Radiotherapy positioning developing solution and positioning developing marking patch

Abstract

The present invention relates to a radiotherapy positioning developer and a developing mark patch, wherein the radiotherapy positioning developer comprises the following raw material components in parts by weight: 5-10 parts of genipin, 0.2-0.8 parts of xanthan gum, 1-10 parts of carmine powder, 80-100 parts of anhydrous ethanol, 1-8 parts of sorbitol, 0.0001-0.4 parts of acetic acid, and 80-100 parts of water. The positioning developing mark patch comprises a hard cross marking peeling layer, a PU film layer, a silicone skeleton layer, an adhesive layer, a developer adsorption layer, and a lower peeling layer. The radiotherapy positioning developer of the present invention not only shortens the reaction time, but also greatly improves the coloring effect, and the skin mark can be maintained for 15-20 days. The positioning developing mark patch of the present invention has an ingenious structure, the effect formed by the patch is more lasting, and the cross marking line is straighter and will not be crooked. Even if the body surface is uneven, it can be operated normally without affecting the normal activities of the patient.

Description

Technical Field

[0001] The invention relates to a radiotherapy positioning developing solution and a developing marking patch, belonging to the field related to skin coloring and the technical field of radiotherapy. Background Art

[0002] At present, malignant tumors have become the main factor threatening the health and life of the people, and have brought heavy economic and social burdens to the country, society, families and individuals. Radiotherapy is one of the main means of treating malignant tumors. Most cancer patients need to receive radiotherapy for different purposes at different stages of the disease. The ideal goal of tumor radiotherapy is to give the tumor target area a sufficiently large therapeutic dose, while minimizing the radiation dose to the surrounding normal tissues, especially important organs and sensitive organs. To achieve this goal, accurate positioning of the tumor is the key.

[0003] Surface marking is a commonly used technology in radiotherapy positioning. In current clinical work, there are no standardized and systematic radiotherapy positioning marking products. Most of them use marking liquid with fuchsin as the main raw material, and bamboo sticks are dipped in the marking liquid for operation. However, this kind of marking liquid contains chemicals, which are toxic and harmful to human skin, and can easily cause skin allergies. Skin marking can only last for 3 to 5 days. Some medical institutions use marking pens, but the lines drawn by the marking pens on the surface of the body are prone to crooked, difficult to use, and can only last for 3 to 5 days, which brings considerable trouble to medical staff. In addition, both the marking liquid with fuchsin as the main raw material and the ordinary marker pen have the problem of easy fading, especially when the weather is hot or the patient is prone to sweating. The above marking liquids will seriously fade in 2 to 3 days [see the attached manual Figure 1 】, repositioning is required to confirm the position of the positioning line, resulting in secondary errors and delaying the patient's treatment. Summary of the invention

[0004] The purpose of the present invention is to overcome the deficiencies in the prior art and provide a radiotherapy positioning developing solution and a positioning developing marking patch.

[0005] The first object of the present invention is achieved by the following technical solutions:

[0006] The radiotherapy localization developing solution is characterized in that the radiotherapy localization developing solution comprises the following raw material components in parts by weight: 5 to 10 parts of genipin, 0.2 to 0.8 parts of xanthan gum, 1 to 10 parts of carmine powder, 80 to 100 parts of anhydrous ethanol, 1 to 8 parts of sorbitol, 0.0001 to 0.4 parts of acetic acid, and 80 to 100 parts of water.

[0007] As a further improvement of the radiotherapy localization developing solution, the radiotherapy localization developing solution is prepared according to the following steps:

[0008] (1) Take xanthan gum powder and purified water, add 0.2 to 0.8 g of xanthan gum powder to 100 ml of purified water, add the xanthan gum powder to purified water at room temperature, stir well to dissolve, and prepare a primary colloid;

[0009] (2) adding 1 to 8% by weight of sorbitol, 0.0001 to 0.4% by weight of acetic acid, and 1 to 10% by weight of carmine powder to the primary colloid obtained in step (1), and then stirring the mixture to obtain an intermediate colloid;

[0010] (3) taking genipin powder and anhydrous ethanol, adding 5 to 10 g of genipin powder to 100 ml of anhydrous ethanol, adding the genipin powder to the anhydrous ethanol, stirring and dissolving, and preparing a genipin ethanol solution;

[0011] (4) Take the intermediate colloid prepared in step (2) and the genipin ethanol solution prepared in step (3), add 80-120 ml of the genipin ethanol solution to every 100 ml of the intermediate colloid, and mix the two thoroughly to form a uniform solution, which is the radiotherapy localization developing solution.

[0012] As a further improvement of the radiotherapy localization developing solution, in the step (1), 0.4 g of xanthan gum powder is added to every 100 ml of pure water.

[0013] As a further improvement of the radiotherapy localization developing solution, in the step (2), 2% by weight of sorbitol, 0.001% by weight of acetic acid, and 5% by weight of carmine powder are added to every 100 ml of the primary colloid.

[0014] As a further improvement of the radiotherapy localization developing solution, in the step (3), 10 g of genipin powder is added to every 100 ml of anhydrous ethanol.

[0015] As a further improvement of the radiotherapy localization developing solution, in the step (4), 100 ml of genipin ethanol solution is added to every 100 ml of the intermediate colloid.

[0016] The second object of the present invention is achieved by the following technical solutions:

[0017] The positioning and developing marking patch is characterized in that it includes a hard cross marking peeling layer, a PU film layer, a silicone skeleton layer, an adhesive layer, a developer adsorption layer and a lower peeling layer; the hard cross marking peeling layer is located at the topmost layer of the entire marking patch, and the hard cross marking peeling layer includes a hard cross marking and an upper peeling layer. The hard cross marking plays a supporting role and keeps coincidence with the laser light during operation, which is convenient for operation and ensures radiotherapy positioning accuracy. The upper peeling layer serves as a carrier of the hard cross marking, which facilitates the peeling of the hard cross marking peeling layer after the operation is completed; the PU film layer is arranged on the lower surface of the hard cross marking peeling layer, and the specification and size of the PU film layer are the same as those of the hard cross marking peeling layer. The layer is used to be closely attached to the skin surface; the silicone skeleton layer is arranged on the lower surface of the PU film layer, the silicone skeleton layer uses the PU film layer as a carrier, the silicone skeleton layer is cross-shaped, and the silicone skeleton layer is made of a silicone material with soft texture and good toughness; the developer absorption layer is arranged on the lower surface of the silicone skeleton layer, the developer absorption layer and the silicone skeleton layer are bonded to each other through an adhesive layer, the developer absorption layer is made of a material that can absorb liquid, and the developer absorption layer absorbs and stores developer, and the developer adopts the radiotherapy positioning developer of the present invention; the lower peeling layer is arranged on the lower surface of the developer absorption layer, as the lowermost layer of the entire marking patch, and is peeled off in advance when used.

[0018] As a further improvement of the positioning and developing mark patch, the hard cross marking is made of PVC material, and the hard cross marking includes an integrally arranged cross-shaped support rib and a support sheet, and the support sheet is diamond-shaped or square-shaped, and the cross-shaped support rib is located on the diagonal of the support sheet, and the four ends of the cross-shaped support rib extend to the midpoints of the four sides of the upper peeling layer, and the cross-shaped support rib coincides with the silicone skeleton layer in the projection direction; two of the diagonals of the upper peeling layer are provided with S-shaped tear notches, and the two ends of the S-shaped tear extend to the corresponding two side edges, respectively.

[0019] As a further improvement of the positioning and developing mark patch, the upper surface of the silicone skeleton layer is arc-shaped along the width direction.

[0020] As a further improvement of the positioning developing mark patch, the developer absorption layer is made of oil-absorbing paper, and the lower peeling layer is made of release paper.

[0021] Compared with the prior art, the present invention has the following advantages:

[0022] 1) After the radiotherapy positioning developer of the present invention is applied to the skin, it adheres to the skin surface, and genipin can react with the surface skin for a long time, greatly improving the coloring effect, and the skin mark can be maintained for 15 to 20 days; since the operation takes a very short time, it does not affect the subsequent operations of radiotherapy positioning and does not prolong the radiotherapy positioning time.

[0023] 2) The positioning and developing marking patch of the present invention has an ingenious structure. Compared with conventional marking pens, the effect formed by the patch is more lasting, and the cross is straighter without any crookedness. It can be operated normally even if the body surface is uneven, and will not affect the patient's normal activities, and the patch position will not change due to the patient's activities. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The figure is a schematic diagram comparing the coloring effects of a marker pen, a magenta marking solution, and the radiotherapy localization developing solution prepared in Examples 1 to 3 at different time points after being applied to the skin respectively.

[0025] Figure 2 This is a schematic diagram of the layer structure of the positioning and developing mark application of Example 5.

[0026] Figure 3 This is a top view of the structure of the hard cross-marked release layer in the positioning and developing mark patch of Example 5.

[0027] Figure 4 This is a top view of the structure of the silicone skeleton layer in the positioning and developing mark patch of Example 5.

[0028] Figure 5 for Figure 4 The AA section enlarged view.

[0029] Explanation of the accompanying drawings: 1-hard cross marking peeling layer, 11-hard cross marking, 12-upper peeling layer, 11a-cross-shaped supporting ribs, 11b-supporting sheet, 12a-S-shaped tear, 2-PU film layer, 3-silicone skeleton layer, 4-adhesive layer, 5-developer adsorption layer, 6-lower peeling layer. DETAILED DESCRIPTION

[0030] The present invention will be further described below in conjunction with specific drawings and embodiments.

[0031] Example 1: Preparation of radiotherapy localization developing solution

[0032] (1) Take xanthan gum powder and purified water, add 0.6 g of xanthan gum powder to 100 ml of purified water, add the xanthan gum powder into purified water at room temperature, stir well to dissolve, and prepare a primary colloid;

[0033] (2) adding 1% by weight of sorbitol, 0.0001% by weight of acetic acid, and 2% by weight of carmine powder to the primary colloid obtained in step (1), and then stirring the mixture to obtain an intermediate colloid;

[0034] (3) taking genipin powder and anhydrous ethanol, adding 10 g of genipin powder to 100 ml of anhydrous ethanol, adding the genipin powder to the anhydrous ethanol, stirring and dissolving, and preparing a genipin ethanol solution;

[0035] (4) Take the intermediate colloid prepared in step (2) and the genipin ethanol solution prepared in step (3), add 100 ml of the intermediate colloid to 100 ml of the genipin ethanol solution, and mix the two thoroughly to form a uniform solution, which is the radiotherapy localization developing solution.

[0036] Example 2: Preparation of radiotherapy localization developing solution

[0037] (1) Take xanthan gum powder and purified water, add 0.2 g of xanthan gum powder to purified water at room temperature, stir well to dissolve, and prepare a primary colloid;

[0038] (2) adding 2% by weight of sorbitol, 0.1% by weight of acetic acid, and 5% by weight of carmine powder to the primary colloid obtained in step (1), and then stirring the mixture to obtain an intermediate colloid;

[0039] (3) taking genipin powder and anhydrous ethanol, adding 5 g of genipin powder to 100 ml of anhydrous ethanol, adding the genipin powder to the anhydrous ethanol, stirring and dissolving, and preparing a genipin ethanol solution;

[0040] (4) Take the intermediate colloid prepared in step (2) and the genipin ethanol solution prepared in step (3), add 80 ml of the genipin ethanol solution to every 100 ml of the intermediate colloid, and mix the two thoroughly to form a uniform solution, which is the radiotherapy localization developing solution.

[0041] Example 3: Preparation of radiotherapy localization developing solution

[0042] (1) Take xanthan gum powder and purified water, add 0.8 g of xanthan gum powder to 100 ml of purified water, add the xanthan gum powder into purified water at room temperature, stir well to dissolve, and prepare a primary colloid;

[0043] (2) adding 8% by weight of sorbitol, 0.4% by weight of acetic acid, and 10% by weight of carmine powder to the primary colloid obtained in step (1), and then stirring the mixture to obtain an intermediate colloid;

[0044] (3) taking genipin powder and anhydrous ethanol, adding 8 g of genipin powder to 100 ml of anhydrous ethanol, adding the genipin powder to the anhydrous ethanol, stirring and dissolving, and preparing a genipin ethanol solution;

[0045] (4) Take the intermediate colloid prepared in step (2) and the genipin ethanol solution prepared in step (3), add 120 ml of the genipin ethanol solution to every 100 ml of the intermediate colloid, and mix the two thoroughly to form a uniform solution, which is the radiotherapy localization developing solution.

[0046] In the present invention, the genipin powder can be 98% genipin powder or 95% genipin powder, and the total usage amount only needs to be kept consistent.

[0047] Example 4: Coloring comparison test

[0048] Using the radiotherapy positioning developer prepared in Example 1 and Example 2 as raw materials, two developing positioning marking patches with the structure of the present invention were prepared; using the radiotherapy positioning developer in Example 3 as raw materials, a marking pen was prepared; then the two developing positioning marking patches and marking pens with the structure of the present invention were used to perform a skin marking comparison test with a traditional magenta marking pen and a marker pen, and the skin was bathed normally and the coloring effects at different results and time points were recorded. The results are as follows Figure 1 shown.

[0049] from Figure 1 It can be seen that after the developing positioning marker patch made of the radiotherapy positioning developer of Example 1 and Example 2 of the present invention is applied to the skin surface, the developer adhering to the skin surface continues to react with the skin surface. Since the operation time is very short, it does not affect the subsequent operation of radiotherapy positioning, does not prolong the radiotherapy positioning time, and can be operated normally under the condition of uneven body surface. The skin mark can be maintained for 15 to 20 days or even longer. Compared with the magenta marker pen and the mark pen, the marking pen made of the radiotherapy positioning developer of Example 3 can be maintained for a longer time, but the effect is slightly worse than that of the developing positioning marker patch.

[0050] The skin is composed of the epidermis, dermis and subcutaneous tissue. The epidermis is composed of the basement membrane, basal layer and stratum corneum. Due to the metabolism of the skin, basal cells differentiate and proliferate to form new keratinocytes, and the aged keratinocytes fall off. This metabolic cycle is usually 2 to 4 weeks. As the aged keratinocytes fall off, the blue color produced by genipin contacting the skin gradually fades. Therefore, the coloring time of genipin on the skin is 2 to 4 weeks. However, due to the effects of sweat, washing and rubbing, the coloring time is generally about 15 to 20 days.

[0051] The mechanism of genipin skin dyeing is: after genipin contacts the skin, it undergoes a cross-linking reaction with the keratinocytes in the outer layer of the skin to form a blue substance, gardenia blue pigment. Generally speaking, genipin develops color 2 to 4 hours after contacting the skin. It is light blue at first, then the color gradually deepens to navy blue or blue-black, and slowly fades after 10 to 15 days. Since the longer the reaction time between genipin and the skin, the better the coloring effect, it has not yet been used in radiotherapy positioning. The radiotherapy positioning developer of the present invention uses genipin as the main raw material, and it is reasonably proportioned with xanthan gum powder, carmine powder, sorbitol powder, acetic acid, anhydrous ethanol and other substances. Genipin is used as the main raw material, and increasing the concentration of genipin can accelerate the reaction speed and improve the coloring effect. Xanthan gum is dissolved in pure water to form xanthan gum colloid. Since xanthan gum colloid has adhesiveness, the developer can adhere to the surface of the skin, so that genipin continues to react with the skin, thereby improving the coloring effect. Anhydrous ethanol is not only an excellent solvent for genipin, but also an important raw material for the developer to dry. Carmine powder is non-toxic, red, and easily soluble in water, making it easy to display the trajectory of the drawn positioning line. Acetic acid is a pH regulator, and genipin can increase the reaction rate with the skin and intensify the coloring effect in a weak acid environment. Sorbitol is a humectant that can extend the storage time.

[0052] Example 5

[0053] like Figure 1 to Figure 3 As shown, Example 5 discloses a positioning and developing marking patch, comprising a hard cross marking peeling layer 1, a PU film layer 2, a silicone skeleton layer 3, an adhesive layer 4, a developer adsorption layer 5 and a lower peeling layer 6; the hard cross marking peeling layer 1 is located at the top layer of the entire marking patch, the hard cross marking peeling layer 1 comprises a hard cross marking 11 and an upper peeling layer 12, the hard cross marking 11 plays a supporting role, and keeps coincidence with the laser light during operation, which is convenient for operation and ensures radiotherapy positioning accuracy, and the upper peeling layer 12 serves as a carrier of the hard cross marking 11, which is convenient for peeling off the hard cross marking peeling layer 1 after the operation is completed; the PU film layer 2 is arranged on the lower surface of the hard cross marking peeling layer 1, and the specification and size of the PU film layer 2 are the same as those of the hard cross marking peeling layer 1, The PU film layer 2 is used to be closely attached to the skin surface; the silicone skeleton layer 3 is arranged on the lower surface of the PU film layer 2, the silicone skeleton layer 3 uses the PU film layer 2 as a carrier, the silicone skeleton layer 3 is cross-shaped, and the silicone skeleton layer 3 is made of a silicone material with soft texture and good toughness; the developer adsorption layer 5 is arranged on the lower surface of the silicone skeleton layer 3, the developer adsorption layer 5 and the silicone skeleton layer 3 are bonded to each other through the adhesive layer 4, the developer adsorption layer 5 is made of a material that can absorb liquid, and the developer adsorption layer 5 absorbs and stores developer, and the developer uses the radiotherapy positioning developer in Examples 1 to 3; the lower peeling layer 6 is arranged on the lower surface of the developer adsorption layer 5, as the lowermost layer of the entire marking patch, and is peeled off in advance when used.

[0054] When using it, first tear off the lower peeling layer 6, and then stick the positioning development mark patch on the appropriate position of the patient's skin. During the operation, it is necessary to make sure that the hard cross mark 11 in the hard cross mark peeling layer 1 is kept overlapped with the laser light. After sticking, the hard cross mark peeling layer 1 is peeled off. Figure 2 The mark formed by applying the positioning developing marking patch of the present invention is shown in the figure. It can be seen from the mark that compared with the conventional marking pen, the effect formed by the patch is more durable, and the cross is straighter and not crooked.

[0055] like Figure 3 As shown, in this embodiment 5, the hard cross mark 11 is made of PVC material, and the hard cross mark 11 includes an integrally arranged cross-shaped support rib 11a and a support sheet 11b, and the support sheet 11b is rhombus or square, and the cross-shaped support rib 11a is located on the diagonal of the support sheet 11b, and the four ends of the cross-shaped support rib 11a extend to the midpoints of the four sides of the upper peeling layer 12 respectively, and the cross-shaped support rib 11a coincides with the silicone skeleton layer 3 in the projection direction; two of the diagonals of the upper peeling layer 12 are provided with S-shaped tear 12a, and the two ends of the S-shaped tear 12a extend to the corresponding two side edges respectively.

[0056] like Figure 4 As shown, in this embodiment 5, the upper surface of the silicone skeleton layer 3 is arc-shaped along the width direction. With such a configuration, when the silicone skeleton layer 3 is attached to the skin surface and fastened by the PU film layer 2, its position will be relatively stable and generally will not change with the movement of the human body. The silicone skeleton layer 3 is the core layer of the entire positioning and developing marking application. The size of the silicone skeleton layer 3 can be adjusted as needed. Preferably, the width of the silicone skeleton layer 3 is set to 1.5-2.5mm, so that the width of the marking line formed is appropriately thick. The silicone skeleton layer 3 is preferably made of food-grade silicone material, which is soft and tough, has good skin fit, can still be operated in uneven places on the skin, and is also very safe and not easy to cause skin allergies. The PU film layer 2 in the present invention serves as a carrier of the silicone skeleton layer 3. When used, it is tightly attached to the skin surface, is not easy to cause skin allergies, and has excellent waterproof performance.

[0057] In the present invention, the developer absorption layer 5 is preferably made of oil-absorbing paper, which can absorb the developer well and absorb part of the oil on the skin surface to improve the coloring effect. Of course, the developer absorption layer 5 can also be made of other materials similar to oil-absorbing paper, as long as it can achieve the purpose of absorbing the developer.

[0058] In the present invention, the lower peeling layer 6 is preferably made of release paper, which is used to protect the developer absorption layer 5 pre-soaked with developer from contamination, making it convenient for product storage and operation. The adhesive layer 4 can be made of existing medical grade adhesive that is not easy to cause skin allergies, or it can be made of natural plant adhesive.

[0059] The above description is only a preferred embodiment of the present invention, and the above specific embodiment is not intended to limit the present invention. Various deformations and modifications may occur within the scope of the technical concept of the present invention, and any modification, modification or equivalent replacement made by a person of ordinary skill in the art based on the above description shall fall within the scope of protection of the present invention.

Claims

1. A radiotherapy localization developing solution, characterized in that: The radiotherapy localization developing solution comprises the following raw material components in parts by weight: 5-10 parts of genipin, 0.2-0.8 parts of xanthan gum, 1-10 parts of carmine powder, 80-100 parts of anhydrous ethanol, 1-8 parts of sorbitol, 0.0001-0.4 parts of acetic acid, and 80-100 parts of water; the radiotherapy localization developing solution is prepared according to the following steps: (1) Take xanthan gum powder and purified water, add 0.2 to 0.8 g of xanthan gum powder to 100 ml of purified water, add the xanthan gum powder to purified water at room temperature, stir well to dissolve, and prepare a primary colloid; (2) Adding 1 to 8% by weight of sorbitol, 0.0001 to 0.4% by weight of acetic acid, and 1 to 10% by weight of carmine powder to the primary colloid obtained in step (1), and then stirring the mixture to obtain an intermediate colloid; (3) Take genipin powder and anhydrous ethanol, add 5 to 10 g of genipin powder to 100 ml of anhydrous ethanol, add the genipin powder to the anhydrous ethanol, stir well to dissolve, and prepare a genipin ethanol solution; (4) Take the intermediate colloid prepared in step (2) and the genipin ethanol solution prepared in step (3), add 80 to 120 ml of the genipin ethanol solution to every 100 ml of the intermediate colloid, and mix the two thoroughly to form a uniform solution, which is the radiotherapy localization developing solution.

2. The radiotherapy localization developing solution according to claim 1, characterized in that: In the step (1), 0.4 g of xanthan gum powder is added to every 100 ml of purified water.

3. The radiotherapy localization developing solution according to claim 2, characterized in that: In the step (2), 2% by weight of sorbitol, 0.001% by weight of acetic acid, and 5% by weight of carmine powder are added to every 100 ml of the primary colloid.

4. The radiotherapy localization developing solution according to claim 3, characterized in that: In the step (3), 10 g of genipin powder is added to every 100 ml of anhydrous ethanol.

5. The radiotherapy localization developing solution according to claim 4, characterized in that: In the step (4), 100 ml of genipin ethanol solution is added to every 100 ml of the intermediate colloid.

6. Positioning and developing marking patch, characterized in that: The present invention comprises a hard cross marking peeling layer (1), a PU film layer (2), a silicone skeleton layer (3), an adhesive layer (4), a developer adsorption layer (5) and a lower peeling layer (6); the hard cross marking peeling layer (1) is located at the top layer of the entire marking patch, the hard cross marking peeling layer (1) comprises a hard cross marking (11) and an upper peeling layer (12), the hard cross marking (11) plays a supporting role, and keeps coincidence with the laser light during operation, so as to facilitate operation and ensure radiotherapy positioning accuracy, and the upper peeling layer (12) serves as a carrier of the hard cross marking (11), so as to facilitate peeling of the hard cross marking peeling layer (1) after the operation is completed; the PU film layer (2) is arranged on the lower surface of the hard cross marking peeling layer (1), the specification and size of the PU film layer (2) are the same as those of the hard cross marking peeling layer (1), and the PU film layer (2) is used to tightly The silicone skeleton layer (3) is closely attached to the skin surface; the silicone skeleton layer (3) is arranged on the lower surface of the PU film layer (2), the silicone skeleton layer (3) uses the PU film layer (2) as a carrier, the silicone skeleton layer (3) is in a cross shape, and the silicone skeleton layer (3) is made of a silicone material with a soft texture and good toughness; the developer absorption layer (5) is arranged on the lower surface of the silicone skeleton layer (3), the developer absorption layer (5) and the silicone skeleton layer (3) are bonded to each other through an adhesive layer (4), the developer absorption layer (5) is made of a material capable of absorbing liquid, the developer absorption layer (5) absorbs and stores developer, and the developer is the radiotherapy positioning developer according to any one of claims 1 to 5; the lower peeling layer (6) is arranged on the lower surface of the developer absorption layer (5), serving as the lowermost layer of the entire marking patch, and is peeled off in advance when in use.

7. The positioning and developing marking patch according to claim 6, characterized in that: The hard cross marking (11) is made of PVC material, and comprises an integrally arranged cross-shaped support rib (11a) and a support sheet (11b); the support sheet (11b) is rhombus-shaped or square-shaped; the cross-shaped support rib (11a) is located on the diagonal of the support sheet (11b); the four ends of the cross-shaped support rib (11a) respectively extend to the midpoints of the four sides of the upper peeling layer (12); and the cross-shaped support rib (11a) coincides with the silicone skeleton layer (3) in the projection direction; two of the diagonal portions of the upper peeling layer (12) are provided with S-shaped tearing notches (12a); the two ends of the S-shaped tearing notches (12a) respectively extend to two corresponding side edges.

8. The positioning and developing marking patch according to claim 6, characterized in that: The upper surface of the silicone skeleton layer (3) is arc-shaped along the width direction.

9. The positioning and developing marking patch according to claim 6, characterized in that: The developer absorption layer (5) is made of oil-absorbing paper, and the lower peeling layer (6) is made of release paper.

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