Composition for preventing and treating infantile eczema and preparation method of composition

Abstract

The invention discloses a composition for preventing and treating infantile eczema and a preparation method of the composition. The composition comprises 4-[1-(3-methoxy-1-phenylpropyl)-1H-pyrazol-4-group]-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidine, allantoin, and a pharmaceutically acceptable carrier, wherein the weight ratio between a compound of a formula I and the allantoinis (3 to 7):(0.2 to 0.6). The composition has excellent effects on treating and improving the pediatric eczema.

Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a composition for preventing and treating infantile eczema and a preparation method thereof. Background technique

[0002] Eczema (eczema) is a clinically common allergic skin disease mainly manifested as redness, swelling and itching, which may be accompanied by symptoms such as chapping, blistering, bleeding, scabbing, and peeling. Pediatric eczema, also known as atopic dermatitis (AD), atopic dermatitis, and atopic dermatitis, is a chronic, relapsing, inflammatory skin condition that is more common in infancy and can be extended to childhood and adulthood. Diseases are mainly caused by allergies or intolerances to food, inhalants or contact substances. Children with eczema often have a red rash on the skin first, followed by rough and desquamated skin, and the eczema performance can be aggravated in the case of hot and humid conditions. Because eczema often recurs, it often...

Examples

Embodiment 1

[0028] Each component of the composition described in the present embodiment and consumption thereof are as shown in the following table:

[0029] components Dosage Compound of formula I 3g Allantoin 0.2g Carbomer 940 15g Tragacanth Gum 10g Cross-linked sodium polyacrylate (SDB-L-400) 5g Sodium carboxymethyl cellulose 5g Sodium edetate 1g Tween 80 2g Benzalkonium chloride 1g Propylene Glycol 150g water Add to 1000g

[0030] Its preparation method is: 1) mix the compound of formula I and allantoin evenly; 2) will account for the propylene glycol of 25% of the total weight of propylene glycol and the water of 25% of the total weight of water are mixed to form a mixed medium, heated to 45 ℃, then add the mixture obtained in step 1) under stirring and make it fully dissolved; 3) Carbomer 940, tragacanth gum, cross-linked sodium polyacrylate, sodium carboxymethylcellulose, Sodium acetate, Tween 80, be...

Embodiment 2

[0032] Each component of the composition described in the present embodiment and consumption thereof are as shown in the following table:

[0033] components Dosage Compound of formula I 5g Allantoin 0.4g Carbomer 940 20g Tragacanth Gum 15g Cross-linked sodium polyacrylate (SDB-L-400) 10g Sodium carboxymethyl cellulose 10g Sodium edetate 1g Tween 80 2g Benzalkonium chloride 1g Propylene Glycol 150g water Add to 1000g

[0034] Its preparation method is: 1) mix the compound of formula I and allantoin evenly; 2) will account for the propylene glycol of 25% of the total weight of propylene glycol and the water of 25% of the total weight of water are mixed to form a mixed medium, heated to 45 ℃, then add the mixture obtained in step 1) under stirring and make it fully dissolved; 3) Carbomer 940, tragacanth gum, cross-linked sodium polyacrylate, sodium carboxymethylcellulose, Sodium acetate, Tween 80, ...

Embodiment 3

[0036] Each component of the composition described in the present embodiment and consumption thereof are as shown in the following table:

[0037]

[0038]

[0039]Its preparation method is: 1) mix the compound of formula I and allantoin evenly; 2) will account for the propylene glycol of 25% of the total weight of propylene glycol and the water of 25% of the total weight of water are mixed to form a mixed medium, heated to 45 ℃, then add the mixture obtained in step 1) under stirring and make it fully dissolved; 3) Carbomer 940, tragacanth gum, cross-linked sodium polyacrylate, sodium carboxymethylcellulose, Sodium acetate, Tween 80, benzalkonium chloride, the remaining amount of propylene glycol and the remaining amount of water are stirred at 45°C until a uniform gel matrix is ​​obtained; 4) Add the mixture obtained in step 2) to step 3) while it is hot In the obtained gel matrix, stir and mix and cool to obtain a gel.

technical field

[0001] The invention relates to the technical field of medicine, in particular to a composition for preventing and treating infantile eczema and a preparation method thereof. Background technique

[0002] Eczema (eczema) is a clinically common allergic skin disease mainly manifested as redness, swelling and itching, which may be accompanied by symptoms such as chapping, blistering, bleeding, scabbing, and peeling. Pediatric eczema, also known as atopic dermatitis (AD), atopic dermatitis, and atopic dermatitis, is a chronic, relapsing, inflammatory skin condition that is more common in infancy and can be extended to childhood and adulthood. Diseases are mainly caused by allergies or intolerances to food, inhalants or contact substances. Children with eczema often have a red rash on the skin first, followed by rough and desquamated skin, and the eczema performance can be aggravated in the case of hot and humid conditions. Because eczema often recurs, it often...

Examples

Embodiment 1

[0028] Each component of the composition described in the present embodiment and consumption thereof are as shown in the following table:

[0029] components Dosage Compound of formula I 3g Allantoin 0.2g Carbomer 940 15g Tragacanth Gum 10g Cross-linked sodium polyacrylate (SDB-L-400) 5g Sodium carboxymethyl cellulose 5g Sodium edetate 1g Tween 80 2g Benzalkonium chloride 1g Propylene Glycol 150g water Add to 1000g

[0030] Its preparation method is: 1) mix the compound of formula I and allantoin evenly; 2) will account for the propylene glycol of 25% of the total weight of propylene glycol and the water of 25% of the total weight of water are mixed to form a mixed medium, heated to 45 ℃, then add the mixture obtained in step 1) under stirring and make it fully dissolved; 3) Carbomer 940, tragacanth gum, cross-linked sodium polyacrylate, sodium carboxymethylcellulose, Sodium acetate, Tween 80, be...

Embodiment 2

[0032] Each component of the composition described in the present embodiment and consumption thereof are as shown in the following table:

[0033] components Dosage Compound of formula I 5g Allantoin 0.4g Carbomer 940 20g Tragacanth Gum 15g Cross-linked sodium polyacrylate (SDB-L-400) 10g Sodium carboxymethyl cellulose 10g Sodium edetate 1g Tween 80 2g Benzalkonium chloride 1g Propylene Glycol 150g water Add to 1000g

[0034] Its preparation method is: 1) mix the compound of formula I and allantoin evenly; 2) will account for the propylene glycol of 25% of the total weight of propylene glycol and the water of 25% of the total weight of water are mixed to form a mixed medium, heated to 45 ℃, then add the mixture obtained in step 1) under stirring and make it fully dissolved; 3) Carbomer 940, tragacanth gum, cross-linked sodium polyacrylate, sodium carboxymethylcellulose, Sodium acetate, Tween 80, ...

Embodiment 3

[0036] Each component of the composition described in the present embodiment and consumption thereof are as shown in the following table:

[0037]

[0038]

[0039]Its preparation method is: 1) mix the compound of formula I and allantoin evenly; 2) will account for the propylene glycol of 25% of the total weight of propylene glycol and the water of 25% of the total weight of water are mixed to form a mixed medium, heated to 45 ℃, then add the mixture obtained in step 1) under stirring and make it fully dissolved; 3) Carbomer 940, tragacanth gum, cross-linked sodium polyacrylate, sodium carboxymethylcellulose, Sodium acetate, Tween 80, benzalkonium chloride, the remaining amount of propylene glycol and the remaining amount of water are stirred at 45°C until a uniform gel matrix is ​​obtained; 4) Add the mixture obtained in step 2) to step 3) while it is hot In the obtained gel matrix, stir and mix and cool to obtain a gel.

Images