclear magnetic resonance spectrum of furanized hyaluronic acid synth...

Embodiment 2

[0058] In this example, the polymer composite nanomolybdenum disulfide flake self-healing hydrogel based on thermoreversible Diels-Alder reaction and its preparation method comprise the following steps:

[0059] Step 1: Add mercapto-polyethylene glycol-maleimide (19.32mg) and 0.3mL nano-thin molybdenum disulfide flakes (0.1mg / mL) solution into the container, and stir the mixed solution for 12h;

[0060] Step 2: Add furanated hyaluronic acid (4.5 mg) to the mixed solution in the above step 1, and stir to dissolve it completely;

[0061] Step 3: Seal the mixed solution in the mixed solution in the above step 2, and place it in an environment of 40° C. for 1 hour;

[0062] Step 4: Put the prepared polymer composite hydrogel in an incubator for 6 hours of aging to obtain a polymer composite nanomolybdenum disulfide self-healing hydrogel based on the thermoreversible Diels-Alder reaction.

[0063] All test results show that the polymer composite nano molybdenum disulfide sheet sel...